Themistocles L. Assimes

va palo alto health care system

H指数:99

被引数:6.9万

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Ancestry-specific DNA methylation signatures of smoking and associations with atherosclerotic cardiovascular disease risk: findings from the Million Veteran Program

吸烟的祖先特异性DNA甲基化特征及其与动脉粥样硬化性心血管疾病风险的关系：百万军人计划的研究结果

Genome Medicine

IF11.2

2026-09-100

Linkage disequilibrium and allelic heterogeneity explain variation in coronary artery disease risk at 9p21 across populations and reduced effect in Africans

连锁不平衡和等位基因异质性解释了9p21位点多个人群中冠状动脉疾病风险的差异以及非洲人群中的减弱效应

American Journal of Human Genetics

IF8.1

2026-07-010

PRE

Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations

不同人群1,158,017个体血脂的全外显子组关联研究

Nature Genetics

IF29

2026-05-250

OAAI

Satoshi Koyama; Zhi Yu; Seung Hoan Choi; Sean J. Jurgens; Margaret Sunitha Selvaraj; Derek Klarin; Jennifer E. Huffman; Shoa L. Clarke; Selena K. Zhang; Michael N. Trinh; Akshaya Ravi; Jacqueline S. Dron; Catherine Spinks; Ida Surakka; Aarushi Bhatnagar; Kim Lannery; Whitney Hornsby; Scott M. Damrauer; Kyong-Mi Chang; Julie A. Lynch; Themistocles L. Assimes; Philip S. Tsao; Daniel J. Rader; Kelly Cho; Gina M. Peloso; Patrick T. Ellinor; Yan V. Sun; Peter W. F. Wilson; Pradeep Natarajan

Causal relationship between epigenetic markers and type 2 diabetes in West African populations: a Mendelian randomisation analysis

西非人群中表观遗传标记与2型糖尿病的因果关系：一项孟德尔随机化分析

Diabetologia

IF10.2

2026-04-240

OAAI

Simulated patient systems powered by large language model-based AI agents offer potential for transforming medical education

基于大型语言模型AI代理的模拟病人系统为医学教育转型提供了潜力

Communications Medicine

IF6.3

2025-12-190

OAAI

An Exploratory Study for Proteomic-Based Markers of Joint Pain and Chronic Back Pain

基于蛋白质组学标记物的关节疼痛和慢性背痛的探索性研究

European Journal of Pain

IF3.4

2025-10-310

OAAI

Polygenic risk score for type 2 diabetes shows context-dependent effects across populations

2型糖尿病的多基因风险评分在人群中显示出依赖情境的影响

Nature Communications

IF15.7

2025-10-010

OAAI

Boya Guo; Yanwei Cai; Daeeun Kim; Roelof A. J. Smit; Zhe Wang; Kruthika R. Iyer; Austin T. Hilliard; Jeffrey Haessler; Ran Tao; K. Alaine Broadaway; Yujie Wang; Nikita Pozdeyev; Frederik F. Stæger; Chaojie Yang; Brett Vanderwerff; Amit D. Patki; Lauren Stalbow; Meng Lin; Nicholas Rafaels; Jonathan Shortt; Laura Wiley; Maggie Stanislawski; Jack Pattee; Lea Davis; Peter S. Straub; Megan M. Shuey; Nancy J. Cox; Nanette R. Lee; Marit E. Jørgensen; Peter Bjerregaard; Christina Larsen; Torben Hansen; Ida Moltke; James B. Meigs; Daniel O. Stram; Xianyong Yin; Xiang Zhou; Kyong-Mi Chang; Shoa L. Clarke; Rodrigo Guarischi-Sousa; Joanna Lankester; Philip S. Tsao; Steven Buyske; Mariaelisa Graff; Laura M. Raffield; Quan Sun; Lynne R. Wilkens; Christopher S. Carlson; Charles B. Easton; Simin Liu; JoAnn E. Manson; Loïc L. Marchand; Christopher A. Haiman; Karen L. Mohlke; Penny Gordon-Larsen; Anders Albrechtsen; Michael Boehnke; Stephen S. Rich; Ani Manichaikul; Jerome I. Rotter; Noha A. Yousri; Ryan M. Irvin; Chris Gignoux; Kari E. North; Ruth J. F. Loos; Themistocles L. Assimes; Ulrike Peters; Charles Kooperberg; Sridharan Raghavan; Heather M. Highland; Burcu F. Darst

Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems

系统时代：一种单次血液甲基化检测方法，用于量化11个生理系统中的衰老异质性

Nature Aging

IF19.4

2025-09-150

PRE

CYP2C19 Polymorphisms and Clinical Outcomes Following Percutaneous Coronary Intervention in the Million Veteran Program

CYP2C19多态性与经皮冠状动脉介入治疗后百万退伍军人计划中的临床结局

Clinical Pharmacology & Therapeutics

IF5.5

2025-06-030

OAAI

Bidirectional associations of zinc supplement intake with biological ageing interacted by metabolic equivalent of task: A large-scale population-based Biobank study

锌补充剂摄入与生物衰老的双向关联：受代谢当量调节的大规模人群生物银行研究

Clinical Nutrition

IF7.4

2025-05-020

Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk

罕见的有害CCR2变异与较低的生命周期心血管风险相关

GENOME MEDICINE

IF11.2

2025-03-211

Georgakis, Marios K.; Malik, Rainer; Bounkari, Omar El; Hasbani, Natalie R.; Li, Jiang; Huffman, Jennifer E.; Shakt, Gabrielle; Tack, Reinier W. P.; Kimball, Tamara N.; Asare, Yaw; Morrison, Alanna C.; Tsao, Noah L.; Judy, Renae; Mitchell, Braxton D.; Xu, Huichun; Montasser, May E.; Do, Ron; Kenny, Eimear E.; Loos, Ruth J. F.; Terry, James G.; Carr, John Jeffrey; Bis, Joshua C.; Psaty, Bruce M.; Longstreth, W. T.; Young, Kendra A.; Lutz, Sharon M.; Cho, Michael H.; Broome, Jai; Khan, Alyna T.; Wang, Fei Fei; Heard-Costa, Nancy; Seshadri, Sudha; Vasan, Ramachandran S.; Palmer, Nicholette D.; Freedman, Barry I.; Bowden, Donald W.; Yanek, Lisa R.; Kral, Brian G.; Becker, Lewis C.; Peyser, Patricia A.; Bielak, Lawrence F.; Ammous, Farah; Carson, April P.; Hall, Michael E.; Raffield, Laura M.; Rich, Stephen S.; Post, Wendy S.; Tracy, Russel P.; Taylor, Kent D.; Guo, Xiuqing; Mahaney, Michael C.; Curran, Joanne E.; Blangero, John; Clarke, Shoa L.; Haessler, Jeffrey W.; Hu, Yao; Assimes, Themistocles L.; Kooperberg, Charles; Bernhagen, Juergen; Anderson, Christopher D.; Damrauer, Scott M.; Zand, Ramin; Rotter, Jerome I.; de Vries, Paul S.; Dichgans, Martin

Premorbid predictors of death at initial presentation of coronary heart disease in the Women's Health Initiative study

AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY

IF5.9

2025-03-010

Insights from the largest diverse ancestry sex-specific disease map for genetically predicted height

基于遗传预测身高所得的最大异质性祖先别特异性疾病图谱的见解

NPJ GENOMIC MEDICINE

IF4.8

2025-02-270

Papadopoulou, A.; Litkowski, E. M.; Graff, M.; Wang, Z.; Smit, R. A. J.; Chittoor, G.; Dinsmore, I.; Josyula, N. S.; Lin, M.; Shortt, J.; Zhu, W.; Vedantam, S. L.; Yengo, L.; Wood, A. R.; Berndt, S. I.; Holm, I. A.; Mentch, F. D.; Hakonarson, H.; Kiryluk, K.; Weng, C.; Jarvik, G. P.; Crosslin, D.; Carrell, D.; Kullo, I. J.; Dikilitas, O.; Hayes, M. G.; Wei, W. Q.; Edwards, D. R. V.; Assimes, T. L.; Hirschhorn, J. N.; Below, J. E.; Gignoux, C. R.; Justice, A. E.; Loos, R. J. F.; Sun, Y. V.; Raghavan, S.; Deloukas, P.; North, K. E.; Marouli, E.

Unveiling the Genetic Landscape of Coronary Artery Disease Through Common and Rare Structural Variants

通过常见和罕见的结构变异揭示冠状动脉疾病的遗传景观

JOURNAL OF THE AMERICAN HEART ASSOCIATION

IF5.3

2025-02-181

OAAI

Iyer, Kruthika R.; Clarke, Shoa L.; Guarischi-Sousa, Rodrigo; Gjoni, Ketrin; Heath, Adam S.; Young, Erica P.; Stitziel, Nathan O.; Laurie, Cecelia; Broome, Jai G.; Khan, Alyna T.; Lewis, Joshua P.; Xu, Huichun; Montasser, May E.; Ashley, Kellan E.; Hasbani, Natalie R.; Boerwinkle, Eric; Morrison, Alanna C.; Chami, Nathalie; Do, Ron; Rocheleau, Ghislain; Lloyd-Jones, Donald M.; Lemaitre, Rozenn N.; Bis, Joshua C.; Floyd, James S.; Kinney, Gregory L.; Bowden, Donald W.; Palmer, Nicholette D.; Benjamin, Emelia J.; Nayor, Matthew; Yanek, Lisa R.; Kral, Brian G.; Becker, Lewis C.; Kardia, Sharon L. R.; Smith, Jennifer A.; Bielak, Lawrence F.; Norwood, Arnita F.; Min, Yuan-I; Carson, April P.; Post, Wendy S.; Rich, Stephen S.; Herrington, David; Guo, Xiuqing; Taylor, Kent D.; Manson, JoAnn E.; Franceschini, Nora; Pollard, Katherine S.; Mitchell, Braxton D.; Loos, Ruth J. F.; Fornage, Myriam; Hou, Lifang; Psaty, Bruce M.; Young, Kendra A.; Regan, Elizabeth A.; Freedman, Barry I.; Vasan, Ramachandran S.; Levy, Daniel; Mathias, Rasika A.; Peyser, Patricia A.; Raffield, Laura M.; Kooperberg, Charles; Reiner, Alex P.; Rotter, Jerome I.; Jun, Goo; de Vries, Paul S.; Assimes, Themistocles L.

Associations between accurate measures of adiposity and fitness, blood proteins, and insulin sensitivity among South Asians and Europeans

FRONTIERS IN ENDOCRINOLOGY

IF4.6

2025-01-200

OAAI

Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries

全基因组关联分析确定不同祖先年龄相关性黄斑变性的不同遗传结构

NATURE GENETICS

IF31.8

2024-12-020

PRE

Gorman, Bryan R.; Voloudakis, Georgios; Igo, Robert P., Jr.; Kinzy, Tyler; Halladay, Christopher W.; Bigdeli, Tim B.; Zeng, Biao; Venkatesh, Sanan; Bailey, Jessica N. Cooke; Crawford, Dana C.; Markianos, Kyriacos; Dong, Frederick; Schreiner, Patrick A.; Zhang, Wen; Hadi, Tamer; Anger, Matthew D.; Stockwell, Amy; Melles, Ronald B.; Yin, Jie; Choquet, Helene; Kaye, Rebecca; Patasova, Karina; Patel, Praveen J.; Yaspan, Brian L.; Jorgenson, Eric; Hysi, Pirro G.; Lotery, Andrew J.; Gaziano, J. Michael; Tsao, Philip S.; Fliesler, Steven J.; Sullivan, Jack M.; Greenberg, Paul B.; Wu, Wen-Chih; Assimes, Themistocles L.; Pyarajan, Saiju; Roussos, Panos; Peachey, Neal S.; Iyengar, Sudha K.

Associations of blood lipids and LDL cholesterol lowering drug-targets with colorectal cancer risk: a Mendelian randomisation study

BRITISH JOURNAL OF CANCER

IF6.8

2024-11-230