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M

Milan Štefek

Koc University

29H指数
162论文数
3.6K被引数
收录论文 53
发表时间
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A comparative study to assess two doses of a novel aldose reductase inhibitor (ARI)/Antioxidant drug candidate Cemtirestat, the current ARI drug Epalrestat, and the antioxidant Stobadine on Fructose- and Streptozotocin-Induced hepatic and pancreatic stress responses in rats一项比较研究，旨在评估两种剂量的新型醛糖还原酶抑制剂（ARI）/抗氧化剂药物候选物Cemtirestat、当前ARI药物Epalrestat以及抗氧化剂Stobadine对果糖和链脲佐菌素诱导的大鼠肝脏和胰腺应激反应的影响。
errJOURNAL OF DIABETES AND METABOLIC DISORDERS
IF1.6
err2025-12-01
err0
PREAI
errDagistanli, Fatma Kaya; Ceylan, Asli F.; Elmazoglu, Zubeyir; Efendiyeva, Nigar; Saribas, Sanem Gulistan; Pilafi, Belisa Kaleci; Stefek, Milan; Ulusu, Nuriye Nuray; Karasu, Cimen
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Rational design and synthesis of novel N-benzylindole-based epalrestat analogs as selective aldose reductase inhibitors: An unexpected discovery of a new glucose-lowering agent (AK-4) acting as a mitochondrial uncoupler
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-01-01
err0
PREAI
errKousaxidis, Antonios; Paoli, Paolo; Kovacikova, Lucia; Genovese, Massimo; Santi, Alice; Stefek, Milan; Petrou, Anthi; Nicolaou, Ioannis
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Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39
errJOURNAL OF STRUCTURAL BIOLOGY-X
IF5.1
err2024-12-01
err1
errOAAI
errZilecka, Eva; Klima, Martin; Stefek, Milan; Dejmek, Milan; Nencka, Radim; Boura, Evzen
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Cemtirestat dimerization in liposomes and erythrocytes exposed to peroxyl radicals was reverted by thiol-disulfide exchange with GSH
errFREE RADICAL RESEARCH
IF2.9
err2024-01-18
err1
PREAI
errKovacikova, Lucia; Prnova, Marta S.; Bodo, Pavol; Stefek, Milan
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err收藏
Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors
errACS INFECTIOUS DISEASES
IF3.8
err2023-09-20
err7
errOAAI
errInniss, Nicole L.; Kozic, Jan; Li, Fengling; Rosas-Lemus, Monica; Minasov, George; Rybacek, Jiri; Zhu, Yingjie; Pohl, Radek; Shuvalova, Ludmilla; Rulisek, Lubomir; Brunzelle, Joseph S.; Bednarova, Lucie; Stefek, Milan; Kormanik, Jan Michael; Andris, Erik; Sebestik, Jaroslav; Li, Alice Shi Ming; Brown, Peter J.; Schmitz, Uli; Saikatendu, Kumar; Chang, Edcon; Nencka, Radim; Vedadi, Masoud; Satchell, Karla J. F.
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The Effects of Prolonged Treatment with Cemtirestat on Bone Parameters Reflecting Bone Quality in Non-Diabetic and Streptozotocin-Induced Diabetic Rats
errPHARMACEUTICALS
IF4.8
err2023-04-21
err5
errOAAI
errMartiniakova, Monika; Kovacova, Veronika; Mondockova, Vladimira; Svik, Karol; Londzin, Piotr; Folwarczna, Joanna; Prnova, Marta Soltesova; Stefek, Milan; Omelka, Radoslav
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Novel rhodanine based inhibitors of aldose reductase of non-acidic nature with p-hydroxybenzylidene functional group
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2023-01-01
err6
PREAI
errKratky, Martin; Sramel, Peter; Bodo, Pavol; Prnova, Marta Soltesova; Kovacikova, Lucia; Majekova, Magdalena; Vinsova, Jarmila; Stefek, Milan
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A molecular hybridization approach for the design of selective aldose reductase (ALR2) inhibitors and exploration of their activities against protein tyrosine phosphatase 1B (PTP1B)
errJOURNAL OF MOLECULAR STRUCTURE
IF4.7
err2023-01-01
err8
PREAI
errKousaxidis, Antonios; Petrou, Anthi; Rouvim, Philippa; Bodo, Pavol; Stefek, Milan; Nicolaou, Ioannis; Geronikaki, Athina
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Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2021-11-01
err20
PREAI
errSiddique, Mohd Usman Mohd; Thakur, Abhishek; Shilkar, Deepak; Yasmin, Sabina; Halakova, Dominika; Kovacikova, Lucia; Prnova, Marta Soltesova; Stefek, Milan; Acevedo, Orlando; Dasararaju, Gayathri; Devadasan, Velmurugan; Mondal, Susanta Kumar; Jayaprakash, Venkatesan
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Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications
errMOLECULES
IF4.6
err2021-05-12
err17
errOAAI
errKovacikova, Lucia; Prnova, Marta Soltesova; Majekova, Magdalena; Bohac, Andrej; Karasu, Cimen; Stefek, Milan
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Novel substituted N-benzyl(oxotriazinoindole) inhibitors of aldose reductase exploiting ALR2 unoccupied interactive pocket
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2021-01-01
err5
errOAAI
errHlavac, Matus; Kovacikova, Lucia; Prnova, Marta Soltesova; Addova, Gabriela; Hanquet, Gilles; Stefek, Milan; Bohac, Andrej
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Design synthesis and evaluation of novel aldose reductase inhibitors: The case of indolyl-sulfonyl-phenols
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2020-08-01
err14
PREAI
errKoutsopoulos, Konstantinos; Lavrentaki, Vasiliki; Antoniou, Ioakeim; Kousaxidis, Antonios; Lefkopoulou, Matina; Tsantili-Kakoulidou, Anna; Kovacikova, Lucia; Stefek, Milan; Nicolaou, Ioannis
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Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2019-12-10
err21
errOAAI
errHlavac, Matus; Kovacikova, Lucia; Prnova, Marta Soltesova; Sramel, Peter; Addova, Gabriela; Majekova, Magdalena; Hanquet, Gilles; Bohac, Andrej; Stefek, Milan
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Triglyceride-lowering effect of the aldose reductase inhibitor cemtirestat-another factor that may contribute to attenuation of symptoms of peripheral neuropathy in STZ-diabetic rats
errNAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
IF3.1
err2019-12-05
err17
PREAI
errPrnova, Marta Soltesova; Kovacikova, Lucia; Svik, Karol; Bezek, Stefan; Elmazoglu, Zubeyir; Karasu, Cimen; Stefek, Milan
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3-Mercapto-5H-1,2,4-Triazino[5,6-b]Indole-5-Acetic Acid (Cemtirestat) Alleviates Symptoms of Peripheral Diabetic Neuropathy in Zucker Diabetic Fatty (ZDF) Rats: A Role of Aldose Reductase
errNEUROCHEMICAL RESEARCH
IF3.8
err2019-01-28
err18
PREAI
errPrnova, Marta Soltesova; Svik, Karol; Bezek, Stefan; Kovacikova, Lucia; Karasu, Cimen; Stefek, Milan
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Artichoke leaf extract, as AKR1B1 inhibitor, decreases sorbitol level in the rat eye lenses under high glucose conditions ex vivo
errPHYTOTHERAPY RESEARCH
IF6.3
err2018-08-15
err7
PREAI
errSusanikova, Ivana; Ballekova, Jana; Stefek, Milan; Hosek, Jan; Mucaji, Pavel
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Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2017-12-01
err14
PREAI
errMajekova, Magdalena; Ballekova, Jana; Prnova, Marta; Stefek, Milan
err分享
err收藏
Opposing roles of the aldo-keto reductases AKR1B1 and AKR1B10 in colorectal cancer
errCELLULAR ONCOLOGY
IF4.8
err2017-09-19
err50
PREAI
errTaskoparan, Betul; Seza, Esin Gulce; Demirkol, Secil; Tuncer, Sinem; Stefek, Milan; Gure, Ali Osmay; Banerjee, Sreeparna
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Enhancing activity and selectivity in a series of pyrrol-1-yl-1hydroxypyrazole-based aldose reductase inhibitors: The case of trifluoroacetylation
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2017-04-01
err16
errOAAI
errPapastavrou, Nikolaos; Chatzopoulou, Maria; Ballekova, Jana; Cappiello, Mario; Moschini, Roberta; Balestri, Francesco; Patsilinakos, Alexandros; Ragno, Rino; Stefek, Milan; Nicolaou, Ioannis
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CHNQ, a novel 2-Chloro-1,4-naphthoquinone derivative of quercetin, induces oxidative stress and autophagy both in vitro and in vivo
errARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
IF3
err2016-04-01
err22
PREAI
errEnayat, Shabnam; Ceyhan, M. Seyma; Taskoparan, Betul; Stefek, Milan; Banerjee, Sreeparna
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