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Timothy P. Hughes

south australian health & medical research institute

94H指数
801论文数
5.6W被引数
收录论文 158
发表时间
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Mitochondrial DNA mutations are associated with impaired oxidative phosphorylation and enhanced imatinib response in chronic myeloid leukemia线粒体DNA突变与慢性髓性白血病中氧化磷酸化受损和伊马替尼敏感性增强相关
errHemaSphere
IF14.6
err2026-09-08
err0
errOAAI
errIlaria S. Pagani; Vaidehi Krishnan; John F. Ouyang; Chung H. Kok; BeiJun Chen; Kian Leong Lee; Cong M. Pham; Paul Wang; Elyse Page; Phuong Dang; Verity A. Saunders; Jane James; Kelly Lim; Stefano Mangiola; Yingnan Gao; Naranie Shanmuganathan; Agnes Yong; Susan Branford; Charles Chuah; David T. Yeung; Deborah L. White; Vignir G. Helgason; Daniel Thomas; S. Tiong Ong; Timothy P. Hughes; David M. Ross
err分享
err收藏
Asciminib monotherapy in patients with BCR::ABL1 T315I-mutated chronic-phase chronic myeloid leukemia: phase 1 trial final resultsAsciminib单药治疗BCR::ABL1 T315I突变慢性期慢性粒细胞白血病：1期试验最终结果
errLeukemia
IF13.4
err2026-07-16
err0
errOAAI
errJorge E. Cortes; Delphine Rea; Michael J. Mauro; Andreas Hochhaus; Dong-Wook Kim; Koji Sasaki; Fabian Lang; Michael C. Heinrich; Massimo Breccia; Michael Deininger; Yeow-Tee Goh; Jeroen J. W. M. Janssen; Moshe Talpaz; Valle Gómez García de Soria; Philipp le Coutre; Francois-Xavier Mahon; Daniel J. DeAngelo; Andrea Damon; Shruti Kapoor; Gessami Sanchez-Olle; Matthias Hoch; Nithya Agrawal; Sara Quenet; Timothy P. Hughes
err分享
err收藏
Direct measurement of in vivo BCR::ABL1 kinase inhibition reveals stronger potency of asciminib as compared with imatinib and nilotinib体内BCR::ABL1激酶抑制的直接测量显示阿西美哌的活性比伊马替尼和尼洛替尼更强
errLeukemia
IF13.4
err2026-06-11
err0
errOAAI
errChung Hoow Kok; Naranie Shanmuganathan; Verity A. Saunders; Phuong Dang; Deborah White; Susan Branford; David Yeung; Timothy P. Hughes
err分享
err收藏
From fatal disease to functional cure: 25 years of tyrosine kinase inhibition in chronic myeloid leukemia从致命性疾病到功能性治愈：慢性髓性白血病酪氨酸激酶抑制25年
errLeukemia
IF13.4
err2026-05-22
err0
errOAAI
errAndreas Hochhaus; Moshe Talpaz; Giuseppe Saglio; Jorge E. Cortes; Timothy Hughes; Jane Apperley; Oliver Hantschel; Delphine Rea; Peter Schuld; Hagop Kantarjian
err分享
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Allosteric and ATP-Pocket BCR::ABL1 Inhibition In Vitro, and Characterising Ex Vivo Thrombo-Inflammatory Biomarkers and Thrombin Generation in Asciminib-Treated CML Patients别构和ATP-口袋BCR::ABL1体外抑制，以及表征异体asciminib治疗CML患者中的血栓-炎症生物标志物和凝血酶生成
errInternational Journal of Molecular Sciences
IF4.9
err2026-04-18
err0
errOAAI
errMusab M. A. Omar; Majed A. Alanazi; David T. Yeung; Timothy P. Hughes; Denise E. Jackson
err分享
err收藏
Asciminib Demonstrates Superior Efficacy and Safety in Newly Diagnosed Chronic Myeloid Leukemia in ASC4FIRSTAsciminib在asc4首先在新诊断的慢性粒细胞白血病中表现出优异的疗效和安全性
errBlood
IF23.1
err2025-12-17
err0
errOAAI
errJorge E. Cortes; Timothy P. Hughes; Jianxiang Wang; Dong-Wook Kim; Dennis Dong Hwan Kim; Jiri Mayer; Yeow-Tee Goh; Philipp le Coutre; Gabriel Etienne; Inho Kim; David J. Andorsky; Felice Bombaci; Ghayas C. Issa; Naoto Takahashi; Shruti Kapoor; Rajendra Jinwal; Kamel Malek; Tracey McCulloch; Lillian Yau; Richard A. Larson
err分享
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Enhanced detection of splice altering variants in hematologic malignancies using targeted RNA-seq data通过靶向RNA测序数据增强血液系统恶性肿瘤中剪接改变变异的检测
errThe Journal of Molecular Diagnostics
IF0
err2025-10-10
err0
PREAI
errMuneeza Maqsood; John Toubia; Carol Wadham; Naranie Shanmuganathan; Nur Hezrin Shahrin; Adelina Fernandes; Joe McConnell; Verity Saunders; Dominik Kaczorowski; Rosalie R. Kenyon; Ming Lin; Timothy P. Hughes; Chung Hoow Kok; Susan Branford
err分享
err收藏
Asciminib for Philadelphia chromosome-positive leukemiasAciclibimib用于费城染色体阳性白血病
errHAEMATOLOGICA
IF7.9
err2025-10-01
err0
errOAAI
errHughes, Timothy P.; White, Deborah L.; Yeung, David T.
err分享
err收藏
Lipid Storage and Therapy Resistance in Chronic Myeloid Leukaemia: A Novel Perspective on Targeting Metabolic Vulnerabilities脂质储存和治疗抵抗在慢性髓性白血病中的作用：靶向代谢脆弱性的新视角
errCancers 2025, Vol. 17, Page 3033
IF0
err2025-09-23
err0
errOAAI
errMolly Tolland; David M. Ross; Deborah White; Timothy P. Hughes; Ilaria S. Pagani
err分享
err收藏
Impact of ASXL1 at diagnosis in CML patients receiving frontline potent TKIs: high risk of kinase domain mutationsASVL1在诊断时对接受一线强效TKI治疗的CML患者的影响：激酶域突变的高风险
errBlood
IF23.1
err2025-09-04
err0
PREAI
errNaranie Shanmuganathan; David T. Yeung; Carol Wadham; Adelina Fernandes; Muneeza Maqsood; NurHezrin Shahrin; Verity Saunders; Rosalie R. Kenyon; Ming Lin; John Toubia; Joe McConnell; Dominic Kaczorowski; David M. Ross; Agnes S. M. Yong; Lynette Chee; Jake Shortt; Nicholas Viiala; Jodi Braley; Chung Hoow Kok; Timothy P. Hughes
err分享
err收藏
2025 European LeukemiaNet recommendations for the management of chronic myeloid leukemia2025欧洲白血病网关于慢性粒细胞白血病治疗的建议
errLeukemia
IF13.4
err2025-07-11
err0
errOAAI
errJane F. Apperley; Dragana Milojkovic; Nicholas C. P. Cross; Henrik Hjorth-Hansen; Andreas Hochhaus; Hagop Kantarjian; Jeffrey H. Lipton; Hemant Malhotra; Dietger Niederwieser; Jerald Radich; Philippe Rousselot; Susanne Saussele; Charles A. Schiffer; Richard Silver; Simona Soverini; Leif Stenke; Anna Turkina; Luis Felipe Casado; Fausto Castagnetti; Francisco Cervantes; Richard E. Clark; Jorge Cortes; Michael Deininger; Timothy P. Hughes; Jeroen Janssen; Qian Jiang; Dong-Wook Kim; Richard A. Larson; Francois X. Mahon; Michael Mauro; Jiri Mayer; Franck E. Nicolini; Fabrizio Pane; Delphine Rea; Johan Richter; Gianantonio Rosti; Giuseppe Saglio; Rüdiger Hehlmann
err分享
err收藏
Asciminib remained superior vs bosutinib in late-line CML-CP after nearly 4 years of follow-up in ASCEMBLAsciminib在ASCEMBL研究中经过近4年的随访后，在晚期慢性粒细胞白血病慢性期（CML-CP）中仍优于bosutinib。
errBlood Advances
IF7.1
err2025-05-09
err0
errOAAI
errMichael J. Mauro; Yosuke Minami; Andreas Hochhaus; Elza Lomaia; Sergey Voloshin; Anna Turkina; Dong-Wook Kim; Jane F. Apperley; Jorge E. Cortes; Andre Abdo; Laura Maria Fogliatto; Dennis Dong Hwan Kim; Philipp le Coutre; Susanne Saussele; Mario Annunziata; Timothy P. Hughes; Naeem Chaudhri; Lynette Chee; Valentin García-Gutiérrez; Koji Sasaki; Carla Boquimpani; Shruti Kapoor; Noemi Espurz; Vishal Dhamal; Delphine Rea
err分享
err收藏
The evolution of treatment-free remission无治疗缓解的演变
errBLOOD
IF23.1
err2025-02-27
err0
PREAI
errHughes, Timothy P.; Yong, Agnes S. M.; Ross, David M.
err分享
err收藏
Asciminib add-on to imatinib demonstrates sustained high rates of ongoing therapy and deep molecular responses with prolonged follow-up in the ASC4MORE studyAsciminib对伊马替尼的补充在ASC4MORE研究中显示持续的高治疗率和深度分子反应，并延长随访时间
errJOURNAL OF HEMATOLOGY & ONCOLOGY
IF40.4
err2024-12-18
err0
errOAAI
errHughes, Timothy P.; Saglio, Giuseppe; Geissler, Jan; Kim, Dong-Wook; Lomaia, Elza; Mayer, Jiri; Turkina, Anna; Kapoor, Shruti; Cardoso, Ana Paula; Nieman, Becki; Quenet, Sara; Cortes, Jorge E.
err分享
err收藏
CBL Variants in Chronic Myelomonocytic Leukemia Exhibit a Complex Sub-Clone Architecture with a High Frequency of RING Domain Mutations Sufficient to Induce GM-CSF HypersensitivityCBL变体在慢性髓系单核细胞白血病中表现出复杂的亚克隆结构，并伴有高频RING结构域突变，足以诱导GM-CSF高敏感性。
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errLim, Kelly; Kutyna, Monika; Kan, Winnie; Lopez, Angel F.; Brown, Anna; Yong, Agnes S. M.; Lane, Steven W.; Fong, Chun Yew; Hughes, Timothy P.; Yeung, David T.; Ross, David M.; Hiwase, Devendra; Thomas, Daniel
err分享
err收藏
Imatinib-Sensitive Chronic Myeloid Leukaemia Is Associated with mtDNA Mutations and Reduced Oxphos Capacity伊马替尼敏感的慢性髓系白血病与mtDNA突变和降低的氧化磷酸化能力相关
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errPagani, Ilaria Stefania; Krishnan, Vaidehi; Ouyang, John; Kok, Chung How; Chen, Beijun; Page, Elyse C.; Dang, Phuong; Saunders, Verity A.; James, Jane; Lim, Kelly; Shanmuganathan, Naranie; Branford, Susan; Chuah, Charles; Yeung, David T.; Thomas, Daniel; Hughes, Timothy P.; Ong, Sin Tiong; Ross, David M.
err分享
err收藏
Asciminib monotherapy in patients with chronic-phase chronic myeloid leukemia with the T315I mutation after ≥1 prior tyrosine kinase inhibitor: 2-year follow-up results在酪氨酸激酶抑制剂治疗 ≥ 1个T315I突变的慢性期慢性粒细胞白血病患者中单药治疗: 2年随访结果
errLEUKEMIA
IF13.4
err2024-05-16
err8
errOAAI
errCortes, Jorge E.; Sasaki, Koji; Kim, Dong-Wook; Hughes, Timothy P.; Etienne, Gabriel; Mauro, Michael J.; Hochhaus, Andreas; Lang, Fabian; Heinrich, Michael C.; Breccia, Massimo; Deininger, Michael; Goh, Yeow Tee; Janssen, Jeroen J. W. M.; Talpaz, Moshe; de Soria, Valle Gomez Garcia; le Coutre, Philipp; Deangelo, Daniel J.; Damon, Andrea; Cacciatore, Silvia; Polydoros, Fotis; Agrawal, Nithya; Rea, Delphine
err分享
err收藏
Are there new relevant therapeutic endpoints in the modern era of the BCR::ABL1 tyrosine kinase inhibitors in chronic myeloid leukemia?
errLEUKEMIA
IF13.4
err2024-03-26
err5
PREAI
errKantarjian, Hagop; Branford, Susan; Breccia, Massimo; Cortes, Jorge; Haddad, Fadi G.; Hochhaus, Andreas; Hughes, Timothy; Issa, Ghayas C.; Jabbour, Elias; Nicolini, Franck E.; Sasaki, Koji; Xavier-Mahon, Francois
err分享
err收藏
Adverse outcomes for chronic myeloid leukemia patients with splenomegaly and low in vivo kinase inhibition on imatinib
errBLOOD CANCER JOURNAL
IF11.6
err2023-09-11
err0
errOAAI
errKok, Chung H.; Saunders, Verity A.; Dang, Phuong; Shanmuganathan, Naranie; White, Deborah; Branford, Susan; Yeung, David; Hughes, Timothy P.
err分享
err收藏
The acquisition order of leukemic drug resistance mutations is directed by the selective fitness associated with each resistance mechanism
errSCIENTIFIC REPORTS
IF3.9
err2023-08-11
err0
errOAAI
errLeow, Benjamin C. S.; Kok, Chung H.; Yeung, David T.; Hughes, Timothy P.; White, Deborah L.; Eadie, Laura N.
err分享
err收藏

研究方向

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