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Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology 单细胞和空间分析揭示结核分枝杆菌诱导的肌成纤维细胞是肺病理学的驱动因素 Mbano, Ian M.; Liu, Nuo; Wadsworth II, Marc H.; Chambers, Mark J.; Mpotje, Thabo; Asowata, Osaretin E.; Nyquist, Sarah K.; Nargan, Kievershen; Ramsuran, Duran; Karim, Farina; Hughes, Travis K.; Bromley, Joshua D.; Krause, Robert; Naidoo, Threnesan; Tezera, Liku B.; Reichmann, Michaela T.; Ganchua, Sharie Keanne; Kloverpris, Henrik N.; Dullabh, Kaylesh J.; Madansein, Rajhmun; Triana, Sergio; Steyn, Adrie J. C.; Berger, Bonnie; Marakalala, Mohlopheni J.; Fortune, Sarah M.; Flynn, JoAnne L.; Elkington, Paul T.; Shalek, Alex K.; Leslie, Alasdair 分享 收藏
Single-cell profiling reveals a role for tuberculosis-induced myofibroblasts in the immunopathology of infected lungs Liu, Nuo; Mbano, Ian Maheti; Wardsworth, Marc; Chambers, Mark; Mpotje, Thabo; Asowata, Osaretin; Nyquist, Sarah; Nargan, Kievershen; Ramsuran, Duran; Karim, Farina; Hughes, Travis; Bromley, Joshua; Krause, Robert; Tezera, Liku; Reichmann, Michaela; Keanne, Sharie; Ganchua, C.; Kloverpris, Henrik; Dullabh, Kaylesh; Madansein, Rajhmun; Triana, Sergio; Steyn, Adrie; Berger, Bonnie; Marakalala, Mohlopheni; Fortune, Sarah; Flynn, Joanne L.; Elkington, Paul T.; Shalek, Alex K.; Leslie, Alasdair 分享 收藏
Elevated Plasma Matrix Metalloproteinases Are Associated With Mycobacterium tuberculosis Bloodstream Infection and Mortality in Human Immunodeficiency Virus-Associated Tuberculosis 血浆基质金属蛋白酶升高与结核分枝杆菌血流感染和人类免疫缺陷病毒相关结核病的死亡率有关 Walker, Naomi F.; Schutz, Charlotte; Ward, Amy; Barr, David; Opondo, Charles; Shey, Muki; Elkington, Paul T.; Wilkinson, Katalin A.; Wilkinson, Robert J.; Meintjes, Graeme 分享 收藏
B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles 人类结核病中的b细胞异质性突出了区室特异性表型和功能作用 Krause, Robert; Ogongo, Paul; Tezera, Liku; Ahmed, Mohammed; Mbano, Ian; Chambers, Mark; Ngoepe, Abigail; Magnoumba, Magalli; Muema, Daniel; Karim, Farina; Khan, Khadija; Lumamba, Kapongo; Nargan, Kievershen; Madansein, Rajhmun; Steyn, Adrie; Shalek, Alex K.; Elkington, Paul; Leslie, A., I 分享 收藏
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An HLA- E- targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis 靶向hla-e的TCR双特异性分子可重定向针对结核分枝杆菌的T细胞免疫 Paterson, Rachel L.; La Manna, Marco P.; De Souza, Victoria Arena; Walker, Andrew; Gibbs-Howe, Dawn; Kulkarni, Rakesh; Fergusson, Joannah R.; Mulakkal, Nitha Charles; Monteiro, Mauro; Bunjobpol, Wilawan; Dembek, Marcin; Martin-Urdiroz, Magdalena; Grant, Tressan; Barber, Claire; Garay-Baquero, Diana J.; Tezera, Liku Bekele; Lowne, David; Britton-Rivet, Camille; Pengelly, Robert; Chepisiuk, Natalia; Singh, Praveen K.; Woon, Amanda P.; Powlesland, Alex S.; Mccully, Michelle L.; Caccamo, Nadia; Salio, Mariolina; Badami, Giusto Davide; Dorrell, Lucy; Knox, Andrew; Robinson, Ross; Elkington, Paul; Dieli, Francesco; Lepore, Marco; Leonard, Sarah; Godinho, Luis F. 分享 收藏
Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model CD200R的骨髓细胞表达在活动性结核病中受到调节，并在仿生模型中调节结核分枝杆菌感染 Ahmed, Mohamed; Tezera, Liku B.; Herbert, Nicholas; Chambers, Mark; Reichmann, Michaela T.; Nargan, Kievershen; Kloverpris, Henrik; Karim, Farina; Hlatshwayo, Mbali; Madensein, Rajhmun; Habesh, Munir; Hoque, Monjural; Steyn, Adrie J. C.; Elkington, Paul T.; Leslie, Alasdair J. 分享 收藏
Integrated plasma proteomics identifies tuberculosis-specific diagnostic biomarkers 综合血浆蛋白质组学鉴定结核病特异性诊断生物标志物 Schiff, Hannah F.; Walker, Naomi F.; Ugarte-Gil, Cesar; Tebruegge, Marc; Manousopoulou, Antigoni; Garbis, Spiros D.; Mansour, Salah; Wong, Pak Ho (Michael); Rockett, Gabrielle; Piazza, Paolo; Niranjan, Mahesan; Vallejo, Andres F.; Woelk, Christopher H.; Wilkinson, Robert J.; Tezera, Liku B.; Garay-Baquero, Diana; Elkington, Paul 分享 收藏
Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10 Ahmed, Mohamed; Mackenzie, Jared; Tezera, Liku; Krause, Robert; Truebody, Barry; Garay-Baquero, Diana; Vallejo, Andres; Govender, Katya; Adamson, John; Fisher, Hayden; Essex, Jonathan W.; Mansour, Salah; Elkington, Paul; Steyn, Adrie J. C.; Leslie, Alasdair 分享 收藏
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Towards an artificial human lung: modelling organ-like complexity to aid mechanistic understanding Humbert, Maria Victoria; Spalluto, Cosma Mirella; Bell, Joseph; Blume, Cornelia; Conforti, Franco; Davies, Elizabeth R.; Dean, Lareb S. N.; Elkington, Paul; Haitchi, Hans Michael; Jackson, Claire; Jones, Mark G.; Loxham, Matthew; Lucas, Jane S.; Morgan, Hywel; Polak, Marta; Staples, Karl J.; Swindle, Emily J.; Tezera, Liku; Watson, Alastair; Wilkinson, Tom M. A. 分享 收藏
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Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis Walker, N. F.; Karim, F.; Moosa, M. Y. S.; Moodley, S.; Mazibuko, M.; Khan, K.; Sterling, T. R.; van der Heijden, Y. F.; Grant, A. D.; Elkington, P. T.; Pym, A.; Leslie, A. 分享 收藏
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Doxycycline host-directed therapy in human pulmonary tuberculosis Miow, Qing Hao; Vallejo, Andres F.; Wang, Yu; Hong, Jia Mei; Bai, Chen; Teo, Felicia S. W.; Wang, Alvin D. Y.; Loh, Hong Rong; Tan, Tuan Zea; Ding, Ying; She, Hoi Wah; Gan, Suay Hong; Paton, Nicholas, I; Lum, Josephine; Tay, Alicia; Chee, Cynthia B. E.; Tambyah, Paul A.; Polak, Marta E.; Wang, Yee Tang; Singhal, Amit; Elkington, Paul T.; Friedland, Jon S.; Ong, Catherine W. M. 分享 收藏
Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets Reichmann, Michaela T.; Tezera, Liku B.; Vallejo, Andres F.; Vukmirovic, Milica; Xiao, Rui; Reynolds, James; Jogai, Sanjay; Wilson, Susan; Marshall, Ben; Jones, Mark G.; Leslie, Alasdair; D'Armiento, Jeanine M.; Kaminski, Naftali; Polak, Marta E.; Elkington, Paul 分享 收藏
A Personal Respirator to Improve Protection for Healthcare Workers Treating COVID-19 (PeRSo) Elkington, Paul T.; Dickinson, Alexander S.; Mavrogordato, Mark N.; Spencer, Daniel C.; Gillams, Richard J.; De Grazia, Antonio; Rosini, Sebastian; Garay-Baquero, Diana J.; Diment, Laura E.; Mahobia, Nitin; Mant, Alexandra; Baynham, Tom; Morgan, Hywel 分享 收藏
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