Simon J. Cook - Publications, H-index & Citations

Simon J. Cook

University of Dundee

60H指数

243论文数

1.3W被引数

收录论文 102

发表时间

Monitoring glacier evolution and assessing glacial lake outburst flood (GLOF) susceptibility in the Bolivian Andes 监测玻利维亚安第斯山脉的冰川演变并评估冰川湖爆发洪水 (GLOF) 敏感性

Journal of Glaciology

IF2.6

2026-01-31

OAAI

Jamie Luke MacManaway; Simon J. Cook; Mark E. Cutler

RAF inhibitors activate the integrated stress response by direct activation of GCN2 RAF抑制剂通过直接激活GCN2来激活整合应激反应

Nature Communications

IF15.7

2025-11-17

OAAI

Rebecca Gilley; Andrew M. Kidger; Graham Neill; Eve Morrison; Paul Severson; Dominic P. Byrne; Niall S. Kenneth; Gideon Bollag; Chao Zhang; Taiana Maia de Oliveira; Patrick A. Eyers; Richard Bayliss; Glenn R. Masson; Simon J. Cook

Hypoxia drives HIF2-dependent reversible macrophage cell cycle entry

CELL REPORTS

IF6.9

2024-07-01

OAAI

Meng, Bo; Zhao, Na; Mlcochova, Petra; Ferreira, Isabella A. T. M.; Ortmann, Brian M.; Davis, Tanja; Wit, Niek; Rehwinkel, Jan; Cook, Simon; Maxwell, Patrick H.; Nathan, James A.; Gupta, Ravindra K.

EU-LIFE charter of independent life science research institutes 欧盟-独立生命科学研究机构的生命宪章

FEBS LETTERS

IF3

2024-03-21

OAAI

Superti-Furga, Giulio; Agostinho, Marta; Bury, Jo; Cook, Simon; Durinx, Christine; Ender, Anita; van Luenen, Henri; Lund, Anders H.; Medema, Rene H.; Miaczynska, Marta; Nickel, Dorthe; Pelicci, Pier Giuseppe; Puisieux, Alain; Ripatti, Samuli; Sander, Maike; Schubeler, Dirk; Serrano, Luis; Sommer, Thomas; Sonne-Hansen, Katrine; Tomancak, Pavel; Vives, Joan; Vontas, John; Bettencourt-Dias, Monica

Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway

BIOCHEMICAL JOURNAL

IF4.3

2024-03-07

OAAI

Weatherdon, Laura; Stuart, Kate; Cassidy, Megan; de la Gandara, Alberto Moreno; Okkenhaug, Hanneke; Muellener, Markus; Mckenzie, Grahame; Cook, Simon J.; Gilley, Rebecca

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

BIOCHEMICAL JOURNAL

IF4.3

2023-05-04

OAAI

Balmanno, Kathryn; Kidger, Andrew M.; Byrne, Dominic P.; Sale, Matthew J.; Nassman, Nejma; Eyers, Patrick A.; Cook, Simon J.

ΔRaf-1:ER* bypasses the cyclic AMP block of extracellular signal-regulated kinase 1 and 2 activation but not CDK2 activation or cell cycle reentry

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Balmanno, K; Millar, T; McMahon, M; Cook, SJ

Escape from G1 arrest during acute MEK inhibition drives the acquisition of drug resistance

NAR CANCER

IF3.2

2022-10-17

OAAI

Channathodiyil, Prasanna; May, Kieron; Segonds-Pichon, Anne; Smith, Paul D.; Cook, Simon J.; Houseley, Jonathan

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-04-25

OAAI

Miller, Duncan C.; Reuillon, Tristan; Molyneux, Lauren; Blackburn, Timothy; Cook, Simon J.; Edwards, Noel; Endicott, Jane A.; Golding, Bernard T.; Griffin, Roger J.; Hardcastle, Ian; Harnor, Suzannah J.; Heptinstall, Amy; Lochhead, Pamela; Martin, Mathew P.; Martin, Nick C.; Myers, Stephanie; Newell, David R.; Noble, Richard A.; Phillips, Nicole; Rigoreau, Laurent; Thomas, Huw; Tucker, Julie A.; Wang, Lan-Zhen; Waring, Michael J.; Wong, Ai-Ching; Wedge, Stephen R.; Noble, Martin E. M.; Cano, Celine

Environmental Sustainability and Supply Resilience of Cobalt

SUSTAINABILITY

IF3.3

2022-03-30

OAAI

Earl, Cathryn; Shah, Izhar Hussain; Cook, Simon; Cheeseman, Christopher Robert

IKKα plays a major role in canonical NF-KB signalling in colorectal cells

BIOCHEMICAL JOURNAL

IF4.3

2022-02-04

OAAI

Prescott, Jack A.; Balmanno, Kathryn; Mitchell, Jennifer P.; Okkenhaug, Hanneke; Cook, Simon J.

Inhibitory feedback control of NF-KB signalling in health and disease

BIOCHEMICAL JOURNAL

IF4.3

2021-07-16

109

OAAI

Prescott, Jack A.; Mitchell, Jennifer P.; Cook, Simon J.

CDK1, the Other 'Master Regulator' of Autophagy

TRENDS IN CELL BIOLOGY

IF18.1

2021-02-01

OAAI

Odle, Richard, I; Florey, Oliver; Ktistakis, Nicholas T.; Cook, Simon J.

Inhibition of RAF dimers: it takes two to tango

BIOCHEMICAL SOCIETY TRANSACTIONS

IF4.3

2020-12-24

OAAI

Cook, Frazer A.; Cook, Simon J.

Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for ...

BIOCHEMICAL SOCIETY TRANSACTIONS

IF4.3

2020-09-11

OAAI

Cook, Simon J.; Tucker, Julie A.; Lochhead, Pamela A.

Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors

NATURE COMMUNICATIONS

IF15.7

2020-03-13

OAAI

Lochhead, Pamela A.; Tucker, Julie A.; Tatum, Natalie J.; Wang, Jinhua; Oxley, David; Kidger, Andrew M.; Johnson, Victoria P.; Cassidy, Megan A.; Gray, Nathanael S.; Noble, Martin E. M.; Cook, Simon J.

Macroautophagy is repressed during mitosis - seeing is believing

AUTOPHAGY

IF14.3

2020-02-20

OAAI

Odle, Richard I.; Cook, Simon J.

Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2

MOLECULAR CANCER THERAPEUTICS

IF5.5

2020-02-06

OAAI

Kidger, Andrew M.; Munck, Joanne M.; Saini, Harpreet K.; Balmanno, Kathryn; Minihane, Emma; Courtin, Aurelie; Graham, Brent; O'Reilly, Marc; Odle, Richard; Cook, Simon J.

An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis 有丝分裂过程中mTORC1-to-CDK1开关维持自噬抑制

MOLECULAR CELL

IF16.6

2020-01-01

OAAI

Odle, Richard I.; Walker, Simon A.; Oxley, David; Kidger, Andrew M.; Balmanno, Kathryn; Gilley, Rebecca; Okkenhaug, Hanneke; Florey, Oliver; Ktistakis, Nicholas T.; Cook, Simon J.

Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors

NATURE COMMUNICATIONS

IF15.7

2019-11-14

OAAI

Sale, Matthew J.; Minihane, Emma; Monks, Noel R.; Gilley, Rebecca; Richards, Frances M.; Schifferli, Kevin P.; Andersen, Courtney L.; Davies, Emma J.; Vicente, Mario Aladren; Ozono, Eiko; Markovets, Aleksandra; Dry, Jonathan R.; Drew, Lisa; Flemington, Vikki; Proia, Theresa; Jodrell, Duncan I.; Smith, Paul D.; Cook, Simon J.

研究方向