Nicholas Furnham - Publications, H-index & Citations

Nicholas Furnham

London School of Hygiene & Tropical Medicine

30H指数

85论文数

4.1K被引数

收录论文 39

发表时间

Workflow for Crystallographic Fragment Screening by Crystal Soaking for Protein Targets: A Case Study on Thioredoxin Glutathione Reductase from Schistosoma mansoni 利用晶体浸泡进行蛋白质靶点晶体学片段筛选的工作流程：以曼氏血吸虫硫氧还蛋白谷胱甘肽还原酶为例

BIO-PROTOCOL

IF1.1

2026-04-20

PREAI

Neto, Lauro R. S.; Montoya, Bogar O.; Brandao-Neto, Jose; Parker, Kelly; von Delft, Frank; Furnham, Nicholas; Owens, Raymond J.; Silva-Jr, Floriano P.

Unveiling the ghost: machine learning's impact on the landscape of virology

JOURNAL OF GENERAL VIROLOGY

IF4.3

2025-01-13

PREAI

Bowyer, Sebastian; Allen, David J.; Furnham, Nicholas

Fragment library screening by X-ray crystallography and binding site analysis on thioredoxin glutathione reductase of Schistosoma mansoni

SCIENTIFIC REPORTS

IF3.9

2024-01-18

OAAI

Neto, Lauro Ribeiro de Souza; Montoya, Bogar Omar; Brandao-Neto, Jose; Verma, Anil; Bowyer, Sebastian; Moreira-Filho, Jose Teofilo; Dantas, Rafael Ferreira; Neves, Bruno Junior; Andrade, Carolina Horta; von Delft, Frank; Owens, Raymond J.; Furnham, Nicholas; Silva-Jr, Floriano Paes

Optimisation-based modelling for explainable lead discovery in malaria

ARTIFICIAL INTELLIGENCE IN MEDICINE

IF6.2

2024-01-01

OAAI

Li, Yutong; Cardoso-Silva, Jonathan; Kelly, John M.; Delves, Michael J.; Furnham, Nicholas; Papageorgiou, Lazaros G.; Tsoka, Sophia

A computational method for predicting the most likely evolutionary trajectories in the stepwise accumulation of resistance mutations

ELIFE

IF0

2023-12-22

OAAI

Eccleston, Ruth Charlotte; Manko, Emilia; Campino, Susana; Clark, Taane G.; Furnham, Nicholas

Editorial: Current approaches in infectious disease drug discovery

FRONTIERS IN CHEMISTRY

IF4.2

2022-11-30

OAAI

Silva-Jr, Floriano P.; Panda, Siva S.; Andrade, Carolina Horta; Furnham, Nicholas

Novel computational models offer alternatives to animal testing for assessing eye irritation and corrosion potential of chemicals

ARTIFICIAL INTELLIGENCE IN THE LIFE SCIENCES

IF5.4

2021-12-01

OAAI

Silva, Arthur C.; Borba, Joyce V. V. B.; Alves, Vinicius M.; Hall, Steven U. S.; Furnham, Nicholas; Kleinstreuer, Nicole; Muratov, Eugene; Tropsha, Alexander; Andrade, Carolina Horta

Structural and Genomic Insights Into Pyrazinamide Resistance in Mycobacterium tuberculosis Underlie Differences Between Ancient and Modern Lineages

FRONTIERS IN MOLECULAR BIOSCIENCES

IF4

2021-07-23

OAAI

Tunstall, Tanushree; Phelan, Jody; Eccleston, Charlotte; Clark, Taane G.; Furnham, Nicholas

Schistosomiasis Drug Discovery in the Era of Automation and Artificial Intelligence 自动化和人工智能时代的血吸虫病药物发现

FRONTIERS IN IMMUNOLOGY

IF5.9

2021-05-31

OAAI

Moreira-Filho, Jose T.; Silva, Arthur C.; Dantas, Rafael F.; Gomes, Barbara F.; Souza Neto, Lauro R.; Brandao-Neto, Jose; Owens, Raymond J.; Furnham, Nicholas; Neves, Bruno J.; Silva-Junior, Floriano P.; Andrade, Carolina H.

Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches

SCIENTIFIC REPORTS

IF3.9

2020-10-22

OAAI

Portelli, Stephanie; Myung, Yoochan; Furnham, Nicholas; Vedithi, Sundeep Chaitanya; Pires, Douglas E. V.; Ascher, David B.

In silico Strategies to Support Fragment-to-Lead Optimization in Drug Discovery 在药物发现中支持片段到引线优化的计算机策略

FRONTIERS IN CHEMISTRY

IF4.2

2020-02-18

140

OAAI

de Souza Neto, Lauro Ribeiro; Moreira-Filho, Jose Teofilo; Neves, Bruno Junior; Maidana, Rocio Lucia Beatriz Riveros; Guimaraes, Ana Carolina Ramos; Furnham, Nicholas; Andrade, Carolina Horta; Silva, Floriano Paes, Jr.

Computationally-guided drug repurposing enables the discovery of kinase targets and inhibitors as new schistosomicidal agents

plos biology

IF3.6

2018-10-22

OAAI

Giuliani, Sandra; Silva, Arthur C.; Borba, Joyce V. V. B.; Ramos, Pablo I. P.; Paveley, Ross A.; Muratov, Eugene N.; Andrade, Carolina Horta; Furnham, Nicholas

Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis

SCIENTIFIC REPORTS

IF3.9

2018-10-18

OAAI

Portelli, Stephanie; Phelan, Jody E.; Ascher, David B.; Clark, Taane G.; Furnham, Nicholas

Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis (vol 50, pg 307, 2018)

NATURE GENETICS

IF31.8

2018-04-19

OAAI

Coll, Francesc; Phelan, Jody; Hill-Cawthorne, Grant A.; Nair, Mridul B.; Mallard, Kim; Ali, Shahjahan; Abdallah, Abdallah M.; Alghamdi, Saad; Alsomali, Mona; Ahmed, Abdallah O.; Portelli, Stephanie; Oppong, Yaa; Alves, Adriana; Bessa, Theolis Barbosa; Campino, Susana; Caws, Maxine; Chatterjee, Anirvan; Crampin, Amelia C.; Dheda, Keertan; Furnham, Nicholas; Glynn, Judith R.; Grandjean, Louis; Dang Minh Ha; Hasan, Rumina; Hasan, Zahra; Hibberd, Martin L.; Joloba, Moses; Jones-Lopez, Edward C.; Matsumoto, Tomoshige; Miranda, Anabela; Moore, David J.; Mocillo, Nora; Panaiotov, Stefan; Parkhill, Julian; Penha, Carlos; Perdigao, Joao; Portugal, Isabel; Rchiad, Zineb; Robledo, Jaime; Sheen, Patricia; Shesha, Nashwa Talaat; Sirgel, Frik A.; Sola, Christophe; Sousa, Erivelton Oliveira; Streicher, Elizabeth M.; Van Helden, Paul; Viveiros, Miguel; Warren, Robert M.; McNerney, Ruth; Pain, Arnab; Clark, Taane G.

To what extent do structural changes in catalytic metal sites affect enzyme function?

JOURNAL OF INORGANIC BIOCHEMISTRY

IF3.2

2018-02-01

OAAI

Valasatava, Yana; Rosato, Antonio; Furnham, Nicholas; Thornton, Janet M.; Andreini, Claudia

Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis 耐多药和广泛耐药结核分枝杆菌的全基因组分析

NATURE GENETICS

IF31.8

2018-01-22

244

PREAI

Understanding enzyme function evolution from a computational perspective

CURRENT OPINION IN STRUCTURAL BIOLOGY

IF7

2017-12-01

OAAI

Tyzack, Jonathan D.; Furnham, Nicholas; Sillitoe, Ian; Orengo, Christine M.; Thornton, Janet M.

Mechanism and Catalytic Site Atlas (M-CSA): a database of enzyme reaction mechanisms and active sites

NUCLEIC ACIDS RESEARCH

IF13.1

2017-11-02

148

OAAI

Ribeiro, Antonio J. M.; Holliday, Gemma L.; Furnham, Nicholas; Tyzack, Jonathan D.; Ferris, Katherine; Thornton, Janet M.

Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-07-22

OAAI

Neves, Bruno J.; Dantas, Rafael F.; Senger, Mario R.; Melo-Filho, Cleber C.; Valente, Walter C. G.; de Almeida, Ana C. M.; Rezende-Neto, Joao M.; Lima, Elid F. C.; Paveley, Ross; Furnham, Nicholas; Muratov, Eugene; Kamentsky, Lee; Carpenter, Anne E.; Braga, Rodolpho C.; Silva-Junior, Floriano P.; Andrade, Carolina Horta

QSAR-Driven Discovery of Novel Chemical Scaffolds Active against Schistosoma mansoni

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2016-06-16

OAAI

Melo-Filho, Cleber C.; Dantas, Rafael F.; Braga, Rodolpho C.; Neves, Bruno J.; Senger, Mario R.; Valente, Walter C. G.; Rezende-Neto, Joao M.; Chaves, Willian T.; Muratov, Eugene N.; Paveley, Ross A.; Furnham, Nicholas; Kamentsky, Lee; Carpenter, Anne E.; Silva-Junior, Floriano P.; Andrade, Carolina H.

研究方向