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On-demand GLUT3 expression augments CAR T cell metabolic fitness and antitumor efficacy in preclinical models of glioblastoma 按需GLUT3表达增强CAR T细胞在胶质母细胞瘤临床前模型中的代谢适应性和抗肿瘤效果 Yamaguchi, Junya; Watanabe, Keisuke; Nakamura, Akihiro; Lin, Nina Yi-Tzu; Maeda, Sachi; Sugiyama, Daisuke; Kato, Shinichiro; Nagata, Akihito; Nishinakamura, Hitomi; Itahashi, Kota; Koyama, Shohei; Mizoguchi, Hiroyuki; Shiraki, Yukihiro; Enomoto, Atsushi; Ohka, Fumiharu; Motomura, Kazuya; Tsukada, Yuichiro; Ito, Masaaki; Maeda, Yuka; Ueda, Ryuzo; Natsume, Atsushi; Saito, Ryuta; Nishikawa, Hiroyoshi 分享 收藏
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KRAS mutations disrupt interactions between CD8+ T cells and antigen-presenting cells in the tumor microenvironment of biliary tract cancer KRAS突变破坏胆道肿瘤微环境中CD8+ T细胞与抗原呈递细胞之间的相互作用 Terasaki, Fumihiro; Kumagai, Shogo; Fukuda, Akito; Tanaka, Yosuke; Irie, Takuma; Ito, Sachiko; Yamada, Mihoko; Onoe, Shunsuke; Mizuno, Takashi; Kokuryo, Toshio; Koyama, Shohei; Karube, Kennosuke; Nishikawa, Hiroyoshi; Ebata, Tomoki 分享 收藏
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Phase I study on neoadjuvant combination immunotherapy with mogamulizumab and nivolumab for solid tumors I期研究：使用mogamulizumab和nivolumab联合新辅助免疫疗法治疗实体瘤 Jinushi, Koichi; Saito, Takuro; Kurose, Koji; Suzuki, Susumu; Kojima, Takashi; Takahara, Taishi; Makino, Tomoki; Ogawa, Tetsuya; Nishikawa, Hiroyoshi; Iida, Shinsuke; Nakajima, Jun; Doki, Yuichiro; Oka, Mikio; Ueda, Ryuzo; Wada, Hisashi 分享 收藏
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Sustained inhibition of CSF1R signaling augments antitumor immunity through inhibiting tumor-associated macrophages Sato, Takahiko; Sugiyama, Daisuke; Koseki, Jun; Kojima, Yasuhiro; Hattori, Satomi; Sone, Kazuki; Nishinakamura, Hitomi; Ishikawa, Tomohiro; Ishikawa, Yuichi; Kato, Takuma; Kiyoi, Hitoshi; Nishikawa, Hiroyoshi 分享 收藏
Identification of microenvironment features associated with primary resistance to anti-PD-1/PD-L1+antiangiogenesis in gastric cancer through spatial transcriptomics and plasma proteomics 通过空间转录组学和血浆蛋白质组学鉴定与胃癌anti-PD-1/PD-L1抗血管生成相关的微环境特征 Cousin, Sophie; Guegan, Jean-Philippe; Shitara, Kohei; Palmieri, Lola Jade; Metges, Jean Philippe; Pernot, Simon; Fukuoka, Shota; Koyama, Shohei; Nishikawa, Hiroyoshi; Bellera, Carine A.; Adenis, Antoine; Gomez-Roca, Carlos A.; Cassier, Philippe Alexandre; Hollebecque, Antoine; Cantarel, Coralie; Kind, Michele; Soubeyran, Isabelle; Vanhersecke, Lucile; Bessede, Alban; Italiano, Antoine 分享 收藏
An open label phase II study of lenvatinib with pembrolizumab and FLOT in the neoadjuvant and adjuvant treatment for patients with gastric and gastroesophageal junction adenocarcinoma (EPOC2001) 一项开放标签II期研究，评估lenvatinib联合pembrolizumab和FLOT在胃及胃食管结合部腺癌患者新辅助及辅助治疗中的应用（EPOC2001）。 Kawazoe, A.; Koyama, S.; Nakayama, I.; Wakabayashi, M.; Furuya, H.; Tsukamoto, K.; Tamura, H.; Ikeno, T.; Sato, A.; Kojima, M.; Kuwata, T.; Fujita, T.; Kinoshita, T.; Nishikawa, H.; Shitara, K. 分享 收藏
Three-year outcomes of preoperative chemoradiotherapy plus nivolumab in microsatellite stable and microsatellite instability-high locally advanced rectal cancer 术前放化疗联合nivolumab治疗微卫星稳定和微卫星不稳定高位局部晚期直肠癌的三年预后 Tsukada, Yuichiro; Bando, Hideaki; Inamori, Koji; Wakabayashi, Masashi; Togashi, Yosuke; Koyama, Shohei; Kotani, Daisuke; Yuki, Satoshi; Komatsu, Yoshito; Homma, Shigenori; Taketomi, Akinobu; Uemura, Mamoru; Kato, Takeshi; Fukui, Makoto; Nakamura, Naoki; Kojima, Motohiro; Kawachi, Hiroshi; Kirsch, Richard; Yoshida, Tsutomu; Sato, Akihiro; Nishikawa, Hiroyoshi; Ito, Masaaki; Yoshino, Takayuki 分享 收藏
Definitive chemoradiotherapy induces T-cell-inflamed tumor microenvironment in unresectable locally advanced esophageal squamous cell carcinoma 根治性放化疗诱导不可切除的局部晚期食管鳞状细胞癌的T细胞炎性肿瘤微环境 Habu, Takumi; Kumagai, Shogo; Bando, Hideaki; Fujisawa, Takeshi; Mishima, Saori; Kotani, Daisuke; Nakamura, Masaki; Hojo, Hidehiro; Sakashita, Shingo; Kinoshita, Takahiro; Yano, Tomonori; Mitsunaga, Shuichi; Nishikawa, Hiroyoshi; Koyama, Shohei; Kojima, Takashi 分享 收藏
On-Site Stimulation of Dendritic Cells by Cancer-Derived Extracellular Vesicles on a Core-Shell Nanowire Platform Zhang, Min; Ono, Miki; Kawaguchi, Shota; Iida, Mikiko; Chattrairat, Kunanon; Zhu, Zetao; Nagashima, Kazuki; Yanagida, Takeshi; Yamaguchi, Junya; Nishikawa, Hiroyoshi; Natsume, Atsushi; Baba, Yoshinobu; Yasui, Takao 分享 收藏
Prospective study on eribulin efficacy in advanced and metastatic breast cancer: changes in TGF-β compared to other standard chemotherapy agents (KBCSG-TR 2018, POTENTIAL) Nakayama, Takahiro; Yoshinami, Tersuhiro; Fujisawa, Fumie; Nishio, Minako; Yamanaka, Takashi; Yamashita, Toshinari; Oshiro, Chiya; Izui, Ayaka; Tomioka, Nobumoto; Maeda, Hideki; Shimoda, Masafumi; Shimazu, Kenzo; Tsuneizumi, Michiko; Matsunuma, Ryoichi; Bando, Hiroko; Ueda, Aya; Yasojima, Hiroyuki; Okada, Kumiko; Inoue, Kenichi; Kai, Yuichiro; Yoshidome, Katsuhide; Kawaguchi, Hidetoshi; Nagahashi, Masayuki; Oshima, Kazuteru; Kashiwagi, Shinichiro; Iwasa, Tsutomu; Taruno, Kanae; Tsuyuki, Shigeru; Tsukamoto, Fumine; Morimoto, Takashi; Kittaka, Nobuyoshi; Higuchi, Toru; Naito, Yoichi; Saita, Ryotaro; Nishikawa, Hiroyoshi; Sugiyama, Daisuke; Miyoshi, Yasuo; Uchida, Yohei; Yamada, Tomomi; Masuda, Norikazu 分享 收藏
CD106 in Tumor-Specific Exhausted CD8+ T Cells Mediates Immunosuppression by Inhibiting TCR Signaling Naoi, Yuto; Morinaga, Takao; Nagasaki, Joji; Ariyasu, Ryo; Ueda, Youki; Yamashita, Kazuo; Zhou, Wenhao; Kawashima, Shusuke; Kawase, Katsushige; Honobe-Tabuchi, Akiko; Ohnuma, Takehiro; Kawamura, Tatsuyoshi; Umeda, Yoshiyasu; Kawahara, Yu; Nakamura, Yasuhiro; Kiniwa, Yukiko; Yamasaki, Osamu; Fukushima, Satoshi; Kawazu, Masahito; Suzuki, Yutaka; Nishikawa, Hiroyoshi; Hanazawa, Toyoyuki; Ando, Mizuo; Inozume, Takashi; Togashi, Yosuke 分享 收藏
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Simultaneous activation of innate immune suppressive components impairs antitumor efficacy of immunotherapy against the innate immune system Nishinakamura, Hitomi; Shinya, Sayoko; Irie, Takuma; Sakihama, Shugo; Ioroi, Tadaaki; Naito, Takeo; Watanabe, Keisuke; Sugiyama, Daisuke; Tamiya, Motohiro; Yoshida, Tatsuya; Hase, Tetsunari; Yoshida, Takao; Karube, Kennosuke; Maeda, Yuka; Koyama, Shohei; Nishikawa, Hiroyoshi 分享 收藏
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