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Difluorinated thromboxane A2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors Allen, Megan F.; Hutchinson, James L.; Keith, Michael; Mallah, Shahida; Corey, Robin A.; Trory, Justin S.; Jing, Changcheng; Fang, Huaquan; Wei, Liang; Bennett, Steven H.; Aggarwal, Varinder K.; Mundell, Stuart J.; Hers, Ingeborg 分享 收藏
Ticagrelor inverse agonist activity at the P2Y12 receptor is non-reversible versus its endogenous agonist adenosine 5'-diphosphate Khalil, Jawad; Dimofte, Tudor; Roberts, Timothy; Keith, Michael; Amaradasa, Kumuthu; Hindle, Matthew S.; Bancroft, Sukhinder; Hutchinson, James L.; Naseem, Khalid; Johnson, Thomas; Mundell, Stuart J. 分享 收藏
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Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19 Goudswaard, Lucy J.; Williams, Christopher M.; Khalil, Jawad; Burley, Kate L.; Hamilton, Fergus; Arnold, David; Milne, Alice; Lewis, Phil A.; Heesom, Kate J.; Mundell, Stuart J.; Davidson, Andrew D.; Poole, Alastair W.; Hers, Ingeborg 分享 收藏
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Tetherin/BST2, a physiologically and therapeutically relevant regulator of platelet receptor signalling Zhao, Xiaojuan; Alibhai, Dominic; Sun, Ting; Khalil, Jawad; Hutchinson, James L.; Olzak, Kaya; Williams, Christopher M.; Li, Yong; Sessions, Richard; Cross, Stephen; Seager, Richard; Aungraheeta, Riyaad; Leard, Alan; McKinnon, Caroline M.; Phillips, David; Zhang, Lei; Poole, Alastair W.; Banting, George; Mundell, Stuart J. 分享 收藏
Pharmacodynamic Comparison of Ticagrelor Monotherapy Versus Ticagrelor and Aspirin in Patients After Percutaneous Coronary Intervention: The TEMPLATE (Ticagrelor Monotherapy and Platelet Reactivity) Randomized Controlled Trial 替格瑞洛单药治疗与替格瑞洛和阿司匹林在经皮冠状动脉介入术后患者中的药效学比较: 模板 (替格瑞洛单药治疗和血小板反应性) 随机对照试验 Johnson, Thomas W.; Baos, Sarah; Collett, Laura; Hutchinson, James L.; Nkau, Martin; Molina, Maria; Aungraheeta, Riyaad; Reilly-Stitt, Christopher; Bowles, Ruth; Reeves, Barnaby C.; Rogers, Chris A.; Mundell, Stuart J.; Baumbach, Andreas; Mumford, Andrew D. 分享 收藏
Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling Unsworth, Amanda J.; Bye, Alexander P.; Sage, Tanya; Gaspar, Renato S.; Eaton, Nathan; Drew, Caleb; Stainer, Alexander; Kriek, Neline; Volberding, Peter J.; Hutchinson, James L.; Riley, Ryan; Jones, Sarah; Mundell, Stuart J.; Cui, Weiguo; Falet, Herve; Gibbins, Jonathan M. 分享 收藏
Receptor homodimerization plays a critical role in a novel dominant negative P2RY12 variant identified in a family with severe bleeding Mundell, S. J.; Rabbolini, D.; Gabrielli, S.; Chen, Q.; Aungraheeta, R.; Hutchinson, J. L.; Kilo, T.; Mackay, J.; Ward, C. M.; Stevenson, W.; Morel-Kopp, M. -C. 分享 收藏
A novel thromboxane A2 receptor N42S variant results in reduced surface expression and platelet dysfunction Nisar, Shaista P.; Lordkipanidze, Marie; Jones, Matthew L.; Dawood, Ban B.; Murden, Sherina; Cunningham, Margaret R.; Mumford, Andrew D.; Wilde, Jonathan T.; Watson, Steve P.; Mundell, Stuart J.; Lowe, Gillian C. 分享 收藏
Diversity and impact of rare variants in genes encoding the platelet G protein-coupled receptors Jones, Matthew L.; Norman, Jane E.; Morgan, Neil V.; Mundell, Stuart J.; Lordkipanidze, Marie; Lowe, Gillian C.; Daly, Martina E.; Simpson, Michael A.; Drake, Sian; Watson, Steve P.; Mumford, Andrew D. 分享 收藏
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Impaired thromboxane receptor dimerization reduces signaling efficiency: A potential mechanism for reduced platelet function in vivo Capra, Valerie; Mauri, Mario; Guzzi, Francesca; Busnelli, Marta; Accomazzo, Maria Rosa; Gaussem, Pascale; Nisar, Shaista P.; Mundell, Stuart J.; Parenti, Marco; Rovati, G. Enrico 分享 收藏
Whole exome sequencing identifies genetic variants in inherited thrombocytopenia with secondary qualitative function defects Johnson, Ben; Lowe, Gillian C.; Futterer, Jane; Lordkipanidze, Marie; MacDonald, David; Simpson, Michael A.; Sanchez-Guiu, Isabel; Drake, Sian; Bem, Danai; Leo, Vincenzo; Fletcher, Sarah J.; Dawood, Ban; Rivera, Jose; Allsup, David; Biss, Tina; Bolton-Maggs, Paula H. B.; Collins, Peter; Curry, Nicola; Grimley, Charlotte; James, Beki; Makris, Mike; Motwani, Jayashree; Pavord, Sue; Talks, Katherine; Thachil, Jecko; Wilde, Jonathan; Williams, Mike; Harrison, Paul; Gissen, Paul; Mundell, Stuart; Mumford, Andrew; Daly, Martina E.; Watson, Steve P.; Morgan, Neil V. 分享 收藏
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