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H

Hiroaki Ochiiwa

taiho pharmaceutical
H指数:7
被引数:407

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Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2) (vol 67, pg 4655, 2024)

基于片段的SH2结构域蛋白酪氨酸磷酸酶-2（SHP2）别构抑制剂的发现（vol 67, pg 4655, 2024）

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-05-080
PRE
Day, James E. H.; Berdini, Valerio; Castro, Joan; Chessari, Gianni; Davies, Thomas G.; Day, Philip J.; Denis, Jeffrey D. St; Fujiwara, Hideto; Fukaya, Satoshi; Hamlett, Christopher C. F.; Hearn, Keisha; Hiscock, Steven D.; Holvey, Rhian S.; Ito, Satoru; Kandola, Navrohit; Kodama, Yasuo; Liebeschuetz, John W.; Martins, Vanessa; Matsuo, Kenichi; Mortenson, Paul N.; Muench, Sandra; Nakatsuru, Yoko; Ochiiwa, Hiroaki; Palmer, Nicholas; Peakman, Torren; Price, Amanda; Reader, Michael; Rees, David C.; Rich, Sharna J.; Shah, Alpesh; Shibata, Yoshihiro; Smyth, Tomoko; Twigg, David G.; Wallis, Nicola G.; Williams, Glyn; Wilsher, Nicola E.; Woodhead, Andrew; Shimamura, Tadashi; Johnson, Christopher N.
Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-03-113
PRE
Day, James E. H.; Berdini, Valerio; Castro, Joan; Chessari, Gianni; Davies, Thomas G.; Day, Philip J.; St. Denis, Jeffrey D.; Fujiwara, Hideto; Fukaya, Satoshi; Hamlett, Christopher C. F.; Hearn, Keisha; Hiscock, Steven D.; Holvey, Rhian S.; Ito, Satoru; Kandola, Navrohit; Kodama, Yasuo; Liebeschuetz, John W.; Martins, Vanessa; Matsuo, Kenichi; Mortenson, Paul N.; Muench, Sandra; Nakatsuru, Yoko; Ochiiwa, Hiroaki; Palmer, Nicholas; Peakman, Torren; Price, Amanda; Reader, Michael; Rees, David C.; Rich, Sharna J.; Shah, Alpesh; Shibata, Yoshihiro; Smyth, Tomoko; Twigg, David G.; Wallis, Nicola G.; Williams, Glyn; Wilsher, Nicola E.; Woodhead, Andrew; Shimamura, Tadashi; Johnson, Christopher N.
TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia
ONCOGENE
IF7.3
2021-01-0823
OAAI
Ochiiwa, Hiroaki; Ailiken, Guzhanuer; Yokoyama, Masataka; Yamagata, Kazuyuki; Nagano, Hidekazu; Yoshimura, Chihoko; Muraoka, Hiromi; Ishida, Keiji; Haruma, Tomonori; Nakayama, Akitoshi; Hashimoto, Naoko; Murata, Kazutaka; Nishimura, Motoi; Kawashima, Yusuke; Ohara, Osamu; Ohkubo, Shuichi; Tanaka, Tomoaki
The Novel VEGF Receptor/MET-Targeted Kinase Inhibitor TAS-115 Has Marked In Vivo Antitumor Properties and a Favorable Tolerability Profile
MOLECULAR CANCER THERAPEUTICS
IF5.5
2013-12-0534
OAAI
Fujita, Hidenori; Miyadera, Kazutaka; Kato, Masanori; Fujioka, Yayoi; Ochiiwa, Hiroaki; Huang, Jinhong; Ito, Kimihiro; Aoyagi, Yoshimi; Takenaka, Toru; Suzuki, Takamasa; Ito, Satoko; Hashimoto, Akihiro; Suefuji, Takashi; Egami, Kosuke; Kazuno, Hideki; Suda, Yoshimitsu; Nishio, Kazuto; Yonekura, Kazuhiko
The prominent safety profile of TAS-115, a novel c-Met plus VEGFR dual kinase inhibitor can lead to potentiate the efficacy via durable inhibition of angiogenesis
CANCER RESEARCH
IF16.6
2011-04-010
PRE
Ochiiwa, Hiroaki; Fujita, Hidenori; Ito, Kimihiro; Takenaka, Toru; Huang, Jinhong; Ito, Satoko; Suzuki, Takamasa; Egami, Kousuke; Suefuji, Takashi; Sato, Ayako; Sato, Tsudoi; Fujioka, Yayoi; Kato, Masanori; Aoyagi, Yoshimi; Hashimoto, Akihiro; Kazuno, Hideki; Miyadera, Kazutaka; Suda, Yoshimitsu; Yonekura, Kazuhiko

研究方向

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H
Hidenori Fujita
H 指数:9论文数:41被引数:407
H
Hiroshi Sootome
H 指数:9论文数:82被引数:1,335
Y
Yayoi Fujioka
H 指数:8论文数:50被引数:374
K
Kazuhiko Yonekura
H 指数:15论文数:88被引数:1,617
K
Kazutaka Miyadera
H 指数:21论文数:106被引数:2,496
Y
Yoko Nakatsuru
H 指数:29论文数:121被引数:4,628
K
Kimihiro Ito
H 指数:13论文数:97被引数:661
T
Teruhiro Utsugi
H 指数:22论文数:209被引数:2,166
T
Takamasa Suzuki
H 指数:32论文数:441被引数:5,174
S
Satoko Ito
H 指数:13论文数:144被引数:691