Ladislav Vyklický - Publications, H-index & Citations

Ladislav Vyklický

czech academy of sciences

56H指数

267论文数

9.8K被引数

收录论文 35

发表时间

Positive modulators of N-methyl-D-aspartate receptor: structure–activity relationship study on steroidal C-17 and C-20 oxime ethers N-甲基-D-天冬氨酸受体阳性调节剂：类固醇C-17和C-20肟醚的结构-活性关系研究

rsc adv.

IF0

2026-04-17

OAAI

Santosh Kumar Adla; Barbora Hrčka Krausová; Bohdan Kysilov; Karel Kudláček; Radko Souček; Miloš Budešínský; Jan Voldřich; Ladislav Vyklický; Eva Kudová

Mice carrying a GluN2B protein-truncating variant have altered NMDA receptor subunit composition and their behavior recapitulates patient phenotypes

Cellular and Molecular Life Sciences

IF6.2

2026-01-30

OAAI

Klevinda Fili; Viktor Kuchtiak; Eni Tomovic; Miriam Candelas Serra; Agnieszka Kubik-Zahorodna; Karel Harant; Paulina Bozikova; Jiri Cerny; Miloslav Korinek; Barbora Hrcka Krausova; Vera Abramova; Mark Dobrovolski; Fatma Elzahraa S. Abdel Rahman; Jan Prochazka; Ales Balik; Tereza Smejkalova; Ladislav Vyklicky

Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids

CELLULAR AND MOLECULAR LIFE SCIENCES

IF6.2

2024-01-12

OAAI

Kysilov, Bohdan; Kuchtiak, Viktor; Krausova, Barbora Hrcka; Balik, Ales; Korinek, Miloslav; Fili, Klevinda; Dobrovolski, Mark; Abramova, Vera; Chodounska, Hana; Kudova, Eva; Bozikova, Paulina; Cerny, Jiri; Smejkalova, Tereza; Vyklicky, Ladislav

Effects of Pregnanolone Glutamate and Its Metabolites on GABAA and NMDA Receptors and Zebrafish Behavior

ACS CHEMICAL NEUROSCIENCE

IF3.9

2023-05-01

PREAI

Abramova, Vera; Alvarado, Vanessa Leal; Hill, Martin; Smejkalova, Tereza; Maly, Michal; Vales, Karel; Dittert, Ivan; Bozikova, Paulina; Kysilov, Bohdan; Krausova, Barbora Hrcka; Vyklicky, Vojtech; Balik, Ales; Fili, Klevinda; Korinek, Miloslav; Chodounska, Hana; Kudova, Eva; Ciz, David; Martinovic, Jan; Cerny, Jiri; Bartunek, Petr; Vyklicky, Ladislav

Pregnane-based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss-of-function disease-associated GRIN mutations

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2022-04-08

OAAI

Kysilov, Bohdan; Hrcka Krausova, Barbora; Vyklicky, Vojtech; Smejkalova, Tereza; Korinek, Miloslav; Horak, Martin; Chodounska, Hana; Kudova, Eva; Cerny, Jiri; Vyklicky, Ladislav

Evidence for the Association between the Intronic Haplotypes of Ionotropic Glutamate Receptors and First-Episode Schizophrenia

JOURNAL OF PERSONALIZED MEDICINE

IF3

2021-11-25

OAAI

Hirschfeldova, Katerina; Cerny, Jiri; Bozikova, Paulina; Kuchtiak, Viktor; Rausch, Tobias; Benes, Vladimir; Spaniel, Filip; Gregus, David; Horacek, Jiri; Vyklicky, Ladislav; Balik, Ales

Pharmacokinetic, pharmacodynamic, and behavioural studies of deschloroketamine in Wistar rats Wistar大鼠中去氯酮胺的药代动力学，药效学和行为研究

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2021-10-31

OAAI

Stefkova-Mazochova, Kristyna; Danda, Hynek; Dehaen, Wim; Jurasek, Bronislav; Sichova, Klara; Pinterova-Leca, Nikola; Mazoch, Vladimir; Krausova, Barbora Hrcka; Kysilov, Bohdan o; Smejkalova, Tereza; Vyklicky, Ladislav; Kohout, Michal; Hajkova, Katerina; Svozil, Daniel; Horsley, Rachel R.; Kuchar, Martin; Palenicek, Tomas

Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia

BIOMOLECULES

IF4.8

2021-07-14

OAAI

Holubova, Kristina; Chvojkova, Marketa; Krausova, Barbora Hrcka; Vyklicky, Vojtech; Kudova, Eva; Chodounska, Hana; Vyklicky, Ladislav; Vales, Karel

Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2021-06-22

OAAI

Smejkalova, Tereza; Korinek, Miloslav; Krusek, Jan; Hrcka Krausova, Barbora; Candelas Serra, Miriam; Hajdukovic, Dragana; Kudova, Eva; Chodounska, Hana; Vyklicky, Ladislav

Cholesterol modulates presynaptic and postsynaptic properties of excitatory synaptic transmission

SCIENTIFIC REPORTS

IF3.9

2020-07-28

OAAI

Korinek, Miloslav; Gonzalez-Gonzalez, Inmaculada M.; Smejkalova, Tereza; Hajdukovic, Dragana; Skrenkova, Kristyna; Krusek, Jan; Horak, Martin; Vyklicky, Ladislav

Positive Modulators of the N-Methyl-D-aspartate Receptor: Structure-Activity Relationship Study of Steroidal 3-Hemiesters

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-04-30

PREAI

Krausova, Barbora; Slavikova, Barbora; Nekardova, Michaela; Hubalkova, Pavla; Vyklicky, Vojtech; Chodounska, Hana; Vyklicky, Ladislav; Kudova, Eva

The LILI Motif of M3-S2 Linkers Is a Component of the NMDA Receptor Channel Gate

FRONTIERS IN MOLECULAR NEUROSCIENCE

IF3.8

2018-04-06

OAAI

Ladislav, Marek; Cerny, Jiri; Krusek, Jan; Horak, Martin; Balik, Ales; Vyklicky, Ladislav

Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit

FRONTIERS IN MOLECULAR NEUROSCIENCE

IF3.8

2018-04-06

OAAI

Vyklicky, Vojtech; Krausova, Barbora; Cerny, Jiri; Ladislav, Marek; Smejkalova, Tereza; Kysilov, Bohdan; Korinek, Miloslav; Danacikova, Sarka; Horak, Martin; Chodounska, Hana; Kudova, Eva; Vyklicky, Ladislav

Function, Expression, and Pharmacology of Disease-Associated Mutations of NMDA Receptors

BIOPHYSICAL JOURNAL

IF3.1

2018-02-01

OAAI

Vyklilcky, Vojtech; Kamsova, Barbora; Kysilov, Bohdan; Ladislav, Marek; Hubalkova, Pavla; Smejkalova, Tereza; Horak, Martin; Chodounska, Hana; Kudova, Eva; Cerny, Jiri; Vyklicky, Ladislav

Total Synthesis of &ITent&IT-Pregnanolone Sulfate and Its Biological Investigation at the NMDA Receptor

ORGANIC LETTERS

IF5

2018-01-24

PREAI

Kapras, Vojtech; Vyklicky, Vojtech; Budesinsky, Milos; Cisarova, Ivana; Vyklicky, Ladislav; Chodounska, Hana; Jahn, Ullrich

Shared CaM- and S100A1-binding epitopes in the distal TRPM4 N terminus

FEBS JOURNAL

IF4.2

2017-12-29

OAAI

Bousova, Kristyna; Herman, Petr; Vecer, Jaroslav; Bednarova, Lucie; Monincova, Lenka; Majer, Pavel; Vyklicky, Ladislav; Vondrasek, Jiri; Teisinger, Jan

The pharmacology of tacrine at N-methyl-D-aspartate receptors

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

IF3.9

2017-04-01

PREAI

Horak, Martin; Holubova, Kristina; Nepovimova, Eugenie; Krusek, Jan; Kaniakova, Martina; Korabecny, Jan; Vyklicky, Ladislav; Kuca, Kamil; Stuchlik, Ales; Ricny, Jan; Vales, Karel; Soukup, Ondrej

The characterization of a novel S100A1 binding site in the N-terminus of TRPM1

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

IF2.8

2016-09-01

PREAI

Jirku, Michaela; Lansky, Zdenek; Bednarova, Lucie; Sulc, Miroslav; Monincova, Lenka; Majer, Pavel; Vyklicky, Ladislav; Vondrasek, Jiri; Teisinger, Jan; Bousova, Kristyna

Neurosteroid-like Inhibitors of N-Methyl-D-aspartate Receptor: Substituted 2-Sulfates and 2-Hemisuccinates of Perhydrophenanthrene

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-04-26

PREAI

Slavikova, Barbora; Chodounska, Hana; Nekardova, Michaela; Vyklicky, Vojtech; Ladislav, Marek; Hubalkova, Pavia; Krausova, Barbora; Vykticky, Ladislav; Kudova, Eva

Characterization of the part of N-terminal PIP2 binding site of the TRPM1 channel TRPM1通道N端PIP2结合位点的部分表征

BIOPHYSICAL CHEMISTRY

IF2.2

2015-12-01

PREAI

Jirku, Michaela; Bumba, Ladislav; Bednarova, Lucie; Kubala, Martin; Sulc, Miroslav; Franek, Miloslav; Vyklicky, Ladislav; Vondrasek, Jiri; Teisinger, Jan; Bousova, Kristyna

研究方向