未登录 Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9 ATX968的发现：一种可口服的DHX9别构抑制剂 Daniels, Matthew H.; Castro, Jennifer; Lee, Young-Tae; Gotur, Deepali; Knockenhauer, Kevin E.; Grigoriu, Simina; Lockbaum, Gordon J.; Cheong, Jae Eun; Lu, Chuang; Brennan, David; Buker, Shane M.; Liu, Julie; Yao, Shihua; Sparling, Brian A.; Sickmier, E. Allen; Ribich, Scott; Blakemore, Steve J.; Silver, Serena J.; Boriack-Sjodin, P. Ann; Duncan, Kenneth W.; Copeland, Robert A. 分享 收藏
Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor 外切核糖核酸酶XRN1作为癌症靶点的表征及腺苷-3',5'-二磷酸作为强效酶抑制剂的鉴定 Lockbaum, Gordon J.; Lynes, Maureen M.; Shen, Sophie A.; Liu, Julie; Holt, Nicholas; Nayak, Sunaina P.; Knockenhauer, Kevin E.; Yao, Shihua; Sickmier, E. Allen; Raman, Anugraha; Wu, Jie; Case, April; Shehaj, Livia; Buker, Shane M.; Grigoriu, Simina; Ribich, Scott; Blakemore, Stephen J.; Sparling, Brian A.; Duncan, Kenneth W.; Copeland, Robert A.; Silver, Serena J.; Boriack-Sjodin, P. Ann 分享 收藏
Seroprevalence of Anti-SARS-CoV-2 IgG Antibodies in Healthcare Personnel in El Salvador Prior to Vaccination Campaigns Ramirez, Jose Elias Aguilar; Maliga, Adrianna; Stewart, Allison; Lino, Allison; Oliva, Jose Eduardo; Sandoval, Xochitl; Zielinski-Gutierrez, Emily; Chacon-Fuentes, Rafael; Suchdev, Parminder S.; Zelaya, Susana; Sanchez, Mario; Recinos, Delmy Lisseth; Lopez, Beatriz; Hawes, Ella; Liu, Julie; Ronca, Shannon E.; Gunter, Sarah M.; Murray, Kristy O.; Dominguez, Rhina 分享 收藏
Small molecule inhibitors of RNA modifying enzymes as precision cancer therapeutics Copeland, Robert A.; Castro, Jennifer; Daniels, Matthew H.; Gotur, Deepali; Lee, Young-Tae; Yao, Shihua; Brennan, David; Johnston, Brian T.; Laidlaw, Monique; Pai, Sunaina; Wu, Jie; Bansal, Rishabh; Raman, Anugraha; Buker, Shane M.; Liu, Julie; Sickmier, E. Allen; Knockenhauer, Kevin; Lu, Chuang; Blakemore, Stephen J.; Silver, Serena J.; Boriack-Sjodin, P. Ann; Duncan, Kenneth W.; Sager, Jason A. 分享 收藏
Development of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen 开发有效的Mcl-1抑制剂: 源自DNA编码的化学文库筛选的大环的结构研究 Hekking, Koen F. W.; Maroto, Sergio; van Kekem, Kees; Haasjes, Frank S.; Slootweg, Jack C.; Oude Alink, Patrick G. B.; Dirks, Ron; Sardana, Malvika; Bolster, Marjon G.; Kuijpers, Brian; Smith, Dennis; Doodeman, Robin; Scheepstra, Marcel; Zech, Birgit; Mulvihill, Mark; Renzetti, Louis M.; Babiss, Lee; Centrella, Paolo A.; Clark, Matthew A.; Cuozzo, John W.; Guie, Marie-Aude; Sigel, Eric; Habeshian, Sevan; Hupp, Christopher D.; Liu, Julie; Thomson, Heather A.; Zhang, Ying; Keefe, Anthony D.; Muller, Gerhard; Gremmen, Stijn 分享 收藏
DHX9 inhibition as a novel therapeutic modality in microsatellite instable colorectal cancer Castro, Jennifer; Daniels, Matthew H.; Brennan, David; Johnston, Brian T.; Bansal, Rishabh; Laidlaw, Monique; Lu, Chuang; Gotur, Deepali; Lee, Young-Tae; Knockenhauer, Kevin; Case, April; Wu, Jie; Raman, Anugraha; Cheong, Jae Eun; Liu, Julie; Buker, Shane M.; Sickmier, E. Allen; Blakemore, Stephen J.; Boriack-Sjodin, P. Ann; Duncan, Kenneth W.; Silver, Serena J.; Ribich, Scott; Copeland, Robert A. 分享 收藏
Characterization of selective, allosteric inhibitors of human XRN1 Lockbaum, Gordon J.; Sickmier, E. Allen; Sparling, Brian A.; Knockenhauer, Kevin; Holt, Nicholas; Liu, Julie; Lynes, Maureen M.; Grigoriu, Simina; Duncan, Kenneth W.; Copeland, Robert A.; Boriack-Sjodin, P. Ann 分享 收藏
Targeting DHX9 inhibition as a novel therapeutic modality in microsatellite instable colorectal cancer Castro, Jennifer; Daniels, Matthew H.; Lu, Chuang; Brennan, David; Gotur, Deepali; Lee, Young-Tae; Knockenhauer, Kevin; Case, April; Wu, Jie; Buker, Shane M.; Liu, Julie; Sparling, Brian A.; Sickmier, E. Allen; Blakemore, Stephen J.; Boriack-Sjodin, P. Ann; Duncan, Kenneth W.; Ribich, Scott; Copeland, Robert A. 分享 收藏
Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry 使用DNA编码化学发现的新型不可逆共价BTK抑制剂 Guilinger, John P.; Archana, Archna; Augustin, Martin; Bergmann, Andreas; Centrella, Paolo A.; Clark, Matthew A.; Cuozzo, John W.; Daether, Maike; Guie, Marie-Aude; Habeshian, Sevan; Kiefersauer, Reiner; Krapp, Stephan; Lammens, Alfred; Lercher, Lukas; Liu, Julie; Liu, Yanbin; Maskos, Klaus; Mrosek, Michael; Pfluegler, Klaus; Siegert, Markus; Thomson, Heather A.; Tian, Xia; Zhang, Ying; Makino, Debora L. Konz; Keefe, Anthony . D. 分享 收藏
Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening Lee, Esther C. Y.; McRiner, Andrew J.; Georgiadis, Katy E.; Liu, Julie; Wang, Zooey; Ferguson, Andrew D.; Levin, Benjamin; von Rechenberg, Moritz; Hupp, Christopher D.; Monteiro, Michael, I; Keefe, Anthony D.; Olszewski, Allison; Eyermann, Charles J.; Centrella, Paolo; Liu, Yanbin; Arora, Shilpi; Cuozzo, John W.; Zhang, Ying; Clark, Matthew A.; Huguet, Christelle; Kohlmann, Anna 分享 收藏
Discovery of 2,4-1H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors Veerman, Johan J. N.; Bruseker, Yorik B.; Damen, Eddy; Heijne, Erik H.; van Bruggen, Wendy; Hekking, Koen F. W.; Winkel, Rob; Hupp, Christopher D.; Keefe, Anthony D.; Liu, Julie; Thomson, Heather A.; Zhang, Ying; Cuozzo, John W.; McRiner, Andrew J.; Mulvihill, Mark J.; van Rijnsbergen, Peter; Zech, Birgit; Renzetti, Louis M.; Babiss, Lee; Muller, Gerhard 分享 收藏
Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition Mimasu, Shinya; Yamagishi, Hiroaki; Kubo, Satoshi; Kiyohara, Mie; Matsuda, Toshihiro; Yahata, Toshiko; Thomson, Heather A.; Hupp, Christopher D.; Liu, Julie; Okuda, Takao; Kakefuda, Kenichi 分享 收藏
Novel, potent, and selective small-molecule inhibitors modulating immuno-oncology targets CD73, A2A/A2B adenosine receptors and CSF1R discovered via DNA-encoded library screening McRiner, Andrew J.; Andersen, Jannik N.; Fouser, Lynette A.; Zhang, Junyi; Certel, Kaan; Cuozzo, John; Chan, Betty; Chandran, Ragunath; Clark, Matt; Gikunju, Diana; Hupp, Christopher D.; Keefe, Anthony D.; Liu, Julie; Liu, Yanbin; Monteiro, Michael; Olszewski, Allison; Von Rechenberg, Moritz; Resnicow, Daniel; Thomson, Heather A.; Troast, Dawn M.; Wang, Zooey; Westlund, Neil; Zhang, Ying; Zhou, Fei; Zhu, Xiaotian; Briskin, Michael; Ezzeddine, Diala 分享 收藏
Discovery of novel potent allele-selective KRAS-G12C covalent inhibitors stemming from DNA-encoded library McCort, Gary; Arrebola, Rosalia; Calvet, Loreley; Ronan, Baptiste; Vergne, Fabrice; Duffieux, Francis; Rak, Alexey; Meaux, Isabelle; Papin, David; Fassy, Florence; Delorme, Cecile; Matthieu, Magali; Nicolas, Jean-Paul; Marcireau, Christophe; Steier, Valerie; Abecassis, Pierre-Yves; Czepczor, Valerie; Thomson, Heather A.; Hupp, Christopher D.; Guilinger, J. P.; Zhang, Ying; Keefe, Anthony D.; Cuozzo, John W.; Liu, Julie; Debussche, Laurent 分享 收藏
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Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2) Lovering, Frank; Kirincich, Steve; Wang, Weiheng; Combs, Kerry; Resnick, Lynn; Sabalski, Joan E.; Butera, John; Liu, Julie; Parris, Kevin; Telliez, J. B. 分享 收藏
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Pharmacologic inhibition of Tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood* Hall, J. Perry; Kurdi, Yahya; Hsu, Sang; Cuozzo, John; Liu, Julie; Telliez, Jean-Baptiste; Seidl, Katherine J.; Winkler, Aaron; Hu, Yonghan; Green, Neal; Askew, G. Roger; Tam, Steve; Clark, James D.; Lin, Lih-Ling 分享 收藏
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