Discovery of Truncated Cyclic Peptides Targeting an Induced-Fit Pocket on PCSK9CHEMMEDCHEMIF3.42024-10-220PRE
Clearance of plasma PCSK9 via the asialoglycoprotein receptor mediated by heterobifunctional ligandsCELL CHEMICAL BIOLOGYIF7.22023-01-0112OAAI
Identification of a PCSK9-LDLR disruptor peptide with in vivo functionCELL CHEMICAL BIOLOGYIF7.22022-02-0132OAAI
Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in HumansJOURNAL OF MEDICINAL CHEMISTRYIF6.82017-05-2420PREAI
A role for the hinge/ear domain of the beta chains in the incorporation of AP complexes into clathrin-coated pits and coated vesiclesCELLULAR AND MOLECULAR LIFE SCIENCESIF6.22014-02-1014OA
Intestinally Targeted Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors Robustly Suppress Postprandial TriglyceridesACS MEDICINAL CHEMISTRY LETTERSIF42012-04-0927OAAI
Dual-acting peptide with prolonged glucagon-like peptide-1 receptor agonist and glucagon receptor antagonist activity for the treatment of type 2 diabetesJOURNAL OF ENDOCRINOLOGYIF3.92007-02-0145OAAI
Engineering of a VPAC2 receptor peptide agonist to impart dipeptidyl peptidase IV stability and enhance in vivo glucose disposalJOURNAL OF MEDICINAL CHEMISTRYIF6.82006-11-1810PREAI
Design of a long acting peptide functioning as both a glucagon-like peptide-1 receptor agonist and a glucagon receptor antagonistJOURNAL OF BIOLOGICAL CHEMISTRYIF3.92006-05-01137OAAI
Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucoseJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICSIF3.82005-12-0180PREAI
Mice deficient in the insulin-regulated membrane aminopeptidase show substantial decreases in glucose transporter GLUT4 levels but maintain normal glucose homeostasisJOURNAL OF BIOLOGICAL CHEMISTRYIF3.92002-05-01114OAAI