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Anne Y. Saiki

Amgen
H指数:21
被引数:4,938

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LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers

LKB1调控JNK依赖性应激信号传导以及KRAS突变型肺癌的凋亡依赖性

NATURE COMMUNICATIONS
IF15.7
2025-05-020
OA
Li, Chendi; Syed, Mohammed Usman; Nimbalkar, Anahita; Shen, Yi; Vieira, Melissa D.; Fraser, Cameron; Inde, Zintis; Qin, Xingping; Ouyang, Jian; Kreuzer, Johannes; Clark, Sarah E.; Kelley, Grace; Hensley, Emily M.; Morris, Robert; Lazaro, Raul; Belmonte, Brian; Oh, Audris; Walcott, Makeba; Nabel, Christopher S.; Caenepeel, Sean; Saiki, Anne Y.; Rex, Karen; Lipford, J. Russell; Heist, Rebecca S.; Lin, Jessica J.; Haas, Wilhelm; Sarosiek, Kristopher; Hughes, Paul E.; Hata, Aaron N.
Identification of Structurally Novel KRASG12C Inhibitors through Covalent DNA-Encoded Library Screening

通过共价DNA编码库筛选鉴定结构新颖的KRASG12C抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-02-110
OA
Huang, David; Manoni, Francesco; Sun, Zhen; Liu, Rongfeng; Allen, Jennifer R.; Banerjee, Abhisek; Cee, Victor J.; Eshon, Josephine; Frohn, Michael J.; Kaller, Matthew R.; Lee, Heejun; Li, Cui; Li, Xun; Lopez, Patricia; Ma, Vu; Medina, Jose M.; Mohr, Christopher; Mukhina, Olga A.; Pickrell, Alexander J.; Stellwagen, John; Wu, Wenting; Zhang, Wenhan; Zhu, Kai; Dahal, Upendra P.; Hu, Liaoyuan A.; Leavitt, Monica; Li, Wencui; Li, Yu; Ma, Yingli; Rex, Karen; Saiki, Anne Y.; Wang, Paul; Sun, Yaping; Dai, Dongcheng; Tamayo, Nuria A.; Lanman, Brian A.
Diverse alterations associated with resistance to KRAS(G12C) inhibition
Nature
IF48.5
2021-11-100
PRE
Yulei Zhao; Yonina R. Murciano-Goroff; Jenny Y. Xue; Agnes Ang; Jessica Lucas; Trang T. Mai; Arnaud F. Da Cruz Paula; Anne Y. Saiki; Deanna Mohn; Pragathi Achanta; Ann E. Sisk; Kanika S. Arora; Rohan S. Roy; Dongsung Kim; Chuanchuan Li; Lee P. Lim; Mark Li; Amber Bahr; Brian R. Loomis; Elisa de Stanchina; Jorge S. Reis-Filho; Britta Weigelt; Michael Berger; Gregory Riely; Kathryn C. Arbour; J. Russell Lipford; Bob T. Li; Piro Lito
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-12-10511
OAAI
Lanman, Brian A.; Allen, Jennifer R.; Allen, John G.; Amegadzie, Albert K.; Ashton, Kate S.; Booker, Shon K.; Chen, Jian Jeffrey; Chen, Ning; Frohn, Michael J.; Goodman, Guy; Kopecky, David J.; Liu, Longbin; Lopez, Patricia; Low, Jonathan D.; Ma, Vu; Minatti, Ana E.; Nguyen, Thomas T.; Nishimura, Nobuko; Pickrell, Alexander J.; Reed, Anthony B.; Shin, Youngsook; Siegmund, Aaron C.; Tamayo, Nuria A.; Tegley, Christopher M.; Walton, Mary C.; Wang, Hui-Ling; Wurz, Ryan P.; Xue, May; Yang, Kevin C.; Achanta, Pragathi; Bartberger, Michael D.; Canon, Jude; Hollis, L. Steven; McCarter, John D.; Mohr, Christopher; Rex, Karen; Saiki, Anne Y.; San Miguel, Tisha; Volak, Laurie P.; Wang, Kevin H.; Whittington, Douglas A.; Zech, Stephan G.; Lipford, J. Russell; Cee, Victor J.
Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2019-08-2089
OAAI
Shin, Youngsook; Jeong, Joon Won; Wurz, Ryan P.; Achanta, Pragathi; Arvedson, Tara; Bartberger, Michael D.; Campuzano, Iain D. G.; Fucini, Ray; Hansen, Stig K.; Ingersoll, John; Iwig, Jeffrey S.; Lipford, J. Russell; Ma, Vu; Kopecky, David J.; McCarter, John; San Miguel, Tisha; Mohr, Christopher; Sabet, Sudi; Saiki, Anne Y.; Sawayama, Andrew; Sethofer, Steven; Tegley, Christopher M.; Volak, Laurie P.; Yang, Kevin; Lanman, Brian A.; Erlanson, Daniel A.; Cee, Victor J.
The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents

MDM2抑制剂AMG 232显示出强大的抗肿瘤功效，并增强了p53-Inducing细胞毒性剂的活性

MOLECULAR CANCER THERAPEUTICS
IF5.5
2015-03-09125
OAAI
Canon, Jude; Osgood, Tao; Olson, Steven H.; Saiki, Anne Y.; Robertson, Rebecca; Yu, Dongyin; Eksterowicz, John; Ye, Qiuping; Jin, Lixia; Chen, Ada; Zhou, Jing; Cordover, David; kaufman, Stephen; Kendall, Richard; Oliner, Jonathan D.; Coxon, Angela; Radinsky, Robert
Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2-p53 Interaction
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-12-0463
PREAI
Rew, Yosup; Sun, Daqing; Yan, Xuelei; Beck, Hilary P.; Canon, Jude; Chen, Ada; Duquette, Jason; Eksterowicz, John; Fox, Brian M.; Fu, Jiasheng; Gonzalez, Ana Z.; Houze, Jonathan; Huang, Xin; Jiang, Min; Jin, Lixia; Li, Yihong; Li, Zhihong; Ling, Yun; Lo, Mei-Chu; Long, Alexander M.; McGee, Lawrence R.; McIntosh, Joel; Oliner, Jonathan D.; Osgood, Tao; Saiki, Anne Y.; Shaffer, Paul; Wang, Yu Chung; Wortman, Sarah; Yakowec, Peter; Ye, Qiuping; Yu, Dongyin; Zhao, Xiaoning; Zhou, Jing; Medina, Julio C.; Olson, Steven H.
Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2014-07-0924
OAAI
Yu, Ming; Wang, Yingcai; Zhu, Jiang; Bartberger, Michael D.; Canon, Jude; Chen, Ada; Chow, David; Eksterowicz, John; Fox, Brian; Fu, Jiasheng; Gribble, Michael; Huang, Xin; Li, Zhihong; Liu, Jiwen (Jim); Lo, Mei-chu; McMinn, Dustin; Oliner, Jonathan D.; Osgood, Tao; Rew, Yosup; Saiki, Anne Y.; Shaffer, Paul; Yan, Xuelei; Ye, Qiuping; Yu, Dongyin; Zhao, Xiaoning; Zhou, Jing; Olson, Steven H.; Medina, Julio C.; Sun, Daqing
Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-03-2761
PREAI
Gonzalez, Ana Z.; Li, Zhihong; Beck, Hilary P.; Canon, Jude; Chen, Ada; Chow, David; Duquette, Jason; Eksterowicz, John; Fox, Brian M.; Fu, Jiasheng; Huang, Xin; Houze, Jonathan; Jin, Lixia; Li, Yihong; Ling, Yun; Lo, Mei-Chu; Long, Alexander M.; McGee, Lawrence R.; McIntosh, Joel; Oliner, Jonathan D.; Osgood, Tao; Rew, Yosup; Saiki, Anne Y.; Shaffer, Paul; Wortman, Sarah; Yakowec, Peter; Yan, Xuelei; Ye, Qiuping; Yu, Dongyin; Zhao, Xiaoning; Zhou, Jing; Olson, Steven H.; Sun, Daqing; Medina, Julio C.
Selective and Potent Morpholinone Inhibitors of the MDM2-p53 Protein-Protein Interaction
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-03-0484
PREAI
Gonzalez, Ana Z.; Eksterowicz, John; Bartberger, Michael D.; Beck, Hilary P.; Canon, Jude; Chen, Ada; Chow, David; Duquette, Jason; Fox, Brian M.; Fu, Jiasheng; Huang, Xin; Houze, Jonathan B.; Jin, Lixia; Li, Yihong; Li, Zhihong; Ling, Yun; Lo, Mei-Chu; Long, Alexander M.; McGee, Lawrence R.; McIntosh, Joel; McMinn, Dustin L.; Oliner, Jonathan D.; Osgood, Tao; Rew, Yosup; Saiki, Anne Y.; Shaffer, Paul; Wortman, Sarah; Yakowec, Peter; Yan, Xuelei; Ye, Qiuping; Yu, Dongyin; Zhao, Xiaoning; Zhou, Jing; Olson, Steven H.; Medina, Julio C.; Sun, Daqing

研究方向

暂未获取到该数据
J
Jude Canon
H 指数:31论文数:188被引数:7,580
J
Jonathan D. Oliner
H 指数:30论文数:128被引数:8,842
T
Tao Osgood
H 指数:16论文数:75被引数:3,780
J
Jing Zhou
H 指数:30论文数:91被引数:3,263
A
Ada Chen
H 指数:20论文数:126被引数:2,332
Q
Qiuping Ye
H 指数:24论文数:230被引数:2,161
D
Dongyin Yu
H 指数:17论文数:66被引数:2,350
X
Xiaoning Zhao
H 指数:51论文数:259被引数:1.0万
X
Xin Huang
H 指数:16论文数:24被引数:1,509
Y
Yosup Rew
H 指数:24论文数:55被引数:1,826