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J

John A. Tallarico

novartis

49H指数
126论文数
1.1W被引数
收录论文 69
发表时间
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Discovery of EGT710; an Oral Nonpeptidomimetic Reversible Covalent SARS-CoV-2 Main Protease InhibitorEGT710的发现：一种口服非肽类拟似可逆共价SARS-CoV-2主蛋白酶抑制剂
errJournal of Medicinal Chemistry
IF6.8
err2026-02-09
err0
PREAI
errJulien P. N. Papillon; Jun Yuan; Matthew J. Hesse; Lei Zhang; Richard I. Robinson; Nathaniel F. Ware; Viktor Hornak; Rajeshri G. Karki; Tom Kirrane; Keira Garland; Sajan Joseph; Stephanie A. Moquin; Suresh B. Lakshminarayana; Laura Tandeske; Dustin Dovala; Mark Knapp; Elizabeth Ornelas; Daniel Fuller; Pei-i Ho; Xuping Xie; Katarina Vulic; Suzanne M. Skolnik; Jinhai Gao; Mark Zambrowski; Meike Spiess; José S. Duca; Scott A. Busby; Markus Schirle; Michael Robinson; Pei-Yong Shi; Heinz E. Moser; Christopher Sarko; James E. Bradner; Thierry T. Diagana; John A. Tallarico
err分享
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The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice组蛋白H3赖氨酸36去甲基化酶KDM2A/FBXL11调控聚comb介导的基因沉默和雄性小鼠的生殖细胞发育
errNature Communications
IF15.7
err2025-07-23
err0
errOAAI
errMichael T. Bocker; Grigorios Fanourgakis; Kristie Wetzel; Pavel A. Komarov; Hélène Royo; Alexia Rohmer; Sunwoo Chun; Ching-Yeu Liang; Hubertus Kohler; Taiping Chen; Xiaohong Mao; Mark A. Labow; Reginald A. Valdez; Michael B. Stadler; Dirk G. de Rooij; Paola Capodieci; John Tallarico; Antoine H. F. M. Peters; Thomas B. Nicholson
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Ophiobolin A Covalently Targets Mitochondrial Complex IV Leading to Metabolic Collapse in Cancer Cells
errACS CHEMICAL BIOLOGY
IF3.8
err2024-05-13
err1
PREAI
errGowans, Flor A.; Thach, Danny Q.; Zhu, Zhouyang; Wang, Yangzhi; Poblano, Belen E. Altamirano; Dovala, Dustin; Tallarico, John A.; Mckenna, Jeffrey M.; Schirle, Markus; Maimone, Thomas J.; Nomura, Daniel K.
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Activation of human STING by a molecular glue-like compound通过分子胶样化合物激活人类STING
errNATURE CHEMICAL BIOLOGY
IF13.7
err2023-10-12
err11
errOAAI
errLi, Jie; Canham, Stephen M.; Wu, Hua; Henault, Martin; Chen, Lihao; Liu, Guoxun; Chen, Yu; Yu, Gary; Miller, Howard R.; Hornak, Viktor; Brittain, Scott M.; Michaud, Gregory A.; Tutter, Antonin; Broom, Wendy; Digan, Mary Ellen; Mcwhirter, Sarah M.; Sivick, Kelsey E.; Pham, Helen T.; Chen, Christine H.; Tria, George S.; Mckenna, Jeffery M.; Schirle, Markus; Mao, Xiaohong; Nicholson, Thomas B.; Wang, Yuan; Jenkins, Jeremy L.; Jain, Rishi K.; Tallarico, John A.; Patel, Sejal J.; Zheng, Lianxing; Ross, Nathan T.; Cho, Charles Y.; Zhang, Xuewu; Bai, Xiao-Chen; Feng, Yan
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Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications (vol 144, pg 701, 2022)
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-09-14
err0
PREAI
errHenning, Nathaniel J.; Manford, Andrew G.; Spradlin, Jessica N.; Brittain, Scott M.; Zhang, Erika; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Rape, Michael; Nomura, Daniel K.
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Rational Chemical Design of Molecular Glue Degraders (vol 9, pg 915, 2023)
errACS CENTRAL SCIENCE
IF10.4
err2023-07-21
err0
errOAAI
errToriki, Ethan S.; Papatzimas, James W.; Nishikawa, Kaila; Dovala, Dustin; Frank, Andreas O.; Hesse, Matthew J.; Dankova, Daniela; Song, Jae-Geun; Bruce-Smythe, Megan; Struble, Heidi; Garcia, Francisco J.; Brittain, Scott M.; Kile, Andrew C.; McGregor, Lynn M.; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Nomura, Daniel K.
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err收藏
Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-06-12
err8
PREAI
errDing, Jian; Liu, Lulu; Chiang, Ying-Ling; Zhao, Mengxi; Liu, Hejun; Yang, Fei; Shen, Lingling; Lin, Ying; Deng, Huiwen; Gao, Jingyan; Sage, David R.; West, Laura; Llamas, Luis A.; Hao, Xin; Kawatkar, Sameer; Li, En; Jain, Rishi K.; Tallarico, John A.; Canham, Stephen M.; Wang, He
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Accelerating antiviral drug discovery: lessons from COVID-19加速抗病毒药物的发现: 新型冠状病毒肺炎的教训
errNATURE REVIEWS DRUG DISCOVERY
IF101.8
err2023-05-12
err64
errOAAI
errvon Delft, Annette; Hall, Matthew D.; Kwong, Ann D.; Purcell, Lisa A.; Saikatendu, Kumar Singh; Schmitz, Uli; Tallarico, John A.; Lee, Alpha A. A.
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err收藏
Rational Chemical Design of Molecular Glue Degraders分子胶降解剂的合理化学设计
errACS CENTRAL SCIENCE
IF10.4
err2023-04-11
err58
errOAAI
errToriki, Ethan S.; Papatzimas, James W.; Nishikawa, Kaila; Dovala, Dustin; Frank, Andreas O.; Hesse, Matthew J.; Dankova, Daniela; Song, Jae-Geun; Bruce-Smythe, Megan; Struble, Heidi; Garcia, Francisco J.; Brittain, Scott M.; Kile, Andrew C.; McGregor, Lynn M.; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Nomura, Daniel K.
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err收藏
Mechanism of Resistance to the WDR5 Inhibitor in MLL-Rearranged Leukemia
errACS CHEMICAL BIOLOGY
IF3.8
err2023-04-07
err3
PREAI
errLiu, Lulu; Shen, Lingling; Ding, Zhilou; He, Miao; Li, En; Tallarico, John A.; Jain, Rishi K.; Wang, He
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err收藏
Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-KB化学蛋白质组学-启用了针对nf-kb的共价分子胶降解剂的发现
errCELL CHEMICAL BIOLOGY
IF7.2
err2023-04-01
err48
errOAAI
errKing, Elizabeth A.; Cho, Yoojin; Hsu, Nathan S.; Dovala, Dustin; Mckenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Nomura, Daniel K.
err分享
err收藏
Targeted Protein Degradation through E2 Recruitment通过E2募集靶向蛋白质降解
errACS CHEMICAL BIOLOGY
IF3.8
err2023-03-20
err27
errOAAI
errForte, Nafsika; Dovala, Dustin; Hesse, Matthew J.; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Nomura, Daniel K.
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Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy用于癌症免疫治疗的选择性IKZF2胶降解剂的发现和表征
errCELL CHEMICAL BIOLOGY
IF7.2
err2023-03-01
err59
errOAAI
errBonazzi, Simone; d'Hennezel, Eva; Beckwith, Rohan E. J.; Xu, Lei; Fazal, Aleem; Magracheva, Anna; Ramesh, Radha; Cernijenko, Artiom; Antonakos, Brandon; Bhang, Hyo-eun C.; Caro, Roxana Garcia; Cobb, Jennifer S.; Ornelas, Elizabeth; Ma, Xiaolei; Wartchow, Charles A.; Clifton, Matthew C.; Forseth, Ry R.; Fortnam, Bethany Hughes; Lu, Hongbo; Csibi, Alfredo; Tullai, Jennifer; Carbonneau, Seth; Thomsen, Noel M.; Larrow, Jay; Chie-Leon, Barbara; Hainzl, Dominik; Gu, Yi; Lu, Darlene; Meyer, Matthew J.; Alexander, Dylan; Kinyamu-Akunda, Jacqueline; Sabatos-Peyton, Catherine A.; Dales, Natalie A.; Zecri, Frederic J.; Jain, Rishi K.; Shulok, Janine; Wang, Y. Karen; Briner, Karin; Porter, Jeffery A.; Tallarico, John A.; Engelman, Jeffrey A.; Dranoff, Glenn; Bradner, James E.; Visser, Michael; Solomon, Jonathan M.
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Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction
errACS CHEMICAL BIOLOGY
IF3.8
err2023-01-03
err20
PREAI
errDing, Jian; Li, Guo; Liu, Hejun; Liu, Lulu; Lin, Ying; Gao, Jingyan; Zhou, Guoqiang; Shen, Lingling; Zhao, Mengxi; Yu, Yanyan; Guo, Weihui; Hommel, Ulrich; Ottl, Johannes; Blank, Jutta; Aubin, Nicola; Wei, Yi; He, Hu; Sage, David R.; Atadja, Peter W.; Li, En; Jain, Rishi K.; Tallarico, John A.; Canham, Stephen M.; Chiang, Ying-Ling; Wang, He
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An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2022-12-09
err19
errOAAI
errGonzalez-Valero, Angel; Reeves, Audrey G.; Page, Annika C. S.; Moon, Patrick J.; Miller, Edward; Coulonval, Katia; Crossley, Steven W. M.; Xie, Xiao; He, Dan; Musacchio, Patricia Z.; Christian, Alec H.; McKenna, Jeffrey M.; Lewis, Richard A.; Fang, Eric; Dovala, Dustin; Lu, Yipin; McGregor, Lynn M.; Schirle, Markus; Tallarico, John A.; Roger, Pierre P.; Toste, F. Dean; Chang, Christopher J.
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Deubiquitinase-targeting chimeras for targeted protein stabilization用于靶向蛋白质稳定的去泛素酶靶向嵌合体
errNATURE CHEMICAL BIOLOGY
IF13.7
err2022-02-24
err160
errOAAI
errHenning, Nathaniel J.; Boike, Lydia; Spradlin, Jessica N.; Ward, Carl C.; Liu, Gang; Zhang, Erika; Belcher, Bridget P.; Brittain, Scott M.; Hesse, Matthew J.; Dovala, Dustin; McGregor, Lynn M.; Misiolek, Rachel Valdez; Plasschaert, Lindsey W.; Rowlands, David J.; Wang, Feng; Frank, Andreas O.; Fuller, Daniel; Estes, Abigail R.; Randal, Katelyn L.; Panidapu, Anoohya; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Nomura, Daniel K.
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Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications发现用于靶向蛋白质降解应用的共价FEM1B招募者
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2022-01-07
err110
errOAAI
errHenning, Nathaniel J.; Manford, Andrew G.; Spradlin, Jessica N.; Brittain, Scott M.; Zhang, Erika; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Rape, Michael; Nomura, Daniel K.
err分享
err收藏
Photo-Brook rearrangement of acyl silanes as a strategy for photoaffinity probe design
errChemical Science
IF7.4
err2022-01-01
err17
errOAAI
errPage, Annika C. S.; Scholz, Spencer O.; Keenan, Katherine N.; Spradlin, Jessica N.; Belcher, Bridget P.; Brittain, Scott M.; Tallarico, John A.; McKenna, Jeffrey M.; Schirle, Markus; Nomura, Daniel K.; Toste, F. Dean
err分享
err收藏
CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism
errCELL CHEMICAL BIOLOGY
IF7.2
err2021-10-01
err18
errOAAI
errCho, Hyelim; Shen, Qiong; Zhang, Lydia H.; Okumura, Mikiko; Kawakami, Akinori; Ambrose, Jessi; Sigoillot, Frederic; Miller, Howard R.; Gleim, Scott; Cobos-Correa, Amanda; Wang, Ying; Piechon, Philippe; Roma, Guglielmo; Eggimann, Fabian; Moore, Charles; Aspesi, Peter, Jr.; Mapa, Felipa A.; Burks, Heather; Ross, Nathan T.; Krastel, Philipp; Hild, Marc; Maimone, Thomas J.; Fisher, David E.; Nomura, Daniel K.; Tallarico, John A.; Canham, Stephen M.; Jenkins, Jeremy L.; Forrester, William C.
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Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury
errCELL CHEMICAL BIOLOGY
IF7.2
err2021-09-01
err16
errOAAI
errLarraufie, Marie-Helene; Gao, Xiaolin; Xia, Xiaobo; Devine, Patrick J.; Kallen, Joerg; Liu, Dong; Michaud, Gregory; Harsch, Andreas; Savage, Nik; Ding, Jian; Tan, Kian; Mihalic, Manuel; Roggo, Silvio; Canham, Stephen M.; Bushell, Simon M.; Krastel, Philipp; Gao, Jinhai; Izaac, Aude; Altinoglu, Erhan; Lustenberger, Philipp; Salcius, Michael; Harbinski, Fred; Williams, Eric T.; Zeng, Liling; Loureiro, Joseph; Cong, Feng; Fryer, Christy J.; Klickstein, Lloyd; Tallarico, John A.; Jain, Rishi K.; Rothman, Deborah M.; Wang, Shaowen
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研究方向

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合作学者
合作期刊
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Ramnik J. Xavier
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F
F. Dean Toste
H 指数: 141 · 论文数: 801
L
Leonard I. Zon
H 指数: 135 · 论文数: 854
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