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J

Joachim Rudolph

Genentech

37H指数
169论文数
4.9K被引数
收录论文 52
发表时间
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Contemporary design of small-molecule kinase modulators: orthosteric, allosteric and induced-proximity strategies小分子激酶调节剂的当代设计: 正构，变构和诱导邻近策略
errNature Reviews Drug Discovery
IF101.8
err2026-04-28
err0
PREAI
errJoachim Rudolph; Klaus P. Hoeflich; Arvin C. Dar
err分享
err收藏
Discovery and Characterization of Divarasib (GDC-6036); a Potent Covalent Inhibitor of KRAS G12CDivarasib (GDC-6036)的发现与表征：一种强效的KRAS G12C共价抑制剂
errJournal of Medicinal Chemistry
IF6.8
err2026-03-02
err0
PREAI
errNicholas F. Endres; Steven Do; Rana Mroue; Jack A. Terrett; Matt Saabye; Angela Oh; Thomas Hunsaker; Emily Chan; John C. Tran; Lan K. Nguyen; Qihui Lian; Taylur P. Ma; Thomas Garner; Luca Gerosa; Maureen Beresini; Aaron Boudreau; Sarah M. Bronner; Patrick Cyr; Noriko Ishisoko; Yevgeniy Izrayelit; Fan Jiang; Terry Kellar; Hank La; Sharada Labadie; Matthew Lardy; Liling Liu; Wendy Liu; Sarah Miller; Joachim Rudolph; Emile Plise; Benjamin D. Sellers; Cheng Shao; Weiru Wang; Yanguang Wang; Wentao Wei; Susan Wong; Christine Yu; Kebing Yu; Po-Wai Yuen; Richard Zang; Chenghong Zhang; Yuhui Zhou; Xiaoyu Zhu; John G. Quinn; Xin Ye; James R. Kiefer; Jialin Mao; Marie Evangelista; Mark Merchant; Matthew L. Landry; Sushant Malhotra; Hans E. Purkey
err分享
err收藏
Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera化学诱导的内质网应激传感器IRE1的降解，通过一种VHL招募嵌合体实现
errNature Communications
IF15.7
err2025-12-11
err0
errOAAI
errJin Du; Elisia Villemure; Matthew Johnson; Caleigh Azumaya; Catarina J. Gaspar; Scot Marsters; David Lawrence; Scott Foster; Alexis Rohou; Tommy K. Cheung; Christopher M. Rose; Thomas Garner; Soo Ro; Kevin Clark; Maureen H. Beresini; Marie-Gabrielle Braun; Joachim Rudolph; Peter Hsu; Avi Ashkenazi
err分享
err收藏
Rational design of potent small-molecule SMARCA2/A4 degraders acting via the recruitment of FBXO22通过FBXO22招募作用实现的高效小分子SMARCA2/A4降解剂的理性设计
errNature Communications
IF15.7
err2025-11-03
err0
errOAAI
errElisia Villemure; Tom Januario; Mingshuo Zeng; Hanna G. Budayeva; Benjamin T. Walters; Aaron Lictao; Ke Sherry Li; Xiaofen Ye; Caroline L. Gilchrist; Bridget Hoag; Nicholas F. Endres; Peter L. Hsu; John Chan; Tommy K. Cheung; Michael R. Costa; Jean-Philippe Fortin; Noriko Ishisoko; Brett M. Babin; Joyce Liu; Alexandra Frommlet; Joachim Rudolph; Robert L. Yauch
err分享
err收藏
NRF2 supports non-small cell lung cancer growth independently of CBP/p300-enhanced glutathione synthesisNRF2支持非小细胞肺癌的生长，且该作用独立于CBP/p300增强的谷胱甘肽合成。
errEMBO REPORTS
IF6.2
err2025-05-14
err0
errOAAI
errConrad, Ryan J.; Mondo, James A.; Wang, Mike Lingjue; Liu, Peter S.; Lai, Zijuan; Choudhury, Feroza K.; Li, Qingling; Wong, Weng Ruh; Lee, James; Shanahan, Frances; Lin, Eva; Martin, Scott; Rudolph, Joachim; Moffat, John G.; Sangaraju, Dewakar; Sandoval, Wendy; Sterne-Weiler, Timothy; Foster, Scott A.
err分享
err收藏
A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth一种非酶依赖性，依赖于inositol-requiring enzyme 1的控制癌症细胞周期进展和肿瘤生长。
errPLOS BIOLOGY
IF7.2
err2025-04-10
err0
errOAAI
errZuazo-Gaztelu, Iratxe; Lawrence, David; Oikonomidi, Ioanna; Marsters, Scot; Pechuan-Jorge, Ximo; Gaspar, Catarina J.; Kan, David; Segal, Ehud; Clark, Kevin; Beresini, Maureen; Braun, Marie-Gabrielle; Rudolph, Joachim; Modrusan, Zora; Choi, Meena; Sandoval, Wendy; Reichelt, Mike; Dewitt, David C.; Kujala, Pekka; van Dijk, Suzanne; Klumperman, Judith
err分享
err收藏
Medicinal Chemistry Reviews, Volume 59《药物化学评论》，第59卷
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-01-31
err0
PREAI
errRudolph, Joachim; Watkins, William J.
err分享
err收藏
Medicinal Chemistry Reviews, Volume 59
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2025-01-31
err0
PREAI
errRudolph, Joachim; Watkins, William J.
err分享
err收藏
Heteroaryl Glutarimides and Dihydrouracils as Cereblon Ligand Scaffolds for Molecular Glue Degrader Discovery杂芳基戊二酰亚胺和二氢尿嘧啶作为用于分子胶降解剂发现的Cereblon配体支架
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2024-11-15
err0
PREAI
errZhou, Yuebiao; Garrigues, Star L.; Villemure, Elisia; Ishisoko, Noriko; Nguyen, Huy Q.; Hamidi, Nikkia K.; Vogt, Rebecca; Wang, Yong; Blake, Robert A.; Rudolph, Joachim; Nilewski, Christian
err分享
err收藏
Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-05-15
err0
PREAI
errBraun, Marie-Gabrielle; Ashkenazi, Avi; Beveridge, Ramsay E.; Castanedo, Georgette; Wallweber, Heidi Ackerly; Beresini, Maureen H.; Clark, Kevin R.; De Bruyn, Tom; Fu, Liqiang; Gibbons, Paul; Jiang, Fan; Kaufman, Susan; Kan, David; Kiefer, James R.; Leclerc, Jean-Philippe; Lemire, Alexandre; Ly, Cuong; Segal, Ehud; Sims, Jessica; Wang, Weiru; Wei, Wentao; Zhao, Liang; Schwarz, Jacob B.; Rudolph, Joachim
err分享
err收藏
Allosteric Inhibitors of the SARS-COV-2 Papain-like Protease Domain Induce Proteasomal Degradation of Its Parent Protein NSP3
errACS CHEMICAL BIOLOGY
IF3.8
err2023-12-27
err0
PREAI
errCockram, Peter E.; Walters, Benjamin T.; Lictao, Aaron; Shanahan, Frances; Wertz, Ingrid E.; Foster, Scott A.; Rudolph, Joachim
err分享
err收藏
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation
errCANCER DISCOVERY
IF33.3
err2023-09-15
err5
errOAAI
errMader, Mary M.; Rudolph, Joachim; Hartung, Ingo V.; Uehling, David; Workman, Paul; Zuercher, William
err分享
err收藏
Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-07-05
err34
errOAAI
errHartung, Ingo V.; Rudolph, Joachim; Mader, Mary M.; Mulder, Monique P. C.; Workman, Paul
err分享
err收藏
Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors
errNATURE BIOTECHNOLOGY
IF41.7
err2022-01-06
err7
errOAAI
errDavies, Christopher W.; Oh, Angela J.; Mroue, Rana; Steffek, Micah; Bruning, John M.; Xiao, Yang; Feng, Siyu; Jayakar, Sangeeta; Chan, Emily; Arumugam, Vidhyalakshmi; Uribe, Sean Carlo; Drummond, Jake; Frommlet, Alexandra; Lu, Cheng; Franke, Yvonne; Merchant, Mark; Koeppen, Hartmut; Quinn, John G.; Malhotra, Sushant; Do, Steve; Gazzard, Lewis; Purkey, Hans E.; Rudolph, Joachim; Mulvihill, Melinda M.; Koerber, James T.; Wang, Weiru; Evangelista, Marie
err分享
err收藏
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α
errNATURE COMMUNICATIONS
IF15.7
err2021-12-15
err37
errOAAI
errLe Thomas, Adrien; Ferri, Elena; Marsters, Scot; Harnoss, Jonathan M.; Lawrence, David A.; Zuazo-Gaztelu, Iratxe; Modrusan, Zora; Chan, Sara; Solon, Margaret; Chalouni, Cecile; Li, Weihan; Koeppen, Hartmut; Rudolph, Joachim; Wang, Weiru; Wu, Thomas D.; Walter, Peter; Ashkenazi, Avi
err分享
err收藏
Emerging Trends in Cancer Drug Discovery-From Drugging the Undruggable to Overcoming Resistance
errCANCER DISCOVERY
IF33.3
err2021-04-02
err26
errOAAI
errRudolph, Joachim; Settleman, Jeff; Malek, Shiva
err分享
err收藏
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3H)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2021-03-29
err20
PREAI
errHuestis, Malcolm P.; Dela Cruz, Darlene; DiPasquale, Antonio G.; Durk, Matthew R.; Eigenbrot, Charles; Gibbons, Paul; Gobbi, Alberto; Hunsaker, Thomas L.; La, Hank; Leung, Dennis H.; Liu, Wendy; Malek, Shiva; Merchant, Mark; Moffat, John G.; Muli, Christine S.; Orr, Christine J.; Parr, Brendan T.; Shanahan, Frances; Sneeringer, Christopher J.; Wang, Weiru; Yen, Ivana; Yin, Jianping; Siu, Michael; Rudolph, Joachim
err分享
err收藏
Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands
errNATURE COMMUNICATIONS
IF15.7
err2020-12-14
err25
errOAAI
errFerri, Elena; Le Thomas, Adrien; Wallweber, Heidi Ackerly; Day, Eric S.; Walters, Benjamin T.; Kaufman, Susan E.; Braun, Marie-Gabrielle; Clark, Kevin R.; Beresini, Maureen H.; Mortara, Kyle; Chen, Yung-Chia A.; Canter, Breanna; Phung, Wilson; Liu, Peter S.; Lammens, Alfred; Ashkenazi, Avi; Rudolph, Joachim; Wang, Weiru
err分享
err收藏
Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2020-10-16
err8
errOAAI
errBeveridge, Ramsay E.; Wallweber, Heidi Ackerly; Ashkenazi, Avi; Beresini, Maureen; Clark, Kevin R.; Gibbons, Paul; Ghiro, Elise; Kaufman, Susan; Larivee, Alexandre; Leblanc, Melissa; Leclerc, Jean-Philippe; Lemire, Alexandre; Ly, Cuong; Rudolph, Joachim; Schwarz, Jacob B.; Srivastava, Sanjay; Wang, Weiru; Zhao, Liang; Braun, Marie-Gabrielle
err分享
err收藏
IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment
errCANCER RESEARCH
IF16.6
err2020-06-02
err54
errOAAI
errHarnoss, Jonathan M.; Le Thomas, Adrien; Reichelt, Mike; Guttman, Ofer; Wu, Thomas D.; Marsters, Scot A.; Shemorry, Anna; Lawrence, David A.; Kan, David; Segal, Ehud; Merchant, Mark; Totpal, Klara; Crocker, Lisa M.; Mesh, Kathryn; Dohse, Monika; Solon, Margaret; Modrusan, Zora; Rudolph, Joachim; Koeppen, Hartmut; Walter, Peter; Ashkenazi, Avi
err分享
err收藏

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