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M

Michael Downes

Salk Institute for Biological Studies

83H指数
318论文数
3.8W被引数
收录论文 123
发表时间
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SMRT regulation of nuclear receptors orchestrates bile acid homeostasisSMRT调控核受体协调胆汁酸稳态
errExperimental and Molecular Medicine
IF12.9
err2026-09-09
err0
errOAAI
errKyeongkyu Kim; Sungsoon Fang; Suk-Hyun Hong; Han Cho; Mathias Leblanc; Sandra Jacinto; Bernd Schnabl; Annette R. Atkins; Ruth T. Yu; Christopher Liddle; Morgan L. Truitt; Weiwei Fan; Chae Min Lee; Michael Downes; Ronald M. Evans
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FGF1 orchestrates circadian hepatic triglyceride secretion成纤维细胞生长因子1调控肝脏甘油三酯分泌的昼夜节律
errNature Communications
IF15.7
err2026-03-01
err0
errOAAI
errSermikli, Benan Pelin; Liu, Sihao; Kim, Kyeongkyu; Hases, Linnea; van Zutphen, Tim; Untereiner, Ashley; Torres, Jocelyn; He, Mingxiao; Crossley, Lillian; Dai, Yang; Zhu, Jonathan; Koopari, Chandra Lekha; Fan, Weiwei; Truitt, Morgan L.; Jonker, Johan W.; Atkins, Annette R.; Downes, Michael; Evans, Ronald M.
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Multi-layered transcriptional control of glycogen metabolism coordinates thermogenic remodeling of white adipocytes in male mice多层级转录调控糖原代谢，协调雄性小鼠白色脂肪细胞的产热重塑。
errNature Communications
IF15.7
err2025-12-16
err0
errOAAI
errHaipeng Fu; Seoyeon Lee; Nathan R. Zemke; Weiwei Fan; Yunqing Wang; James Garza; David Tin; Bryce Villao; Bichen Zhang; Xianda Ma; Jinyang Zhang; Tangran Dong; Yuyao Ren; Michael Downes; Ronald M. Evans; Bing Ren; Alan R. Saltiel
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Neutrophils preserve energy storage in sympathetically activated adipocytes中性粒细胞维持交感神经激活的脂肪细胞中的能量储存
errNature
IF48.5
err2025-12-10
err0
PREAI
errSeunghwan Son; Cindy Xu; Haipeng Fu; Churaibhon Wisessaowapak; Joseph M. Valentine; Garam An; Janice Jang; Maddox Dinh; Yang Dai; Weiwei Fan; Ruth T. Yu; Michael Downes; Wei Ying; Yuliya Skorobogatko; Ronald M. Evans; Alan R. Saltiel
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FGF1 ameliorates hepatic steatosis through acute activation of the Unfolded Protein Response and VLDL productionFGF1通过急性激活未折叠蛋白反应和VLDL产生来改善肝脂肪变性。
errJHEP Reports
IF7.5
err2025-10-30
err0
errOAAI
errTim van Zutphen; Dicky Struik; Weilin Liu; Sihao Liu; Benan Pelin Sermikli; Justina C. Wolters; Henkjan J. Verkade; Annette R. Atkins; Michael Downes; Ronald M. Evans; Johan W. Jonker
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Phase IB Trial of High Dose Ascorbic Acid + Nab-Paclitaxel + Cisplatin + Gemcitabine in Patients With Untreated Metastatic Pancreatic Cancer.I期B临床试验：高剂量抗坏血酸 + Nab-紫杉醇 + 顺铂 + 吉西他滨，用于未治疗的转移性胰腺癌患者。
errRedox Biology
IF11.9
err2025-10-25
err0
errOAAI
errGayle S. Jameson; S.Danielle LeGrand; Michael S. Gordon; Denise J. Roe; Betsy C. Wertheim; Kellen Olszewski; Josh Rabinowitz; Ron Evans; Michael Downes; Morgan Truitt; Ron Korn; Haiyong Han; Richard M. Miller; Michael T. Barrett; David Propper; Daniel D. Von Hoff; Erkut Borazanci
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Adipocyte Heparan Sulfate Determines Type 2 Diabetes Susceptibility in Mice via FGF1-Mediated Glucose Regulation.脂肪细胞硫酸乙酰肝素通过FGF1介导的葡萄糖调节确定小鼠2型糖尿病易感性。
errMolecular Metabolism
IF6.6
err2025-10-08
err0
errOAAI
errChung-Jui Yu; Ariane R. Pessentheiner; Sihao Liu; Sarah Wax; Marissa L. Maciej-Hulme; Chelsea D. Painter; Bastian Ramms; Daniel R. Sandoval; Anthony Quach; Natalie DeForest; G.Michelle Ducasa; Chiara Tognaccini; Caroline Labib; Norah Al-Azzam; Friederike Haumann; Greg Trieger; Patrick Secrest; Amit Majithia; Aaron C. Petrey; Kamil Godula; Annette R. Atkins; Michael Downes; Ronald M. Evans; Philip L.S.M. Gordts
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Estrogen- related receptors regulate innate and adaptive muscle mitochondrial energetics through cooperative and distinct actions雌激素相关受体通过协同和独特的作用调节先天性和适应性肌肉线粒体能量代谢。
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2025-05-12
err0
errOAAI
errFan, Weiwei; Oh, Tae Gyu; Wang, Hui J.; Crossley, Lillian; He, Mingxiao; Robbins, Hunter; Koopari, Chandra; Dai, Yang; Truitt, Morgan L.; Liddle, Christopher; Yu, Ruth T.; Atkins, Annette R.; Downes, Michael; Evans, Ronald M.
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The human milk oligosaccharide 3′sialyllactose reduces low-grade inflammation and atherosclerosis development in mice
errJCI INSIGHT
IF6.1
err2024-11-08
err0
errOAAI
errPessentheiner, Ariane R.; Spann, Nathanael J.; Autran, Chloe A.; Oh, Tae Gyu; Grunddal, Kaare, V; Coker, Joanna K. C.; Painter, Chelsea D.; Ramms, Bastian; Chiang, Austin W. T.; Wang, Chen-Vi; Hsiao, Jason; Wang, Viwen; Quach, Anthony; Booshehri, Laela M.; Hammond, Alexandra; Tognaccini, Chiara; Latasiewicz, Joanna; Willemsen, Lisa; Zengler, Karsten; Winther, Menno P. J. de; Hoffman, Hal M.; Philpott, Martin; Cribbs, Adam P.; Oppermann, Udo; Lewis, Nathan E.; Witztum, Joseph L.; Vu, Ruth; Atkins, Annette R.; Downes, Michael; Evans, Ron M.; Glass, Christopher K.; Bode, Lars; Gordts, Philip L. S. M.
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Functional inversion of circadian regulator REV- ERBα leads to tumorigenic gene reprogramming
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-10-09
err0
errOAAI
errYang, Yatian; Zhang, Xiong; Cai, Demin; Zheng, Xingling; Zhao, Xuan; Zou, June X.; Zhang, Jin; Borowsky, Alexander D.; Dall'Era, Marc A.; Corey, Eva; Mitsiades, Nicholas; Kung, Hsing-Jien; Chen, Xinbin; Li, Jian Jian; Downes, Michael; Evans, Ronald M.; Chen, Hong-Wu
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Evaluating and interpreting scGPT: A foundation model for singlecell biology in real-world cancer clinical trial data
errCANCER RESEARCH
IF16.6
err2024-09-15
err0
PREAI
errTan, Runzi; Cui, Haotian; Wang, Bo; Perez, Kimberly; Costa, Andressa Dias; Jordan, Alexander; Karacic, Thomas; Elganainy, Dalia; Gui, Dan Y.; Kim, Suryun; Yuan, Chen; Truitt, Morgan; Downes, Michael; Evans, Ronald; Oh, Tae Gyu; O'Dwyer, Peter; Aguirre, Andrew; Nowak, Jonathan A.; Wolpin, Brian; Cristea, Simona
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Vitamin D Receptor Regulates Liver Regeneration After Partial Hepatectomy in Male Mice
errENDOCRINOLOGY
IF3.3
err2024-07-04
err1
errOAAI
errElangovan, Harendran; Stokes, Rebecca A.; Keane, Jeremy; Chahal, Sarinder; Samer, Caroline; Agoncillo, Miguel; Yu, Josephine; Chen, Jennifer; Downes, Michael; Evans, Ronald M.; Liddle, Christopher; Gunton, Jenny E.
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Phase II open label trial of Minnelide™ in patients with chemotherapy refractory metastatic pancreatic cancer
errCANCER RESEARCH
IF16.6
err2024-04-05
err0
PREAI
errPropper, David; Borazanci, Erkut; O'Dwyer, Peter J.; Von Hoff, Daniel; Hartlebury, Joseph; Antal, Corina E.; Evan, Gerard I.; Han, HaiYong; Downes, Michael; Evans, Ronald; Rabinowitz, Joshua; Petricoin, Emmanuel; Saluja, Ashok; Velagapudi, Mohana; Patel, Hitendra
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Targeting nuclear receptor corepressors for reversible male contraception
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-02-20
err2
errOAAI
errHong, Suk - Hyun; Castro, Glenda; Wang, Dan; Nofsinger, Russell; Kane, Maureen; Folias, Alexandra; Atkins, Annette R.; Yu, Ruth T.; Napoli, Joseph L.; Sassone-Corsi, Paolo; de Rooij, Dirk G.; Liddle, Christopher; Downes, Michael; Evans, Ronald M.
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Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation
errNATURE METABOLISM
IF20.8
err2024-01-29
err19
errOAAI
errXia, Wenmin; Veeragandham, Preethi; Cao, Yu; Xu, Yayun; Rhyne, Torrey E.; Qian, Jiaxin; Hung, Chao-Wei; Zhao, Peng; Jones, Ying; Gao, Hui; Liddle, Christopher; Yu, Ruth T.; Downes, Michael; Evans, Ronald M.; Ryden, Mikael; Wabitsch, Martin; Wang, Zichen; Hakozaki, Hiroyuki; Schoneberg, Johannes; Reilly, Shannon M.; Huang, Jianfeng; Saltiel, Alan R.
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Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function
errCIRCULATION
IF38.6
err2024-01-16
err7
PREAI
errXu, Weiyi; Billon, Cyrielle; Li, Hui; Wilderman, Andrea; Qi, Lei; Graves, Andrea; Rideb, Jernie Rae Dela Cruz; Zhao, Yuanbiao; Hayes, Matthew; Yu, Keyang; Losby, McKenna; Hampton, Carissa S.; Adeyemi, Christiana M.; Hong, Seok Jae; Nasiotis, Eleni; Fu, Chen; Oh, Tae Gyu; Fan, Weiwei; Downes, Michael; Welch, Ryan D.; Evans, Ronald M.; Milosavljevic, Aleksandar; Walker, John K.; Jensen, Brian C.; Pei, Liming; Burris, Thomas; Zhang, Lilei
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A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activationTLR4/TRAF6-dependent信号通路介导NCoR共激活因子复合物形成促进炎症基因激活
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-01-02
err3
errOAAI
errAbe, Yohei; Kofman, Eric R.; Ouyang, Zhengyu; Cruz-Becerra, Grisel; Spann, Nathanael J.; Seidman, Jason S.; Troutman, Ty D.; Stender, Joshua D.; Taylor, Havilah; Fan, Weiwei; Link, Verena M.; Shen, Zeyang; Sakai, Juro; Downes, Michael; Evans, Ronald M.; Kadonaga, James T.; Rosenfeld, Michael G.; Glass, Christopher K.
err分享
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Inhibiting stromal Class I HDACs curbs pancreatic cancer progression
errNATURE COMMUNICATIONS
IF15.7
err2023-12-06
err4
errOAAI
errLiang, Gaoyang; Oh, Tae Gyu; Hah, Nasun; Tiriac, Herve; Shi, Yu; Truitt, Morgan; Antal, Corina; Atkins, Annette; Li, Yuwenbin; Fraser, Cory; Ng, Serina; Pinto, Antonio; Nelson, Dylan; Estepa, Gabriela; Bashi, Senada; Banayo, Ester; Dai, Yang; Liddle, Christopher; Yu, Ruth; Hunter, Tony; Engle, Dannielle; Han, Haiyong; Von Hoff, Daniel; Downes, Michael; Evans, Ronald
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Zinc accumulation in Atriplex lentiformis is driven by plant genes and the soil microbiome
errSCIENCE OF THE TOTAL ENVIRONMENT
IF8
err2023-11-01
err2
errOAAI
errKushwaha, Priyanka; Tran, Alexandria; Quintero, Diego; Song, Miranda; Yu, Qi; Yu, Ruth; Downes, Michael; Evans, Ronald M.; Babst-Kostecka, Alicja; Schroeder, Julian I.; Maier, Raina M.
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RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1(3-and RNA-dependent co-activator of osteoclast gene expressionRANK配体将NCoR/HDAC3共阻遏物转化为PGC1 (破骨细胞基因表达的3-和RNA依赖性共激活因子
errMOLECULAR CELL
IF16.6
err2023-10-01
err7
errOAAI
errAbe, Yohei; Kofman, Eric R.; Almeida, Maria; Ouyang, Zhengyu; Ponte, Filipa; Mueller, Jasmine R.; Cruz-Becerra, Grisel; Sakai, Mashito; Prohaska, Thomas A.; Spann, Nathanael J.; Resende-Coelho, Ana; Seidman, Jason S.; Stender, Joshua D.; Taylor, Havilah; Fan, Weiwei; Link, Verena M.; Cobo, Isidoro; Schlachetzki, Johannes C. M.; Hamakubo, Takao; Jepsen, Kristen; Sakai, Juro; Downes, Michael; Evans, Ronald M.; Yeo, Gene W.; Kadonaga, James T.; Manolagas, Stavros C.; Rosenfeld, Michael G.; Glass, Christopher K.
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