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Lingtian Zhang

University of Arkansas System

H指数:12

被引数:339

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工作经历

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Progress in Research and Prospects for Application of Precision Gene-Editing Technology Based on CRISPR-Cas9 in the Genetic Improvement of Sheep and Goats

基于CRISPR-Cas9的精准基因编辑技术在绵羊和山羊遗传改良中的研究进展及应用前景

AGRICULTURE-BASEL

IF3.6

2024-03-184

OA

Discovery of fused benzimidazole-imidazole autophagic flux inhibitors for treatment of triple-negative breast cancer

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2022-10-0111

PRE

Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-01-279

OA

Discovery of 4-aminoquinolines as highly selective TGFbR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2021-12-013

PREAI

Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2021-12-0115

OAAI

Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors

新型非激酶tgf β 途径抑制剂酞嗪的发现和生物学评价

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2021-11-012

OAAI

Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases

SCIENTIFIC REPORTS

IF3.9

2021-08-098

OAAI

Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2021-04-0123

OAAI

Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation

吡咯并 [2，3-d] 嘧啶衍生物作为RET抑制剂的设计、合成及生物学评价

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2020-11-0125

OAAI

Discovery of SP-96, the first non-ATP-competitive Aurora Kinase B inhibitor, for reduced myelosuppression

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2020-10-0129

PREAI

Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-04-1628

OAAI

Rational Design, Synthesis and Biological Evaluation of Pyrimidine-4,6-diamine derivatives as Type-II inhibitors of FLT3 Selective Against c-KIT

SCIENTIFIC REPORTS

IF3.9

2018-02-2720

OAAI

Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts

CHEMICAL COMMUNICATIONS

IF4.2

2018-01-0135

OAAI

Sulfation of afimoxifene, endoxifen, raloxifene, and fulvestrant by the human cytosolic sulfotransferases (SULTs): A systematic analysis

JOURNAL OF PHARMACOLOGICAL SCIENCES

IF2.9

2015-07-0121

OAAI