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M

Meagan B. Ryan

Harvard University
H指数:16
被引数:2,416

个人简介

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CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment

CHK1保护致癌KRAS表达细胞免受DNA损伤，是胰腺癌治疗的靶点

CELL REPORTS
IF6.9
2021-11-0123
OAAI
Klomp, Jennifer E.; Lee, Ye S.; Goodwin, Craig M.; Papke, Bjorn; Klomp, Jeff A.; Waters, Andrew M.; Stalnecker, Clint A.; DeLiberty, Jonathan M.; Drizyte-Miller, Kristina; Yang, Runying; Diehl, J. Nathaniel; Yin, Hongwei H.; Pierobon, Mariaelena; Baldelli, Elisa; Ryan, Meagan B.; Li, Siqi; Peterson, Jackson; Smith, Amber R.; Neal, James T.; McCormick, Aaron K.; Kuo, Calvin J.; Counter, Christopher M.; Petricoin, Emanuel F.; Cox, Adrienne D.; Bryant, Kirsten L.; Der, Channing J.
Clinical Acquired Resistance to KRASG12C Inhibition through a novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS-MAPK Reactivation

通过新型KRAS Switch-II口袋突变和融合ras-mapk再激活的多克隆改变对KRASG12C抑制的临床获得性抗性

CANCER DISCOVERY
IF33.3
2021-04-06308
OA
Tanaka, Noritaka; Lin, Jessica J.; Li, Chendi; Ryan, Meagan B.; Zhang, Junbing; Kiedrowski, Lesli A.; Michel, Alexa G.; Syed, Mohammed U.; Fella, Katerina A.; Sakhi, Mustafa; Baiev, Islam; Juric, Dejan; Gainor, Justin F.; Klempner, Samuel J.; Lennerz, Jochen K.; Siravegna, Giulia; Bar-Peled, Liron; Hata, Aaron N.; Heist, Rebecca S.; Corcoran, Ryan B.
WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop
CELL REPORTS
IF6.9
2019-01-0163
OAAI
Agajanian, Megan J.; Walker, Matthew P.; Axtman, Alison D.; Ruela-de-Sousa, Roberta R.; Serafin, D. Stephen; Rabinowitz, Alex D.; Graham, David M.; Ryan, Meagan B.; Tamir, Tigist; Nakamichi, Yuko; Gammons, Melissa V.; Bennett, James M.; Counago, Rafael M.; Drewry, David H.; Elkins, Jonathan M.; Gileadi, Carina; Gileadi, Opher; Godoi, Paulo H.; Kapadia, Nirav; Mueller, Susanne; Santiago, Andre S.; Sorrell, Fiona J.; Wells, Carrow I.; Fedorov, Oleg; Willson, Timothy M.; Zuercher, William J.; Major, Michael B.
A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution
CELL REPORTS
IF6.9
2017-07-0181
OAAI
Anderson, Grace R.; Winter, Peter S.; Lin, Kevin H.; Nussbaum, Daniel P.; Cakir, Merve; Stein, Elizabeth M.; Soderquist, Ryan S.; Crawford, Lorin; Leeds, Jim C.; Newcomb, Rachel; Stepp, Priya; Yip, Catherine; Wardell, Suzanne E.; Tingley, Jennifer P.; Ali, Moiez; Xu, Mengmeng; Ryan, Meagan; McCall, Shannon J.; McRee, Autumn J.; Counter, Christopher M.; Der, Channing J.; Wood, Kris C.

研究方向

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C
Channing J. Der
H 指数:127论文数:1,046被引数:7.1万
K
Klaus P. Hoeflich
H 指数:47论文数:267被引数:1.1万
M
Margit Hagel
H 指数:12论文数:74被引数:1,710
Y
Yongxin Han
H 指数:36论文数:171被引数:4,458
A
Adrienne D. Cox
H 指数:73论文数:517被引数:1.9万
R
Ryan B. Corcoran
H 指数:63论文数:728被引数:2.2万
A
Arvin C. Dar
H 指数:22论文数:112被引数:3,264
M
Michael Hale
H 指数:17论文数:88被引数:1,345
C
Chaoyang Ye
H 指数:13论文数:76被引数:2,622
B
Bradley Quade
H 指数:8论文数:61被引数:682