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Italo Tempera

The Wistar Institute

H指数:27

被引数:2,225

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EBNA1 inhibitors reveal CDC7 and POU2F1 as direct functional targets in EBV epithelial cancers

EBNA1抑制剂揭示CDC7和POU2F1是EBV上皮癌中的直接功能靶点

IF4.7

2026-06-100

PRE

Integrated transcriptomic and methylome analysis reveals retinoic acid pathway activation after decitabine treatment in EBV-associated gastric cancer

整合转录组学和甲基组学分析揭示了在EBV相关胃癌中，地西他滨治疗后视黄酸通路的激活

IF4.7

2026-02-010

PRE

The CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membrane

CTLH泛素连接酶的底物ZMYND19和MKLN1在溶酶体膜上负调控mTORC1。

Nature Communications

IF15.7

2025-11-280

OAAI

EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation

EBNA leader蛋白在Epstein-Barr病毒诱导的B细胞转化过程中调控染色质结构重塑。

NUCLEIC ACIDS RESEARCH

IF13.1

2025-07-080

PRE

The DNA loop release factor WAPL suppresses Epstein-Barr virus latent membrane protein expression to maintain the highly restricted latency I program

IF4.9

2024-09-060

OAAI

Host factor KAP1 coordinates temporal control between transcription and replication

宿主因子KAP1协调转录和复制之间的时间控制

TRENDS IN MICROBIOLOGY

IF14.9

2024-02-010

PRE

PARP1 as an Epigenetic Modulator: Implications for the Regulation of Host-Viral Dynamics

PARP1作为表观遗传调节剂: 对宿主病毒动力学调节的影响

IF3.3

2024-01-301

OAAI

Decitabine disrupts EBV genomic epiallele DNA methylation patterns around CTCF binding sites to increase chromatin accessibility and lytic transcription in gastric cancer

IF4.7

2023-10-315

OAAI

The three-dimensional structure of the EBV genome plays a crucial role in regulating viral gene expression in EBVaGC

EBV基因组的三维结构在调节EBVaGC中的病毒基因表达中起着至关重要的作用。

NUCLEIC ACIDS RESEARCH

IF13.1

2023-10-273

OAAI

Three-Dimensional Chromatin Structure of the EBV Genome: A Crucial Factor in Viral Infection

EBV基因组的三维染色质结构: 病毒感染的关键因素

IF3.5

2023-04-298

OAAI

Global Transcriptome Analysis Reveals That Poly(ADP-Ribose)Polymerase 1 Regulates Gene Expression through EZH2

全局转录组分析揭示聚 (ADP-核糖) 聚合酶1通过EZH2调控基因表达

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-2039

OAAI

Human Cytomegalovirus Utilizes Multiple Viral Proteins to Regulate the Basement Membrane Protein Nidogen 1

人类巨细胞病毒利用多种病毒蛋白调节基底膜蛋白Nidogen 1

JOURNAL OF VIROLOGY

IF3.8

2022-10-262

OA

The nuclear lamina binds the EBV genome during latency and regulates viral gene expression

核层在潜伏期结合EBV基因组并调节病毒基因表达

IF4.9

2022-04-146

OAAI

The three-dimensional structure of Epstein-Barr virus genome varies by latency type and is regulated by PARP1 enzymatic activity

爱泼斯坦-巴尔病毒基因组的三维结构因潜伏期类型而异，并受PARP1酶活性的调节

NATURE COMMUNICATIONS

IF15.7

2022-01-1729

OAAI

EBNA2 driven enhancer switching at the CIITA-DEXI locus suppresses HLA class II gene expression during EBV infection of B-lymphocytes

在B淋巴细胞的EBV感染过程中，ciita-dexi基因座上的EBNA2驱动的增强子转换抑制了HLA II类基因的表达

IF4.9

2021-08-0513

OAAI

TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors

TET2和DNMT3A突变对DNA修复和白血病细胞对PARP抑制剂的敏感性产生不同的影响

CANCER RESEARCH

IF16.6

2021-07-0227

OA

Maifrede, Silvia; Le, Bac Viet; Nieborowska-Skorska, Margaret; Golovine, Konstantin; Sullivan-Reed, Katherine; Dunuwille, Wangisa M. B.; Nacson, Joseph; Hulse, Michael; Keith, Kelsey; Madzo, Jozef; Caruso, Lisa Beatrice; Gazze, Zachary; Lian, Zhaorui; Padella, Antonella; Chitrala, Kumaraswamy N.; Bartholdy, Boris A.; Matlawska-Wasowska, Ksenia; Di Marcantonio, Daniela; Simonetti, Giorgia; Greiner, Georg; Sykes, Stephen M.; Valent, Peter; Paietta, Elisabeth M.; Tallman, Martin S.; Fernandez, Hugo F.; Litzow, Mark R.; Minden, Mark D.; Huang, Jian; Martinelli, Giovanni; Vassiliou, George S.; Tempera, Italo; Piwocka, Katarzyna; Johnson, Neil; Challen, Grant A.; Skorski, Tomasz

EBNA1 inhibitors have potent and selective antitumor activity in xenograft models of Epstein-Barr virus-associated gastric cancer

EBNA1抑制剂在爱泼斯坦-巴尔病毒相关胃癌的异种移植模型中具有有效的选择性抗肿瘤活性

IF5.1

2021-04-3023

OAAI

Epstein-Barr Virus-Encoded Latent Membrane Protein 1 and B-Cell Growth Transformation Induce Lipogenesis through Fatty Acid Synthase

Epstein-barr病毒编码的潜伏膜蛋白1和b细胞生长转化通过脂肪酸合酶诱导脂肪生成

JOURNAL OF VIROLOGY

IF3.8

2021-01-2838

OAAI

TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

TGFβR-SMAD3信号在骨髓微环境中诱导对PARP抑制剂的抗性

IF6.9

2020-10-0120

OAAI

Le, Bac Viet; Podszywalow-Bartnicka, Paulina; Maifrede, Silvia; Sullivan-Reed, Katherine; Nieborowska-Skorska, Margaret; Golovine, Konstantin; Yao, Juo-Chin; Nejati, Reza; Cai, Kathy Q.; Caruso, Lisa Beatrice; Swatler, Julian; Dabrowski, Michal; Lian, Zhaorui; Valent, Peter; Paietta, Elisabeth M.; Levine, Ross L.; Fernandez, Hugo F.; Tallman, Martin S.; Litzow, Mark R.; Huang, Jian; Challen, Grant A.; Link, Daniel; Tempera, Italo; Wasik, Mariusz A.; Piwocka, Katarzyna; Skorski, Tomasz

Poly(ADP-ribosylated) proteins in β-amyloid peptide-stimulated microglial cells

Β-淀粉样肽刺激的小胶质细胞中的聚 (ADP-核糖基化) 蛋白

BIOCHEMICAL PHARMACOLOGY

IF5.6

2019-09-0116

PREAI