Varsha Gandhi - Publications, H-index & Citations

Varsha Gandhi

the university of texas

68H指数

692论文数

1.9W被引数

收录论文 100

发表时间

Docirbrutinib is a pan-mutant BTK inhibitor and inhibits B-cell receptor signaling in chronic lymphocytic leukemia cells in preclinical and early clinical investigations 多西布替尼是一种泛突变BTK抑制剂，并在临床前和早期临床研究中抑制慢性淋巴细胞白血病细胞的B细胞受体信号传导

Blood Cancer Journal

IF11.6

2026-05-07

OAAI

Natalia Timofeeva; Breana Herrera; Hitomi Fujiwara; Tokiko Asami; Hiroko Endo; Mariko Hatakeyama; Fumio Nakajima; Hiroshi Ohmoto; Yu Nishioka; Kyoko Miyamoto; Akinori Arimura; Shady I. Tantawy; Javier Pinilla-Ibarz; Catherine C. Coombs; Nitin Jain; Masaaki Sawa; Varsha Gandhi

Pharmacological profiling in CLL patients during pirtobrutinib therapy and disease progression 在pirtobrutinib治疗期间CLL患者中的药理学特征分析及疾病进展

Blood Cancer Journal

IF11.6

2025-10-27

OAAI

Shady I. Tantawy; Burcu Aslan; Ganiraju Manyam; LaKesla R. Iles; Natalia Timofeeva; Neetu Singh; Nitin Jain; Alessandra Ferrajoli; Philip A. Thompson; Keyur P. Patel; Sai Prasad Desikan; William G. Wierda; Varsha Gandhi

Genomic Determinants of Response and Resistance to Pirtobrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia Pirtobrutinib对复发/难治性慢性淋巴细胞白血病的反应和耐药性的基因组决定因素

Blood

IF23.1

2025-10-10

OAAI

Jennifer R. Brown; Bastien Nguyen; Sai Prasad Desikan; Helen Won; Shady I. Tantawy; Samuel C. McNeely; Narasimha Marella; Hetal S. Randeria; Lauren M. Hanson; Andrew Parker; Salomé Calado Botelho; Jennifer A. Woyach; Krish Patel; Constantine S. Tam; Toby A. Eyre; Chan Y. Cheah; Nirav N. Shah; Paolo Ghia; Wojciech Jurczak; Minna Balbas; Binoj Nair; Paolo Abada; Chunxiao Wang; Denise Wang; Lindsey E. Roeker; Varsha Gandhi; William G. Wierda

The DLEU2/miR-15a/miR-16-1 cluster shapes the immune microenvironment of chronic lymphocytic leukemia

BLOOD CANCER JOURNAL

IF11.6

2024-10-23

OAAI

Zhang, Ronghua; Khare, Priyanka; Banerjee, Priyanka; Ivan, Cristina; Schneider, Sarah; Barbaglio, Federica; Clise-Dwyer, Karen; Jensen, Vanessa Behrana; Thompson, Erika; Mendoza, Marisela; Chiorazzi, Nicholas; Chen, Shih-Shih; Yan, Xiao-Jie Joy; Jain, Nitin; Ghia, Paolo; Caligaris-Cappio, Federico; Mendonsa, Rima; Kasimsetty, Sashi; Swoboda, Ryan; Bayraktar, Recep; Wierda, William; Gandhi, Varsha; Calin, George A.; Keating, Michael J.; Bertilaccio, Maria Teresa Sabrina

Transcriptomic and proteomic differences in BTK-WT and BTK-mutated CLL and their changes during therapy with pirtobrutinib

BLOOD ADVANCES

IF7.1

2024-08-28

OAAI

Aslan, Burcu; Manyam, Ganiraju; Iles, Lakesla R.; Tantawy, Shady I.; Desikan, Sai Prasad; Wierda, William G.; Gandhi, Varsha

DHODH: a promising target in the treatment of T-cell acute lymphoblastic leukemia

BLOOD ADVANCES

IF7.1

2023-11-02

OAAI

Sexauer, Amy N.; Alexe, Gabriela; Gustafsson, Karin; Zanetakos, Elizabeth; Milosevic, Jelena; Ayres, Mary; Gandhi, Varsha; Pikman, Yana; Stegmaier, Kimberly; Sykes, David B.

A phase 1 trial of 8-chloro-adenosine in relapsed/refractory acute myeloid leukemia: An evaluation of safety and pharmacokinetics 8-氯腺苷治疗复发/难治性急性髓系白血病的1期临床试验: 安全性和药代动力学评估

CANCER

IF5.1

2023-10-28

OAAI

Pullarkat, Vinod; Chen, Lisa S.; Palmer, Joycelynne; Zhang, Jianying; Synold, Timothy W.; Buettner, Ralf; Nguyen, Le Xuan Truong; Marcucci, Guido; Tsai, Ni-Chun; Wang, Yan; O'Hearn, James; Gandhi, Varsha; Rosen, Steven T.

Targeting MCL-1 protein to treat cancer: opportunities and challenges 靶向MCL-1蛋白治疗癌症: 机遇与挑战

FRONTIERS IN ONCOLOGY

IF3.3

2023-07-31

OAAI

Tantawy, Shady I.; Timofeeva, Natalia; Sarkar, Aloke; Gandhi, Varsha

Preclinical investigations of the efficacy of the glutaminase inhibitor CB-839 alone and in combinations in chronic lymphocytic leukemia

FRONTIERS IN ONCOLOGY

IF3.3

2023-05-09

OAAI

Timofeeva, Natalia; Ayres, Mary L.; Baran, Natalia; Santiago-O'Farrill, Janice M.; Bildik, Gamze; Lu, Zhen; Konopleva, Marina; Gandhi, Varsha

Curing CLL: one clone at a time

BLOOD ADVANCES

IF7.1

2023-05-09

OAAI

Aslan, Burcu; Tantawy, Shady I.; Gandhi, Varsha

The Bcl-2 family proteins in CLL: Effects by the cytogenetics, microenvironments and therapy

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Chen, Rong; Xiong, Ping; Liu, Chaomei; Chen, Yuling; Jiang, Yingjun; Gandhi, Varsha; Jain, Nitin; Wierda, William; Plunkett, William

A phase 1 study to evaluate the safety, pharmacology, and feasibility of continuous infusion nelarabine in patients with relapsed and/or refractory lymphoid malignancies

CANCER

IF5.1

2022-11-29

PREAI

Boddu, Prajwal C.; Senapati, Jayastu; Ravandi-Kashani, Farhad; Jabbour, Elias J.; Jain, Nitin; Ayres, Mary; Chen, Yuling; Keating, Michael J.; Kantarjian, Hagop M.; Gandhi, Varsha; Kadia, Tapan M.

Mechanisms of MCL-1 Protein Stability Induced by MCL-1 Antagonists in B-Cell Malignancies MCL-1拮抗剂诱导b细胞恶性肿瘤MCL-1蛋白稳定性的机制

CLINICAL CANCER RESEARCH

IF10.2

2022-11-08

OAAI

Tantawy, Shady I.; Sarkar, Aloke; Hubner, Stefan; Tan, Zhi; Wierda, William G.; Eldeib, Abdelraouf; Zhang, Shuxing; Kornblau, Steven; Gandhi, Varsha

Pirtobrutinib inhibits wild-type and mutant Bruton's tyrosine kinase-mediated signaling in chronic lymphocytic leukemia

BLOOD CANCER JOURNAL

IF11.6

2022-05-20

OAAI

Aslan, Burcu; Kismali, Gorkem; Iles, Lakesla R.; Manyam, Ganiraju C.; Ayres, Mary L.; Chen, Lisa S.; Gagea, Mihai; Bertilaccio, Maria Teresa Sabrina; Wierda, William G.; Gandhi, Varsha

Targeting Mcl-1 by AMG-176 During Ibrutinib and Venetoclax Therapy in Chronic Lymphocytic Leukemia

FRONTIERS IN ONCOLOGY

IF3.3

2022-02-22

OAAI

Yi, Xue; Jain, Nitin; Iles, LaKesla R.; Ayres, Mary L.; Wierda, William G.; Gandhi, Varsha

Enhanced Vulnerability of LKB1-Deficient NSCLC to Disruption of ATP Pools and Redox Homeostasis by 8-Cl-Ado LKB1-Deficient NSCLC对8-Cl-Ado破坏ATP池和氧化还原稳态的脆弱性增强

MOLECULAR CANCER RESEARCH

IF4.7

2021-10-15

OAAI

Galan-Cobo, Ana; Stellrecht, Christine M.; Yilmaz, Emrullah; Yang, Chao; Qian, Yu; Qu, Xiao; Akhter, Ishita; Ayres, Mary L.; Fan, Youhong; Tong, Pan; Diao, Lixia; Ding, Jie; Giri, Uma; Gudikote, Jayanthi; Nilsson, Monique; Wierda, William G.; Wang, Jing; Skoulidis, Ferdinandos; Minna, John D.; Gandhi, Varsha; Heymach, John, V

Vecabrutinib inhibits B-cell receptor signal transduction in chronic lymphocytic leukemia cell types with wild-type or mutant Bruton tyrosine kinase

HAEMATOLOGICA

IF7.9

2021-09-09

OAAI

Aslan, Burcu; Hubner, Stefan Edward; Fox, Judith A.; Taverna, Pietro; Wierda, William G.; Kornblau, Steven M.; Gandhi, Varsha

Development and characterization of prototypes for in vitro and in vivo mouse models of ibrutinib-resistant CLL

BLOOD ADVANCES

IF7.1

2021-08-20

OAAI

Aslan, Burcu; Kismali, Gorkem; Chen, Lisa S.; Iles, LaKesla R.; Mahendra, Mikhila; Peoples, Michael; Gagea, Mihai; Fowlkes, Natalie W.; Zheng, Xiaofeng; Wang, Jing; Vellano, Christopher P.; Marszalek, Joseph R.; Bertilaccio, Maria Teresa Sabrina; Gandhi, Varsha

Activation of ATM kinase by ROS generated during ionophore-induced mitophagy in human T and B cell malignancies (vol 476, pg 417, 2021)

MOLECULAR AND CELLULAR BIOCHEMISTRY

IF3.7

2021-05-22

OAAI

Sarkar, Aloke; Gandhi, Varsha

Ibrutinib, fludarabine, cyclophosphamide, and obinutuzumab (iFCG) regimen for chronic lymphocytic leukemia (CLL) with mutated IGHV and without TP53 aberrations

LEUKEMIA

IF13.4

2021-05-18

PREAI

Jain, Nitin; Thompson, Philip; Burger, Jan; Ferrajoli, Alessandra; Takahashi, Koichi; Estrov, Zeev; Borthakur, Gautam; Bose, Prithviraj; Kadia, Tapan; Pemmaraju, Naveen; Sasaki, Koji; Konopleva, Marina; Jabbour, Elias; Garg, Naveen; Wang, Xuemei; Kanagal-Shamanna, Rashmi; Patel, Keyur; Wang, Wei; Jorgensen, Jeffrey; Wang, Sa; Lopez, Wanda; Ayala, Ana; Plunkett, William; Gandhi, Varsha; Kantarjian, Hagop; O'Brien, Susan; Keating, Michael; Wierda, William G.

研究方向