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Discovery and Preclinical Characterization of Fulacimstat (BAY 1142524), a Potent and Selective Chymase Inhibitor As a New Profibrinolytic Approach for Safe Thrombus Resolution Fuerstner, Chantal; Ackerstaff, Jens; Meier, Heinrich; Straub, Alexander; Mittendorf, Joachim; Schamberger, Jens; Schaefer, Martina; Boerngen, Kirsten; Joerissen, Hannah; Zubov, Dmitry; Zimmermann, Katja; Tersteegen, Adrian; Geiss, Volker; Hartmann, Elke; Albrecht-Kuepper, Barbara; D'Orleans-Juste, Pedro; Lapointe, Catherine; Vincent, Laurence; Heitmeier, Stefan; Tinel, Hanna 分享 收藏
Discovery of BAY 2413555, First Selective Positive Allosteric Modulator of the M2 Receptor to Restore Cardiac Autonomic Balance Vakalopoulos, Alexandros; Basting, Daniel; Brechmann, Markus; Teller, Henrik; Boultadakis Arapinis, Melissa; Straub, Alexander; Mittendorf, Joachim; Meininghaus, Mark; Mueller, Thomas; Nowak-Reppel, Katrin; Schaefer, Martina; Wittwer, Matthias; Kullmann, Maximilian; Terjung, Carsten; Lang, Dieter; Poethko, Thorsten; Marquardt, Tobias; Freudenberger, Till; Mondritzki, Thomas; Huser, Jorg; Heckmann, Michael; Tinel, Hanna 分享 收藏
New Generation of sGC Stimulators: Discovery of Imidazo[1,2-a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension Vakalopoulos, Alexandros; Wunder, Frank; Hartung, Ingo, V; Redlich, Gorden; Jautelat, Rolf; Buchgraber, Philipp; Hassfeld, Jorma; V. Gromov, Alexey; Lindner, Niels; Bierer, Donald; Gries, Jorg; Kroh, Walter; Paulsen, Holger; Mittendorf, Joachim; Lang, Dieter; Becker-Pelster, Eva; Brockschnieder, Damian; Geiss, Volker; Li, Volkhart; Straub, Alexander; Knorr, Andreas; Mondritzki, Thomas; Truebel, Hubert; Raschke, Marian; Schaefer, Martina; Thomas, Dirk; Sandner, Peter; Stasch, Johannes-Peter; Follmann, Markus 分享 收藏
BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic?2B Antagonist Meibom, Daniel; Meyer, Jutta; von Buehler, Clemens-Jeremias; Collins, Karl D.; Maassen, Stefanie; Gericke, Kersten Matthias; Huser, Jorg; Mittendorf, Joachim; Hernandez, Nuria Ortega; Schamberger, Jens; Stampfuss, Jan; Straub, Alexander; Torge, Afra; Witowski, Norbert; Wunder, Frank 分享 收藏
Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure Follmann, Markus; Ackerstaff, Jens; Redlich, Gorden; Wunder, Frank; Lang, Dieter; Kern, Armin; Fey, Peter; Griebenow, Nils; Kroh, Walter; Becker-Pelster, Eva-Maria; Kretschmer, Axel; Geiss, Volker; Li, Volkhart; Straub, Alexander; Mittendorf, Joachim; Jautelat, Rolf; Schirok, Hartmut; Schlemmer, Karl-Heinz; Lustig, Klemens; Gerisch, Michael; Knorr, Andreas; Tine, Hanna; Mondritzki, Thomas; Truebel, Hubert; Sandner, Peter; Stasch, Johannes-Peter 分享 收藏
The Chemistry and Biology of Soluble Guanylate Cyclase Stimulators and Activators Follmann, Markus; Griebenow, Nils; Hahn, Michael G.; Hartung, Ingo; Mais, Franz-Josef; Mittendorf, Joachim; Schaefer, Martina; Schirok, Hartmut; Stasch, Johannes-Peter; Stoll, Friederike; Straub, Alexander 分享 收藏
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Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension Mittendorf, Joachim; Weigand, Stefan; Alonso-Alija, Cristina; Bischoff, Erwin; Feurer, Achim; Gerisch, Michael; Kern, Armin; Knorr, Andreas; Lang, Dieter; Muenter, Klaus; Radtke, Martin; Schirok, Hartmut; Schlemmer, Karl-Heinz; Stahl, Elke; Straub, Alexander; Wunder, Frank; Stasch, Johannes-Peter 分享 收藏
Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543:: in vitro studies Stasch, JP; Alonso-Alija, C; Apeler, H; Dembowsky, K; Feurer, A; Minuth, T; Perzborn, E; Schramm, M; Straub, A 分享 收藏
Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide (BAY 59-7939):: An oral, direct factor Xa inhibitor Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E 分享 收藏
Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase (vol 10, pg 1711, 2002) Straub, A; Benet-Buchholz, J; Fröde, R; Kern, A; Kohlsdorfer, C; Schmitt, P; Schwarz, T; Siefert, HM; Stasch, JP 分享 收藏
A new type of Ca-channel modulation by a novel class of 1,4-dihydropyridines Bechem, M; Goldmann, S; Gross, R; Hallermann, S; Hebisch, S; Hutter, J; Rounding, HP; Schramm, M; Stoltefuss, J; Straub, A 分享 收藏
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