未登录 Antiviral target compound profile for pandemic preparedness Demarest, James F.; Draghia-Akli, Ruxandra; Cihlar, Tomas; Bradley, Kenneth; Young, John A. T.; Chandra, Richa; Vaidyanathan, Sujata; Chu-Moyer, Margaret; Lynch, Christopher L.; Campbell, Andrew; Saikatendu, Kumar Singh; Bilello, John P.; Murata, Yoshihiko; van Loock, Marnix; Hurt, Aeron C.; Tellinghuisen, Timothy; Ruggiero, Lee; Mackman, Richard; Hill, Nina M.; Pottage, John C.; van Loock, Marnix 分享 收藏
Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus Kou, Buyu; Zhang, Zhisen; Han, Xingchun; Zhou, Zheng; Xu, Zhiheng; Zhou, Xue; Shen, Fang; Zhou, Yuan; Tian, Xiaojun; Yang, Guang; Young, John A. T.; Qiu, Hongxia; Ottaviani, Giorgio; Mayweg, Alexander; Zhu, Wei; Shen, Hong C.; Liu, Haixia; Hu, Taishan 分享 收藏
Discovery of a first-in-class orally available HBV cccDNA inhibitor 发现一流的口服HBV cccDNA抑制剂 Wang, Li; Zhu, Qihui; Zhang, Jitao David; Zhang, Yaling; Ni, Xiaoju; Xiang, Kunlun; Jiang, Jiaxi; Li, Baocun; Yu, Youjun; Hu, Hui; Zhang, Meifang; Wu, Waikwong; Zeng, Jing; Yan, Zhipeng; Dai, Jieyu; Sun, Kai; Zhang, Xin; Chen, Dongdong; Feng, Song; Sach-Peltason, Lisa; Young, John A. T.; Gao, Lu 分享 收藏
Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection Zhang, Weixing; Guo, Lei; Liu, Haixia; Wu, Guolong; Shi, Houguang; Zhou, Mingwei; Zhang, Zhisen; Kou, Buyu; Hu, Taishan; Zhou, Zheng; Xu, Zhiheng; Zhou, Xue; Zhou, Yuan; Tian, Xiaojun; Yang, Guang; Young, John A. T.; Qiu, Hongxia; Ottaviani, Giorgio; Xie, Jianxun; Mayweg, Alexander, V; Shen, Hong C.; Zhu, Wei 分享 收藏
Toll-Like Receptor 7 Agonist RG7854 Mediates Therapeutic Efficacy and Seroconversion in Woodchucks With Chronic Hepatitis B Wildum, Steffen; Korolowicz, Kyle E.; Suresh, Manasa; Steiner, Guido; Dai, Lue; Li, Bin; Yon, Changsuek; Mudry, Maria Cristina De Vera; Regenass-Lechner, Franziska; Huang, Xu; Hong, Xupeng; Murreddu, Marta G.; Kallakury, Bhaskar V.; Young, John A. T.; Menne, Stephan 分享 收藏
Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling Johnson, Jeffrey R.; Crosby, David C.; Hultquist, Judd F.; Kurland, Andrew P.; Adhikary, Prithy; Li, Donna; Marlett, John; Swann, Justine; Huttenhain, Ruth; Verschueren, Erik; Johnson, Tasha L.; Newton, Billy W.; Shales, Michael; Simon, Viviana A.; Beltrao, Pedro; Frankel, Alan D.; Marson, Alexander; Cox, Jeffery S.; Fregoso, Oliver, I; Young, John A. T.; Krogan, Nevan J. 分享 收藏
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The E3 Ubiquitin-Protein Ligase Cullin 3 Regulates HIV-1 Transcription Langer, Simon; Yin, Xin; Diaz, Arturo; Portillo, Alex J.; Gordon, David E.; Rogers, Umu H.; Marlett, John M.; Krogan, Nevan J.; Young, John A. T.; Pache, Lars; Chanda, Sumit K. 分享 收藏
Efficacy of an Inhibitor of Hepatitis B Virus Expression in Combination With Entecavir and Interferon-α in Woodchucks Chronically Infected With Woodchuck Hepatitis Virus Menne, Stephan; Wildum, Steffen; Steiner, Guido; Suresh, Manasa; Korolowicz, Kyle; Balarezo, Maria; Yon, Changsuek; Murreddu, Marta; Hong, Xupeng; Kallakury, Bhaskar, V; Tucker, Robin; Yang, Song; Young, John A. T.; Javanbakht, Hassan 分享 收藏
Machine-learning based patient classification using Hepatitis B virus full-length genome quasispecies from Asian and European cohorts Mueller-Breckenridge, Alan J.; Garcia-Alcalde, Fernando; Wildum, Steffen; Smits, Saskia L.; de Man, Robert A.; van Campenhout, Margo J. H.; Brouwer, Willem P.; Niu, Jianjun; Young, John A. T.; Najera, Isabel; Zhu, Lina; Wu, Daitze; Racek, Tomas; Hundie, Gadissa Bedada; Lin, Yong; Boucher, Charles A.; van de Vijver, David; Haagmans, Bart L. 分享 收藏
Direct Inhibition of Hepatitis B e Antigen by Core Protein Allosteric Modulator Yan, Zhipeng; Wu, Daitze; Hu, Hui; Zeng, Jing; Yu, Xin; Xu, Zhiheng; Zhou, Zheng; Zhou, Xue; Yang, Guang; Young, John A. T.; Gao, Lu 分享 收藏
PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization PAPD5/7是乙型肝炎病毒RNA稳定所需的宿主因素 Mueller, Henrik; Lopez, Anais; Tropberger, Philipp; Wildum, Steffen; Schmaler, Josephine; Pedersen, Lykke; Han, Xingchun; Wang, Yongguang; Ottosen, Soren; Yang, Song; Young, John A. T.; Javanbakht, Hassan 分享 收藏
Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo Javanbakht, Hassan; Mueller, Henrik; Walther, Johanna; Zhou, Xue; Lopez, Anais; Pattupara, Thushara; Blaising, Julie; Pedersen, Lykke; Albaek, Nanna; Jackerott, Malene; Shi, Tianlai; Ploix, Corinne; Driessen, Wouter; Persson, Robert; Ravn, Jacob; Young, John A. T.; Ottosen, Soren 分享 收藏
In vitro and in vivo antiviral characterization of RO7049389, a novel small molecule capsid assembly modulator for the treatment of chronic hepatitis B Zhou, X.; Zhou, Y.; Tian, X.; Shen, F.; Yang, G.; Zhu, W.; Ottaviani, G.; Xie, J.; Shen, H.; Young, J.; Gao, L. 分享 收藏
A novel orally available small molecule that inhibits hepatitis B virus expression 一种抑制乙型肝炎病毒表达的新型口服小分子 Mueller, Henrik; Wildum, Steffen; Luangsay, Souphalone; Walther, Johanna; Lopez, Anais; Tropberger, Philipp; Ottaviani, Giorgio; Lu, Wenzhe; Parrott, Neil John; Zhang, Jitao David; Schmucki, Roland; Racek, Tomas; Hoflack, Jean-Christophe; Kueng, Erich; Point, Floriane; Zhou, Xue; Steiner, Guido; Luetgehetmann, Marc; Rapp, Gianna; Volz, Tassilo; Dandri, Maura; Yang, Song; Young, John A. T.; Javanbakht, Hassan 分享 收藏
Discovery of Small Molecule Therapeutics for Treatment of Chronic HBV Infection Feng, Song; Gao, Lu; Han, Xingchun; Hu, Taishan; Hu, Yimin; Liu, Haixia; Thomas, Andrew W.; Yan, Zhipeng; Yang, Song; Young, John A. T.; Yun, Hongying; Zhu, Wei; Shen, Hong C. 分享 收藏
Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1 LIM结构域激酶抑制HIV-1的新型小分子抑制剂的发现 Yi, Fei; Guo, Jia; Dabbagh, Deemah; Spear, Mark; He, Sijia; Kehn-Hall, Kylene; Fontenot, Jacque; Yin, Yan; Bibian, Mathieu; Park, Chul Min; Zheng, Ke; Park, Ha Jeung; Soloveva, Veronica; Gharaibeh, Dima; Retterer, Cary; Zamani, Rouzbeh; Pitt, Margaret L.; Naughton, John; Jiang, Yongjun; Shang, Hong; Hakami, Ramin M.; Ling, Binhua; Young, John A. T.; Bavari, Sina; Xu, Xuehua; Feng, Yangbo; Wu, Yuntao 分享 收藏
HBVcircle: A novel tool to investigate hepatitis B virus covalently closed circular DNA Yan, Zhipeng; Zeng, Jing; Yu, Youjun; Xiang, Kunlun; Hu, Hui; Zhou, Xue; Gu, Lili; Wang, Li; Zhao, Jie; Young, John A. T.; Gao, Lu 分享 收藏
Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors Qiu, Zongxing; Lin, Xianfeng; Zhang, Weixing; Zhou, Mingwei; Guo, Lei; Kocer, Buelent; Wu, Guolong; Zhang, Zhisen; Liu, Haixia; Shi, Houguang; Kou, Buyu; Hu, Taishan; Hu, Yimin; Huang, Mengwei; Yan, S. Frank; Xu, Zhiheng; Zhou, Zheng; Qin, Ning; Wang, Yue Fen; Ren, Shuang; Qiu, Hongxia; Zhang, Yuxia; Zhang, Yi; Wu, Xiaoyue; Sun, Kai; Zhong, Sheng; Xie, Jianxun; Ottaviani, Giorgio; Zhou, Yuan; Zhu, Lina; Tian, Xiaojun; Shi, Liping; Shen, Fang; Mao, Yi; Zhou, Xue; Gao, Lu; Young, John A. T.; Wu, Jim Zhen; Yang, Guang; Mayweg, Alexander V.; Shen, Hong C.; Tang, Guozhi; Zhu, Wei 分享 收藏
Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms Zhou, Zheng; Hu, Taishan; Zhou, Xue; Wildum, Steffen; Garcia-Alcalde, Fernando; Xu, Zhiheng; Wu, Daitze; Mao, Yi; Tian, Xiaojun; Zhou, Yuan; Shen, Fang; Zhang, Zhisen; Tang, Guozhi; Najera, Isabel; Yang, Guang; Shen, Hong C.; Young, John A. T.; Qin, Ning 分享 收藏
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