David R. Beier - Publications, H-index & Citations

David R. Beier

Harvard University

64H指数

243论文数

1.8W被引数

收录论文 49

发表时间

Inhibition of Hedgehog signaling does not mitigate polycystic kidney disease severity in a Pkd1 mutant mouse model 抑制Hedgehog信号通路并不能减轻Pkd1突变小鼠模型中多囊肾病的严重程度。

JOURNAL OF CELL SCIENCE

IF3.6

2025-10-01

PREAI

Gombart, Sean K.; Houghtaling, Scott; Ho, Tzu-Hua; Beier, David R.

Centriolar protein PIBF1 is required for craniofacial and forebrain development 中心粒蛋白PIBF1对于颅面和前脑发育是必需的。

Developmental Biology

IF2.1

2025-08-05

PREAI

Lylyan Pimentel; Seungshin Ha; Yanfen Yang; Kim Cochran; Ching-Fang Chang; Scott Houghtaling; Sean K. Gombart; David R. Beier; Samantha A. Brugmann

Mammalian Organ Regeneration In Spiny Mice

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

IF7.4

2022-05-01

PREAI

Okamura, Daryl M.; Nguyen, Elizabeth D.; Collins, Sarah J.; Yoon, Kevin; Gere, Joshua B.; Beier, David R.; Majesky, Mark W.

Differential requirements of tubulin genes in mammalian forebrain development

PLOS GENETICS

IF3.7

2019-08-06

OAAI

Bittermann, Elizabeth; Abdelhamed, Zakia; Liegel, Ryan P.; Menke, Chelsea; Timms, Andrew; Beier, David R.; Stottmann, Rolf W.

Loss of function of Colgant1 disrupts collagen post-translationa modification and causes musculoskeletal defects

DISEASE MODELS & MECHANISMS

IF3.3

2019-06-17

OAAI

Geister, Krista A.; Lopez-Jimenez, Alberto Jose; Houghtaling, Scott; Ho, Tzu-Hua; Vanacore, Roberto; Beier, David R.

Applicability of the Mutation-Selection Balance Model to Population Genetics of Heterozygous Protein-Truncating Variants in Humans

MOLECULAR BIOLOGY AND EVOLUTION

IF5.3

2019-04-19

OAAI

Weghorn, Donate; Balick, Daniel J.; Cassa, Christopher; Kosmicki, Jack A.; Daly, Mark J.; Beier, David R.; Sunyaev, Shamil R.

Reply to 'Selective effects of heterozygous protein-truncating variants'对 “杂合蛋白截短变异的选择性效应” 的答复

NATURE GENETICS

IF31.8

2018-11-26

OAAI

Cassa, Christopher A.; Weghorn, Donate; Balick, Daniel J.; Jordan, Daniel M.; Nusinow, David; Samocha, Kaitlin E.; O'Donnell-Luria, Anne; MacArthur, Daniel G.; Daly, Mark J.; Beier, David R.; Sunyaev, Shamil R.

A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice

DEVELOPMENT

IF3.6

2018-01-09

OAAI

Abdelhamed, Zakia; Vuong, Shawn M.; Hill, Lauren; Shula, Crystal; Timms, Andrew; Beier, David; Campbell, Kenneth; Mangano, Francesco T.; Stottmann, Rolf W.; Goto, June

Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping

DISEASE MODELS & MECHANISMS

IF3.3

2017-07-01

OAAI

Strassman, Alexander; Schnuetgen, Frank; Dai, Qi; Jones, Jennifer C.; Gomez, Angela C.; Pitstick, Lenore; Holton, Nathan E.; Moskal, Russell; Leslie, Erin R.; von Melchner, Harald; Beier, David R.; Bjork, Bryan C.

ZIKA Halting Zika's resurgence with new rapid tests for the virus

BMJ-BRITISH MEDICAL JOURNAL

IF42.7

2017-05-31

PREAI

Dhillon, Ranu S.; Srikrishna, Devabhaktuni; Beier, David

Estimating the selective effects of heterozygous protein-truncating variants from human exome data 从人类外显子组数据估计杂合蛋白截短变体的选择性作用

NATURE GENETICS

IF31.8

2017-04-03

102

OAAI

Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis

HUMAN MOLECULAR GENETICS

IF3.2

2016-04-05

OAAI

Husson, Herve; Moreno, Sarah; Smith, Laurie A.; Smith, Mandy M.; Russo, Ryan J.; Pitstick, Rose; Sergeev, Mikhail; Ledbetter, Steven R.; Bukanov, Nikolay O.; Lane, Monica; Zhang, Kate; Billot, Katy; Carlson, George; Shah, Jagesh; Meijer, Laurent; Beier, David R.; Ibraghimov-Beskrovnaya, Oxana

Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome

DISEASE MODELS & MECHANISMS

IF3.3

2016-01-01

OAAI

Jacobs, Damon T.; Silva, Luciane M.; Allard, Bailey A.; Schonfeld, Michael P.; Chatterjee, Anindita; Talbott, George C.; Beier, David R.; Tran, Pamela V.

Variant mapping and mutation discovery in inbred mice using next-generation sequencing

BMC GENOMICS

IF3.7

2015-11-09

OAAI

Gallego-Llamas, Jabier; Timms, Andrew E.; Geister, Krista A.; Lindsay, Anna; Beier, David R.

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2015-03-24

199

OAAI

Pooler, Amy M.; Polydoro, Manuela; Maury, Eduardo A.; Nicholls, Samantha B.; Reddy, Snigdha M.; Wegmann, Susanne; William, Christopher; Saqran, Lubna; Cagsal-Getkin, Ozge; Pitstick, Rose; Beier, David R.; Carlson, George A.; Spires-Jones, Tara L.; Hyman, Bradley T.

ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning

NATURE COMMUNICATIONS

IF15.7

2015-01-20

OAAI

Czarnecki, Peter G.; Gabriel, George C.; Manning, Danielle K.; Sergeev, Mikhail; Lemke, Kristi; Klena, Nikolai T.; Liu, Xiaoqin; Chen, Yu; Li, You; Agustin, Jovenal T. San; Garnaas, Maija K.; Francis, Richard J.; Tobita, Kimimasa; Goessling, Wolfram; Pazour, Gregory J.; Lo, Cecilia W.; Beier, David R.; Shah, Jagesh V.

Downregulating Hedgehog Signaling Reduces Renal Cystogenic Potential of Mouse Models

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IF9.4

2014-10-01

OAAI

Tran, Pamela V.; Talbott, George C.; Turbe-Doan, Annick; Jacobs, Damon T.; Schonfeld, Michael P.; Silva, Luciane M.; Chatterjee, Anindita; Prysak, Mary; Allard, Bailey A.; Beier, David R.

NEK8 Links the ATR-Regulated Replication Stress Response and S Phase CDK Activity to Renal Ciliopathies

MOLECULAR CELL

IF16.6

2013-08-01

115

OAAI

Choi, Hyo Jei Claudia; Lin, Jia-Ren; Vannier, Jean-Baptiste; Slaats, Gisela G.; Kile, Andrew C.; Paulsen, Renee D.; Manning, Danielle K.; Beier, David R.; Giles, Rachel H.; Boulton, Simon J.; Cimprich, Karlene A.

A mutation in Tubb2b, a human polymicrogyria gene, leads to lethality and abnormal cortical development in the mouse

HUMAN MOLECULAR GENETICS

IF3.2

2013-05-31

OAAI

Stottmann, R. W.; Donlin, M.; Hafner, A.; Bernard, A.; Sinclair, D. A.; Beier, D. R.

Loss of the Ciliary Kinase Nek8 Causes Left-Right Asymmetry Defects

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IF9.4

2013-01-01

OAAI

Manning, Danielle K.; Sergeev, Mikhail; van Heesbeen, Roy G.; Wong, Michael D.; Oh, Jin-Hee; Liu, Yan; Henkelman, R. Mark; Drummond, Iain; Shah, Jagesh V.; Beier, David R.

研究方向