Irena Selicharová - Publications, H-index & Citations

Irena Selicharová

institute of organic chemistry and biochemistry cas

14H指数

42论文数

551被引数

收录论文 15

发表时间

Conformational changes in insulin receptor illuminated by live-cell linear dichroism imaging and a FLIP biosensor 通过活细胞线性二向色性成像和FLIP生物传感器揭示的胰岛素受体构象变化

Scientific Reports

IF3.9

2026-07-29

OAAI

Alina Sakhi; Anna Kertisová; Marta Lubos; Paul Miclea; Petro Khoroshyy; Tereza Nesporova; Frantisek Filandr; Vendula Nagy Marková; Irena Selicharová; Josef Lazar

Expedient single-round selection of hyper-modified aptamer targeting insulin receptor from over-represented dually nucleobase-modified DNA libraries 从过表达的含双核苷碱基修饰的DNA文库中快速单轮筛选靶向胰岛素受体的超修饰适配体

Nature Communications

IF15.7

2026-05-27

OAAI

Pablo Alberto Franco-Urquijo; Marek Ondruš; Jaroslav Kurfürst; Jana Škerlová; Irena Selicharová; Lucie Mužíková Čechová; Hana Šváchová; Alena Semerádtová; Anatolij Filimoněnko; Adéla Fejfarová; Jiří Homola; Tomáš Kouba; Michal Hocek

An engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling 一种具有双重胰岛素和IGF-1受体激动作用及不同信号传导的工程化胰岛素类似物

Science Advances

IF12.5

2026-05-15

OAAI

Irena Selicharová; Nicholas S. Kirk; Anna Kertisová; Marta Lubos; Katarína Mitrová; Terezie Ticháčková; Lenka Žáková; Martina Chrudinová; Jana Březinová; Karel Harant; Jan Voldřich; Miroslav Hájek; Derek M. Huffman; Jiří Jiráček

Combinatorial Libraries of Bipodal Binders of the Insulin Receptor

CHEMMEDCHEM

IF3.4

2024-04-11

OAAI

Selicharova, Irena; Fabre, Benjamin; Soledad Garre Hernandez, Maria; Lubos, Marta; Picha, Jan; Voburka, Zdenek; Mitrova, Katarina; Jiracek, Jiri

Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2

COMMUNICATIONS BIOLOGY

IF5.1

2023-08-19

OAAI

Potalitsyn, Pavlo; Mrazkova, Lucie; Selicharova, Irena; Tencerova, Michaela; Ferencakova, Michaela; Chrudinova, Martina; Turnovska, Tereza; Brzozowski, Andrzej Marek; Marek, Ales; Kaminsky, Jakub; Jiracek, Jiri; Zakova, Lenka

Insulin Analogues with Altered Insulin Receptor Isoform Binding Specificities and Enhanced Aggregation Stabilities

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-09-30

PREAI

Panikova, Terezie; Mitrova, Katarina; Halamova, Tereza; Mrzilkova, Karolina; Picha, Jan; Chrudinova, Martina; Kurochka, Andrii; Selicharova, Irena; Zakova, Lenka; Jiracek, Jiri

A radioligand receptor binding assay for measuring of insulin secreted by MIN6 cells after stimulation with glucose, arginine, ornithine, dopamine, and serotonin

ANALYTICAL AND BIOANALYTICAL CHEMISTRY

IF3.8

2021-05-29

PREAI

Asai, Seiya; Zakova, Lenka; Selicharova, Irena; Marek, Ales; Jiracek, Jiri

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2019-11-01

OAAI

Machackova, Katerina; Mlcochova, Kvetoslava; Potalitsyn, Pavlo; Hankova, Katerina; Socha, Ondrej; Budesinski, Milos; Muzdalo, Anja; Lepsik, Martin; Cernekova, Michaela; Radosavljevic, Jelena; Fabry, Milan; Mitrova, Katarina; Chrudinova, Martina; Lin, Jingjing; Yurenko, Yevgen; Hobza, Pavel; Selicharova, Irena; Zakova, Lenka; Jiracek, Jiri

Cross-Linking/Mass Spectrometry Uncovers Details of Insulin-Like Growth Factor Interaction With Insect Insulin Binding Protein Imp-L2

FRONTIERS IN ENDOCRINOLOGY

IF4.6

2019-10-09

OAAI

Pompach, Petr; Viola, Cristina M.; Radosavljevic, Jelena; Lin, Jingjing; Jiracek, Jiri; Brzozowski, Andrzej M.; Selicharova, Irena

A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-10-01

OAAI

Chrudinova, Martina; Zakova, Lenka; Marek, Ales; Socha, Ondrej; Budesinsky, Milos; Hubalek, Martin; Picha, Jan; Machackova, Katerina; Jiracek, Jiri; Selicharova, Irena

Insulin-like Growth Factor 1 Analogs Clicked in the C Domain: Chemical Synthesis and Biological Activities

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-12-11

OAAI

Machackova, Katerina; Collinsova, Michaela; Chrudinova, Martina; Selicharova, Irena; Picha, Jan; Budesinsky, Milos; Vanek, Vaclav; Zakova, Lenka; Brzozowski, Andrzej M.; Jiracek, Jiri

Rational steering of insulin binding specificity by intra-chain chemical crosslinking

SCIENTIFIC REPORTS

IF3.9

2016-01-21

OAAI

Vikova, Jitka; Collinsova, Michaela; Kletvikova, Emilia; Budesinsky, Milos; Kaplan, Vojtech; Zakova, Lenka; Veverka, Vaclav; Hexnerova, Rozlie; Tarazona Avino, Roberto J.; Strakova, Jana; Selicharova, Irena; Vanek, Vaclav; Wright, Daniel W.; Watson, Christopher J.; Turkenburg, Johan P.; Brzozowski, Andrzej M.; Jiracek, Jiri

Phenotyping breast cancer cell lines EM-G3, HCC1937, MCF7 and MDA-MB-231 using 2-D electrophoresis and affinity chromatography for glutathione-binding proteins

BMC CANCER

IF3.4

2010-08-23

OAAI

Mladkova, Jana; Sanda, Miloslav; Matouskova, Eva; Selicharova, Irena

Two-dimensional electrophoretic comparison of metastatic and non-metastatic human breast tumors using in vitro cultured epithelial cells derived from the cancer tissues

BMC CANCER

IF3.4

2008-04-16

OAAI

Vydra, Jan; Selicharova, Irena; Smutna, Katerina; Sanda, Miloslav; Matouskova, Eva; Bursikova, Eva; Prchalova, Marketa; Velenska, Zuzana; Coufal, David; Jiracek, Jiri

2-DE analysis of a new human cell line EM-G3 derived from breast cancer progenitor cells and comparison with normal mammary epithelial cells 乳腺癌祖细胞衍生的新人类细胞系EM-G3的2-DE分析及与正常乳腺上皮细胞的比较

PROTEOMICS

IF3.9

2007-04-27

PREAI

Selicharova, Irena; Smutna, Katerina; Sanda, Miloslav; Ubik, Karel; Matouskova, Eva; Bursikova, Eva; Brozova, Marketa; Vydra, Jan; Jiracek, Jiri

研究方向