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J

James Davidson

vernalis r&d limited
H指数:19
被引数:2,627

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Exploiting a Cryptic Pocket in DsbA through Structure-Guided Parallel Synthesis and Direct-to-Biology Screening

通过结构指导的平行合成和直接生物学筛选来利用DsbA中的隐匿口袋

Journal of Medicinal Chemistry
IF6.8
2026-03-060
PRE
Yildiz Tasdan; Gautham R. Balaji; James Davidson; Naureen Akhtar; Olga Ilyichova; Lucie J. Guetzoyan; Indu R. Chandrashekaran; Wesam Alwan; Helen Cobb; Menachem J. Gunzburg; AbdulBasir Hasanzada; Stephen D. Roughley; James B. Murray; Van C. Thai; Tessa Cliff; Charlene M. Kahler; Biswaranjan Mohanty; Ben Capuano; Bradley C. Doak; Martin J. Scanlon
Structure-Based Discovery of Potent BCL-XL Inhibitors through Rescaffolding

基于骨架修饰的结构指导强效BCL-XL抑制剂发现

Journal of Medicinal Chemistry
IF6.8
2026-01-010
OA
Matyas Timari; Attila Paczal; András Herner; Mark Molnar; Zoltán Madarász; Miklós Nyerges; Simon T. Bedford; Teresa Brooks; James E. P. Davidson; Zoe Daniels; Mark Dodsworth; Pawel Dokurno; James B. Murray; Rachel Parsons; Emma Sanders; Julia Smith; Paul Webb; Neil Whitehead; Roderick E. Hubbard; Jérôme-Benoît Starck; Ana Leticia Maragno; Gaëtane Le Toumelin-Braizat; Laura Bresson; Francesca Rocchetti; Didier Demarles; Frédéric Colland; Olivier Geneste; András Kotschy; Tibor Novak
Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-11-0456
PREAI
Szlavik, Zoltan; Csekei, Marton; Paczal, Attila; Szabo, Zoltan B.; Sipos, Szabolcs; Radics, Gabor; Proszenyak, Agnes; Balint, Balazs; Murray, James; Davidson, James; Chen, Ijen; Dokurno, Pawel; Surgenor, Allan E.; Daniels, Zoe Marie; Hubbard, Roderick E.; Le Toumelin-Braizat, Gaetane; Claperon, Audrey; Lysiak-Auvity, Gaelle; Girard, Anne-Marie; Bruno, Alain; Chanrion, Maia; Colland, Frederic; Maragno, Ana-Leticia; Demarles, Didier; Geneste, Olivier; Kotschy, Andras
S64315 (MIK665) is a potent and selective Mcl1 inhibitor with strong antitumor activity across a diverse range of hematologic tumor models
CANCER RESEARCH
IF16.6
2019-07-0111
PRE
Maragno, Ana Leticia; Mistry, Prakash; Kotschy, Andras; Szlavik, Zoltan; Murray, James; Davidson, James; Le Toumelin-Braizat, Gaetane; Chanrion, Maia; Bruno, Alain; Claperon, Audrey; Maacke, Heiko; Morris, Erick; Wang, Youzhen; Derreal, Alix; Csekei, Marton; Paczal, Attila; Szabo, Zoltan; Sipos, Szabolcs; Proszenyak, Agnes; Balint, Balazs; Surgenor, Allan; Dokurno, Pawel; Matassova, Natalia; Chen, Ijen; Lysiak-Auvity, Gaelle; Girard, Anne-Marie; Grave, Fabienne; Colland, Frederic; Halilovic, Ensar; Geneste, Olivier
Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity

具有细胞活性的选择性Mcl-1抑制剂的结构指导发现

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-06-2452
PREAI
Szlavik, Zoltan; Ondi, Levente; Csekei, Marton; Paczal, Attila; Szabo, Zoltan B.; Radics, Gabor; Murray, James; Davidson, James; Chen, Ijen; Davis, Ben; Hubbard, Roderick E.; Pedder, Christopher; Dokurno, Pawel; Surgenor, Allan; Smith, Julia; Robertson, Alan; LeToumelin-Braiza, Gaetane; Cauqui, Nicolas; Zarka, Marion; Demarles, Didier; Perron-Sierra, Francoise; Claperon, Audrey; Colland, Frederic; Geneste, Olivier; Kotschy, Andras
Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1
ACS OMEGA
IF4.3
2019-05-2347
OAAI
Murray, James B.; Davidson, James; Chen, Ijen; Davis, Ben; Dokurno, Pawel; Graham, Christopher J.; Harris, Richard; Jordan, Allan; Matassova, Natalia; Pedder, Christopher; Ray, Stuart; Roughley, Stephen D.; Smith, Julia; Walmsley, Claire; Wang, Yikang; Whitehead, Neil; Williamson, Douglas S.; Casara, Patrick; Le Diguarher, Thierry; Hickman, John; Stark, Jerome; Kotschy, Andra; Geneste, Olivier; Hubbard, Roderick E.

研究方向

暂未获取到该数据
R
Roderick E. Hubbard
H 指数:53论文数:210被引数:1.7万
A
András Kotschy
H 指数:28论文数:191被引数:3,354
P
P. Dokurno
H 指数:24论文数:110被引数:3,646
O
Olivier Geneste
H 指数:30论文数:94被引数:5,472
I
I‐Jen Chen
H 指数:29论文数:64被引数:3,578
J
James B. Murray
H 指数:40论文数:111被引数:6,133
Z
Zoltán Szlávik
H 指数:18论文数:103被引数:2,066
M
Márton Csékei
H 指数:13论文数:30被引数:1,512
S
Simon Parsons
H 指数:83论文数:1,613被引数:3.1万
B
Balázs Bálint
H 指数:35论文数:105被引数:5,492