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V

Valery Polyakov

Novartis
H指数:18
被引数:990

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荣誉奖项

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Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-04-3014
OA
Lapointe, Guillaume; Skepper, Colin K.; Holder, Lauren M.; Armstrong, Duncan; Bellamacina, Cornelia; Blais, Johanne; Bussiere, Dirksen; Bian, Jianwei; Cepura, Cody; Chan, Helen; Dean, Charles R.; De Pascale, Gianfranco; Dhumale, Bhavesh; Fisher, L. Mark; Fulsunder, Mangesh; Kantariya, Bhavin; Kim, Julie; King, Sean; Kossy, Lauren; Kulkarni, Upendra; Lakshman, Jay; Leeds, Jennifer A.; Ling, Xiaolan; Lvov, Anatoli; Ma, Sylvia; Malekar, Swapnil; McKenney, David; Mergo, Wosenu; Metzger, Louis; Mhaske, Keshav; Moser, Heinz E.; Mostafavi, Mina; Namballa, Sunil; Noeske, Jonas; Osborne, Colin; Patel, Ashish; Patel, Darshit; Patel, Tushar; Piechon, Philippe; Polyakov, Valery; Prajapati, Krunal; Prosen, Katherine R.; Reck, Folkert; Richie, Daryl L.; Sanderson, Mark R.; Satasia, Shailesh; Savani, Bhautik; Selvarajah, Jogitha; Sethuraman, Vijay; Shu, Wei; Tashiro, Kyuto; Thompson, Katherine, V; Vaarla, Krishniah; Vala, Lakhan; Veselkov, Dennis A.; Vo, Jason; Vora, Bhavesh; Wagner, Trixie; Wedel, Laura; Williams, Sarah L.; Yendluri, Satya; Yue, Qin; Yifru, Aregahegn; Zhang, Yong; Rivkin, Alexey
Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-05-0632
OAAI
Ramurthy, Savithri; Taft, Benjamin R.; Aversa, Robert J.; Barsanti, Paul A.; Burger, Matthew T.; Lou, Yan; Nishiguchi, Gisele A.; Rico, Alice; Setti, Lina; Smith, Aaron; Subramanian, Sharadha; Tamez, Victoriano; Tanner, Huw; Wan, Lifeng; Hu, Cheng; Appleton, Brent A.; Mamo, Mulugeta; Tandeske, Laura; Tellew, John E.; Huang, Shenlin; Yue, Qn; Cliaudliary, Apurva; Tian, Hung; Iyer, Raman; Hassan, A. Quamrul; Griner, Lesley A. Mathews; La Bonte, Laura R.; Cooke, Vesselina G.; Van Abbema, Anne; Merritt, Hanne; Gampa, Kalyani; Feng, Fei; Yuan, Jing; Mishina, Yuji; Wang, Yingyun; Haling, Jacob R.; Vaziri, Sepideh; Hekmat-Nejad, Mohammad; Polyakov, Valery; Zang, Richard; Sethuraman, Vijay; Amiri, Payman; Singh, Mallika; Sellers, William R.; Lees, Emma; Shao, Wenlin; Dillon, Michael P.; Stuart, Darrin D.
X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome
CHEMMEDCHEM
IF3.4
2018-08-1629
PREAI
Kallen, Joerg; Bergsdorf, Christian; Arnaud, Bertrand; Bernhard, Mario; Brichet, Murielle; Cobos-Correa, Amanda; Elhajouji, Azeddine; Freuler, Felix; Galimberti, Ivan; Guibourdenche, Christel; Haenni, Simon; Holzinger, Sandra; Hunziker, Juerg; Izaac, Aude; Kaufmann, Markus; Leder, Lukas; Martus, Hans-Joerg; von Matt, Peter; Polyakov, Valery; Roethlisberger, Patrik; Roma, Guglielmo; Stiefl, Nikolaus; Uteng, Marianne; Lerchner, Andreas
Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor
CANCER RESEARCH
IF16.6
2018-07-014
PRE
Stuart, Darrin D.; Shao, Wenlin; Mishina, Yuji; Feng, Yun; Caponigro, Giordano; Cooke, Vesselina G.; Rivera, Stacey; Shen, Fang; Korn, Joshua; Griner, Lesley A. Mathews; Nishiguchi, Giselle; Taft, Benjamin; Wan, Lifeng; Subramanian, Sharadha; Lou, Yan; Setti, Lina; Burger, Matthew; Tamez, Victor; Rico, Alice; Aversa, Robert; Tellew, John; Haling, Jacob R.; Polyakov, Valery; Lambert, Amy; Zang, Richard; Van Abbema, Ann; Hekmat-Nejad, Mohamad; Amiri, Payman; Singh, Mallika; Keen, Nicholas; Dillon, Michael P.; Lees, Emma; Sellers, William R.; Ramurthy, Savithri
Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF
CANCER RESEARCH
IF16.6
2018-03-1430
OAAI
Shao, Wenlin; Mishina, Yuji M.; Feng, Yun; Caponigro, Giordano; Cooke, Vesselina G.; Rivera, Stacy; Wang, Yingyun; Shen, Fang; Korn, Joshua M.; Griner, Lesley A. Mathews; Nishiguchi, Gisele; Rico, Alice; Tellew, John; Haling, Jacob R.; Aversa, Robert; Polyakov, Valery; Zang, Richard; Hekmat-Nejad, Mohammad; Amiri, Payman; Singh, Mallika; Keen, Nicholas; Dillon, Michael P.; Lees, Emma; Ramurthy, Savithri; Sellers, William R.; Stuart, Darrin D.
Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-03-0225
PREAI
Moreau, Robert J.; Skepper, Colin K.; Appleton, Brent A.; Blechschmidt, Anke; Balibar, Carl J.; Benton, Bret M.; Drumm, Joseph E., III; Feng, Brian Y.; Geng, Mei; Li, Cindy; Lindvall, Mika K.; Lingel, Andreas; Lu, Yipin; Mamo, Mulugeta; Mergo, Wosenu; Polyakov, Valery; Smith, Thomas M.; Takeoka, Kenneth; Uehara, Kyoko; Wang, Lisha; Wei, Jun-Rong; Weiss, Andrew H.; Xie, Lili; Xu, Wenjian; Zhang, Qiong; de Vicente, Javier
Design and Discovery of N-(2-Methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-06-0846
PREAI
Nishiguchi, Gisele A.; Rico, Alice; Tanner, Huw; Aversa, Robert J.; Taft, Benjamin R.; Subramanian, Sharadha; Setti, Lina; Burger, Matthew T.; Wan, Lifeng; Tamez, Victoriano; Smith, Aaron; Lou, Yan; Barsanti, Paul A.; Appleton, Brent A.; Mamo, Mulugeta; Tandeske, Laura; Dix, Ina; Tellew, John E.; Huang, Shenlin; Griner, Lesley A. Mathews; Cooke, Vesselina G.; Van Abbema, Anne; Merritt, Hanne; Ma, Sylvia; Gampa, Kalyani; Feng, Fei; Yuan, Jing; Wang, Yingyun; Haling, Jacob R.; Vaziri, Sepideh; Hekmat-Nejad, Mohammad; Jansen, Johanna M.; Polyakov, Valery; Zang, Richard; Sethuraman, Vijay; Amiri, Payman; Singh, Mallika; Lees, Emma; Shao, Wenlin; Stuart, Darrin D.; Dillon, Michael P.; Ramurthy, Savithri
Development of a highly selective B/CRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation
CANCER RESEARCH
IF16.6
2016-07-150
PRE
Shao, Wenlin; Mishina, Yuji; Feng, Yun; Caponigro, Giordano; Ramurthy, Savithri; Cooke, Vesselina; Griner, Lesley; Nishiguchi, Gisele; Rico, Alice; Taft, Ben; Burger, Matthew; Tanner, Huw; Polyakov, Valery; Appleton, Brent; Tellew, John; Zang, Richard; Hekmat-Nejad, Mohammad; Amiri, Payman; Singh, Mallika; Stuart, Darrin
FOCUS - Development of a Global Communication and Modeling Platform for Applied and Computational Medicinal Chemists
JOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
2015-04-1318
PREAI
Stiefl, Nikolaus; Gedeck, Peter; Chin, Donovan; Hunt, Peter; Lindvall, Mika; Spiegel, Katrin; Springer, Clayton; Biller, Scott; Buenemann, Christoph; Kanazawa, Takanori; Kato, Mitsunori; Lewis, Richard; Martin, Eric; Polyakov, Valery; Tommasi, Ruben; van Drie, John; Vash, Brian; Whitehead, Lewis; Xu, Yongjin; Abagyan, Ruben; Raush, Eugene; Totrov, Max
Discovery of a Pyrazine-2-Carboxamide Derivative as a Potent Plasmodium falciparum Inhibitor with Potential for Single-Dose Cure

吡嗪-2-甲酰胺衍生物作为潜在的疟原虫恶性疟原虫强效抑制剂的发现，具有单剂量治愈的潜力

Journal of Medicinal Chemistry
IF6.8
0
PRE
Vanessa M. Marx; Anne-Catherine Mata; Fumiaki Yokokawa; Thomas Kirrane; Richard Huang; Suresh B. Lakshminarayana; Jay Prakash Jain; Judith Straimer; W. Armand Guiguemde; Luying Pei; Upendra Kulkarni; Christopher J. Thompson; Johanna M. Jansen; Patrick S. Lee; Eric J. Martin; Valery R. Polyakov; Nicole Blaquiere; Alexander Burckle; Grace Waldron; Benjamin R. Taft; Erika L. Flannery; Hanna Schulz; Qumber H. Jafri; Katherine Chan; Erika Kim; Harry Cheung; Vida Ahyong; Changbok Lee; Catherine L. Jones; Christopher S. Lunde; Iñigo Angulo-Barturen; María Belén Jiménez-Díaz; Leyre Pernaute-Lau; Christian Scheurer; Sibylle Sax; Sergio Wittlin; Anna Caroline Campos Aguiar; Rafael Victorio Carvalho Guido; Dhelio B. Pereira; Philip J. Rosenthal; Roland A. Cooper; Kyra A. Schindler; David A. Fidock; Brice Campo; Simon F. Campbell; Thierry T. Diagana; Christopher R. Sarko

研究方向

暂未获取到该数据
D
Darrin D. Stuart
H 指数:32论文数:265被引数:3,766
M
Mallika Singh
H 指数:42论文数:315被引数:8,585
L
Lesley A. Mathews Griner
H 指数:20论文数:153被引数:1,616
S
Savithri Ramurthy
H 指数:17论文数:52被引数:1,883
V
Vesselina G. Cooke
H 指数:22论文数:150被引数:5,435
R
Richard Zang
H 指数:17论文数:78被引数:1,675
J
John E. Tellew
H 指数:23论文数:79被引数:1,211
P
Payman Amiri
H 指数:18论文数:54被引数:1,868
A
Alice Rico
H 指数:9论文数:41被引数:317
M
Michael P. Dillon
H 指数:36论文数:217被引数:3,876