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N

Nikolas Fechner

biomedical research, novartis pharma ag

16H指数
35论文数
794被引数
收录论文 17
发表时间
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The changing landscape of medicinal chemistry optimization药物化学优化的变化格局
errNature Reviews Drug Discovery
IF101.8
err2025-07-07
err0
PREAI
errAnita Rácz; Levente M. Mihalovits; Maximilian Beckers; Nikolas Fechner; Nikolaus Stiefl; Finton Sirockin; William McCoull; Emma Evertsson; Malin Lemurell; Gergely Makara; György M. Keserű
err分享
err收藏
Balancing Molecular Size, Activity, Permeability, and Other Properties: Drug Candidates in the Context of Their Chemical Structure Optimization
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-08-13
err0
PREAI
errBeckers, Maximilian; Sirockin, Finton; Fechner, Nikolas; Stiefl, Nikolaus
err分享
err收藏
Prediction of Small-Molecule Developability Using Large-Scale In Silico ADMET Models
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-10-10
err7
PREAI
errBeckers, Maximilian; Sturm, Noe; Sirockin, Finton; Fechner, Nikolas; Stiefl, Nikolaus
err分享
err收藏
MELLODDY: Cross-pharma Federated Learning at Unprecedented Scale Unlocks Benefits in QSAR without Compromising Proprietary InformationMELLODDY: 跨制药联合学习以前所未有的规模在不损害专有信息的情况下解锁QSAR的好处
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2023-08-29
err34
errOAAI
errHeyndrickx, Wouter; Mervin, Lewis; Morawietz, Tobias; Sturm, Noe; Friedrich, Lukas; Zalewski, Adam; Pentina, Anastasia; Humbeck, Lina; Oldenhof, Martijn; Niwayama, Ritsuya; Schmidtke, Peter; Fechner, Nikolas; Simm, Jaak; Arany, Adam; Drizard, Nicolas; Jabal, Rama; Afanasyeva, Arina; Loeb, Regis; Verma, Shlok; Harnqvist, Simon; Holmes, Matthew; Pejo, Balazs; Telenczuk, Maria; Holway, Nicholas; Dieckmann, Arne; Rieke, Nicola; Zumsande, Friederike; Clevert, Djork-Arne; Krug, Michael; Luscombe, Christopher; Green, Darren; Ertl, Peter; Antal, Peter; Marcus, David; Do Huu, Nicolas; Fuji, Hideyoshi; Pickett, Stephen; Acs, Gergely; Boniface, Eric; Beck, Bernd; Sun, Yax; Gohier, Arnaud; Rippmann, Friedrich; Engkvist, Ola; Goeller, Andreas H.; Moreau, Yves; Galtier, Mathieu N.; Schuffenhauer, Ansgar; Ceulemans, Hugo
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PREFER: A New Predictive Modeling Framework for Molecular Discovery
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2023-07-24
err7
PREAI
errLanini, Jessica; Santarossa, Gianluca; Sirockin, Finton; Lewis, Richard; Fechner, Nikolas; Misztela, Hubert; Lewis, Sarah; Maziarz, Krzysztof; Stanley, Megan; Segler, Marwin; Stiefl, Nikolaus; Schneider, Nadine
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25 Years of Small-Molecule Optimization at Novartis: A Retrospective Analysis of Chemical Series Evolution
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2022-11-09
err14
PREAI
errBeckers, Maximilian; Fechner, Nikolas; Stiefl, Nikolaus
err分享
err收藏
Evolution of Novartis' Small Molecule Screening Deck Design诺华小分子筛板设计的演变
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2020-11-03
err36
PREAI
errSchuffenhauer, Ansgar; Schneider, Nadine; Hintermann, Samuel; Auld, Douglas; Blank, Jutta; Cotesta, Simona; Engeloch, Caroline; Fechner, Nikolas; Gaul, Christoph; Giovannoni, Jerome; Jansen, Johanna; Joslin, John; Krastel, Philipp; Lounkine, Eugen; Manchester, John; Monovich, Lauren G.; Pelliccioli, Anna Paola; Schwarze, Manuel; Shultz, Michael D.; Stiefl, Nikolaus; Baeschlin, Daniel K.
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Automated Identification of Chemical Series: Classifying like a Medicinal Chemist
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2020-05-06
err8
PREAI
errKruger, Franziska; Fechner, Nikolas; Stiefl, Nikolaus
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Chiral Cliffs: Investigating the Influence of Chirality on Binding Affinity手性悬崖: 研究手性对结合亲和力的影响
errCHEMMEDCHEM
IF3.4
err2018-06-11
err24
PREAI
errSchneider, Nadine; Lewis, Richard A.; Fechner, Nikolas; Ertl, Peter
err分享
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Chemical Topic Modeling: Exploring Molecular Data Sets Using a Common Text-Mining Approach
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2017-08-09
err20
PREAI
errSchneider, Nadine; Fechner, Nikolas; Landrum, Gregory A.; Stiefl, Nikolaus
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err收藏
Heterogeneous Classifier Fusion for Ligand-Based Virtual Screening: Or, How Decision Making by Committee Can Be a Good Thing
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2013-11-14
err46
PREAI
errRiniker, Sereina; Fechner, Nikolas; Landrum, Gregory A.
err分享
err收藏
jCompoundMapper: An open source Java library and command-line tool for chemical fingerprints
errJOURNAL OF CHEMINFORMATICS
IF5.7
err2011-01-10
err68
errOAAI
errHinselmann, Georg; Rosenbaum, Lars; Jahn, Andreas; Fechner, Nikolas; Zell, Andreas
err分享
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Large-Scale Learning of Structure-Activity Relationships Using a Linear Support Vector Machine and Problem-Specific Metrics
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2011-01-05
err22
PREAI
errHinselmann, Georg; Rosenbaum, Lars; Jahn, Andreas; Fechner, Nikolas; Ostermann, Claude; Zell, Andreas
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Graph kernels for chemical compounds using topological and three-dimensional local atom pair environments
errNEUROCOMPUTING
IF6.5
err2010-12-01
err9
PREAI
errHinselmann, Georg; Fechner, Nikolas; Jahn, Andreas; Eckert, Matthias; Zell, Andreas
err分享
err收藏
Estimation of the applicability domain of kernel-based machine learning models for virtual screening
errJOURNAL OF CHEMINFORMATICS
IF5.7
err2010-03-11
err47
errOAAI
errFechner, Nikolas; Jahn, Andreas; Hinselmann, Georg; Zell, Andreas
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err收藏
Optimal assignment methods for ligand-based virtual screening
errJOURNAL OF CHEMINFORMATICS
IF5.7
err2009-08-25
err83
errOAAI
errJahn, Andreas; Hinselmann, Georg; Fechner, Nikolas; Zell, Andreas
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Atomic Local Neighborhood Flexibility Incorporation into a Structured Similarity Measure for QSAR
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2009-02-18
err17
PREAI
errFechner, Nikolas; Jahn, Andreas; Hinselmann, Georg; Zell, Andreas
err分享
err收藏

研究方向

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合作学者
合作期刊
S
Sarah Lewis
H 指数: 93 · 论文数: 837
Y
Yves Moreau
H 指数: 67 · 论文数: 609
A
Andreas Zell
H 指数: 57 · 论文数: 665
O
Ola Engkvist
H 指数: 55 · 论文数: 429
G
György M. Keserű
H 指数: 50 · 论文数: 418
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