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Machine learning-based in-silico analysis identifies signatures of lysyl oxidases for prognostic and therapeutic response prediction in cancer 基于机器学习的计算机分析可识别赖氨酰氧化酶的特征，以预测癌症的预后和治疗反应 Xu, Qingyu; Ma, Ling; Streuer, Alexander; Altrock, Eva; Schmitt, Nanni; Rapp, Felicitas; Klaer, Alessa; Nowak, Verena; Oblaender, Julia; Weimer, Nadine; Palme, Iris; Goel, Melda; Zhu, Hong-hu; Hofmann, Wolf-Karsten; Nowak, Daniel; Riabov, Vladimir 分享 收藏
Impact of Molecular Aberrations on Discordance Among Modalities of Blast Enumeration for Risk Stratification in Myelodysplastic Neoplasms 分子异常对髓系发育不良性肿瘤风险分层中原始细胞计数不同方法间不一致性的影响 Steiner, Laurenz; Kaur, Navkirandeep; Jann, Johann-Christoph; Fabarius, Alice; Metzgeroth, Georgia; Meggendorfer, Manja; Hofmann, Wolf-Karsten; Jawhar, Mohamad; Nowak, Daniel; Streuer, Alexander 分享 收藏
The Bispecific Innate Cell Engager AFM28 Can Leverage AML Patient's NK Cells in Addition to Allogeneic NK Cells, Enabling Elimination of CDI23+Leukemic Stem and Progenitor Cells in AML and MDS 双特异性先天细胞结合剂AFM28除了可以利用异基因NK细胞外，还能利用AML患者的NK细胞，从而实现对AML和MDS中CDI23+白血病干细胞和祖细胞的清除。 Schmitt, Nanni; Siegler, Jana-Julia; Beck, Alexandra; Hoppe, Lea; Abba, Mohammed; Streuer, Alexander; Klein, Stefan; Hofmann, Wolf-Karsten; Merz, Christian; Pahl, Jens; Nowak, Daniel 分享 收藏
Primary Hematopoietic Cells of Vexas Patients Are Highly Sensitive to Treatment with TAK-243 and Pevonedistat Vexas患者的原发性造血细胞对TAK-243和Pevonedistat治疗高度敏感 Demmerle, Marie; Klaer, Alessa; Streuer, Alexander; Riabov, Vladimir; Altrock, Eva; Rapp, Felicitas; Belzer, Ann-Christin; Klink, Teresa; Hahn, Meret; Hofmann, Franziska; Nowak, Verena; Weimer, Nadine; Oblaender, Julia; Palme, Iris; Goel, Melda; Darwich, Ali; Abba, Mohammed; Metzgeroth, Georgia; Hofmann, Wolf-Karsten; Nowak, Daniel; Schmitt, Nanni 分享 收藏
Cell-type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells 造血干细胞和祖细胞中镶嵌结构变异的细胞类型特异性后果 Grimes, Karen; Jeong, Hyobin; Amoah, Amanda; Xu, Nuo; Niemann, Julian; Raeder, Benjamin; Hasenfeld, Patrick; Stober, Catherine; Rausch, Tobias; Benito, Eva; Jann, Johann-Christoph; Nowak, Daniel; Emini, Ramiz; Hoenicka, Markus; Liebold, Andreas; Ho, Anthony; Shuai, Shimin; Geiger, Hartmut; Sanders, Ashley D.; Korbel, Jan O. 分享 收藏
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Treatment with the apoptosis inhibitor Asunercept reduces clone sizes in patients with lower risk Myelodysplastic Neoplasms Streuer, Alexander; Jann, Johann-Christoph; Boch, Tobias; Mossner, Maximilian; Riabov, Vladimir; Schmitt, Nanni; Altrock, Eva; Xu, Qingyu; Demmerle, Marie; Nowak, Verena; Oblaender, Julia; Palme, Iris; Weimer, Nadine; Rapp, Felicitas; Metzgeroth, Georgia; Hecht, Anna; Hoeger, Thomas; Merz, Christian; Hofmann, Wolf-Karsten; Nolte, Florian; Nowak, Daniel 分享 收藏
ASXL1 mutations are associated with a response to alvocidib and 5-azacytidine combination in myelodysplastic neoplasms Riabov, Vladimir; Xu, Qingyu; Schmitt, Nanni; Streuer, Alexander; Ge, Guo; Bolanos, Lyndsey; Wunderlich, Mark; Jann, Johann-Christoph; Wein, Alina; Altrock, Eva; Demmerle, Marie; Mukherjee, Sanjay; Ali, Abdullah Mahmood; Rapp, Felicitas; Nowak, Verena; Weimer, Nadine; Oblaender, Julia; Palme, Iris; Goel, Melda; Jawhar, Ahmed; Darwich, Ali; Wuchter, Patrick; Weiss, Christel; Raza, Azra; Foulks, Jason M.; Starczynowski, Daniel T.; Yang, Feng-Chun; Metzgeroth, Georgia; Steiner, Laurenz; Jawhar, Mohamad; Hofmann, Wolf-Karsten; Nowak, Daniel 分享 收藏
Distinct and targetable role of calcium-sensing receptor in leukaemia Pereira, Raquel S.; Kumar, Rahul; Cais, Alessia; Paulini, Lara; Kahler, Alisa; Bravo, Jimena; Minciacchi, Valentina R.; Krack, Theresa; Kowarz, Eric; Zanetti, Costanza; Godavarthy, Parimala Sonika; Hoeller, Fabian; Llavona, Pablo; Stark, Tabea; Tascher, Georg; Nowak, Daniel; Meduri, Eshwar; Huntly, Brian J. P.; Muench, Christian; Pampaloni, Francesco; Marschalek, Rolf; Krause, Daniela S. 分享 收藏
Significant improvement of bone marrow-derived MSC expansion from MDS patients by defined xeno-free medium Altrock, Eva; Sens-Albert, Carla; Hofmann, Franziska; Riabov, Vladimir; Schmitt, Nanni; Xu, Qingyu; Jann, Johann-Christoph; Rapp, Felicitas; Steiner, Laurenz; Streuer, Alexander; Nowak, Verena; Oblaender, Julia; Weimer, Nadine; Palme, Iris; Goel, Melda; Darwich, Ali; Wuchter, Patrick; Metzgeroth, Georgia; Jawhar, Mohamad; Hofmann, Wolf-Karsten; Nowak, Daniel 分享 收藏
Inhibition of lysyl oxidases synergizes with 5-azacytidine to restore erythropoiesis in myelodysplastic and myeloid malignancies Xu, Qingyu; Streuer, Alexander; Jann, Johann-Christoph; Altrock, Eva; Schmitt, Nanni; Flach, Johanna; Sens-Albert, Carla; Rapp, Felicitas; Wolf, Julia; Nowak, Verena; Weimer, Nadine; Oblaender, Julia; Palme, Iris; Kuzina, Mariia; Jawhar, Ahmed; Darwich, Ali; Weis, Cleo-Aron; Marx, Alexander; Wuchter, Patrick; Costina, Victor; Jaeger, Evelyn; Sperk, Elena; Neumaier, Michael; Fabarius, Alice; Metzgeroth, Georgia; Nolte, Florian; Steiner, Laurenz; Levkin, Pavel A.; Jawhar, Mohamad; Hofmann, Wolf-Karsten; Riabov, Vladimir; Nowak, Daniel 分享 收藏
Functional analysis of structural variants in single cells using Strand-seq 使用strne-seq对单细胞中的结构变体进行功能分析 Jeong, Hyobin; Grimes, Karen; Rauwolf, Kerstin K.; Bruch, Peter-Martin; Rausch, Tobias; Hasenfeld, Patrick; Benito, Eva; Roider, Tobias; Sabarinathan, Radhakrishnan; Porubsky, David; Herbst, Sophie A.; Erarslan-Uysal, Busra; Jann, Johann-Christoph; Marschall, Tobias; Nowak, Daniel; Bourquin, Jean-Pierre; Kulozik, Andreas E.; Dietrich, Sascha; Bornhauser, Beat; Sanders, Ashley D.; Korbel, Jan O. 分享 收藏
Antigen presentation safeguards the integrity of the hematopoietic stem cell pool 抗原呈递保护造血干细胞池的完整性 Hernandez-Malmierca, Pablo; Vonficht, Dominik; Schnell, Alexandra; Uckelmann, Hannah J.; Bollhagen, Alina; Mahmoud, Mohamed A. A.; Landua, Sophie-Luise; van der Salm, Elise; Trautmann, Christine L.; Raffel, Simon; Gruenschlaeger, Florian; Lutz, Raphael; Ghosh, Michael; Renders, Simon; Correia, Nadia; Donato, Elisa; Dixon, Karin O.; Hirche, Christoph; Andresen, Carolin; Robens, Claudia; Werner, Paula S.; Boch, Tobias; Eisel, David; Osen, Wolfram; Pilz, Franziska; Przybylla, Adriana; Klein, Corinna; Buchholz, Frank; Milsom, Michael D.; Essers, Marieke A. G.; Eichmueller, Stefan B.; Hofmann, Wolf-Karsten; Nowak, Daniel; Huebschmann, Daniel; Hundemer, Michael; Thiede, Christian; Bullinger, Lars; Mueller-Tidow, Carsten; Armstrong, Scott A.; Trumpp, Andreas; Kuchroo, Vijay K.; Haas, Simon 分享 收藏
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia (vol 13, 2, 2022) Lin, Wei-Yu; Fordham, Sarah E.; Hungate, Eric; Sunter, Nicola J.; Elstob, Claire; Xu, Yaobo; Park, Catherine; Quante, Anne; Strauch, Konstantin; Gieger, Christian; Skol, Andrew; Rahman, Thahira; Sucheston-Campbell, Lara; Wang, Junke; Hahn, Theresa; Clay-Gilmour, Alyssa I.; Jones, Gail L.; Marr, Helen J.; Jackson, Graham H.; Menne, Tobias; Collin, Mathew; Ivey, Adam; Hills, Robert K.; Burnett, Alan K.; Russell, Nigel H.; Fitzgibbon, Jude; Larson, Richard A.; Le Beau, Michelle M.; Stock, Wendy; Heidenreich, Olaf; Alharbi, Abrar; Allsup, David J.; Houlston, Richard S.; Norden, Jean; Dickinson, Anne M.; Douglas, Elisabeth; Lendrem, Clare; Daly, Ann K.; Palm, Louise; Piechocki, Kim; Jeffries, Sally; Bornhauser, Martin; Rollig, Christoph; Altmann, Heidi; Ruhnke, Leo; Kunadt, Desiree; Wagenfuhr, Lisa; Cordell, Heather J.; Darlay, Rebecca; Andersen, Mette K.; Fontana, Maria C.; Martinelli, Giovanni; Marconi, Giovanni; Sanz, Miguel A.; Cervera, Jose; Gomez-Segui, Ines; Cluzeau, Thomas; Moreilhon, Chimene; Raynaud, Sophie; Sill, Heinz; Voso, Maria Teresa; Lo-Coco, Francesco; Dombret, Herve; Cheok, Meyling; Preudhomme, Claude; Gale, Rosemary E.; Linch, David; Gaal-Wesinger, Julia; Masszi, Andras; Nowak, Daniel; Hofmann, Wolf-Karsten; Gilkes, Amanda; Porkka, Kimmo; Milosevic Feenstra, Jelena D.; Kralovics, Robert; Grimwade, David; Meggendorfer, Manja; Haferlach, Torsten; Krizsan, Szilvia; Bodor, Csaba; Stolzel, Friedrich; Onel, Kenan; Allan, James M. 分享 收藏
Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation Heil, Joschka; Olsavszky, Victor; Busch, Katrin; Klapproth, Kay; de la Torre, Carolina; Sticht, Carsten; Sandorski, Kajetan; Hoffmann, Johannes; Schoenhaber, Hiltrud; Zierow, Johanna; Winkler, Manuel; Schmid, Christian David; Staniczek, Theresa; Daniels, Deborah E.; Frayne, Jan; Metzgeroth, Georgia; Nowak, Daniel; Schneider, Sven; Neumaier, Michael; Weyer, Vanessa; Groden, Christoph; Groene, Hermann-Josef; Richter, Karsten; Mogler, Carolin; Taketo, Makoto Mark; Schledzewski, Kai; Geraud, Cyrill; Goerdt, Sergij; Koch, Philipp-Sebastian 分享 收藏
Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states 造血系统的单细胞蛋白质基因组参考图可以纯化和大量分析精确定义的细胞状态 Triana, Sergio; Vonficht, Dominik; Jopp-Saile, Lea; Raffel, Simon; Lutz, Raphael; Leonce, Daniel; Antes, Magdalena; Hernandez-Malmierca, Pablo; Ordonez-Rueda, Diana; Ramasz, Beata; Boch, Tobias; Jann, Johann-Christoph; Nowak, Daniel; Hofmann, Wolf-Karsten; Mueller-Tidow, Carsten; Huebschmann, Daniel; Alexandrov, Theodore; Benes, Vladimir; Trumpp, Andreas; Paulsen, Malte; Velten, Lars; Haas, Simon 分享 收藏
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