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J

John E. Burke

university of victoria

54H指数
258论文数
1.5W被引数
收录论文 111
发表时间
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Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin可溶性VPS13C的冷冻电镜结构表明其通过构象开关和钙调蛋白进行调控
errMolecular Cell
IF16.6
err2026-07-07
err0
errOAAI
errDazhi Li; Xinbo Wang; Hongyan Hao; Jessica Eden; Bodan Hu; Emma E. Walsh; Matthew A.H. Parson; Stephanie Hamill; Yuting Li; Guochao Chen; John E. Burke; Pietro De Camilli; Karin M. Reinisch
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ARMH3 acts as a central scaffold at the Golgi/TGN through interactions with Arl5, GBF1, and PI4KBARMH3通过与其他Arl5、GBF1和PI4KB的相互作用在Golgi/TGN处发挥中心支架作用
errJournal of Biological Chemistry
IF3.9
err2026-07-01
err0
PREAI
errScott, Mackenzie K.; Klynsoon, Giselle C. T.; Walsh, Emma E.; Suresh, Sushant; Nyvall, Hunter G.; Burke, John E.
err分享
err收藏
Use of hydrogen deuterium exchange mass spectrometry in tandem with modern structural biology氢氘交换质谱技术与现代结构生物学的联用
errBiochemical Journal
IF4.3
err2026-05-01
err0
PREAI
errNyvall, Hunter G.; Shaw, Alexandria L.; Walsh, Emma E.; Bhatti, Hirsh; Burke, John E.
err分享
err收藏
Activity and dynamics of p110α are not differentially modulated by regulatory subunit isoformsp110α的活性和动力学不会受到调节亚基异构体的差异性调控。
errAdvances in Biological Regulation
IF2.4
err2026-02-01
err2
errOAAI
errBarlow-Busch, Isobel; Walsh, Emma E.; Nyvall, Hunter G.; Burke, John E.
err分享
err收藏
Functional NK engagers from OmniClic, a common light-chain platform producing fully human-sequence antibodies in a chicken host speciesOmniClic平台的功能性NK细胞招募剂，该平台是一种在鸡宿主物种中产生全人源序列抗体的通用轻链平台。
errmAbs
IF7.3
err2025-12-08
err0
errOAAI
errBaisen Zeng; Ingrid Mechin; David Mowrey; Gerry S Rivera; Hunter G Nyvall; Sushant Suresh; John E Burke; William Harriman; Bob Chen; Yasmina Abdiche
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Unconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity钙调素对CHK2激酶的非典型结合抑制其催化活性
errBIOCHEMICAL JOURNAL
IF4.3
err2025-12-01
err0
errOAAI
errHorne, Christopher R.; Wang, Tingting; Young, Samuel N.; Dite, Toby A.; Nyvall, Hunter G.; Suresh, Sushant; Davies, Katherine A.; Castro, Abner Gonzalez; Vaibhav, Vineet; Mather, Lucy J.; Dagley, Laura F.; Belousoff, Matthew J.; Manning, Gerard; Means, Anthony R.; Burke, John E.; Petersen, Janni; Scott, John W.; Murphy, James M.
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Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors作者更正：多样性导向合成产生了新颖的多阶段抗疟抑制剂
errNature
IF48.5
err2025-11-28
err0
PREAI
errNobutaka Kato; Eamon Comer; Tomoyo Sakata-Kato; Arvind Sharma; Manmohan Sharma; Micah Maetani; Jessica Bastien; Nicolas M. Brancucci; Joshua A. Bittker; Victoria Corey; David Clarke; Emily R. Derbyshire; Gillian L. Dornan; Sandra Duffy; Sean Eckley; Maurice A. Itoe; Karin M. J. Koolen; Timothy A. Lewis; Ping S. Lui; Amanda K. Lukens; Emily Lund; Sandra March; Elamaran Meibalan; Bennett C. Meier; Jacob A. McPhail; Branko Mitasev; Eli L. Moss; Morgane Sayes; Yvonne Van Gessel; Mathias J. Wawer; Takashi Yoshinaga; Anne-Marie Zeeman; Vicky M. Avery; Sangeeta N. Bhatia; John E. Burke; Flaminia Catteruccia; Jon C. Clardy; Paul A. Clemons; Koen J. Dechering; Jeremy R. Duvall; Michael A. Foley; Fabian Gusovsky; Clemens H. M. Kocken; Matthias Marti; Marshall L. Morningstar; Benito Munoz; Daniel E. Neafsey; Amit Sharma; Elizabeth A. Winzeler; Dyann F. Wirth; Christina A. Scherer; Stuart L. Schreiber
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Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA开发一种抑制性TTC7B选择性纳米抗体，该抗体能阻断EFR3对PI4KA的招募
errJournal of Biological Chemistry
IF3.9
err2025-11-04
err0
errOAAI
errSushant Suresh; Alexandria L. Shaw; Damilola K. Akintola; Martine Lunke; Sophia Doerr; Pooja Rohilla; Tamas Balla; Calvin K. Yip; Scott D. Hansen; Jennifer A. Cobb; John E. Burke
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CERT1 mutations perturb human development by disrupting sphingolipid homeostasis (Vol 135, e200195, 2025)
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2025-11-03
err1
PREAI
errGehin, Charlotte; Lone, Museer A.; Lee, Winston; Capolupo, Laura; Ho, Sylvia; Adeyemi, Adekemi M.; Gerkes, Erica H.; Stegmann, Alexander P. A.; Lopez-Martin, Estrella; Bermejo-Sanchez, Eva; Martinez-Delgado, Beatriz; Zweier, Christiane; Kraus, Cornelia; Popp, Bernt; Strehlow, Vincent; Grafe, Daniel; Knerr, Ina; Jones, Eppie R.; Zamuner, Stefano; Abriata, Luciano A.; Kunnathully, Vidya; Moeller, Brandon E.; Vocat, Anthony; Rommelaere, Samuel; Bocquete, Jean-Philippe; Ruchti, Evelyne; Limoni, Greta; Van Campenhoudt, Marine; Bourgeat, Samuel; Henklein, Petra; Gilissen, Christian; Van Bon, Bregje W.; Pfundt, Rolph; Willemsen, Marjolein H.; Schieving, Jolanda H.; Leonardi, Emanuela; Soli, Fiorenza; Murgia, Alessandra; Guo, Hui; Zhang, Qiumeng; Xia, Kun; Fagerberg, Christina R.; Beier, Christoph P.; Larsen, Martin J.; Valenzuela, Irene; Fernandez-Alvarez, Paula; Xiong, Shiyi; Smigiel, Robert; Lopez-Gonzalez, Vanesa; Armengol, Lluis; Morleo, Manuela; Selicorni, Angelo; Torella, Annalaura; Blyth, Moira; Cooper, Nicola S.; Wilson, Valerie; Oegema, Renske; Herenger, Yvan; Garde, Aurore; Bruel, Ange-Line; Mau-Them, Frederic Tran; Maddocks, Alexis B. R.; Bain, Jennifer M.; Bhat, Musadiq A.; Costain, Gregory; Kannu, Peter; Marwaha, Ashish; Champaigne, Neena L.; Friez, Michael J.; Richardson, Ellen B.; Gowda, Vykuntaraju K.; Srinivasan, Varunvenkat M.; Gupta, Yask; Lim, Tze Y.; Sanna-Cherchi, Simone; Lemaitre, Bruno; Yamaji, Toshiyuki; Hanada, Kentaro; Burke, John E.; Jaksic, Ana Marija; Mccabe, Brian D.; De Los Rios, Paolo; Hornemann, Thorsten; D'angelo, Giovanni; Gennarino, Vincenzo A.
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SH2-mediated steric occlusion of the C2 domain regulates autoinhibition of SHIP1 inositol 5-phosphataseSH2介导的C2结构域空间遮蔽调控SHIP1肌醇5-磷酸酶的自身抑制
errJournal of Biological Chemistry
IF3.9
err2025-10-07
err0
errOAAI
errEmma E. Drew; Hunter G. Nyvall; Matthew A.H. Parson; Reed K. Talus; John E. Burke; Scott D. Hansen
err分享
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Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitorsPLCγ酶别构位点的表征及其在特异性抑制剂开发中的意义
errBIOCHEMICAL JOURNAL
IF4.3
err2025-10-01
err0
errOAAI
errBunney, Tom D.; Nyvall, Hunter G.; Macrae, Calum; Lalovic, Damjan; Gregory, Ashley; Le Huray, Kyle I. P.; Harvey, Nikita; Pinotsis, Nikos; Kalli, Antreas C.; Waudby, Christopher A.; Burke, John E.; Katan, Matilda
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Molecular basis for regulation of the class I phosphoinositide 3-kinases (PI3Ks), and their targeting in human diseaseI类磷脂酰肌醇3-激酶(PI3Ks)调控的分子基础及其在人类疾病中的靶向治疗
errbiochimica et biophysica acta molecular and cell biology of lipids
IF0
err2025-09-07
err0
PREAI
errAlexandria L. Shaw; Isobel Barlow-Busch; John E. Burke
err分享
err收藏
An advanced toolset to manipulate and monitor subcellular phosphatidylinositol 3,5-bisphosphate一套用于操纵和监测亚细胞磷脂酰肌醇3,5-二磷酸的工具集
errJOURNAL OF CELL BIOLOGY
IF6.4
err2025-03-26
err0
PREAI
errPemberton, Joshua G.; Barlow-Busch, Isobel; Jenkins, Meredith L.; Parson, Matthew A. H.; Sarnyai, Farkas; Bektas, Seyma Nur; Kim, Yeun Ju; Heuser, John E.; Burke, John E.
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DET1 dynamics underlie cooperative ubiquitination by CRL4DET1-COP1 complexesDET1 动力学构成了 CRL4DET1-COP1 复合物介导的协同泛素化作用。
errSCIENCE ADVANCES
IF12.5
err2025-02-28
err0
PREAI
errBurgess, Abigail E.; Loughran, Tarren A.; Turk, Liam S.; Nyvall, Hunter G.; Dunlop, Jessica L.; Jamieson, Sam A.; Curry, Jack R.; Burke, John E.; Filipcik, Pavel; Brown, Simon H. J.; Mace, Peter D.
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Biochemical and structural characterization of Rab3GAP reveals insights into Rab18 nucleotide exchange activityRab3GAP的生物化学和结构表征揭示了其对Rab18核苷酸交换活性的认识
errNATURE COMMUNICATIONS
IF15.7
err2025-01-08
err0
errOAAI
errFairlie, Gage M. J.; Nguyen, Kha M.; Nam, Sung-Eun; Shaw, Alexandria L.; Parson, Matthew A. H.; Shariati, Hannah R.; Wang, Xinyin; Jenkins, Meredith L.; Gong, Michael; Burke, John E.
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Molecular basis for plasma membrane recruitment of PI4KA by EFR3EFR3募集PI4KA质膜的分子基础
errSCIENCE ADVANCES
IF12.5
err2024-12-20
err0
errOAAI
errSuresh, Sushant; Shaw, Alexandria L.; Pemberton, Joshua G.; Scott, Mackenzie K.; Harris, Noah J.; Parson, Matthew A. H.; Jenkins, Meredith L.; Rohilla, Pooja; Alvarez-Prats, Alejandro; Balla, Tamas; Yip, Calvin K.; Burke, John E.
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ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding
errBIOCHEMICAL JOURNAL
IF4.3
err2024-11-28
err1
errOAAI
errGong, Grace Q.; Masson, Glenn R.; Lee, Woo-Jeong; Dickson, James M. J.; Kendall, Jackie D.; Rathinaswamy, Manoj K.; Buchanan, Christina M.; Middleditch, Martin; Owen, Brady M.; Spicer, Julie A.; Rewcastle, Gordon W.; Denny, William A.; Burke, John E.; Shepherd, Peter R.; Williams, Roger L.; Flanagan, Jack U.
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err收藏
Biolayer interferometry for measuring the kinetics of protein-protein interactions and nanobody binding
errNATURE PROTOCOLS
IF16
err2024-11-21
err0
PREAI
errBates, Timothy A.; Gurmessa, Sintayehu K.; Weinstein, Jules B.; Trank-Greene, Mila; Wrynla, Xammy Huu; Anastas, Aidan; Anley, Teketay Wassie; Hinchliff, Audrey; Shinde, Ujwal; Burke, John E.; Tafesse, Fikadu G.
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ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophagesESAT-6在吞噬体pH下发生自我缔合，ESAT-6-specific纳米抗体限制了巨噬细胞中结核分枝杆菌的生长
errELIFE
IF0
err2024-05-28
err3
errOAAI
errBates, Timothy A.; Trank-Greene, Mila; Nguyenla, Xammy; Anastas, Aidan; Gurmessa, Sintayehu K.; Merutka, Ilaria R.; Dixon, Shandee D.; Shumate, Anthony; Groncki, Abigail R.; Parson, Matthew A. H.; Ingram, Jessica R.; Barklis, Eric; Burke, John E.; Shinde, Ujwal; Ploegh, Hidde L.; Tafesse, Fikadu G.
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Novel long-acting covalent PI3Kα inhibitors boost potential action in cancer
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errConstantin, Theodora A.; Bissegger, Lukas; Keles, Erhan; Raguz, Luka; Orbegozo, Clara; Schaefer, Thorsten; Barlow-Busch, Isobel; Burke, John E.; Borsari, Chiara; Wymann, Matthias P.
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研究方向

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