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KRASG12C-inhibitor-based combination therapies for pancreatic cancer: insights from drug screening 胰腺癌的KRASG12C-inhibitor-based联合治疗: 来自药物筛选的见解 Contreras, Constanza Tapia; Falke, Jonas Dominik; Seifert, Dana-Magdalena; Schneider, Carolin; Krauss, Lukas; Fang, Xin; Mueller, Denise; Demirdizen, Engin; Spitzner, Melanie; De Oliveira, Tiago; Schneeweis, Christian; Gaedcke, Jochen; Kaulfuss, Silke; Mirzakhani, Kimia; Wollnik, Bernd; Conrads, Karly; Beissbarth, Tim; Salinas, Gabriela; Huegel, Jonas; Beyer, Nils; Rheinlander, Sophia; Sax, Ulrich; Wirth, Matthias; Conradi, Lena-Christin; Reichert, Maximilian; Ellenrieder, Volker; Strobel, Philipp; Ghadimi, Michael; Grade, Marian; Saur, Dieter; Hessmann, Elisabeth; Schneider, Gunter 分享 收藏
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Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair 二肽基肽酶9触发BRCA2降解并促进DNA损伤修复 Bolgi, Oguz; Silva-Garcia, Maria; Ross, Breyan; Pilla, Esther; Kari, Vijayalakshmi; Killisch, Markus; Spitzner, Melanie; Stark, Nadine; Lenz, Christof; Weiss, Konstantin; Donzelli, Laura; Gorrell, Mark D.; Grade, Marian; Riemer, Jan; Urlaub, Henning; Dobbelstein, Matthias; Huber, Robert; Geiss-Friedlander, Ruth 分享 收藏
Combined targeting of HER-2 and HER-3 represents a promising therapeutic strategy in colorectal cancer Conradi, Lena-Christin; Spitzner, Melanie; Metzger, Anna-Lena; Kisly, Merle; Middel, Peter; Bohnenberger, Hanibal; Gaedcke, Jochen; Ghadimi, Michael B.; Liersch, Torsten; Rueschoff, Joseph; Beissbarth, Tim; Koenig, Alexander; Grade, Marian 分享 收藏
Hepatic arterial infusion of irinotecan and EmboCept® S results in high tumor concentration of SN-38 in a rat model of colorectal liver metastases Kauffels, Anne; Kitzmueller, Marie; Gruber, Andrea; Nowack, Hannah; Bohnenberger, Hanibal; Spitzner, Melanie; Kuthning, Anja; Sprenger, Thilo; Czejka, Martin; Ghadimi, Michael; Sperling, Jens 分享 收藏
The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness Kari, Vijayalakshmi; Raul, Sanjay Kumar; Henck, Jana Maria; Kitz, Julia; Kramer, Frank; Kosinsky, Robyn Laura; Uebelmesser, Nadine; Mansour, Wael Yassin; Eggert, Jessica; Spitzner, Melanie; Najafova, Zeynab; Bastians, Holger; Grade, Marian; Gaedcke, Jochen; Wegwitz, Florian; Johnsen, Steven A. 分享 收藏
Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling Emons, Georg; Spitzner, Melanie; Reineke, Sebastian; Moeller, Janneke; Auslander, Noam; Kramer, Frank; Hu, Yue; Beissbarth, Tim; Wolff, Hendrik A.; Rave-Fraenk, Margret; Hessmann, Elisabeth; Gaedcke, Jochen; Ghadimi, B. Michael; Johnsen, Steven A.; Ried, Thomas; Grade, Marian 分享 收藏
Wnt/β-catenin signaling mediates resistance of colorectal cancer cell lines to chemoradiotherapy Emons, Georg; Spitzner, Melanie; Reineke, Sebastian; Auslander, Noam; Kramer, Frank; Rave-Fraenk, Margret; Gaedcke, Jochen; Ghadimi, Michael; Ried, Thomas; Grade, Marian 分享 收藏
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Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway Activity During Osteoblast Differentiation Hossan, Tareq; Nagarajan, Sankari; Baumgart, Simon J.; Xie, Wanhua; Magallanes, Roberto Tirado; Hernandez, Celine; Chiaroni, Pierre-Marie; Indenbirken, Daniela; Spitzner, Melanie; Thomas-Chollier, Morgane; Grade, Marian; Thieffry, Denis; Grundhoff, Adam; Wegwitz, Florian; Johnsen, Steven A. 分享 收藏
Wnt/β-catenin signaling mediates resistance of colorectal cancer cells to chemoradiotherapy Emons, Georg; Spitzner, Melanie; Reineke, Sebastian; Moeller, Janneke; Kendziorra, Emil; Beissbarth, Tim; Rave-Fraenk, Margret; Gaedcke, Jochen; Ried, Thomas; Ghadimi, Michael; Grade, Marian 分享 收藏
Targeting STAT3 in vitro and in vivo reveals a novel therapeutic strategy to sensitize colorectal cancer cells to chemoradiotherapy Spitzner, Melanie; Roesler, Birte; Bielfeld, Christian; Herzberg, Carolin; Emons, Georg; Gaedcke, Jochen; Rave-Fraenk, Margret; Beissbarth, Tim; Ried, Thomas; Ghadimi, B. Michael; Grade, Marian 分享 收藏
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STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo STAT3抑制对结直肠癌放化疗增敏作用的体内外研究 Spitzner, Melanie; Roesler, Birte; Bielfeld, Christian; Emons, Georg; Gaedcke, Jochen; Wolff, Hendrik A.; Rave-Fraenk, Margret; Kramer, Frank; Beissbarth, Tim; Kitz, Julia; Wienands, Juergen; Ghadimi, B. Michael; Ebner, Reinhard; Ried, Thomas; Grade, Marian 分享 收藏
Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a,-224,-132 and let7g Salendo, Junius; Spitzner, Melanie; Kramer, Frank; Zhang, Xin; Jo, Peter; Wolff, Hendrik A.; Kitz, Julia; Kaulfuss, Silke; Beissbarth, Tim; Dobbelstein, Matthias; Ghadimi, Michael; Grade, Marian; Gaedcke, Jochen 分享 收藏
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Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy 沉默Wnt转录因子TCF4使结直肠癌细胞对 (化学) 放疗敏感 Kendziorra, Emil; Ahlborn, Kerstin; Spitzner, Melanie; Rave-Fraenk, Margret; Emons, Georg; Gaedcke, Jochen; Kramer, Frank; Wolff, Hendrik A.; Becker, Heinz; Beissbarth, Tim; Ebner, Reinhard; Ghadimi, B. Michael; Pukrop, Tobias; Ried, Thomas; Grade, Marian 分享 收藏
Silencing of TCF7L2 sensitizes Wnt/β-catenin signaling-dependent colorectal cancer cells to radiation Kendziorra, Emil; Ahlborn, Kerstin; Spitzner, Melanie; Rave-Fraenk, Margret; Gaedcke, Jochen; Emons, Georg; Kramer, Frank; Beissbarth, Tim; Ebner, Reinhard; Becker, Heinz; Ghadimi, B. Michael; Pukrop, Tobias; Ried, Thomas; Grade, Marian 分享 收藏
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