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P

Piet H. van der Graaf

certara

39H指数
238论文数
5.8K被引数
收录论文 144
发表时间
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From Biological Mechanisms to Causal Inference: Quantitative Systems Pharmacology and Causal Frameworks in Drug Development从生物学机制到因果推断：定量系统药理学和药物开发中的因果框架
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2026-09-24
err0
errOAAI
errThomas Klabunde; Ramon Hernandez; Piet H. van der Graaf; Tommaso Andreani
err分享
err收藏
Clinical Validation of a QSP Model for ISB 2001, a Trispecific T Cell Engager to Support Optimal FIH Study Design in RRMM Patients三特异性T细胞接合剂ISB 2001的定量系统药理学模型临床验证，以支持在复发/难治性多发性骨髓瘤患者中优化首次人体研究的试验设计
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2026-05-28
err0
errOAAI
errVinu Chandralayam Ayyappa Menon; Tomomi Matsuura; Beata Holkova; Girish S. Gudi; Adam Drake; Maria Pihlgren; Piet H. van der Graaf; Sunitha GN; Andrew Garton; Mario Perro; Cyril Konto; Lida Pacaud
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Understanding quantitative effects of anti-amyloid therapies on tau biomarkers and functional outcome. Insights from a comprehensive mechanistic quantitative systems pharmacology study抗淀粉样蛋白疗法对tau生物标志物和功能结局的定量效应：来自一项全面的机制性定量系统药理学研究的见解
errFrontiers in Pharmacology
IF4.8
err2026-04-30
err0
errOAAI
errHG Hugo Geerts; SM Shaina M. Short; AG Athena Grant; PH Piet H. van der Graaf
err分享
err收藏
Seasons of Growth: Reflections on the CPT Editor-in-Training Program《成长的季节：关于CPT Editor-in-Training Program的反思》
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2025-12-01
err2
errOAAI
errVan Hoogdalem, Matthijs W.; Dunn, Allison; Mehanna, Mai; Wen, Ya-Feng; Choi, Yewon (Sofia); Brown, Karen E.; Minichmayr, Iris K.; Smith, D. Max; Cicali, Emily J.; Shahin, Mohamed H.; Giacomini, Kathleen M.; Van Der Graaf, Piet H.
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err收藏
What is History? An Echo of the Past in the Future; A Reflex From the Future on the Past历史是什么？未来中过去的回声；未来对过去的反射
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2025-12-01
err1
errOAAI
errGiacomini, Kathleen M.; Van Der Graaf, Piet H.
err分享
err收藏
Innovations in Clinical Pharmacology: Shaping the Future of Evidence Generation in Research, Development, and Utilization of Medicines临床药理学创新：塑造药品研究、开发和利用中证据生成的未来
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2025-12-01
err0
errOAAI
errVenkatakrishnan, Karthik; Joshi, Amita; Gerding, Alethea; Giacomini, Kathleen M.; van der Graaf, Piet H.
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err收藏
History and Evolution of Innovations in Clinical Pharmacology临床药理学创新的历史与演变
errClinical Pharmacology & Therapeutics
IF5.5
err2025-09-24
err0
PREAI
errLawrence J. Lesko; Piet H. van der Graaf
err分享
err收藏
Interchanging Biosimilars Using Proteomics使用蛋白质组学互换生物类似药
errClinical Pharmacology & Therapeutics
IF5.5
err2025-09-16
err0
PREAI
errPiet H. van der Graaf; Ingolf Cascorbi
err分享
err收藏
Malthus-Informed Drug Development (MIDD)马尔萨斯信息药物开发（MIDD）
errClinical Pharmacology & Therapeutics
IF5.5
err2025-08-14
err0
errOAAI
errPiet H. van der Graaf
err分享
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Model-Informed Drug Development: Bang for the Buck?模型引导药物研发：性价比如何？
errClinical Pharmacology & Therapeutics
IF5.5
err2025-07-18
err0
PREAI
errAllison Dunn; Piet H. van der Graaf
err分享
err收藏
Integrating Pharmacokinetics and Quantitative Systems Pharmacology Approaches in Generative Drug Design整合药代动力学和定量系统药理学方法在生成式药物设计中的应用
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2025-05-09
err0
errOAAI
errvan den Maagdenberg, Helle W.; de Mol van Otterloo, Jikke; van Hasselt, J. G. Coen; van der Graaf, Piet H.; van Westen, Gerard J. P.
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err收藏
Interactions of Therapeutic Antibodies With Presynaptically-Released Misfolded Proteins in Neurodegenerative Diseases. A Spatial Monte-Carlo Simulation Study神经退行性疾病中治疗性抗体与突触前释放的错误折叠蛋白质的相互作用。一项空间蒙特卡洛模拟研究。
errCPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
IF3
err2025-04-28
err0
errOAAI
errJamie Goff; Maryam Khalifa; Shaina M. Short; Piet H. van der Graaf; Hugo Geerts
err分享
err收藏
Combining mechanistic modeling with machine learning as a strategy to predict inflammatory bowel disease clinical scores将机制建模与机器学习相结合作为预测炎症性肠病临床评分的策略
errFRONTIERS IN PHARMACOLOGY
IF4.8
err2025-02-25
err0
errOAAI
errShim, Jaehee V.; Rehberg, Markus; Wagenhuber, Britta; van der Graaf, Piet H.; Chung, Douglas W.
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err收藏
Progress in Clinical Pharmacology in China: An Ongoing Evolution
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2025-02-18
err0
PREAI
errZhao, Liang; van Der Graaf, Piet H.
err分享
err收藏
First-in-Human Dose Selection for T-Cell Engaging Bispecific Antibodies
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2024-12-17
err0
PREAI
errvan Der Graaf, Piet H.
err分享
err收藏
Quantitative Systems Pharmacology-Based Digital Twins Approach Supplements Clinical Trial Data for Enzyme Replacement Therapies in Pompe Disease
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2024-12-04
err2
PREAI
errKaddi, Chanchala; Tao, Mengdi; Bergeler, Silke; George, Kelly; Geerts, Hugo; van der Graaf, Piet H.; Batista, Julie L.; Foster, Meredith; Ortemann-Renon, Catherine; Zaher, Atef; Haack, Kristina An; Zaph, Susana
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Therapeutic Orphan No More: Role for Clinical Pharmacology and Translational Science in Developing Therapeutics for Rare and Neglected Diseases
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2024-11-14
err1
errOAAI
errRamamoorthy, Anuradha; Younis, Islam; Wen, Ya-Feng; Mehanna, Mai; Giacomini, Kathleen M.; van Der Graaf, Piet H.
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QSPRpred: a Flexible Open-Source Quantitative Structure-Property Relationship Modelling Tool
errJOURNAL OF CHEMINFORMATICS
IF5.7
err2024-11-14
err0
errOAAI
errvan den Maagdenberg, Helle W.; Sicho, Martin; Araripe, David Alencar; Luukkonen, Sohvi; Schoenmaker, Linde; Jespers, Michiel; Bequignon, Olivier J. M.; Gonzalez, Marina Gorostiola; van den Broek, Remco L.; Bernatavicius, Andrius; van Hasselt, J. G. Coen; van der Graaf, Piet. H.; van Westen, Gerard J. P.
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TRIBUTE In memoriam Lambertus (Bert) A. Peletier 29 March 1937-16 December 2023: Furthering quantitative pharmacology through applied mathematics
errCPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
IF3
err2024-09-23
err0
errOAAI
errDanhof, Meindert; van Der Graaf, Piet H.; Post, Teun M.; Visser, Sandra A. G.; Zuideveld, Klaas P.; Schmidt, Stephan
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err收藏
Is Pharmacogenetic Testing a Vital Tool for Enhancing Therapeutic Management of Patients Worldwide?
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2024-09-17
err0
PREAI
errGiacomini, Kathleen M.; van Der Graaf, Piet H.
err分享
err收藏

研究方向

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