Bob van de Water - Publications, H-index & Citations

Bob van de Water

leiden academic centre for drug research

61H指数

433论文数

1.3W被引数

收录论文 178

发表时间

Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies 解码SR蛋白调控：激酶、磷酸酶及治疗性靶向策略

Cellular Oncology

IF4.8

2026-02-04

OAAI

Nasi Liu; Fleur van der Ende; Bob van de Water; Sylvia E. Le Dévédec

Integrating human exposome data into next-generation risk assessment: a systematic framework to infer real-life exposure levels and prioritize chemical compounds for testing

Environment International

IF9.7

2026-01-26

OAAI

Yifeng Dai; Bob van de Water; Jaione Telleria; Laura I. Furlong; Roel C.H. Vermeulen; Jelle Vlaanderen

Disrupting CDK9 activity suppresses triple-negative breast cancer and is enhanced by EGFR Inhibition 抑制CDK9活性可抑制三阴性乳腺癌，且该抑制作用可被EGFR抑制增强

Cellular Oncology

IF4.8

2026-01-08

OAAI

Vera E. van der Noord; Ronan P. McLaughlin; Jessica S. Karuntu; Jichao He; A. Mieke Timmermans; Sunita K. C. Basnet; Yi Long; Sarah Al Haj Diab; Solomon Tadesse; Natalie Proost; Bastiaan van Gerwen; Bjørn Siteur; Marieke van de Ven; Chantal Pont; Sylvia E. Le Dévédec; John W. M. Martens; Shudong Wang; Yinghui Zhang; Bob van de Water

Advancing transcriptomics-based mechanistic assessment of nephrotoxicity in vitro using the human RPTEC/TERT1 TXG-MAPr gene co-expression network 利用人RPTEC/TERT1 TXG-MAPr基因共表达网络推进基于转录组学的体外肾毒性机制评估

TOXICOLOGICAL SCIENCES

IF4.1

2025-12-01

OAAI

van Kessel, Hugo W.; Kunnen, Steven J.; Callegaro, Giulia; van de Water, Bob

Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety 定量系统毒理学: 建模以机械地理解和预测药物安全性

Nature Reviews Drug Discovery

IF101.8

2025-10-27

PREAI

Christopher E. Goldring; Giusy Russomanno; Carmen Pin; Panuwat Trairatphisan; Kylie A. Beattie; Ciarán P. Fisher; Janet Piñero; Richard J. Brennan; Diana Clausznitzer; Ian M. Copple; Theo M. de Kok; Carrie A. Duckworth; Laura I. Furlong; Barbara Füzi; Attila Gabor; Louis Gall; Jan Hengstler; Henning Hermjakob; Fiona Hunter; Danyel Jennen; Mikko Koskinen; Steven J. Kunnen; Lieve Lammens; Sebastian Lobentanzer; Marcel Mohr; Elisa Passini; D. Mark Pritchard; Rahuman S. Malik-Sheriff; Blanca Rodríguez; Eric I. Rossman; Julio Saez-Rodríguez; Friedemann Schmidt; Rowena Sison-Young; Inari Soininen; Sean Turner; Bob van de Water; Johan G. C. van Hasselt; Filippo Venezia; Jeffrey A. Willy; Derek J. Leishman; James L. Stevens; Loic Laplanche

Cell type heterogeneity in gene co-expression networks: implications for toxicological research 基因共表达网络中的细胞类型异质性：对毒理学研究的启示

Briefings in Bioinformatics

IF7.7

2025-08-26

OAAI

Imke B Bruns; Yingxue Li; James L Stevens; Bob van de Water; Giulia Callegaro

Distinct lipidomic profiles in breast cancer cell lines relate to proliferation and EMT phenotypes 不同脂质组学特征在乳腺癌细胞系中与增殖和EMT表型相关

biochimica et biophysica acta molecular and cell biology of lipids

IF0

2025-08-05

PREAI

Hanneke Leegwater; Zhengzheng Zhang; Xiaobing Zhang; Xuesong Wang; Thomas Hankemeier; Annelien J.M. Zweemer; Bob van de Water; Erik Danen; Menno Hoekstra; Amy C. Harms; Alida Kindt; Sylvia E. Le Dévédec

Identifying human toxicodynamic variability: A systematic evidence map of the current knowledge 识别人类毒动学变异性：当前知识的系统证据图谱

REGULATORY TOXICOLOGY AND PHARMACOLOGY

IF3.5

2025-06-06

PREAI

Annika Boye Petersen; Lea Bredsdorff; Natasha Tahir; Marije Niemeijer; George E.N. Kass; Aiste Vitkauskaite; Matthijs Moerland; Frederic Y. Bois; Nadia Quignot; Bob van de Water; Susanne Hougaard Bennekou

Towards a quantitative adverse outcome pathway for liver carcinogenesis: From proliferation to prediction 肝脏致癌作用的定量不良结局路径：从增殖到预测

Computational Toxicology

IF2.9

2025-06-01

PREAI

Christina H.J. Veltman; Hiba Khalidi; Elias Zgheib; Bob van de Water; Mirjam Luijten; Jeroen L.A. Pennings

Computational modelling identifies primary mediators of crosstalk between DNA damage and oxidative stress responses 计算建模识别DNA损伤与氧化应激反应之间串扰的主要介导因子

plos biology

IF3.6

2025-03-10

OAAI

Burgers, Elsje J.; Sharma, Raju P.; Eugenio, Carl Joshua S.; Heldring, Muriel M.; Wijaya, Lukas S.; van de Water, Bob; Beltman, Joost B.

Animal-free Safety Assessment of Chemicals: Project Cluster for Implementation of Novel Strategies (ASPIS) definition of new approach methodologies

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

IF2.8

2025-01-29

OAAI

Colbourne, John K.; Escher, Sylvia E.; Lee, Robert; Vinken, Mathieu; van de Water, Bob; Freedman, Jonathan H.

The Long Way from Raw Data to NAM-Based Information: Overview on Data Layers and Processing Steps 从原始数据到NAM（名称）基础信息的漫长路径：数据层和加工步骤概述

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION

IF5.8

2025-01-01

OAAI

Blum, J; Brüll, M; Hengstler, JG; Dietrich, DR; Gruber, AJ; Dipalo, M; Kraushaar, U; Mangas, I; Terron, A; Fritsche, E; Marx-Stoelting, P; Hardy, B; Schepky, A; Escher, SE; Hartung, T; Landsiedel, R; Odermatt, A; Sachana, M; Koch, K; Dönmez, A; Masjosthusmann, S; Bothe, K; Schildknecht, S; Beilmann, M; Beltman, JB; Fitzpatrick, S; Mangerich, A; Rehm, M; Tangianu, S; Zickgraf, FM; Kamp, H; Burger, G; van de Water, B; Kleinstreuer, N; White, A; Leist, M

Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors

ENVIRONMENTAL HEALTH PERSPECTIVES

IF9.8

2024-03-01

OAAI

Niemeijer, Marije; Wiecek, Witold; Fu, Shuai; Huppelschoten, Suzanna; Bouwman, Peter; Baze, Audrey; Parmentier, Celine; Richert, Lysiane; Paules, Richard S.; Bois, Frederic Y.; van de Water, Bob

The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability

LIVER INTERNATIONAL

IF5.2

2024-01-13

OAAI

Vlasveld, Matthijs; Callegaro, Giulia; Fisher, Ciaran; Eakins, Julie; Walker, Paul; Lok, Samantha; van Oost, Siddh; de Jong, Brechtje; Pellegrino-Coppola, Damiano; Burger, Gerhard; Wink, Steven; van de Water, Bob

ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells 通过基因座扩增的ABCB1过表达代表了对抗胰腺癌细胞中紫杉醇耐药性的可行靶标

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IF12.8

2024-01-02

OAAI

Bergonzini, Cecilia; Gregori, Alessandro; Hagens, Tessa M. S.; van der Noord, Vera E.; van de Water, Bob; Zweemer, Annelien J. M.; Coban, Bircan; Capula, Mjriam; Mantini, Giulia; Botto, Asia; Finamore, Francesco; Garajova, Ingrid; McDonnell, Liam A.; Schmidt, Thomas; Giovannetti, Elisa; Danen, Erik H. J.

Cell viability imaging in tumor spheroids via DNA binding of a ruthenium(ii) light-switch complex

CHEMICAL COMMUNICATIONS

IF4.2

2024-01-01

OAAI

Ramu, Vadde; Wijaya, Lukas S.; Beztsinna, Nataliia; van de Griend, Corjan; van de Water, Bob; Bonnet, Sylvestre; Le Devedec, Sylvia E.

A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury

TOXICOLOGICAL SCIENCES

IF4.1

2023-11-28

OAAI

Wijaya, Lukas S.; Gabor, Attila; Pot, Iris E.; van de Have, Luca; Saez-Rodriguez, Julio; Stevens, James L.; Le Devedec, Sylvia E.; Callegaro, Giulia; van de Water, Bob

Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2023-08-24

OAAI

Bequignon, Olivier J. M.; Gomez-Tamayo, Jose C.; Lenselink, Eelke B.; Wink, Steven; Hiemstra, Steven; Lam, Chi Chung; Gadaleta, Domenico; Roncaglioni, Alessandra; Norinder, Ulf; Water, Bob van de; Pastor, Manuel; van Westen, Gerard J. P.

New approach methodologies in human regulatory toxicology-Not if, but how and when!人类监管毒理学的新方法-不是如果，而是如何以及何时!

ENVIRONMENT INTERNATIONAL

IF9.7

2023-08-01

OAAI

Schmeisser, Sebastian; Miccoli, Andrea; von Bergen, Martin; Berggren, Elisabet; Braeuning, Albert; Busch, Wibke; Desaintes, Christian; Gourmelon, Anne; Grafstrom, Roland; Harrill, Joshua; Hartung, Thomas; Herzler, Matthias; Kass, George E. N.; Kleinstreuer, Nicole; Leist, Marcel; Luijten, Mirjam; Marx-Stoelting, Philip; Poetz, Oliver; van Ravenzwaay, Bennard; Roggeband, Rob; Rogiers, Vera; Roth, Adrian; Sanders, Pascal; Thomas, Russell S.; Vinggaard, Anne Marie; Vinken, Mathieu; van de Water, Bob; Luch, Andreas; Tralau, Tewes

New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens-a PARC project

FRONTIERS IN TOXICOLOGY

IF4.6

2023-07-10

OAAI

Audebert, Marc; Assmann, Ann-Sophie; Azqueta, Amaya; Babica, Pavel; Benfenati, Emilio; Bortoli, Sylvie; Bouwman, Peter; Braeuning, Albert; Burgdorf, Tanja; Coumoul, Xavier; Debizet, Kloe; Dusinska, Maria; Ertych, Norman; Fahrer, Joerg; Fetz, Verena; Le Hegarat, Ludovic; de Cerain, Adela Lopez; Heusinkveld, Harm J.; Hogeveen, Kevin; Jacobs, Miriam N.; Luijten, Mirjam; Raitano, Giuseppa; Recoules, Cynthia; Runden-Pran, Elise; Saleh, Mariam; Sovadinova, Iva; Stampar, Martina; Thibol, Lea; Tomkiewicz, Celine; Vettorazzi, Ariane; van de Water, Bob; El Yamani, Naouale; Zegura, Bojana; Oelgeschlaeger, Michael

研究方向