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Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma Smith, Nicola J.; Reddin, Ian; Policelli, Paige; Oh, Sunwoo; Zainal, Nur; Howes, Emma; Jenkins, Benjamin; Tracy, Ian; Edmond, Mark; Sharpe, Benjamin; Amendra, Damian; Zheng, Ke; Egawa, Nagayasu; Doorbar, John; Rao, Anjali; Mahadevan, Sangeetha; Carpenter, Michael A.; Harris, Reuben S.; Ali, Simak; Hanley, Christopher; Buisson, Remi; King, Emma; Thomas, Gareth J.; Fenton, Tim R. 分享 收藏
Induction of the TEAD Coactivator VGLL1 by Estrogen Receptor-Targeted Therapy Drives Resistance in Breast Cancer Gemma, Carolina; Lai, Chun-Fui; Singh, Anup K.; Belfiore, Antonino; Portman, Neil; Milioli, Heloisa Z.; Periyasamy, Manikandan; Raafat, Sara; Nicholls, Alyssa J.; Davies, Claire M.; Patel, Naina R.; Simmons, Georgia M.; Fan, Hailing; Nguyen, Van T. M.; Magnani, Luca; Rakha, Emad; Martin, Lesley-Ann; Lim, Elgene; Coombes, R. Charles; Pruneri, Giancarlo; Buluwela, Laki; Ali, Simak 分享 收藏
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PO2-24-04: Exploring the role and therapeutic potential of Ubiquitin Specific Peptidase 11 (USP11) in estrogen receptor positive breast cancer Moore, Rachel; Blumel, Anna; Ward, Elspeth; Sainsbury, Elizabeth; Conroy, Emer; O'Brien, Fergal; Curtin, Caroline; Ali, Simak; McCarthy, Helen; Gallagher, William; O'Connor, Darran 分享 收藏
Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling De Marchi, Tommaso; Lai, Chun-Fui; Simmons, Georgia M.; Goldsbrough, Isabella; Harrod, Alison; Lam, Thai; Buluwela, Lakjaya; Kjellstrom, Sven; Brueffer, Christian; Saal, Lao H.; Malmstrom, Johan; Ali, Simak; Nimeus, Emma 分享 收藏
The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer (vol 128, pg 2326, 2023) Constantin, Theodora A.; Varela-Carver, Anabel; Greenland, Kyle K.; de Almeida, Gilberto Serrano; Olden, Ellen; Penfold, Lucy; Ang, Simon; Ormrod, Alice; Leach, Damien A.; Lai, Chun-Fui; Ainscow, Edward K.; Bahl, Ash K.; Carling, David; Fuchter, Matthew J.; Ali, Simak; Bevan, Charlotte L. 分享 收藏
Selective inhibition of CDK9 in triple negative breast cancer Mustafa, Ebtihal H.; Laven-Law, Geraldine; Kikhtyak, Zoya; Nguyen, Van; Ali, Simak; Pace, Alex A.; Iggo, Richard; Kebede, Alemwork; Noll, Ben; Wang, Shudong; Winter, Jean M.; Dwyer, Amy R.; Tilley, Wayne D.; Hickey, Theresa E. 分享 收藏
Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition Wilson, Gemma A.; Vuina, Karla; Sava, Georgina; Huard, Caroline; Meneguello, Leticia; Coulombe-Huntington, Jasmin; Bertomeu, Thierry; Maizels, Rory J.; Lauring, Josh; Kriston-Vizi, Janos; Tyers, Mike; Ali, Simak; Bertoli, Cosetta; de Bruin, Robertus A. M. 分享 收藏
Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib (vol 14, 4444, 2023) Coombes, R. C.; Howell, Sacha; Lord, Simon R.; Kenny, Laura; Mansi, Janine; Mitri, Zahi; Palmieri, Carlo; Chap, Linnea I.; Richards, Paul; Gradishar, William; Sardesai, Sagar; Melear, Jason; O'Shaughnessy, Joyce; Ward, Patrick; Chalasani, Pavani; Arkenau, Tobias; Baird, Richard D.; Jeselsohn, Rinath; Ali, Simak; Clack, Glen; Bahl, Ashwani; McIntosh, Stuart; Krebs, Matthew G. 分享 收藏
Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib Coombes, R. Charles; Howell, Sacha; Lord, Simon R.; Kenny, Laura; Mansi, Janine; Mitri, Zahi; Palmieri, Carlo; Chap, Linnea I.; Richards, Paul; Gradishar, William; Sardesai, Sagar; Melear, Jason; O'Shaughnessy, Joyce; Ward, Patrick; Chalasani, Pavani; Arkenau, Tobias; Baird, Richard D.; Jeselsohn, Rinath; Ali, Simak; Clack, Glen; Bahl, Ashwani; McIntosh, Stuart; Krebs, Matthew G. 分享 收藏
The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer Constantin, Theodora A.; Varela-Carver, Anabel; Greenland, Kyle K.; de Almeida, Gilberto Serrano; Olden, Ellen; Penfold, Lucy; Ang, Simon; Ormrod, Alice; Leach, Damien A.; Lai, Chun-Fui; Ainscow, Edward K.; Bahl, Ash K.; Carling, David; Fuchter, Matthew J.; Ali, Simak; Bevan, Charlotte L. 分享 收藏
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Genome engineering for estrogen receptor mutations reveals differential responses to anti-estrogens and new prognostic gene signatures for breast cancer Harrod, Alison; Lai, Chun-Fui; Goldsbrough, Isabella; Simmons, Georgia M.; Oppermans, Natasha; Santos, Daniela B.; Gyorffy, Balazs; Allsopp, Rebecca C.; Toghill, Bradley J.; Balachandran, Kirsty; Lawson, Mandy; Morrow, Christopher J.; Surakala, Manasa; Carnevalli, Larissa S.; Zhang, Pei; Guttery, David S.; Shaw, Jacqueline A.; Coombes, R. Charles; Buluwela, Lakjaya; Ali, Simak 分享 收藏
Shallow WGS of individual CTCs identifies actionable targets for informing treatment decisions in metastatic breast cancer Fernandez-Garcia, Daniel; Nteliopoulos, Georgios; Hastings, Robert K.; Rushton, Amelia; Page, Karen; Allsopp, Rebecca C.; Ambasager, Bana; Gleason, Kelly; Guttery, David S.; Ali, Simak; Coombes, R. Charles; Shaw, Jacqueline A. 分享 收藏
Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence 上皮-间质可塑性决定雌激素受体阳性乳腺癌休眠和上皮再转换驱动复发 Aouad, Patrick; Zhang, Yueyun; De Martino, Fabio; Stibolt, Celine; Ali, Simak; Ambrosini, Giovanna; Mani, Sendurai A.; Maggs, Kelly; Quinn, Hazel M.; Sflomos, George; Brisken, Cathrin 分享 收藏
ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation Li, Zheqi; McGinn, Olivia; Wu, Yang; Bahreini, Amir; Priedigkeit, Nolan M.; Ding, Kai; Onkar, Sayali; Lampenfeld, Caleb; Sartorius, Carol A.; Miller, Lori; Rosenzweig, Margaret; Cohen, Ofir; Wagle, Nikhil; Richer, Jennifer K.; Muller, William J.; Buluwela, Laki; Ali, Simak; Bruno, Tullia C.; Vignali, Dario A. A.; Fang, Yusi; Zhu, Li; Tseng, George C.; Gertz, Jason; Atkinson, Jennifer M.; Lee, Adrian, V; Oesterreich, Steffi 分享 收藏
Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer Baker, Simon C.; Mason, Andrew S.; Slip, Raphael G.; Skinner, Katie T.; Macdonald, Andrew; Masood, Omar; Harris, Reuben S.; Fenton, Tim R.; Periyasamy, Manikandan; Ali, Simak; Southgate, Jennifer 分享 收藏
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