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T

Takashi Saito

riken center for brain science
H指数:70
被引数:1.7万

个人简介

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教育背景

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工作经历

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荣誉奖项

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APOE3 and APOE4 human astrocytes differentially modulate Alzheimer's disease pathology and microglial responses in chimeric mice

APOE3和APOE4人星形胶质细胞在嵌合小鼠中差异调节阿尔茨海默病病理和微胶质细胞反应

Cell Reports
IF6.9
2026-08-010
OAAI
Cruz-Sese, Joan; Miron-Alcala, Marta; Alfonso-Triguero, Maria; Olalde, Jon; Ruiz, Leire; Galbis-Gramage, Nuria; Cortes, Lorea; Escobar, Laura; Preman, Pranav; Snellinx, An; Saito, Takashi; Saido, Takaomi C.; Saiz-Auz, Laura; Rabano-Gutierrez, Alberto; Aransay, Ana M.; Diez, Ibai; Tcw, Julia; Goate, Alison; De Strooper, Bart; Alberdi, Elena; Arranz, Amaia M.
Early and progressive retinal microglial changes in APPNL-F/NL-F mouse model of Alzheimer’s disease revealed by an automated image analysis software

通过自动图像分析软件揭示的appnl-f/nl-f小鼠阿尔茨海默氏病模型的早期和进行性视网膜小胶质细胞变化

Frontiers in Aging Neuroscience
IF4.5
2026-01-300
OAAI
Lidia Sánchez-Puebla†; Inés López-Cuenca†; Miguel A. Sánchez-Puebla†; Ana Granados; Ana I. Ramírez; Juan Llorens; Takaomi C. Saido; Takashi Saito; Carmen Nieto-Vaquero; María A. Moro; Valentín Moreno; José M. Ramírez; Rosa de Hoz
Somatostatin receptor subtypes 1 and 4 regulate neprilysin, the major amyloid-β degrading enzyme in brain

生长抑素受体亚型1和4调节脑内主要的淀粉样蛋白-β降解酶——中性内肽酶。

Journal of Alzheimer’s Disease
IF0
2025-11-190
PRE
Per Nilsson; Karin Sörgjerd; Naomasa Kakiya; Hiroki Sasaguri; Naoto Watamura; Lovisa Johansson; Makoto Shimozawa; Satoshi Tsubuki; Zhulin Zhou; Raul Loera-Valencia; Risa Takamura; Misaki Sekiguchi; Aline Pegel; Stefan Schulz; Takashi Saito; Nobuhisa Iwata; Bengt Winblad; Takaomi C Saido
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds

在缺乏tau种子的情况下，tau的体内过度磷酸化与突触丢失和行为异常相关。

Nature Neuroscience
IF20
2024-12-240
OAAI
Naoto Watamura; Martha S. Foiani; Sumi Bez; Mathieu Bourdenx; Alessia Santambrogio; Claire Frodsham; Elena Camporesi; Gunnar Brinkmalm; Henrik Zetterberg; Saisha Patel; Naoko Kamano; Mika Takahashi; Javier Rueda-Carrasco; Loukia Katsouri; Stephanie Fowler; Emir Turkes; Shoko Hashimoto; Hiroki Sasaguri; Takashi Saito; AFM Saiful Islam; Seico Benner; Toshihiro Endo; Katsuji Kobayashi; Chiho Ishida; Michele Vendruscolo; Masahito Yamada; Karen E. Duff; Takaomi C. Saido
GLP-1 receptor signaling restores aquaporin 4 subcellular polarization in reactive astrocytes and promotes amyloid β clearance in a mouse model of Alzheimer's disease

GLP-1受体信号通路恢复了反应性星形胶质细胞中水通道蛋白4的亚细胞极化，并促进了阿尔茨海默病小鼠模型中β-淀粉样蛋白的清除。

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
IF2.2
2024-12-011
OAAI
Sasaki, Kana; Fujita, Hiroki; Sato, Takehiro; Kato, Shunske; Takahashi, Yuya; Takeshita, Yukio; Kanda, Takashi; Saito, Takashi; Saido, Takamori C.; Hattori, Satoko; Hozumi, Yasukazu; Yamada, Yuichiro; Waki, Hironori
Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models

机器学习在人源化和转基因阿尔茨海默病模型中揭示了显着的自发行为变化和治疗效果

CELL REPORTS
IF6.9
2024-11-010
OAAI
Miller, Stephanie R.; Luxem, Kevin; Lauderdale, Kelli; Nambiar, Pranav; Honma, Patrick S.; Ly, Katie K.; Bangera, Shreya; Bullock, Mary; Shin, Jia; Kaliss, Nick; Qiu, Yuechen; Cai, Catherine; Shen, Kevin; Mallen, K. Dakota; Yan, Zhaoqi; Mendiola, Andrew S.; Saito, Takashi; Saido, Takaomi C.; Pico, Alexander R.; Thomas, Reuben; Roberson, Erik D.; Akassoglou, Katerina; Bauer, Pavol; Remy, Stefan; Palop, Jorge J.
Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab
LIFE SCIENCE ALLIANCE
IF2.9
2024-09-300
OA
Iwata, Nobuhisa; Tsubuki, Satoshi; Sekiguchi, Misaki; Watanabe-Iwata, Kaori; Matsuba, Yukio; Kamano, Naoko; Fujioka, Ryo; Takamura, Risa; Watamura, Naoto; Kakiya, Naomasa; Mihira, Naomi; Morito, Takahiro; Shirotani, Keiro; Mann, David M. A.; Robinson, Andrew C.; Hashimoto, Shoko; Sasaguri, Hiroki; Saito, Takashi; Higuchi, Makoto; Saido, Takaomi C.

研究方向

暂未获取到该数据
T
Takaomi C. Saido
H 指数:112论文数:824被引数:5.0万
H
Hiroki Sasaguri
H 指数:23论文数:99被引数:3,554
Y
Yukio Matsuba
H 指数:16论文数:64被引数:3,503
B
Bart De Strooper
H 指数:142论文数:691被引数:7.7万
S
Shoko Hashimoto
H 指数:17论文数:53被引数:2,290
P
Per Nilsson
H 指数:34论文数:140被引数:5,796
N
Naoto Watamura
H 指数:14论文数:45被引数:685
N
Nobuhisa Iwata
H 指数:56论文数:212被引数:1.6万
S
Shigeo Murayama
H 指数:83论文数:763被引数:3.1万
N
Naoko Kamano
H 指数:9论文数:24被引数:499