张

张海萍 (Haiping Zhang)

department of breast surgery副研究员

H指数:17

被引数:936

个人简介

"张海萍，同济大学附属妇产科医院，副研究员，硕士生导师\n张海萍博士2015年本科毕业于吉林大学，2020年毕业于同济大学生物学，获博士学位，2020年6月入职同济大学附属妇产科医院工作至今。长期专注于DNA损伤修复与衰老机制研究。研究成果以第一作者（含共同）发表于Nature、Nucleic Acids Research、Cell Death and Differentiation、Aging Cell、Cell Death and Disease等期刊，并受邀为Acta Biochimica et Biophysica Sinica撰写综述。\n主持国家自然科学基金青年/面上、上海市自然科学基金青年项目；入选“上海市扬帆计划”及“上海市东方英才计划青年项目”等人才项目。获上海医学科技奖（2022）、同济大学优秀博士论文（2021）等荣誉奖励。\n研究内容\n围绕“DNA损伤修复如何调控衰老”这一关键科学问题，系统识别参与DNA损伤修复的新型衰老相关因子以及探究DNA修复相关蛋白在衰老调控中的新机制，从而为延缓衰老、促进健康衰老提供坚实的理论依据和潜在干预靶标。（1）阐释了促衰老因子cGAS细胞核内调控DNA修复的全新功能(Nature, 2018; Cell Death and Differentiation, 2024)；（2）揭示了DNA修复是增龄相关基因组稳定性下降的关键因素(Aging Cell, 2020)；（3）开发了新型DNA修复检测系统并助力衰老相关疾病研究(Nucleic Acids Research, 2019; Cell Death and Disease, 2025) 。\n代表论文（#共同第一作者，*共同通讯作者）\n1. Zhang H #, Jiang L#, Du X, Qian Z, Wu G *, Jiang Y *, Mao Z * (2024). The cGAS-Ku80 complex regulates the balance between two end joining subpathways. Cell Death and Differentiation. 31, 792-803.\n2. Liu H #, Zhang H #, Wu X #, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R, Jungblut P, Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, Chen J, Wang P, Tang T, Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F, Yan D, Kaufmann S, Chen C, Mao Z * , Ge B * (2018). Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature 563, 131-136.\n3. Zhang H #, Cai B #, Geng A, Tang H, Zhang W, Li S, Jiang Y, Tan R *, Wan X *, Mao Z * (2020). Base excision repair but not DNA double-strand break repair is impaired in aged human adipose-derived stem cells. Aging Cell 19, e13062.\n4. Chen Y #, Zhang H #, Xu Z #, Tang H, Geng A, Cai B, Su T, Shi J, Jiang C, Tian X, Seluanov A, Huang J, Wan X, Jiang Y *, Gorbunova V *, Mao Z * (2019). A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. Nucleic Acids Research 47, 8563-8580.\n5. Dong W #, Zhang H #, Zhuang Z *, Jiang Y * (2025). PIPKIgamma promotes non-homologous end joining through LIG4 to enhance radiotherapy resistance in triple-negative breast cancer. Cell Death and Disease 16, 578.\n6. Zhang H #, Chen Y #, Jiang Y, Mao Z * (2022). DNA double-strand break repair and nucleic acid-related immunity. Acta Biochim Biophys Sin (Shanghai) 54, 828-835. (Invited Review)"