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B

Bob van de Water

Leiden Academic Center for Drug Research
H指数:61
被引数:1.3万

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荣誉奖项

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Systematic assessment of transcriptomic and phenotypic biological profiling for mechanism-based hazard assessment using target-annotated reference chemicals in renal proximal tubular epithelial cells

基于靶向注释参考化学品的肾近端小管上皮细胞转录组学和表型生物学谱的系统评估，用于机制基础的危害评估

Archives of Toxicology
IF6.9
2026-10-310
OAAI
Hugo W. van Kessel; Marlene Wedler; Palle S. Helmke; Dace Žīgure; Stephen S. Ferguson; Joshua Harrill; Gerhard Ecker; Shu Liu; Michael Oelgeschläger; Giulia Callegaro; Bob van de Water
Correction: Applicability of NAMs to support a read-across based hazard assessment workflow for systemic toxicity: a conazole case study

更正：NAMs在支持基于读越法的全身毒性危害评估工作流程中的应用：以唑类化合物为例

Archives of Toxicology
IF6.9
2026-10-210
OAAI
Barira Islam; Jenny Irwan; Lukas Wijaya; Bas ter Braak; Amer Jamalpoor; Tamara Meijer; Clemence Budin; Tjalf de Boer; Shu Liu; Marlene Wedler; Baiba Gukalova; Edgars Liepins; Jaione Telleria; Laura Furlong; Guillame Ollitrault; Sam Davidse; Tessa M. S. Hagens; Sibel Bahtiri; Olivier Taboureau; Nadine Dreser; Philip Marx-Stoelting; Annika Järvinen; Per Artursson; Patrik Lundquist; Kathrin Bothe; Hennicke Kamp; Marcel Leist; Bob van de Water; Andrew White; Mirjam Luijten; Iain Gardner; Sylvia E. Escher
Analytical choices drive toxicogenomic potency estimates: a systematic evaluation of transcriptomic points of departure

分析选择驱动毒理基因组学效力估计：转录组学起始点的系统评价

Toxicological Sciences
IF4.1
2026-09-080
OA
Imke B Bruns; Dayna R Schultz; Emmanuel Demuynck; Friedel Dewulf; Ioannis Theologidis; Steven J Kunnen; Lukas S Wijaya; Ilias Frydas; Nafsika Papaioannou; Elisavet Renieri; Thanasis Papageorgiou; Dimosthenis Sarigiannis; Kyriaki Machera; Birgit Mertens; Jana Asselman; Carsten Weiss; Bob van de Water; Giulia Callegaro
Disrupting CDK9 activity suppresses triple-negative breast cancer and is enhanced by EGFR Inhibition

抑制CDK9活性可抑制三阴性乳腺癌，且该抑制作用可被EGFR抑制增强

Cellular Oncology
IF4.8
2026-01-080
OAAI
Vera E. van der Noord; Ronan P. McLaughlin; Jessica S. Karuntu; Jichao He; A. Mieke Timmermans; Sunita K. C. Basnet; Yi Long; Sarah Al Haj Diab; Solomon Tadesse; Natalie Proost; Bastiaan van Gerwen; Bjørn Siteur; Marieke van de Ven; Chantal Pont; Sylvia E. Le Dévédec; John W. M. Martens; Shudong Wang; Yinghui Zhang; Bob van de Water
Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety

定量系统毒理学: 建模以机械地理解和预测药物安全性

Nature Reviews Drug Discovery
IF101.8
2025-10-270
PRE
Christopher E. Goldring; Giusy Russomanno; Carmen Pin; Panuwat Trairatphisan; Kylie A. Beattie; Ciarán P. Fisher; Janet Piñero; Richard J. Brennan; Diana Clausznitzer; Ian M. Copple; Theo M. de Kok; Carrie A. Duckworth; Laura I. Furlong; Barbara Füzi; Attila Gabor; Louis Gall; Jan Hengstler; Henning Hermjakob; Fiona Hunter; Danyel Jennen; Mikko Koskinen; Steven J. Kunnen; Lieve Lammens; Sebastian Lobentanzer; Marcel Mohr; Elisa Passini; D. Mark Pritchard; Rahuman S. Malik-Sheriff; Blanca Rodríguez; Eric I. Rossman; Julio Saez-Rodríguez; Friedemann Schmidt; Rowena Sison-Young; Inari Soininen; Sean Turner; Bob van de Water; Johan G. C. van Hasselt; Filippo Venezia; Jeffrey A. Willy; Derek J. Leishman; James L. Stevens; Loic Laplanche
The Long Way from Raw Data to NAM-Based Information: Overview on Data Layers and Processing Steps

从原始数据到NAM（名称）基础信息的漫长路径：数据层和加工步骤概述

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
IF5.8
2025-01-013
OA
Blum, J; Brüll, M; Hengstler, JG; Dietrich, DR; Gruber, AJ; Dipalo, M; Kraushaar, U; Mangas, I; Terron, A; Fritsche, E; Marx-Stoelting, P; Hardy, B; Schepky, A; Escher, SE; Hartung, T; Landsiedel, R; Odermatt, A; Sachana, M; Koch, K; Dönmez, A; Masjosthusmann, S; Bothe, K; Schildknecht, S; Beilmann, M; Beltman, JB; Fitzpatrick, S; Mangerich, A; Rehm, M; Tangianu, S; Zickgraf, FM; Kamp, H; Burger, G; van de Water, B; Kleinstreuer, N; White, A; Leist, M
ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells

通过基因座扩增的ABCB1过表达代表了对抗胰腺癌细胞中紫杉醇耐药性的可行靶标

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
IF12.8
2024-01-0211
OAAI
Bergonzini, Cecilia; Gregori, Alessandro; Hagens, Tessa M. S.; van der Noord, Vera E.; van de Water, Bob; Zweemer, Annelien J. M.; Coban, Bircan; Capula, Mjriam; Mantini, Giulia; Botto, Asia; Finamore, Francesco; Garajova, Ingrid; McDonnell, Liam A.; Schmidt, Thomas; Giovannetti, Elisa; Danen, Erik H. J.

研究方向

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S
Sylvia E. Le Dévédec
H 指数:28论文数:134被引数:2,861
E
Erik H.J. Danen
H 指数:50论文数:237被引数:9,244
M
Marcel Leist
H 指数:95论文数:464被引数:2.9万
J
John W.M. Martens
H 指数:100论文数:914被引数:5.0万
M
Marjo de Graauw
H 指数:19论文数:46被引数:1,368
P
Paul Jennings
H 指数:49论文数:278被引数:7,759
S
Steven Wink
H 指数:12论文数:30被引数:864
J
Jan G. Hengstler
H 指数:94论文数:1,074被引数:3.4万
S
Sylvia E. Escher
H 指数:26论文数:152被引数:2,752
E
Esmee Koedoot
H 指数:10论文数:62被引数:470