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Tobias C. Walther

memorial sloan kettering cancer center

75H指数
203论文数
3.1W被引数
收录论文 111
发表时间
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Membrane bridges and nanodomain partitioning govern membrane protein targeting to lipid droplets膜桥和纳米域分区调控膜蛋白靶向脂滴
errNature Cell Biology
IF19.1
err2026-05-26
err0
errOAAI
errArda Mizrak; Jacob Kæstel-Hansen; Jessica Matthias; J. Wade Harper; Nikos S. Hatzakis; Robert V. Farese; Tobias C. Walther
err分享
err收藏
DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic functionDGAT驱动的无效脂质循环具有显著的，但隐蔽的产热功能。
errCell Metabolism
IF30.9
err2026-01-09
err0
errOAAI
errAnand Kumar Sharma; Radhika Khandelwal; Jelena Zurkovic; Fen Long; Tongtong Wang; Revati S. Dewal; Chunyan Wu; Adhideb Ghosh; Klug Manuel; Alaa Othman; Chandramohan Chitraju; Robert V. Farese; Tobias C. Walther; Miroslav Balaz; Christoph Thiele; Christian Wolfrum
err分享
err收藏
The pathogenesis of hepatic steatosis in MASLD: a lipid droplet perspectiveKrahmer, N.; Walther, T.C.; Farese, R.V., Jr. MASLD中肝脂肪变性的发病机制：脂滴视角。J. Clin. Investig. 2025, 135, e198334. [Google Scholar] [CrossRef]
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2025-09-16
err0
errOAAI
errKrahmer, Natalie; Walther, Tobias C.; Farese Jr, Robert V.
err分享
err收藏
Plasma lipidome dysregulation in frontotemporal dementia reveals shared, genotype-specific, and severity-linked alterations额颞叶痴呆中血浆脂质组的失调揭示了共享的、基因型特异性的以及与严重程度相关的改变
errAlzheimer's & Dementia
IF0
err2025-09-08
err0
errOAAI
errYohannes A. Ambaw; Peter A. Ljubenkov; Shubham Singh; Abdi Hamed; Sebastian Boland; Adam L. Boxer; Tobias C. Walther; Robert V. Farese Jr.
err分享
err收藏
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathwayAPOE3基因中的R136S突变通过抑制cGAS-STING-IFN通路赋予对tau病理的抵抗力。
errImmunity
IF26.3
err2025-06-23
err0
PREAI
errSarah Naguib; Chloe Lopez-Lee; Eileen Ruth Torres; Se-In Lee; Jingjie Zhu; Daphne Zhu; Pearly Ye; Kendra Norman; Mingrui Zhao; Man Ying Wong; Yohannes A. Ambaw; Rodrigo Muñoz-Castañeda; Wei Wang; Tark Patel; Maitreyee Bhagwat; Rada Norinsky; Sue-Ann Mok; Tobias C. Walther; Robert V. Farese; Wenjie Luo; Subhash C. Sinha; Zhuhao Wu; Li Fan; Shiaoching Gong; Li Gan
err分享
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Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity脂肪组织中缺乏甘油三酯合成酶的小鼠对饮食诱导的肥胖有抵抗力
errELIFE
IF0
err2023-10-02
err8
errOAAI
errChitraju, Chandramohan; Fischer, Alexander W.; Ambaw, Yohannes A.; Wang, Kun; Yuan, Bo; Hui, Sheng; Walther, Tobias C.; Farese, Robert, V
err分享
err收藏
The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets
errNATURE CELL BIOLOGY
IF19.1
err2023-07-13
err30
errOAAI
errChung, Jeeyun; Park, Joongkyu; Lai, Zon Weng; Lambert, Talley J. J.; Richards, Ruth C. C.; Zhang, Jiuchun; Walther, Tobias C. C.; Farese Jr, Robert V. V.
err分享
err收藏
The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification
errNATURE COMMUNICATIONS
IF15.7
err2023-06-14
err8
errOAAI
errWang, Kun; Lee, Chia-Wei; Sui, Xuewu; Kim, Siyoung; Wang, Shuhui; Higgs, Aidan B.; Baublis, Aaron J.; Voth, Gregory A.; Liao, Maofu; Walther, Tobias C.; Farese, Robert V.
err分享
err收藏
Structure and function of lipid droplet assembly complexes
errCURRENT OPINION IN STRUCTURAL BIOLOGY
IF7
err2023-06-01
err17
errOAAI
errWalther, Tobias C.; Kim, Siyoung; Arlt, Henning; Voth, Gregory A.; Farese Jr, Robert V.
err分享
err收藏
Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis
errNATURE COMMUNICATIONS
IF15.7
err2023-05-29
err4
errOAAI
errSui, Xuewu; Wang, Kun; Song, Kangkang; Xu, Chen; Song, Jiunn; Lee, Chia-Wei; Liao, Maofu; Farese, Robert V., Jr.; Walther, Tobias C.
err分享
err收藏
Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-04-01
err43
errOAAI
errKuersten, S; Arts, GJ; Walther, TC; Englmeier, L; Mattaj, IW
err分享
err收藏
Fitm2 is required for ER homeostasis and normal function of murine liver
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-03-01
err6
errOAAI
errBond, Laura M.; Ibrahim, Ayon; Lai, Zon W.; Walzem, Rosemary L.; Bronson, Roderick T.; Ilkayeva, Olga R.; Walther, Tobias C.; Farese Jr, Robert, V
err分享
err收藏
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis
errNATURE COMMUNICATIONS
IF15.7
err2022-10-07
err38
errOAAI
errBoland, Sebastian; Swarup, Sharan; Ambaw, Yohannes A.; Malia, Pedro C.; Richards, Ruth C.; Fischer, Alexander W.; Singh, Shubham; Aggarwal, Geetika; Spina, Salvatore; Nana, Alissa L.; Grinberg, Lea T.; Seeley, William W.; Surma, Michal A.; Klose, Christian; Paulo, Joao A.; Nguyen, Andrew D.; Harper, J. Wade; Walther, Tobias C.; Farese, Robert V., Jr.
err分享
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Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum
errcold spring harbor perspectives in medicine
IF8.4
err2022-09-12
err23
PREAI
errFarese, Robert V. V.; Walther, Tobias C. C.
err分享
err收藏
Identification of two pathways mediating protein targeting from ER to lipid droplets
errNATURE CELL BIOLOGY
IF19.1
err2022-09-01
err40
errOAAI
errSong, Jiunn; Mizrak, Arda; Lee, Chia-Wei; Cicconet, Marcelo; Lai, Zon Weng; Tang, Wei-Chun; Lu, Chieh-Han; Mohr, Stephanie E.; Farese, Robert V., Jr.; Walther, Tobias C.
err分享
err收藏
Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membraneSeipin跨膜片段在甘油三酸酯成核和膜上的脂滴出芽中起关键作用
errELIFE
IF0
err2022-05-18
err29
errOAAI
errKim, Siyoung; Chung, Jeeyun; Arlt, Henning; Pak, Alexander J.; Farese, Robert V., Jr.; Walther, Tobias C.; Voth, Gregory A.
err分享
err收藏
The phase of fat: Mechanisms and physiology of lipid storage
errFASEB JOURNAL
IF4.2
err2022-05-13
err1
PREAI
errFarese, Robert V., Jr.; Walther, Tobias C.
err分享
err收藏
Seipin forms a flexible cage at lipid droplet formation sites
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2022-02-24
err48
errOAAI
errArlt, Henning; Sui, Xuewu; Folger, Brayden; Adams, Carson; Chen, Xiao; Remme, Roman; Hamprecht, Fred A.; DiMaio, Frank; Liao, Maofu; Goodman, Joel M.; Farese, Robert V., Jr.; Walther, Tobias C.
err分享
err收藏
The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology
errDEVELOPMENTAL CELL
IF8.7
err2022-02-01
err40
errOAAI
errMejhert, Niklas; Gabriel, Katlyn R.; Frendo-Cumbo, Scott; Krahmer, Natalie; Song, Jiunn; Kuruvilla, Leena; Chitraju, Chandramohan; Boland, Sebastian; Jang, Dong-Keun; von Grotthuss, Marcin; Costanzo, Maria C.; Ryden, Mikael; Olzmann, James A.; Flannick, Jason; Burtt, Noel P.; Farese, Robert V., Jr.; Walther, Tobias C.
err分享
err收藏
The CYTOLD and ERTOLD pathways for lipid droplet-protein targeting脂滴蛋白靶向的CYTOLD和ERTOLD途径
errTRENDS IN BIOCHEMICAL SCIENCES
IF11
err2022-01-01
err44
errOAAI
errOlarte, Maria-Jesus; Swanson, Jessica M. J.; Walther, Tobias C.; Farese, Robert V., Jr.
err分享
err收藏

研究方向

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