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Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy Shin, Niu; Stubbs, Matthew; Koblish, Holly; Yue, Eddy W.; Soloviev, Maxim; Douty, Brent; Wang, Kathy He; Wang, Qian; Gao, Mingming; Feldman, Patricia; Yang, Gengjie; Hall, Leslie; Hansbury, Michael; O'Connor, Sybil; Leffet, Lynn; Collins, Robert; Katiyar, Kamna; He, Xin; Waeltz, Paul; Collier, Paul; Lu, Jin; Li, Yun-Long; Li, Yanlong; Liu, Phillip C. C.; Burn, Timothy; Covington, Maryanne; Diamond, Sharon; Shuey, Dana; Roberts, Alan; Yeleswaram, Swamy; Hollis, Greg; Metcalf, Brian; Yao, Wenqing; Huber, Reid; Combs, Andrew; Newton, Robert; Scherle, Peggy 分享 收藏
Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis Bergiers, Isabelle; Andrews, Tallulah; Bolukbasi, Ozge Vergel; Buness, Andreas; Janosz, Ewa; Lopez-Anguita, Natalia; Ganter, Kerstin; Kosim, Kinga; Celen, Cemre; Percin, Gulce Itir; Collier, Paul; Baying, Bianka; Benes, Vladimir; Hemberg, Martin; Lancrin, Christophe 分享 收藏
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The novel FGFR4-selective inhibitor INCB062079 is efficacious in models of hepatocellular carcinoma harboring FGF19 amplification Ruggeri, Bruce; Stubbs, Matthew; Yang, Yan-ou; Juvekar, Ashish; Lu, Liang; Condon, Sindy; DiMatteo, Darlise; Wen, Xiaoming; Collier, Paul; Burn, Timothy; Wu, Liangxing; Wilson, Daniel; Yeleswaram, Swamy; Roberts, Alan; Yao, Wenqing; Hollis, Gregory; Huber, Reid; Scherle, Peggy; Liu, Phillip C. C. 分享 收藏
Selective inhibition of FGFR4 by INCB062079 is efficacious in models of FGF19-and FGFR4-dependent cancers Liu, Phillip C. C.; Lu, Liang; Bowman, Kevin; Stubbs, Matthew C.; Wu, Liangxing; DiMatteo, Darlise; Condon, Sindy; Klabe, Ronald; Qian, Ding-Quan; Wen, Xiaoming; Collier, Paul; Gallagher, Karen; Hansbury, Michael; He, Xin; Ruggeri, Bruce; Yang, Yan-ou; Covington, Maryanne; Burn, Timothy C.; Diamond-Fosbenner, Sharon; Wynn, Richard; Huber, Reid; Yao, Wenqing; Yeleswaram, Swamy; Scherle, Peggy; Hollis, Gregory 分享 收藏
3′ Uridylation controls mature microRNA turnover during CD4 T-cell activation Gutierrez-Vazquez, Cristina; Enright, Anton J.; Rodriguez-Galan, Ana; Perez-Garcia, Arantxa; Collier, Paul; Jones, Matthew R.; Benes, Vladimir; Mizgerd, Joseph P.; Mittelbrunn, Maria; Ramiro, Almudena R.; Sanchez-Madrid, Francisco 分享 收藏
Downmodulation of key inflammatory cell markers with a topical Janus kinase 1/2 inhibitor Punwani, N.; Burn, T.; Scherle, P.; Flores, R.; Shi, J.; Collier, P.; Hertel, D.; Haley, P.; Lo, Y.; Waeltz, P.; Rodgers, J.; Shepard, S.; Vaddi, K.; Yeleswaram, S.; Levy, R.; Williams, W.; Gottlieb, A. B. 分享 收藏
Preclinical characterization of the selective FGFR inhibitor INCB054828 Liu, Phillip C. C.; Wu, Liangxing; Koblish, Holly; Bowman, Kevin; Zhang, Yue; Klabe, Ronald; Leffet, Lynn; DiMatteo, Darlise; Rupar, Mark; Gallagher, Karen; Hansbury, Michael; Zhang, Colin; He, Chunhong; Collier, Paul; Covington, Maryanne; Wynn, Richard; Yeleswaram, Swamy; Vaddi, Kris; Burn, Timothy; Yao, Wenqing; Huber, Reid; Scherle, Peggy; Hollis, Gregory 分享 收藏
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Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation Fridman, Jordan S.; Scherle, Peggy A.; Collins, Robert; Burn, Timothy; Neilan, Claire L.; Hertel, Denise; Contel, Nancy; Haley, Patrick; Thomas, Beth; Shi, Jack; Collier, Paul; Rodgers, James D.; Shepard, Stacey; Metcalf, Brian; Hollis, Gregory; Newton, Robert C.; Yeleswaram, Swamy; Friedman, Steven M.; Vaddi, Kris 分享 收藏
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Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050 Fridman, Jordan S.; Scherle, Peggy A.; Collins, Robert; Burn, Timothy C.; Li, Yanlong; Li, Jun; Covington, Maryanne B.; Thomas, Beth; Collier, Paul; Favata, Margaret F.; Wen, Xiaoming; Shi, Jack; McGee, Ryan; Haley, Patrick J.; Shepard, Stacey; Rodgers, James D.; Yeleswaram, Swamy; Hollis, Greg; Newton, Robert C.; Metcalf, Brian; Friedman, Steven M.; Vaddi, Kris 分享 收藏
Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344 Brodmerkel, CM; Huber, R; Covington, M; Diamond, S; Hall, L; Collins, R; Leffet, L; Gallagher, K; Feldman, P; Collier, P; Stow, M; Gu, XM; Baribaud, F; Shin, N; Thomas, B; Burn, T; Hollis, G; Yeleswaram, S; Solomon, K; Friedman, S; Wang, AL; Xue, CB; Newton, RC; Scherle, P; Vaddi, K 分享 收藏
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