Paul S. Hoffman - Publications, H-index & Citations

Paul S. Hoffman

University of Virginia

54H指数

167论文数

7.9K被引数

收录论文 36

发表时间

Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth 线粒体解偶联剂抑制致癌性E2F1活性和前列腺癌生长

CELL REPORTS MEDICINE

IF10.6

2025-01-01

OAAI

Hawsawi, Ohuod; Xue, Weinan; Du, Tingting; Guo, Mengqi; Yu, Xiaolin; Zhang, Mingyi; Hoffman, Paul S.; Bollag, Roni; Li, Jun; Zhou, Jia; Wang, Hongbo; Zhang, Junran; Fu, Zheng; Chen, Xiaoguang; Yan, Chunhong

New functions of pirin proteins and a 2-ketoglutarate: Ferredoxin oxidoreductase ortholog in Bacteroides fragilis metabolism and their impact on antimicrobial susceptibility to metronidazole and amixicile

MICROBIOLOGYOPEN

IF4.6

2024-08-07

OAAI

Gough, Andrea M.; Parker, Anita C.; O'Bryan, Patricia J.; Whitehead, Terence R.; Roy, Sourav; Garcia, Brandon L.; Hoffman, Paul S.; Jeffrey Smith, C.; Rocha, Edson R.

Non-human Primate Macaca mulatta as an Animal Model for Testing Efficacy of Amixicile as a Targeted Anti-periodontitis Therapy

FRONTIERS IN ORAL HEALTH

IF3.1

2021-11-05

OAAI

Gui, Qin; Lyons, Denver J.; Deeb, Janina Golob; Belvin, B. Ross; Hoffman, Paul S.; Lewis, Janina P.

Antibacterial Discovery: 21st Century Challenges

ANTIBIOTICS-BASEL

IF4.6

2020-04-28

OAAI

Hoffman, Paul S.

The small molecule nitazoxanide selectively disrupts BAM-mediated folding of the outer membrane usher protein

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2019-09-01

OAAI

Psonis, John J.; Chahales, Peter; Henderson, Nadine S.; Rigel, Nathan W.; Hoffman, Paul S.; Thanassi, David G.

Amixicile Reduces Severity of Cryptosporidiosis but Does Not Have In Vitro Activity against Cryptosporidium

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2018-12-01

OAAI

Bartelt, Luther A.; Bolick, David T.; Kolling, Glynis L.; Stebbins, Erin; Huston, Christopher D.; Guerrant, Richard L.; Hoffman, Paul S.

Antimicrobial activity of amixicile against Treponema denticola and other oral spirochetes associated with periodontal disease

JOURNAL OF PERIODONTOLOGY

IF3.8

2018-09-05

PREAI

Reed, Lucas A.; O'Bier, Nathaniel S.; Oliver, Lee D., Jr.; Hoffman, Paul S.; Marconi, Richard T.

Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer

NATURE CHEMICAL BIOLOGY

IF13.7

2017-10-30

114

PREAI

Qu, Yi; Olsen, Jan Roger; Yuan, Xing; Cheng, Phil F.; Levesque, Mitchell P.; Brokstad, Karl A.; Hoffman, Paul S.; Oyan, Anne Margrete; Zhang, Weidong; Kalland, Karl-Henning; Ke, Xisong

Amixicile, a novel strategy for targeting oral anaerobic pathogens

SCIENTIFIC REPORTS

IF3.9

2017-09-05

OAAI

Hutcherson, Justin A.; Sinclair, Kathryn M.; Belvin, Benjamin R.; Gui, Qin; Hoffman, Paul S.; Lewis, Janina P.

Enhanced Klebsiella pneumoniae Carbapenemase Expression from a Novel Tn4401 Deletion

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2017-06-01

OAAI

Cheruvanky, Anita; Stoesser, Nicole; Sheppard, Anna E.; Crook, Derrick W.; Hoffman, Paul S.; Weddle, Erin; Carroll, Joanne; Sifri, Costi D.; Chai, Weidong; Barry, Katie; Ramakrishnan, Girija; Mathers, Amy J.

Synthesis and Antimicrobial Evaluation of Amixicile-Based Inhibitors of the Pyruvate-Ferredoxin Oxidoreductases of Anaerobic Bacteria and Epsilonproteobacteria

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2016-07-01

OAAI

Kennedy, Andrew J.; Bruce, Alexandra M.; Gineste, Catherine; Ballard, T. Eric; Olekhnovich, Igor N.; Macdonald, Timothy L.; Hoffman, Paul S.

Nitazoxanide Inhibits Pilus Biogenesis by Interfering with Folding of the Usher Protein in the Outer Membrane

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2016-04-01

OAAI

Chahales, Peter; Hoffman, Paul S.; Thanassi, David G.

Preclinical Studies of Amixicile, a Systemic Therapeutic Developed for Treatment of Clostridium difficile Infections That Also Shows Efficacy against Helicobacter pylori

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2014-08-01

OAAI

Hoffman, Paul S.; Bruce, Alexandra M.; Olekhnovich, Igor; Warren, Cirle A.; Burgess, Stacey L.; Hontecillas, Raquel; Viladomiu, Monica; Bassaganya-Riera, Josep; Guerrant, Richard L.; Macdonald, Timothy L.

Improved Flavodoxin Inhibitors with Potential Therapeutic Effects against Helicobacter pylori Infection

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2013-07-26

PREAI

Galano, Juan J.; Alias, Miriam; Perez, Reyes; Velazquez-Campoy, Adrian; Hoffman, Paul S.; Sancho, Javier

Persistent G. lamblia impairs growth in a murine malnutrition model

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2013-05-24

OAAI

Bartelt, Luther A.; Roche, James; Kolling, Glynis; Bolick, David; Noronha, Francisco; Naylor, Caitlin; Hoffman, Paul; Warren, Cirle; Singer, Steven; Guerrant, Richard

Vancomycin Treatment's Association with Delayed Intestinal Tissue Injury, Clostridial Overgrowth, and Recurrence of Clostridium difficile Infection in Mice

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2013-02-01

OAAI

Warren, Cirle A.; van Opstal, Edward J.; Riggins, Mary S.; Li, Yuesheng; Moore, John H.; Kolling, Glynis L.; Guerrant, Richard L.; Hoffman, Paul S.

Germination and Amplification of Anthrax Spores by Soil-Dwelling Amoebas

APPLIED AND ENVIRONMENTAL MICROBIOLOGY

IF3.7

2012-11-15

OAAI

Dey, Rafik; Hoffman, Paul S.; Glomski, Ian J.

Structure of RdxA - an oxygen-insensitive nitroreductase essential for metronidazole activation in Helicobacter pylori RdxA的结构-幽门螺杆菌中甲硝唑活化所必需的氧不敏感的硝基还原酶

FEBS JOURNAL

IF4.2

2012-11-07

OAAI

Martinez-Julvez, Marta; Rojas, Adriana L.; Olekhnovich, Igor; Espinosa Angarica, Vladimir; Hoffman, Paul S.; Sancho, Javier

Amixicile, a Novel Inhibitor of Pyruvate:Ferredoxin Oxidoreductase, Shows Efficacy against Clostridium difficile in a Mouse Infection Model

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2012-08-01

OAAI

Warren, Cirle A.; van Opstal, Edward; Ballard, T. Eric; Kennedy, Andrew; Wang, Xia; Riggins, Mary; Olekhnovich, Igor; Warthan, Michelle; Kolling, Glynis L.; Guerrant, Richard L.; Macdonald, Timothy L.; Hoffman, Paul S.

Synthesis and Antimicrobial Evaluation of Nitazoxanide-Based Analogues: Identification of Selective and Broad Spectrum Activity

CHEMMEDCHEM

IF3.4

2010-12-29

OAAI

Ballard, T. Eric; Wang, Xia; Olekhnovich, Igor; Koerner, Taylor; Seymour, Craig; Salamoun, Joseph; Warthan, Michelle; Hoffman, Paul S.; Macdonald, Timothy L.

研究方向