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H

Hiroshi Shiku

Mie University

74H指数
777论文数
2.2W被引数
收录论文 136
发表时间
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Introducing arginine residues into scFv in CAR-T cells shows promising antitumor effects将精氨酸残基引入CAR-T细胞中的scFv显示出有希望的抗肿瘤效果
errMolecular Therapy
IF12
err2025-12-09
err0
errOAAI
errShingo Maeta; Atsushi Fukunaga; Yuriko Egashira; Yasushi Akahori; Linan Wang; Naohiro Seo; Yusuke Atarashi; Daisuke Ejima; Hiroshi Fujiwara; Hiroshi Shiku
err分享
err收藏
Fast on-rates of chimeric antigen receptors enhance the sensitivity to peptide MHC via antigen rebinding (vol 300, 107651, 2024)
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-12-01
err0
errOAAI
errHiratsuka, Hiroyuki; Akahori, Yasushi; Maeta, Shingo; Egashira, Yuriko; Shiku, Hiroshi
err分享
err收藏
Decoding NY-ESO-1 TCR T cells: transcriptomic insights reveal dual mechanisms of tumor targeting in a melanoma murine xenograft model解码NY-ESO-1 TCR T细胞: 转录组学的见解揭示了黑色素瘤小鼠异种移植模型中肿瘤靶向的双重机制
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2024-11-26
err0
errOAAI
errAlsalloum, Alaa; Alrhmoun, Saleh; Perik-Zavosdkaia, Olga; Fisher, Marina; Volynets, Marina; Lopatnikova, Julia; Perik-Zavodskii, Roman; Shevchenko, Julia; Philippova, Julia; Solovieva, Olga; Zavjalov, Evgenii; Kurilin, Vasily; Shiku, Hiroshi; Silkov, Alexander; Sennikov, Sergey
err分享
err收藏
Fast on-rates of chimeric antigen receptors enhance the sensitivity to peptide MHC via antigen rebinding
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-09-01
err1
errOAAI
errHiratsuka, Hiroyuki; Akahori, Yasushi; Maeta, Shingo; Egashira, Yuriko; Shiku, Hiroshi
err分享
err收藏
Preclinical evaluation of a novel CAR-T therapy utilizing a scFv antibody highly specific to MAGE-A4p230-239/HLA-A*02:01 complex
errMOLECULAR THERAPY
IF12
err2024-03-01
err7
errOAAI
errWang, Linan; Matsumoto, Masahiro; Akahori, Yasushi; Seo, Naohiro; Shirakura, Kazuko; Kato, Takuma; Katsumoto, Yoichi; Miyahara, Yoshihiro; Shiku, Hiroshi
err分享
err收藏
Exhaustion, rather than lack of infiltration and persistence, of CAR-T cells hampers the efficacy of CAR-T therapy in an orthotopic PDAC xenograft model
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2024-01-01
err1
errOAAI
errTakeuchi, Yuta; Wang, Yizheng; Sasaki, Katsunori; Sato, Osamu; Tsuchikawa, Takahiro; Wang, Linan; Amaishi, Yasunori; Okamoto, Sachiko; Mineno, Junichi; Hirokawa, Yoshifumi; Hatanaka, Kanako C.; Hatanaka, Yutaka; Kato, Takuma; Shiku, Hiroshi; Hirano, Satoshi
err分享
err收藏
Phase I trial of NY-ESO-1 TCR-T cell therapy combined with nanoparticulate vaccine but without lymphodepletion for STS
errANNALS OF ONCOLOGY
IF65.4
err2023-11-01
err0
errOAAI
errIshihara, Mikiya; Nishida, Yoshihiro; Kitano, Shigehisa; Kawai, Akira; Harada, Naozumi; Miyahara, Yoshihiro; Hattori, Hiroyoshi; Takada, Kohichi; Emori, Makoto; Kakunaga, Shigeki; Endo, Makoto; Matsumoto, Yoshihiro; Sasada, Tetsuro; Sato, Eiichi; Yamada, Tomomi; Matsumine, Akihiko; Nagata, Yasuhiro; Kageyama, Shinichi; Shiku, Hiroshi
err分享
err收藏
TCR-Engineered Lymphocytes Targeting NY-ESO-1: In Vitro Assessment of Cytotoxicity against Tumors靶向NY-ESO-1的TCR工程化淋巴细胞: 体外评估对肿瘤的细胞毒性
errBIOMEDICINES
IF3.9
err2023-10-16
err4
errOAAI
errAlsalloum, Alaa; Alrhmoun, Saleh; Shevchenko, Julia; Fisher, Marina; Philippova, Julia; Perik-Zavodskii, Roman; Perik-Zavodskaia, Olga; Lopatnikova, Julia; Kurilin, Vasily; Volynets, Marina; Akahori, Yasushi; Shiku, Hiroshi; Silkov, Alexander; Sennikov, Sergey
err分享
err收藏
A phase 1 trial of NY-ESO-1-specific TCR-engineered T-cell therapy combined with a lymph node-targeting nanoparticulate peptide vaccine for the treatment of advanced soft tissue sarcoma
errINTERNATIONAL JOURNAL OF CANCER
IF4.7
err2023-02-17
err30
errOAAI
errIshihara, Mikiya; Nishida, Yoshihiro; Kitano, Shigehisa; Kawai, Akira; Muraoka, Daisuke; Momose, Fumiyasu; Harada, Naozumi; Miyahara, Yoshihiro; Seo, Naohiro; Hattori, Hiroyoshi; Takada, Kohichi; Emori, Makoto; Kakunaga, Shigeki; Endo, Makoto; Matsumoto, Yoshihiro; Sasada, Tetsuro; Sato, Eiichi; Yamada, Tomomi; Matsumine, Akihiko; Nagata, Yasuhiro; Watanabe, Takashi; Kageyama, Shinichi; Shiku, Hiroshi
err分享
err收藏
The role of metabolism on regulatory T cell development and its impact in tumor and transplantation immunity代谢在调节性T细胞发育中的作用及其在肿瘤和移植免疫中的作用
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2022-12-07
err10
errOAAI
errBulygin, Aleksey S.; Khantakova, Julia N.; Shkaruba, Nadezhda S.; Shiku, Hiroshi; Sennikov, Sergey S.
err分享
err收藏
TETRASPANIN MOLECULE CD9 AS A NOVEL MARKER OF TUMOR-REACTIVE T CELLS
errJOURNAL FOR IMMUNOTHERAPY OF CANCER
IF10.6
err2022-11-07
err0
errOAAI
errMiyahara, Yoshihiro; Yamane, Makiko; Hayashi, Tae; Toiyama, Yuji; Hiranuka, Kazushi; Kishi, Hiroyuki; Shiku, Hiroshi
err分享
err收藏
EBAG9 silencing exerts an immune checkpoint function without aggravating adverse effectsEBAG9沉默发挥免疫检查点功能而不加重不良反应
errMOLECULAR THERAPY
IF12
err2022-11-01
err3
errOAAI
errWirges, Anthea; Bunse, Mario; Joedicke, Jara J.; Blanc, Eric; Gudipati, Venugopal; Moles, Michael W.; Shiku, Hiroshi; Beule, Dieter; Huppa, Johannes B.; Hoepken, Uta E.; Rehm, Armin
err分享
err收藏
Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion-exchange method
errJOURNAL OF EXTRACELLULAR VESICLES
IF14.5
err2022-03-14
err44
errOAAI
errSeo, Naohiro; Nakamura, Junko; Kaneda, Tsuguhiro; Tateno, Hiroaki; Shimoda, Asako; Ichiki, Takanori; Furukawa, Koichi; Hirabayashi, Jun; Akiyoshi, Kazunari; Shiku, Hiroshi
err分享
err收藏
HDAC Inhibition for Optimized Cellular Immunotherapy of NY-ESO-1-Positive Soft Tissue Sarcoma
errBIOMEDICINES
IF3.9
err2022-02-03
err3
errOAAI
errGong, Wenjie; Wang, Lei; Schubert, Maria-Luisa; Kleist, Christian; Neuber, Brigitte; Wang, Sanmei; Yang, Mingya; Huckelhoven-Krauss, Angela; Wu, Depei; Schmitt, Anita; Muller-Tidow, Carsten; Shiku, Hiroshi; Schmitt, Michael; Sellner, Leopold
err分享
err收藏
Evaluation of Production Protocols for the Generation of NY-ESO-1-Specific T Cells
errCELLS
IF5.2
err2021-01-14
err2
errOAAI
errGong, Wenjie; Wang, Lei; Stock, Sophia; Ni, Ming; Schubert, Maria-Luisa; Neuber, Brigitte; Kleist, Christian; Huckelhoven-Krauss, Angela; Wu, Depei; Muller-Tidow, Carsten; Schmitt, Anita; Shiku, Hiroshi; Schmitt, Michael; Sellner, Leopold
err分享
err收藏
STRUCTURAL OPTIMIZATION OF ANTI-CEA-GITR-CAR TO REDUCE TONIC SIGNALING AND IMPROVE ANTIGENSPECIFIC REACTIVITY
errJOURNAL FOR IMMUNOTHERAPY OF CANCER
IF10.6
err2020-11-09
err0
PREAI
errAmaishi, Yasunori; Okubo, Yu; Wang, Yizheng; Wang, Linan; Kato, Takuma; Okamoto, Sachiko; Shiku, Hiroshi; Mineno, Junichi
err分享
err收藏
MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression relationships in solid tumours
errBMC CANCER
IF3.4
err2020-06-29
err38
errOAAI
errIshihara, Mikiya; Kageyama, Shinichi; Miyahara, Yoshihiro; Ishikawa, Takeshi; Ueda, Shugo; Soga, Norihito; Naota, Hiroaki; Mukai, Katsumi; Harada, Naozumi; Ikeda, Hiroaki; Shiku, Hiroshi
err分享
err收藏
Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance靶向肿瘤相关巨噬细胞的抗原递送克服了肿瘤免疫抗性
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2019-02-11
err114
errOAAI
errMuraoka, Daisuke; Seo, Naohiro; Hayashi, Tae; Tahara, Yoshiro; Fujii, Keisuke; Tawara, Isao; Miyahara, Yoshihiro; Okamori, Kana; Yagita, Hideo; Imoto, Seiya; Yamaguchi, Rui; Komura, Mitsuhiro; Miyano, Satoru; Goto, Masahiro; Sawada, Shin-ichi; Asai, Akira; Ikeda, Hiroaki; Akiyoshi, Kazunari; Harada, Naozumi; Shiku, Hiroshi
err分享
err收藏
Exosomal regulation of lymphocyte homing to the gut
errBLOOD ADVANCES
IF7.1
err2018-12-27
err56
errOAAI
errPark, Eun Jeong; Prajuabjinda, Onmanee; Soe, Zay Yar; Darkwah, Samuel; Appiah, Michael G.; Kawamoto, Eiji; Momose, Fumiyasu; Shiku, Hiroshi; Shimaoka, Motomu
err分享
err收藏
Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells
errNATURE COMMUNICATIONS
IF15.7
err2018-01-30
err157
errOAAI
errSeo, Naohiro; Shirakura, Yoshitaka; Tahara, Yoshiro; Momose, Fumiyasu; Harada, Naozumi; Ikeda, Hiroaki; Akiyoshi, Kazunari; Shiku, Hiroshi
err分享
err收藏

研究方向

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