Klaus Okkenhaug - Publications, H-index & Citations

Klaus Okkenhaug

university of cambridge

66H指数

186论文数

2.1W被引数

收录论文 99

发表时间

Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species 肿瘤源性抗氧化剂通过剥夺T细胞的活性氧来抑制免疫

Science

IF45.8

2026-09-03

PREAI

Alexander J. Wesolowski; Ardon M. Pillay; Panagiota Vardaka; Rabab Nasrallah; Randy Greaves; Housaiyin Li; Iliana Loffreda; Chelsea Jenkin; Andrew M. James; Alica Nübling; Christopher J. Ward; Teresa von Linde; Alberto G. Conti; Sheue-Fen Tzeng; Layla Dahmani; Alexander C. Evans; Sarah K. Whiteside; Yumi Yamashita-Kanemaru; Charlotte J. Imianowski; Jie Yang; Ignacio Moraga Gonzalez; Jack Chapman; Aws Al-Deka; Klaus Okkenhaug; Michael P. Murphy; Bartlomiej Swiatczak; Geoffrey Guittard; Enrico Lugli; Lukas Flatz; Ping-Chih Ho; Robert L. Eil; Rahul Roychoudhuri

Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy 微调BACH2剂量平衡了stemness和效应子功能，以增强抗肿瘤T细胞治疗

Nature Immunology

IF27.6

2026-01-16

OAAI

Alberto G. Conti; Alexander C. Evans; Teresa von Linde; Christian Deo T. Deguit; Sarah K. Whiteside; Alexander J. Wesolowski; Charlotte J. Imianowski; Yumi Yamashita-Kanemaru; Layla Dahmani; Jack Chapman; Ardon M. Pillay; Aws Al-Deka; Randy Greaves; Oliver Burton; Panagiota Vardaka; Shienny Sampurno; Iván Pérez-Núñez; Nicole Y. L. Saw; Jie Yang; Andrew J. M. Howden; Klaus Okkenhaug; Suman Mitra; Bartlomiej Swiatczak; Ian A. Parish; Rahul Roychoudhuri

Perturbing local steroidogenesis to improve breast cancer immunity 扰动局部类固醇生成以改善乳腺癌免疫

NATURE COMMUNICATIONS

IF15.7

2025-04-26

OAAI

Zhao, Qiuchen; Pramanik, Jhuma; Lu, Yongjin; Homer, Natalie Z. M.; Imianowski, Charlotte J.; Zhang, Baojie; Iqbal, Muhammad; Shaji, Sanu Korumadathil; Morris, Andrew Conway; Roychoudhuri, Rahul; Okkenhaug, Klaus; Qiu, Pengfei; Mahata, Bidesh

Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses 肠道菌群衍生的六酰化脂多糖增强癌症免疫治疗反应

NATURE MICROBIOLOGY

IF19.4

2025-02-10

OAAI

Sardar, Puspendu; Beresford-Jones, Benjamin S.; Xia, Wangmingyu; Shabana, Omar; Suyama, Satoshi; Ramos, Ruben J. F.; Soderholm, Amelia T.; Tourlomousis, Panagiotis; Kuo, Paula; Evans, Alexander C.; Imianowski, Charlotte J.; Conti, Alberto G.; Wesolowski, Alexander J.; Baker, Natalie M.; Mccord, Emily A. L.; Okkenhaug, Klaus; Whiteside, Sarah K.; Bryant, Clare E.; Cross, Justin R.

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development

FRONTIERS IN IMMUNOLOGY

IF5.9

2024-11-27

OAAI

Courreges, Christina J. F.; Davenport, Elizabeth C. M.; Bilanges, Benoit; Rebollo-Gomez, Elena; Hukelmann, Jens; Schoenfelder, Priya; Edgar, James R.; Sansom, David; Scudamore, Cheryl L.; Roychoudhuri, Rahul; Garden, Oliver A.; Vanhaesebroeck, Bart; Okkenhaug, Klaus

PI3K Inhibitors in Hematology: When One Door Closes…血液学中的PI3K抑制剂: 当一扇门关闭时…

CLINICAL CANCER RESEARCH

IF10.2

2024-07-05

PREAI

Skanland, Sigrid S.; Okkenhaug, Klaus; Davids, Matthew S.

Intratumoral antigen signaling traps CD8+ T cells to confine exhaustion to the tumor site

SCIENCE IMMUNOLOGY

IF16.3

2024-05-24

OAAI

Takahashi, Munetomo; So, Tsz Y.; Chamberlain-Evans, Vitalina; Hughes, Robert; Yam-Puc, Juan Carlos; Kania, Katarzyna; Ruhle, Michelle; Mann, Tiffeney; Schuijs, Martijn J.; Coupland, Paul; Naisbitt, Dean; Halim, Timotheus Y. F.; Lyons, Paul A.; Lio, Pietro; Roychoudhuri, Rahul; Okkenhaug, Klaus; Adams, David J.; Smith, Ken G. C.; Jodrell, Duncan I.; Chapman, Michael A.; Thaventhiran, James E. D.

Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion

SCIENCE IMMUNOLOGY

IF16.3

2023-12-15

OAAI

Whiteside, Sarah K.; Grant, Francis M.; Alvisi, Giorgia; Clarke, James; Tang, Leqi; Imianowski, Charlotte J.; Zhang, Baojie; Evans, Alexander C.; Wesolowski, Alexander J.; Conti, Alberto G.; Yang, Jie; Lauder, Sarah N.; Clement, Mathew; Humphreys, Ian R.; Dooley, James; Burton, Oliver; Liston, Adrian; Alloisio, Marco; Voulaz, Emanuele; Langhorne, Jean; Okkenhaug, Klaus; Lugli, Enrico; Roychoudhuri, Rahul

Tissue-resident B cells orchestrate macrophage polarisation and function 组织驻留b细胞协调巨噬细胞极化和功能

NATURE COMMUNICATIONS

IF15.7

2023-11-04

OAAI

Suchanek, Ondrej; Ferdinand, John R.; Tuong, Zewen K.; Wijeyesinghe, Sathi; Chandra, Anita; Clauder, Ann-Katrin; Almeida, Larissa N.; Clare, Simon; Harcourt, Katherine; Ward, Christopher J.; Bashford-Rogers, Rachael; Lawley, Trevor; Manz, Rudolf A.; Okkenhaug, Klaus; Masopust, David; Clatworthy, Menna R.

Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion 注意差距: RASA2和RASA3 GTPase激活蛋白作为T细胞活化和粘附的守门人

TRENDS IN IMMUNOLOGY

IF13.9

2023-11-01

OAAI

Johansen, Kristoffer H.; Golec, Dominic P.; Okkenhaug, Klaus; Schwartzberg, Pamela L.

Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release SARS-CoV-2 ORF3a和刺突蛋白的Tetherin拮抗作用增强了病毒释放

EMBO REPORTS

IF6.2

2023-10-11

OAAI

Stewart, Hazel; Palmulli, Roberta; Johansen, Kristoffer H.; Mcgovern, Naomi; Shehata, Ola M.; Carnell, George W.; Jackson, Hannah K.; Lee, Jin S.; Brown, Jonathan C.; Burgoyne, Thomas; Heeney, Jonathan L.; Okkenhaug, Klaus; Firth, Andrew E.; Peden, Andrew A.; Edgar, James R.

An open label trial of nemiralisib, an inhaled PI3 kinase delta inhibitor for the treatment of Activated PI3 kinase Delta Syndrome

PULMONARY PHARMACOLOGY & THERAPEUTICS

IF2.8

2023-04-01

OAAI

Begg, Malcolm; Amour, Augustin; Jarvis, Emily; Tang, Teresa; Franco, Sara Santos; Want, Andrew; Beerahee, Misba; Fernando, Disala; Karkera, Yakshitha; Sander, Clare; Southworth, Thomas; Singh, Dave; Clark, Jonathan; Nejentsev, Sergey; Okkenhaug, Klaus; Condliffe, Alison; Chandra, Anita; Cahn, Anthony; Hall, Edward Banham

Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/β-Arrestin/cAMP Phosphodiesterase 4 Complex

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

OAAI

Bjorgo, Elisa; Solheim, Silje A.; Abrahamsen, Hilde; Baillie, George S.; Brown, Kim M.; Berge, Torunn; Okkenhaug, Klaus; Houslay, Miles D.; Tasken, Kjetil

Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/b-Arrestin/cAMP Phosphodiesterase 4 Complex (vol 30, pg 1660, 2010)

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-02-27

OAAI

Bjorgo, Elisa; Solheim, Silje A.; Abrahamsen, Hilde; Baillie, George S.; Brown, Kim M.; Berge, Torunn; Okkenhaug, Klaus; Houslay, Miles D.; Tasken, Kjetil

BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2022-09-30

OAAI

Imianowski, Charlotte J.; Whiteside, Sarah K.; Lozano, Teresa; Evans, Alexander C.; Benson, Jayme D.; Courreges, Christina J. F.; Sadiyah, Firas; Lau, Colleen M.; Zandhuis, Nordin D.; Grant, Francis M.; Schuijs, Martijn J.; Vardaka, Panagiota; Kuo, Paula; Soilleux, Elizabeth J.; Yang, Jie; Sun, Joseph C.; Kurosaki, Tomohiro; Okkenhaug, Klaus; Halim, Timotheus Y. F.; Roychoudhuri, Rahul

A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells 靶向PI3K效应物的CRISPR筛选将RASA3鉴定为T细胞中LFA-1-mediated粘附的负调节因子

SCIENCE SIGNALING

IF6.6

2022-07-19

OAAI

Johansen, Kristoffer H.; Golec, Dominic P.; Huang, Bonnie; Park, Chung; Thomsen, Julie H.; Preite, Silvia; Cannons, Jennifer L.; Garcon, Fabien; Schrom, Edward C.; Courreges, Christina J. F.; Veres, Tibor Z.; Harrison, James; Nus, Meritxell; Phelan, James D.; Bergmeier, Wolfgang; Kehrl, John H.; Okkenhaug, Klaus; Schwartzberg, Pamela L.

Activated PI3K6 syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model

brain behavior and immunity

IF3.5

2021-12-01

OAAI

Serra, Ines; Manusama, Olivia R.; Kaiser, Fabian M. P.; Floriano, Izi Izumi; Wahl, Lucas; van der Zalm, Christian; IJspeert, Hanna; van Hagen, P. Martin; van Beveren, Nico J. M.; Arend, Sandra M.; Okkenhaug, Klaus; Pel, Johan J. M.; Dalm, Virgil A. S. H.; Badura, Aleksandra

PI3K inhibitors are finally coming of age (Jun, 10.1038/s41573-021-00209-1, 2021)

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2021-09-01

OAAI

Vanhaesebroeck, Bart; Perry, Matthew W. D.; Brown, Jennifer R.; Andre, Fabrice; Okkenhaug, Klaus

The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection

BLOOD ADVANCES

IF7.1

2021-08-17

OAAI

Pantarelli, Chiara; Pan, Dingxin; Chetwynd, Stephen; Stark, Anne-Katrien; Hornigold, Kirsti; Machin, Polly; Crossland, Laraine; Cleary, Simon J.; Baker, Martin J.; Hampson, Elizabeth; Mandel, Anna; Segonds-Pichon, Anne; Walker, Rachael; Veer, Cornelis van 't; Riffo-Vasquez, Yanira; Okkenhaug, Klaus; Pitchford, Simon; Welch, Heidi C. E.

PI3K in T Cell Adhesion and Trafficking PI3K在T细胞粘附和运输中的作用

FRONTIERS IN IMMUNOLOGY

IF5.9

2021-08-06

OAAI

Johansen, Kristoffer H.; Golec, Dominic P.; Thomsen, Julie H.; Schwartzberg, Pamela L.; Okkenhaug, Klaus

研究方向