未登录Polygenic risk score adds to a clinical risk score in the prediction of cardiovascular disease in a clinical setting
Samani, Nilesh J.; Beeston, Emma; Greengrass, Chris; Riveros-McKay, Fernando; Debiec, Radoslaw; Lawday, Daniel; Wang, Qingning; Budgeon, Charley A.; Braund, Peter S.; Bramley, Richard; Kharodia, Shireen; Newton, Michelle; Marshall, Andrea; Krzeminski, Andre; Zafar, Azhar; Chahal, Anuj; Heer, Amadeeep; Khunti, Kamlesh; Joshi, Nitin; Lakhani, Mayur; Farooqi, Azhar; Plagnol, Vincent; Donnelly, Peter; Weale, Michael E.; Nelson, Christopher P. .png)
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收藏A polygenic risk score added to a QRISK®2 cardiovascular disease risk calculator demonstrated robust clinical acceptance and clinical utility in the primary care setting添加到qri确定的多基因风险评分®2心血管疾病风险计算器在初级保健环境中显示出强大的临床接受度和临床实用性Fuat, Ahmet; Adlen, Ella; Monane, Mark; Coll, Ruth; Groves, Sarah; Little, Elizabeth; Wild, Jonathan; Kamali, Farzan J.; Soni, Yusuf; Haining, Shona; Riding, Helen; Riveros-Mckay, Fernando; Peneva, Iliana; Lachapelle, Alexander; Giner-Delgado, Carla; Weale, Michael E.; Plagnol, Vincent; Harrison, Seamus; Donnelly, Peter 分享 收藏 分享 收藏 Development of the HT&Me intervention to support women with breast cancer to adhere to adjuvant endocrine therapy and improve quality of lifeStewart, Sarah-Jane F.; Slodkowska-Barabasz, Joanna; McGeagh, Lucy; Moon, Zoe; Brett, Jo; Wells, Mary; Brown, Morven C.; Turner, Mark; Horne, Robert; Fenlon, Deborah; Rehman, Farah; Cain, Henry; Donnelly, Peter; Harmer, Victoria; Turner, Lesley; Rose, Jan; Sharp, Linda; Watson, Eila; SWEET Res Team 分享 收藏 Genotyping and population characteristics of the China Kadoorie Biobank中国嘉道理生物银行的基因分型和种群特征Walters, Robin G.; Millwood, Iona Y.; Lin, Kuang; Valle, Dan Schmidt; McDonnell, Pandora; Hacker, Alex; Avery, Daniel; Edris, Ahmed; Fry, Hannah; Cai, Na; Kretzschmar, Warren W.; Ansari, M. Azim; Lyons, Paul A.; Collins, Rory; Donnelly, Peter; Hill, Michael; Peto, Richard; Shen, Hongbing; Jin, Xin; Nie, Chao; Xu, Xun; Guo, Yu; Yu, Canqing; Lv, Jun; Clarke, Robert J.; Li, Liming; Chen, Zhengming 分享 收藏 分享 收藏 分享 收藏 Altering the Binding Properties of PRDM9 Partially Restores Fertility across the Species BoundaryDavies, Benjamin; Gupta Hinch, Anjali; Cebrian-Serrano, Alberto; Alghadban, Samy; Becker, Philipp W.; Biggs, Daniel; Hernandez-Pliego, Polinka; Preece, Chris; Moralli, Daniela; Zhang, Gang; Myers, Simon; Donnelly, Peter 分享 收藏 分享 收藏 The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination IntermediatesHinch, Anjali Gupta; Becker, Philipp W.; Li, Tao; Moralli, Daniela; Zhang, Gang; Bycroft, Clare; Green, Catherine; Keeney, Scott; Shi, Qinghua; Davies, Benjamin; Donnelly, Peter 分享 收藏 Sequencing of human genomes with nanopore technologyBowden, Rory; Davies, Robert W.; Heger, Andreas; Pagnamenta, Alistair T.; de Cesare, Mariateresa; Oikkonen, Laura E.; Parkes, Duncan; Freeman, Colin; Dhalla, Fatima; Patel, Smita Y.; Popitsch, Niko; Ip, Camilla L. C.; Roberts, Hannah E.; Salatino, Silvia; Lockstone, Helen; Lunter, Gerton; Taylor, Jenny C.; Buck, David; Simpson, Michael A.; Donnelly, Peter 分享 收藏 分享 收藏 Phenome-wide association studies across large population cohorts support drug target validation跨大人群队列的全表型组关联研究支持药物靶标验证Diogo, Dorothee; Tian, Chao; Franklin, Christopher S.; Alanne-Kinnunen, Mervi; March, Michael; Spencer, Chris C. A.; Vangjeli, Ciara; Weale, Michael E.; Mattsson, Hannele; Kilpelainen, Elina; Sleiman, Patrick M. A.; Reilly, Dermot F.; McElwee, Joshua; Maranville, Joseph C.; Chatterjee, Arnaub K.; Bhandari, Aman; Nguyen, Khanh-Dung H.; Estrada, Karol; Reeve, Mary-Pat; Hutz, Janna; Bing, Nan; John, Sally; Macarthur, Daniel G.; Salomaa, Veikko; Ripatti, Samuli; Hakonarson, Hakon; Daly, Mark J.; Palotie, Aarno; Hinds, David A.; Donnelly, Peter; Fox, Caroline S.; Day-Williams, Aaron G.; Plenge, Robert M.; Runz, Heiko 分享 收藏 分享 收藏 Long-read whole genome sequencing and comparative analysis of six strains of the human pathogen Orientia tsutsugamushiBatty, Elizabeth M.; Chaemchuen, Suwittra; Blacksell, Stuart; Richards, Allen L.; Paris, Daniel; Bowden, Rory; Chan, Caroline; Lachumanan, Ramkumar; Day, Nicholas; Donnelly, Peter; Chen, Swaine; Salje, Jeanne 分享 收藏 Insights into Platypus Population Structure and History from Whole-Genome Sequencing从全基因组测序洞察鸭嘴兽种群结构和历史Martin, Hilary C.; Batty, Elizabeth M.; Hussin, Julie; Westall, Portia; Daish, Tasman; Kolomyjec, Stephen; Piazza, Paolo; Bowden, Rory; Hawkins, Margaret; Grant, Tom; Moritz, Craig; Grutzner, Frank; Gongora, Jaime; Donnelly, Peter 分享 收藏 A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disabilityDavies, Benjamin; Brown, Laurence A.; Cais, Ondrej; Watson, Jake; Clayton, Amber J.; Chang, Veronica T.; Biggs, Daniel; Preece, Christopher; Hernandez-Pliego, Polinka; Krohn, Jon; Bhomra, Amarjit; Twigg, Stephen R. F.; Rimmer, Andrew; Kanapin, Alexander; Sen, Arjune; Zaiwalla, Zenobia; McVean, Gil; Foster, Russell; Donnelly, Peter; Taylor, Jenny C.; Blair, Edward; Nutt, David; Aricescu, A. Radu; Greger, Ingo H.; Peirson, Stuart N.; Flint, Jonathan; Martin, Hilary C. 分享 收藏 An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans欧洲人2型糖尿病的扩展全基因组关联研究Scott, Robert A.; Scott, Laura J.; Maegi, Reedik; Marullo, Letizia; Gaulton, Kyle J.; Kaakinen, Marika; Pervjakova, Natalia; Pers, Tune H.; Johnson, Andrew D.; Eicher, John D.; Jackson, Anne U.; Ferreira, Teresa; Lee, Yeji; Ma, Clement; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Qi, Lu; Van Zuydam, Natalie R.; Mahajan, Anubha; Chen, Han; Almgren, Peter; Voight, Ben F.; Grallert, Harald; Mueller-Nurasyid, Martina; Ried, Janina S.; Rayner, Nigel W.; Robertson, Neil; Karssen, Lennart C.; Van Leeuwen, Elisabeth M.; Willems, Sara M.; Fuchsberger, Christian; Kwan, Phoenix; Teslovich, Tanya M.; Chanda, Pritam; Li, Man; Lu, Yingchang; Dina, Christian; Thuillier, Dorothee; Yengo, Loic; Jiang, Longda; Sparso, Thomas; Kestler, Hans A.; Chheda, Himanshu; Eisele, Lewin; Gustafsson, Stefan; Franberg, Mattias; Strawbridge, Rona J.; Benediktsson, Rafn; Hreidarsson, Astradur B.; Kong, Augustine; Sigurdsson, Gunnar; Kerrison, Nicola D.; Luan, Jian'an; Liang, Liming; Meitinger, Thomas; Roden, Michael; Thorand, Barbara; Esko, Tonu; Mihailov, Evelin; Fox, Caroline; Liu, Ching-Ti; Rybin, Denis; Isomaa, Bo; Lyssenko, Valeriya; Tuomi, Tiinamaija; Couper, David J.; Pankow, James S.; Grarup, Niels; Have, Christian T.; Jorgensen, Marit E.; Jorgensen, Torben; Linneberg, Allan; Cornelis, Marilyn C.; Van Dam, Rob M.; Hunter, David J.; Kraft, Peter; Sun, Qi; Edkins, Sarah; Owen, Katharine R.; Perry, John R. B.; Wood, Andrew R.; Zeggini, Eleftheria; Tajes-Fernandes, Juan; Abecasis, Goncalo R.; Bonnycastle, Lori L.; Chines, Peter S.; Stringham, Heather M.; Koistinen, Heikki A.; Kinnunen, Leena; Sennblad, Bengt; Muehleisen, Thomas W.; Noethen, Markus M.; Pechlivanis, Sonali; Baldassarre, Damiano; Gertow, Karl; Humphries, Steve E.; Tremoli, Elena; Klopp, Norman; Meyer, Julia; Steinbach, Gerald; Wennauer, Roman; Eriksson, Johan G.; Mannisto, Satu; Peltonen, Leena; Tikkanen, Emmi; Charpentier, Guillaume; Eury, Elodie; Lobbens, Stephane; Gigante, Bruna; Leander, Karin; McLeod, Olga; Bottinger, Erwin P.; Gottesman, Omri; Ruderfer, Douglas; Blueher, Matthias; Kovacs, Peter; Tonjes, Anke; Maruthur, Nisa M.; Scapoli, Chiara; Erbel, Raimund; Joeckel, Karl-Heinz; Moebus, Susanne; De Faire, Ulf; Hamsten, Anders; Stumvoll, Michael; Deloukas, Panagiotis; Donnelly, Peter J.; Frayling, Timothy M.; Hattersley, Andrew T.; Ripatti, Samuli; Salomaa, Veikko; Pedersen, Nancy L.; Boehm, Bernhard O.; Bergman, Richard N.; Collins, Francis S.; Mohlke, Karen L.; Tuomilehto, Jaakko; Hansen, Torben; Pedersen, Oluf; Barroso, Ines; Lannfelt, Lars; Ingelsson, Erik; Lind, Lars; Lindgren, Cecilia M.; Cauchi, Stephane; Froguel, Philippe; Loos, Ruth J. F.; Balkau, Beverley; Boeing, Heiner; Franks, Paul W.; Gurrea, Aurelio Barricarte; Palli, Domenico; Van der Schouw, Yvonne T.; Altshuler, David; Groop, Leif C.; Langenberg, Claudia; Wareham, Nicholas J.; Sijbrands, Eric; Van Duijn, Cornelia M.; Florez, Jose C.; Meigs, James B.; Boerwinkle, Eric; Gieger, Christian; Strauch, Konstantin; Metspalu, Andres; Morris, Andrew D.; Palmer, Colin N. A.; Hu, Frank B.; Thorsteinsdottir, Unnur; Stefansson, Kari; Dupuis, Josee; Morris, Andrew P.; Boehnke, Michael; McCarthy, Mark I.; Prokopenko, Inga 分享 收藏 A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk在芬兰人群中富集的低频失活AKT2变体与空腹胰岛素水平和2型糖尿病风险相关Manning, Alisa; Highland, Heather M.; Gasser, Jessica; Sim, Xueling; Tukiainen, Taru; Fontanillas, Pierre; Grarup, Niels; Rivas, Manuel A.; Mahajan, Anubha; Locke, Adam E.; Cingolani, Pablo; Pers, Tune H.; Vinuela, Ana; Brown, Andrew A.; Wu, Ying; Flannick, Jason; Fuchsberger, Christian; Gamazon, Eric R.; Gaulton, Kyle J.; Im, Hae Kyung; Teslovich, Tanya M.; Blackwell, Thomas W.; Bork-Jensen, Jette; Burtt, Noel P.; Chen, Yuhui; Green, Todd; Hartl, Christopher; Kang, Hyun Min; Kumar, Ashish; Ladenvall, Claes; Ma, Clement; Moutsianas, Loukas; Pearson, Richard D.; Perry, John R. B.; Rayner, N. William; Robertson, Neil R.; Scott, Laura J.; van de Bunt, Martijn; Eriksson, Johan G.; Jula, Antti; Koskinen, Seppo; Lehtimaki, Terho; Palotie, Aarno; Raitakari, Olli T.; Jacobs, Suzanne B. R.; Wessel, Jennifer; Chu, Audrey Y.; Scott, Robert A.; Goodarzi, Mark O.; Blancher, Christine; Buck, Gemma; Buck, David; Chines, Peter S.; Gabriel, Stacey; Gjesing, Anette P.; Groves, Christopher J.; Hollensted, Mette; Huyghe, Jeroen R.; Jackson, Anne U.; Jun, Goo; Justesen, Johanne Marie; Mangino, Massimo; Murphy, Jacquelyn; Neville, Matt; Onofrio, Robert; Small, Kerrin S.; Stringham, Heather M.; Trakalo, Joseph; Banks, Eric; Carey, Jason; Carneiro, Mauricio O.; DePristo, Mark; Farjoun, Yossi; Fennell, Timothy; Goldstein, Jacqueline I.; Grant, George; de Angelis, Martin Hrabe; Maguire, Jared; Neale, Benjamin M.; Poplin, Ryan; Purcell, Shaun; Schwarzmayr, Thomas; Shakir, Khalid; Smith, Joshua D.; Strom, Tim M.; Wieland, Thomas; Lindstrom, Jaana; Brandslund, Ivan; Christensen, Cramer; Surdulescu, Gabriela L.; Lakka, Timo A.; Doney, Alex S. 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Y.; Bowden, Donald W.; Freedman, Barry I.; Esko, Tonu; Magi, Reedik; Milani, Lili; Mihailov, Evelin; Metspalu, Andres; Narisu, Narisu; Kinnunen, Leena; Bonnycastle, Lori L.; Swift, Amy; Pasko, Dorota; Wood, Andrew R.; Fadista, Joao; Pollin, Toni I.; Barzilai, Nir; Atzmon, Gil; Glaser, Benjamin; Thorand, Barbara; Strauch, Konstantin; Peters, Annette; Roden, Michael; Mueller-Nurasyid, Martina; Liang, Liming; Kriebel, Jennifer; Illig, Thomas; Grallert, Harald; Gieger, Christian; Meisinger, Christa; Lannfelt, Lars; Musani, Solomon K.; Griswold, Michael; Taylor, Herman A., Jr.; Wilson, Gregory, Sr.; Correa, Adolfo; Oksa, Heikki; Scott, William R.; Afzal, Uzma; Tan, Sian-Tsung; Loh, Marie; Chambers, John C.; Sehmi, Jobanpreet; Kooner, Jaspal Singh; Lehne, Benjamin; Cho, Yoon Shin; Lee, Jong-Young; Han, Bok-Ghee; Karajamaki, Annemari; Qi, Qibin; Qi, Lu; Huang, Jinyan; Hu, Frank B.; Melander, Olle; Orho-Melander, Marju; Below, Jennifer E.; Aguilar, David; Wong, Tien Yin; Liu, Jianjun; Khor, Chiea-Chuen; Chia, Kee Seng; Lim, Wei Yen; Cheng, Ching-Yu; Chan, Edmund; Tai, E. Shyong; Aung, Tin; Linneberg, Allan; Isomaa, Bo; Meitinger, Thomas; Tuomi, Tiinamaija; Hakaste, Liisa; Kravic, Jasmina; Jorgensen, Marit E.; Lauritzen, Torsten; Deloukas, Panos; Stirrups, Kathleen E.; Owen, Katharine R.; Farmer, Andrew J.; Frayling, Timothy M.; O'Rahilly, Stephen P.; Walker, Mark; Levy, Jonathan C.; Hodgkiss, Dylan; Hattersley, Andrew T.; Kuulasmaa, Teemu; Stancakova, Alena; Barroso, Ines; Bharadwaj, Dwaipayan; Chan, Juliana; Chandak, Giriraj R.; Daly, Mark J.; Donnelly, Peter J.; Ebrahim, Shah B.; Elliott, Paul; Fingerlin, Tasha; Froguel, Philippe; Hu, Cheng; Jia, Weiping; Ma, Ronald C. W.; McVean, Gilean; Park, Taesung; Prabhakaran, Dorairaj; Sandhu, Manjinder; Scott, James; Sladek, Rob; Tandon, Nikhil; Teo, Yik Ying; Zeggini, Eleftheria; Watanabe, Richard M.; Koistinen, Heikki A.; Kesaniemi, Y. Antero; Uusitupa, Matti; Spector, Timothy D.; Salomaa, Veikko; Rauramaa, Rainer; Palmer, Colin N. A.; Prokopenko, Inga; Morris, Andrew D.; Bergman, Richard N.; Collins, Francis S.; Lind, Lars; Ingelsson, Erik; Tuomilehto, Jaakko; Karpe, Fredrik; Groop, Leif; Jorgensen, Torben; Hansen, Torben; Pedersen, Oluf; Kuusisto, Johanna; Abecasis, GonOalo; Bell, Graeme I.; Blangero, John; Cox, Nancy J.; Duggirala, Ravindranath; Seielstad, Mark; Wilson, James G.; Dupuis, Josee; Ripatti, Samuli; Hanis, Craig L.; Florez, Jose C.; Mohlke, Karen L.; Meigs, James B.; Laakso, Markku; Morris, Andrew P.; Boehnke, Michael; Altshuler, David; McCarthy, Mark I.; Gloyn, Anna L.; Lindgren, Cecilia M. 分享 收藏 分享 收藏 
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