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D

Darrin D. Stuart

Novartis
H指数:32
被引数:3,766

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Discovery of STX-721, a Covalent, Potent, and Highly Mutant-Selective EGFR/HER2 Exon20 Insertion Inhibitor for the Treatment of Non-Small Cell Lung Cancer

发现STX-721，一种用于治疗非小细胞肺癌的共价、强效且高度突变选择性的EGFR/HER2外显子20插入抑制剂。

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-01-170
PRE
Milgram, Benjamin C.; Borrelli, Deanna R.; Brooijmans, Natasja; Henderson, Jack A.; Hilbert, Brendan J.; Huff, Michael R.; Ito, Takahiro; Jackson, Erica L.; Jonsson, Philip; Ladd, Brendon; O'Hearn, Erin L.; Pagliarini, Raymond A.; Roberts, Simon A.; Ronseaux, Sebastien; Stuart, Darrin D.; Wang, Weixue; Guzman-Perez, Angel
Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers
MOLECULAR CANCER THERAPEUTICS
IF5.5
2019-12-0240
OAAI
Hao, Huai-Xiang; Wang, Hongyun; Liu, Chen; Kovats, Steven; Velazquez, Roberto; Lu, Hengyu; Pant, Bhavesh; Shirley, Matthew; Meyer, Matthew J.; Pu, Minying; Lim, Joanne; Fleming, Michael; Alexander, Leigh Ann; Farsidjani, Ali; LaMarche, Matthew J.; Moody, Susan; Silver, Serena J.; Caponigro, Giordano; Stuart, Darrin D.; Abrams, Tinya J.; Hammerman, Peter S.; Williams, Juliet; Engelman, Jeffrey A.; Goldoni, Silvia; Mohseni, Morvarid
Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-05-0632
OAAI
Ramurthy, Savithri; Taft, Benjamin R.; Aversa, Robert J.; Barsanti, Paul A.; Burger, Matthew T.; Lou, Yan; Nishiguchi, Gisele A.; Rico, Alice; Setti, Lina; Smith, Aaron; Subramanian, Sharadha; Tamez, Victoriano; Tanner, Huw; Wan, Lifeng; Hu, Cheng; Appleton, Brent A.; Mamo, Mulugeta; Tandeske, Laura; Tellew, John E.; Huang, Shenlin; Yue, Qn; Cliaudliary, Apurva; Tian, Hung; Iyer, Raman; Hassan, A. Quamrul; Griner, Lesley A. Mathews; La Bonte, Laura R.; Cooke, Vesselina G.; Van Abbema, Anne; Merritt, Hanne; Gampa, Kalyani; Feng, Fei; Yuan, Jing; Mishina, Yuji; Wang, Yingyun; Haling, Jacob R.; Vaziri, Sepideh; Hekmat-Nejad, Mohammad; Polyakov, Valery; Zang, Richard; Sethuraman, Vijay; Amiri, Payman; Singh, Mallika; Sellers, William R.; Lees, Emma; Shao, Wenlin; Dillon, Michael P.; Stuart, Darrin D.
Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor
CANCER RESEARCH
IF16.6
2018-07-014
PRE
Stuart, Darrin D.; Shao, Wenlin; Mishina, Yuji; Feng, Yun; Caponigro, Giordano; Cooke, Vesselina G.; Rivera, Stacey; Shen, Fang; Korn, Joshua; Griner, Lesley A. Mathews; Nishiguchi, Giselle; Taft, Benjamin; Wan, Lifeng; Subramanian, Sharadha; Lou, Yan; Setti, Lina; Burger, Matthew; Tamez, Victor; Rico, Alice; Aversa, Robert; Tellew, John; Haling, Jacob R.; Polyakov, Valery; Lambert, Amy; Zang, Richard; Van Abbema, Ann; Hekmat-Nejad, Mohamad; Amiri, Payman; Singh, Mallika; Keen, Nicholas; Dillon, Michael P.; Lees, Emma; Sellers, William R.; Ramurthy, Savithri
Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF
CANCER RESEARCH
IF16.6
2018-03-1430
OAAI
Shao, Wenlin; Mishina, Yuji M.; Feng, Yun; Caponigro, Giordano; Cooke, Vesselina G.; Rivera, Stacy; Wang, Yingyun; Shen, Fang; Korn, Joshua M.; Griner, Lesley A. Mathews; Nishiguchi, Gisele; Rico, Alice; Tellew, John; Haling, Jacob R.; Aversa, Robert; Polyakov, Valery; Zang, Richard; Hekmat-Nejad, Mohammad; Amiri, Payman; Singh, Mallika; Keen, Nicholas; Dillon, Michael P.; Lees, Emma; Ramurthy, Savithri; Sellers, William R.; Stuart, Darrin D.
Design and Discovery of N-(2-Methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-06-0846
PREAI
Nishiguchi, Gisele A.; Rico, Alice; Tanner, Huw; Aversa, Robert J.; Taft, Benjamin R.; Subramanian, Sharadha; Setti, Lina; Burger, Matthew T.; Wan, Lifeng; Tamez, Victoriano; Smith, Aaron; Lou, Yan; Barsanti, Paul A.; Appleton, Brent A.; Mamo, Mulugeta; Tandeske, Laura; Dix, Ina; Tellew, John E.; Huang, Shenlin; Griner, Lesley A. Mathews; Cooke, Vesselina G.; Van Abbema, Anne; Merritt, Hanne; Ma, Sylvia; Gampa, Kalyani; Feng, Fei; Yuan, Jing; Wang, Yingyun; Haling, Jacob R.; Vaziri, Sepideh; Hekmat-Nejad, Mohammad; Jansen, Johanna M.; Polyakov, Valery; Zang, Richard; Sethuraman, Vijay; Amiri, Payman; Singh, Mallika; Lees, Emma; Shao, Wenlin; Stuart, Darrin D.; Dillon, Michael P.; Ramurthy, Savithri
Development of a highly selective B/CRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation
CANCER RESEARCH
IF16.6
2016-07-150
PRE
Shao, Wenlin; Mishina, Yuji; Feng, Yun; Caponigro, Giordano; Ramurthy, Savithri; Cooke, Vesselina; Griner, Lesley; Nishiguchi, Gisele; Rico, Alice; Taft, Ben; Burger, Matthew; Tanner, Huw; Polyakov, Valery; Appleton, Brent; Tellew, John; Zang, Richard; Hekmat-Nejad, Mohammad; Amiri, Payman; Singh, Mallika; Stuart, Darrin

研究方向

暂未获取到该数据
P
Payman Amiri
H 指数:18论文数:54被引数:1,868
S
Savithri Ramurthy
H 指数:17论文数:52被引数:1,883
W
William R. Sellers
H 指数:118论文数:816被引数:8.5万
G
Giordano Caponigro
H 指数:35论文数:358被引数:1.8万
N
Nancy Pryer
H 指数:27论文数:73被引数:9,199
S
Sharadha Subramanian
H 指数:13论文数:35被引数:562
M
Meghna Das Thakur
H 指数:20论文数:61被引数:3,256
D
David A. Ruddy
H 指数:33论文数:365被引数:1.3万
R
Richard Zang
H 指数:17论文数:78被引数:1,675
J
John E. Tellew
H 指数:23论文数:79被引数:1,211