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Alan V. Smrcka

department of pharmacology

57H指数
244论文数
1.2W被引数
收录论文 108
发表时间
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Mechanisms for Enhancement of μ-Opioid Receptor-Mediated Antinociception in the Central Nervous System Through Gallein-Dependent Modulation of Downstream G Protein βγ Subunit Signaling通过加林因依赖的下游G蛋白βγ亚单位信号调控增强中枢神经系统μ-阿片受体介导的镇痛作用的机制
errMolecular Pharmacology
IF3
err2026-04-20
err0
errOAAI
errJacob A. Ormes; Alan V. Smrcka; Emily M. Jutkiewicz
err分享
err收藏
G Protein Gαq Subunits Engage Targets in the Nucleus Involved in Chromatin Remodeling and Gene ExpressionG蛋白Gαq亚基与涉及染色质重塑和基因表达的细胞核靶点相互作用
errJournal of Biological Chemistry
IF3.9
err2026-02-25
err0
errOAAI
errJoseph Loomis; Naincy Chandan; Michael Burroughs; Saji Abraham; Rongxi Zhang; Yiyi Cao; Matthew J. Brody; Gregory G. Tall; Alan V. Smrcka
err分享
err收藏
Activation of GPR97/ADGRG3 by its tethered agonist; but not by beclomethasone; induces neutrophil polarization and migrationGPR97/ADGRG3被其内源性配体激活；但倍氯米松不能激活；可诱导中性粒细胞的极化和迁移
errScience Signaling
IF6.6
err2026-02-17
err0
PREAI
errTyler Bernadyn; Frank Kwarcinski; Naincy Chandan; Riya Gandhi; Yuling Feng; Michael Holinstat; Carole A. Parent; Alan V. Smrcka; Gregory G. Tall
err分享
err收藏
Biasing G-protein βγ Subunit Downstream Signaling Enhances the Analgesic Effects of Endogenous Opioid Receptor Agonists during Nitroglycerin-Induced Thermal Hypersensitivity通过调控G蛋白βγ亚基下游信号传导增强内源性阿片受体激动剂在硝酸甘油诱导的热超敏反应中的镇痛效果
errMolecular Pharmacology
IF3
err2025-08-06
err0
errOAAI
errFarzanna A. Mohamed; Alan V. Smrcka; Emily M. Jutkiewicz
err分享
err收藏
GoLoco/GPR Motif-Dependent Regulation of Rap1GAP1 by Gαo is Disrupted by Gαo Encephalopathy VariantsGoLoco/GPR基序依赖的Rap1GAP1的Gαo调节被Gαo脑病变异体破坏
errJournal of Biological Chemistry
IF3.9
err2025-07-01
err0
errOAAI
errNathalie L. Momplaisir; Naincy R. Chandan; Beiyun Wang; Elaine Qu; Alan V. Smrcka
err分享
err收藏
Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathyGβ1γ2亚基对电压门控钠离子通道的神经调制：对GNB1相关脑病的意义
errNeurobiology of Disease
IF5.6
err2025-06-05
err0
errOAAI
errNicholas Denomme; Samantha L. Hodges; Luis Lopez-Santiago; Yukun Yuan; Julie M. Ziobro; Joe Minton; Chunling Chen; Yan Chen; Jacob M. Hull; James Offord; Alan V. Smrcka; Lori L. Isom
err分享
err收藏
Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening通过全基因组CRISPR筛选对细胞Lp(a)摄取的功能性探究
errATHEROSCLEROSIS
IF5.7
err2025-04-01
err1
errOAAI
errKhan, Taslima G.; Cunha, Juliana Bragazzi; Raut, Chinmay; Burroughs, Michael; Vyas, Hitarthi S.; Leix, Kyle; Goonewardena, Sascha N.; Smrcka, Alan V.; Speliotes, Elizabeth K.; Emmer, Brian T.
err分享
err收藏
Examining Promiscuity of a G(3y Inhibitor, Gallein, for Enhancement of Antinociceptive Effects研究G(3y抑制剂的交联性，Gallein，以提高镇痛效果
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2025-03-01
err0
PREAI
errOrmes, Jacob A.; Mueller, Matthew R.; Smrcka, Alan; Jutkiewicz, Emily M.
err分享
err收藏
Gaq-SPRED1 Interaction: Unraveling a Novel Mechanism in GPCR Regulation of Ras SignalingGaq-SPRED1相互作用：揭示GPCR调控Ras信号通路的全新机制
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2025-03-01
err0
PREAI
errZhang, Rongxi; Chandan, Naincy R.; Loomis, Joseph F.; Smrcka, Alan, V
err分享
err收藏
Encephalopathy-Associated GNAO1 Mutant Effects on Rap1GAP1 Localization脑病相关GNAO1突变对Rap1GAP1定位的影响
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2025-03-01
err0
PREAI
errQu, Elaine; Momplaisir, Nathalie; Smrcka, Alan; Chandan, Nancy
err分享
err收藏
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state神经发育障碍突变将g蛋白锁定在短暂的预激活状态
errNATURE COMMUNICATIONS
IF15.7
err2024-08-05
err0
errOAAI
errKnight, Kevin M.; Krumm, Brian E.; Kapolka, Nicholas J.; Ludlam, W. Grant; Cui, Meng; Mani, Sepehr; Prytkova, Iya; Obarow, Elizabeth G.; Lefevre, Tyler J.; Wei, Wenyuan; Ma, Ning; Huang, Xi-Ping; Fay, Jonathan F.; Vaidehi, Nagarajan; Smrcka, Alan V.; Slesinger, Paul A.; Logothetis, Diomedes E.; Martemyanov, Kirill A.; Roth, Bryan L.; Dohlman, Henrik G.
err分享
err收藏
Internalized β2-Adrenergic Receptors Oppose PLC-Dependent Hypertrophic Signaling
errCIRCULATION RESEARCH
IF16.2
err2024-07-05
err1
PREAI
errWei, Wenhui; Smrcka, Alan V.
err分享
err收藏
A PACAP-activated network for secretion requires coordination of Ca2+influx and Ca2+mobilization
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2024-07-01
err2
errOAAI
errChen, Xiaohuan; Bell, Nicole A.; Coffman, Breanna L.; Rabino, Agustin A.; Garcia-Mata, Rafael; Kammermeier, Paul J.; Yule, David, I; Axelrod, Daniel; V. Smrcka, Alan; Giovannucci, David R.; Anantharam, Arun
err分享
err收藏
Biasing G bc Downstream Signaling with Gallein Inhibits Development of Morphine Tolerance and Potentiates Morphine-Induced Nociception in a Tolerant State
errMOLECULAR PHARMACOLOGY
IF3
err2024-07-01
err0
errOAAI
errSanchez, Gissell A.; Smrcka, Alan, V; Jutkiewicz, Emily M.
err分享
err收藏
A Genome-wide CRISPR Screen Identifies The LDL Receptor As The Primary Mediator Of Lp(a) Uptake By HuH7 Cells
errARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
IF7.4
err2024-05-01
err0
PREAI
errCunha, Juliana Bragazzi; Khan, Taslima Gani; Leix, Kyle; Burroughs, Michael; Smrcka, Alan; Emmer, Brian T.
err分享
err收藏
Stabilization of interdomain interactions in G protein α subunits as a determinant of Gαi subtype signaling specificity
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-05-01
err1
errOAAI
errLefevre, Tyler J.; Wei, Wenyuan; Mukhaleva, Elizaveta; Venkata, Sai Pranathi Meda; Chandan, Naincy R.; Abraham, Saji; Li, Yong; Dessauer, Carmen W.; Vaidehi, Nagarajan; V. Smrcka, Alan
err分享
err收藏
Identification of a sequence of the activity-dependent neuroprotective protein (ADNP) that is necessary for its interaction with G??i1
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2023-06-01
err0
errOAAI
errMomplaisir, Nathalie; Chandan, Naincy R.; Smrcka, Alan V.
err分享
err收藏
Blockade of selective Gbγ signaling pathway by gallein decreases development of opioid tolerance
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2023-06-01
err0
errOAAI
errSmrcka, Alan V.; Sanchez, Gissell; Jutkiewicz, Emily M. M.
err分享
err收藏
Opposing effects of β2-ARs on β1-ARs on phospholipase C-mediated cardiac hypertrophic signaling
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2023-06-01
err0
errOAAI
errWei, Wenhui; Smrcka, Alan V.
err分享
err收藏
SMARCD3: A Link Between G??q and Chromatin Remodeling?
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2023-06-01
err0
errOAAI
errLoomis, Joseph; Chandan, Naincy R.; Smrcka, Alan V.
err分享
err收藏

研究方向

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