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Targeting processive transcription for Myc-driven circuitry in medulloblastoma 靶向髓母细胞瘤中Myc驱动的通路进行持续转录 Sobral, Lays Martin; Walker, Faye M.; Madhavan, Krishna; Janko, Elizabeth; Donthula, Sahiti; Danis, Etienne; Bompada, Pradeep; Balakrishnan, Ilango; Wang, Dong; Pierce, Angela; Haag, Mary M.; Carstens, Billie J.; Serkova, Natalie J.; Foreman, Nicholas K.; Venkataraman, Sujatha; Veo, Bethany; Vibhakar, Rajeev; Dahl, Nathan A. 分享 收藏
H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition H3K27M弥漫性中线胶质瘤是同源重组缺陷，并通过PARP抑制对放疗和NK细胞介导的抗肿瘤免疫敏感 Guo, Yupei; Li, Zian; Parsels, Leslie A.; Wang, Zhuwen; Parsels, Joshua D.; Dalvi, Anushka; The, Stephanie; Hu, Nan; Valvo, Victoria M.; Doherty, Robert; Peterson, Erik; Wang, Xinjun; Venkataraman, Sujatha; Agnihotri, Sameer; Venneti, Sriram; Wahl, Daniel R.; Green, Michael D.; Lawrence, Theodore S.; Koschmann, Carl; Morgan, Meredith A.; Zhang, Qiang 分享 收藏
Loss of LDOC1 by chromatin compaction in mesenchymal tumor cells is required for PFA1 ependymoma growth 间质肿瘤细胞中染色质压缩导致的LDOC1丢失是PFA1室管膜瘤生长所必需的。 de Sousa, Graziella Ribeiro; Calzadilla, Annaliese J.; Grimaldo, Enrique; Donson, Andrew M.; Sobral, Lays Martin; Jones, Kendra M.; Liu, Tian; Amani, Vladimir; Venkataraman, Sujatha; Dahl, Nathan A.; Levy, Jean M. Mulcahy; Phang, Tzu; Vibhakar, Rajeev; Hankinson, Todd; Handler, Michael; Valera, Elvis Terci; Foreman, Nicholas K.; Griesinger, Andrea M. 分享 收藏
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Developing a safe and potent tumor-targeting gated CAR-T cell therapy for DIPG: A deadly pediatric brain tumor Venkataraman, Sujatha; Balakrishnan, Ilango; Leach, Lillie; Madhavan, Krishna; Pierce, Angela; Michlin, Joshua; Obrecht, Joshua; Brunt, Breauna; Fry, Terry; Vibhakar, Rajeev; Kohler, Eric M. 分享 收藏
Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy Walker, Faye M.; Sobral, Lays Martin; Danis, Etienne; Sanford, Bridget; Balakrishnan, Ilango; Wang, Dong; Pierce, Angela; Karam, Sana; Serkova, Natalie J.; Foreman, Nicholas K.; Venkataraman, Sujatha; Dowell, Robin; Vibhakar, Rajeev; Dahl, Nathan A. 分享 收藏
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COMBINATORIAL BH3-MIMETIC STRATEGY FOR OVERCOMING RADIORESISTANCE IN PEDIATRIC HIGH-GRADE GLIOMA Madhavan, Krishna; Donthula, Sahiti; Walker, Faye M.; Sobral, Lays Martin; Balakrishnan, Ilango; Pierce, Angela; Karam, Sana D.; Serkova, Natalie J.; Venkataraman, Sujatha; Dahl, Nathan A. 分享 收藏
DUAL TARGETING OF PROCESSIVE TRANSCRIPTION FOR MYC-DRIVEN CIRCUITRY IN MEDULLOBLASTOMA Walker, Faye M.; Madhavan, Krishna; Sobral, Lays Martin; Donthula, Sahiti; Balakrishnan, Ilango; Wang, Dong; Pierce, Angela; Veo, Bethany; Karam, Sana D.; Serkova, Natalie J.; Foreman, Nicholas K.; Venkataraman, Sujatha; Vibhakar, Rajeev; Dahl, Nathan A. 分享 收藏
Rapid P-TEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy Walker, Faye M.; Sobral, Lays Martin; Danis, Etienne; Sanford, Bridget; Donthula, Sahiti; Balakrishnan, Ilango; Wang, Dong; Pierce, Angela; Karam, Sana D.; Kargar, Soudabeh; Serkova, Natalie J.; Foreman, Nicholas K.; Venkataraman, Sujatha; Dowell, Robin; Vibhakar, Rajeev; Dahl, Nathan A. 分享 收藏
EYA2 tyrosine phosphatase inhibition reduces MYC and prevents medulloblastoma progression Wolin, Arthur R.; Vincent, Melanie Y.; Hotz, Taylor; Purdy, Stephen C.; Rosenbaum, Sheera R.; Hughes, Connor J.; Hsu, Jessica Y.; Oliphant, Michael U. J.; Armstrong, Brock; Wessells, Veronica; Varella-Garcia, Marileila; Galbraith, Matthew D.; Pierce, Angela; Wang, Dong; Venkataraman, Sujatha; Danis, Etienne; Veo, Bethany; Serkova, Natalie; Espinosa, Joaquin M.; Gustafson, Daniel L.; Vibhakar, Rajeev; Ford, Heide L. 分享 收藏
RAPID PTEFB-DEPENDENT TRANSCRIPTIONAL REORGANIZATION UNDERPINS THE GLIOMA ADAPTIVE RESPONSE TO RADIOTHERAPY Walker, Faye; Sobral, Lays Martin; Danis, Etienne; Sanford, Bridget; Balakrishnan, Ilango; Wang, Dong; Pierce, Angela; Karam, Sana; Serkova, Natalie; Foreman, Nicholas; Venkataraman, Sujatha; Dowell, Robin; Vibhakar, Rajeev; Dahl, Nathan 分享 收藏
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PRECLINICAL TESTING OF THE EFFICACY AND SAFETY OF CRISPR/CAS9 GENE EDITED CAR-T CELL THERAPY FOR DIFFUSE MIDLINE GLIOMA (DMG) Balakrishnan, Ilango; Leach, Lillie; Pierce, Angela; Lakshmanachetty, Senthilnath; Madhavan, Krishna; Fosmire, Susan; Chatwin, Hannah; Green, Adam; Fry, Terry; Vibhakar, Rajeev; Kohler, Eric. M.; Venkataraman, Sujatha 分享 收藏
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Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma DeSisto, John; Lucas, John T.; Xu, Ke; Donson, Andrew; Lin, Tong; Sanford, Bridget; Wu, Gang; Tran, Quynh T.; Hedges, Dale; Hsu, Chih-Yang; Armstrong, Gregory T.; Arnold, Michael; Bhatia, Smita; Flannery, Patrick; Lemma, Rakeb; Hardie, Lakotah; Schueller, Ulrich; Venkataraman, Sujatha; Hoffman, Lindsey M.; Dorris, Kathleen; Levy, Jean M. Mulcahy; Hankinson, Todd C.; Handler, Michael; Liu, Arthur K.; Foreman, Nicholas; Vibhakar, Rajeev; Jones, Kenneth; Allen, Sariah; Zhang, Jinghui; Baker, Suzanne J.; Merchant, Thomas E.; Orr, Brent A.; Green, Adam L. 分享 收藏
A novel PLK1 inhibitor onvansertib effectively sensitizes MYC-driven medulloblastoma to radiotherapy 一种新型PLK1抑制剂onvansertib可有效提高MYC驱动的髓母细胞瘤对放疗的敏感性 Wang, Dong; Veo, Bethany; Pierce, Angela; Fosmire, Susan; Madhavan, Krishna; Balakrishnan, Ilango; Donson, Andrew; Alimova, Irina; Sullivan, Kelly D.; Joshi, Molishree; Erlander, Mark; Ridinger, Maya; Foreman, Nicholas K.; Venkataraman, Sujatha; Vibhakar, Rajeev 分享 收藏
Neoplastic and immune single-cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma 肿瘤和免疫单细胞转录组学定义了儿童髓母细胞瘤的亚组特异性肿瘤内异质性 Riemondy, Kent A.; Venkataraman, Sujatha; Willard, Nicholas; Nellan, Anandani; Sanford, Bridget; Griesinger, Andrea M.; Amani, Vladimir; Mitra, Siddhartha; Hankinson, Todd C.; Handler, Michael H.; Sill, Martin; Ocasio, Jennifer; Weir, Seth J.; Malawsky, Daniel S.; Gershon, Timothy R.; Garancher, Alexandra; Wechsler-Reya, Robert J.; Hesselberth, Jay R.; Foreman, Nicholas K.; Donson, Andrew M.; Vibhakar, Rajeev 分享 收藏
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