Mark A. Murcko - Publications, H-index & Citations

Mark A. Murcko

disruptive biomedical llc

49H指数

114论文数

1.6W被引数

收录论文 37

发表时间

Mapping the avoid-ome: a systematic open-science approach to predictive ADMET 绘制规避组：一种系统性的开放科学方法用于预测ADMET

Nature Communications

IF15.7

2026-05-25

OAAI

James S. Fraser; Steven Edgar; L. Naomi Handly; Sriram Kosuri; John D. Chodera; Mark Murcko; W. Patrick Walters

Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-09-29

PREAI

Taylor, Alexander M.; Williams, Bret R.; Giordanetto, Fabrizio; Kelley, Elizabeth H.; Lescarbeau, Andre; Shortsleeves, Kelley; Tang, Yong; Walters, W. Patrick; Arrazate, Alfonso; Bowman, Christine; Brophy, Erin; Chan, Emily W.; Deshmukh, Gauri; Greisman, Jack B.; Hunsaker, Thomas L.; Kipp, D. Randal; Lopez-Larrocha, Pablo Saenz; Maddalo, Danilo; Martin, Iain J.; Maragakis, Paul; Merchant, Mark; Murcko, Mark; Nisonoff, Hunter; Nguyen, Vi; Nguyen, Vy; Orozco, Olivia; Owen, Christopher; Pierce, Levi; Schmidt, Molly; Shaw, David E.; Smith, Sherri; Therrien, Eric; Tran, John C.; Watters, Jim; Waters, Nigel J.; Wilbur, Jeremy; Willmore, Lindsay

Principles and functions of condensate modifying drugs

FRONTIERS IN MOLECULAR BIOSCIENCES

IF4

2022-11-22

OAAI

Patel, Avinash; Mitrea, Diana; Namasivayam, Vigneshwaran; Murcko, Mark A. A.; Wagner, Michael; Klein, Isaac A. A.

Modulating biomolecular condensates: a novel approach to drug discovery 调节生物分子缩合物: 药物发现的新方法

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2022-08-16

124

OAAI

Mitrea, Diana M.; Mittasch, Matthaus; Gomes, Beatriz Ferreira; Klein, Isaac A.; Murcko, Mark A.

Assessing the impact of generative AI on medicinal chemistry 评估生成性AI对药物化学的影响

NATURE BIOTECHNOLOGY

IF41.7

2020-01-30

110

PREAI

Walters, W. Patrick; Murcko, Mark

What Makes a Great Medicinal Chemist? A Personal Perspective

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-05-10

OAAI

Murcko, Mark A.

Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2015-03-01

174

OAAI

Byrn, Randal A.; Jones, Steven M.; Bennett, Hamilton B.; Bral, Chris; Clark, Michael P.; Jacobs, Marc D.; Kwong, Ann D.; Ledeboer, Mark W.; Leeman, Joshua R.; McNeil, Colleen F.; Murcko, Mark A.; Nezami, Azin; Perola, Emanuele; Rijnbrand, Rene; Saxena, Kumkum; Tsai, Alice W.; Zhou, Yi; Charifson, Paul S.

Accurate and Reliable Prediction of Relative Ligand Binding Potency in Prospective Drug Discovery by Way of a Modern Free-Energy Calculation Protocol and Force Field

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2015-02-12

991

OAAI

Wang, Lingle; Wu, Yujie; Deng, Yuqing; Kim, Byungchan; Pierce, Levi; Krilov, Goran; Lupyan, Dmitry; Robinson, Shaughnessy; Dahlgren, Markus K.; Greenwood, Jeremy; Romero, Donna L.; Masse, Craig; Knight, Jennifer L.; Steinbrecher, Thomas; Beuming, Thijs; Damm, Wolfgang; Harder, Ed; Sherman, Woody; Brewer, Mark; Wester, Ron; Murcko, Mark; Frye, Leah; Farid, Ramy; Lin, Teng; Mobley, David L.; Jorgensen, William L.; Berne, Bruce J.; Friesner, Richard A.; Abel, Robert

Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-07-24

208

PREAI

Clark, Michael P.; Ledeboer, Mark W.; Davies, Ioana; Byrn, Randal A.; Jones, Steven M.; Perola, Emanuele; Tsai, Alice; Jacobs, Marc; Nti-Addae, Kwame; Bandarage, Upul K.; Boyd, Michael J.; Bethiel, Randy S.; Court, John J.; Deng, Hongbo; Duffy, John P.; Dorsch, Warren A.; Farmer, Luc J.; Gao, Huai; Gu, Wenxin; Jackson, Katrina; Jacobs, Dylan H.; Kennedy, Joseph M.; Ledford, Brian; Liang, Jianglin; Maltais, Francois; Murcko, Mark; Wang, Tiansheng; Wannamaker, M. Woods; Bennett, Hamilton B.; Leeman, Joshua R.; McNeil, Colleen; Taylor, William P.; Memmott, Christine; Jiang, Min; Rijnbrand, Rene; Bral, Christopher; Germann, Ursula; Nezami, Azin; Zhang, Yuegang; Salituro, Francesco G.; Bennani, Youssef L.; Charifson, Paul S.

The surprising link between hair curlers and drug discovery

DRUG DISCOVERY TODAY

IF7.5

2013-03-01

PREAI

Murcko, Mark

Alpha shock

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

IF3.1

2012-01-04

OAAI

Murcko, Mark A.; Walters, W. Patrick

What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2011-08-31

329

PREAI

Walters, W. Patrick; Green, Jeremy; Weiss, Jonathan R.; Murcko, Mark A.

The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2011-08-04

OAAI

Duffy, John P.; Harrington, Edmund M.; Salituro, Francesco G.; Cochran, John E.; Green, Jeremy; Gao, Huai; Bemis, Guy W.; Evindar, Ghotas; Galullo, Vincent P.; Ford, Pamella J.; Germann, Ursula A.; Wilson, Keith P.; Bellon, Steven F.; Chen, Guanging; Taslimi, Paul; Jones, Peter; Huang, Cassey; Pazhanisamy, S.; Wang, Yow-Ming; Murcko, Mark A.; Su, Michael S. S.

Drug Discovery: aiming for the moon?

DRUG DISCOVERY TODAY

IF7.5

2009-10-01

PREAI

Murcko, Mark

Kinase-likeness and kinase-privileged fragments: Toward virtual polypharmacology

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2008-02-21

PREAI

Aronov, Alex M.; McClain, Brian; Moody, Cameron Stuver; Murcko, Mark A.