Derin B. Keskin - Publications, H-index & Citations

Derin B. Keskin

Dana-Farber Cancer Institute

43H指数

270论文数

1.5W被引数

收录论文 79

发表时间

Personalized neoantigen-targeting cancer vaccines in ovarian cancer: a phase 1 trial 卵巢癌中个性化新抗原靶向癌症疫苗：一项1期临床试验

Nature Medicine

IF50

2026-10-14

PREAI

MacLean C. Sellars; Jessica A. Frank; Bohoon Shim; Allison Vanasse; Ruolin Liu; Cleo Forman; Chloe R. Tu; Kyohei K. Tabata; Antonia Kowelewski; Su-Chun Cheng; Catherine Song; Kan Xiong; Pia Jain; Andjela Crnjac; Haley E. Sax; Vipheaviny Chea; Wesley Lu; J. Thomas Janes; Micah Rickles-Young; Amit Sud; Savni Sarolkar; Martin Hayes; Oriol Olive; Haley Greenslade; Carrie Cibulskis; Nir Hacohen; Edward F. Fritsch; Shuqiang Li; Kenneth J. Livak; Nabihah Tayob; Elizabeth H. Stover; Carolyn Krasner; Rebecca Porter; Ursula Matulonis; Gad Getz; Giacomo Oliveira; Patrick A. Ott; Jeremy M. Simon; Viktor A. Adalsteinsson; Derin B. Keskin; Panagiotis A. Konstantinopoulos; Catherine J. Wu

Evolution of tumor subclones and T-cell dynamics underlie variable ibrutinib responses in Waldenström macroglobulinemia 肿瘤亚克隆的演化和T细胞动态是华氏巨球蛋白血症中伊布替尼反应差异的基础

Blood

IF23.1

2026-02-13

PREAI

Hao Sun; Romanos Sklavenitis-Pistofidis; Shirong Liu; Xia Liu; Nicholas Tsakmaklis; John M. Hatcher; Maria Luisa Guerrera; Amanda Kofides; Andres Ramirez-Gamero; Abigail L. Peachey; Shuqiang Li; Derin B. Keskin; Vipheaviny Chea; Nawoo Kim; Haoxiang Lyu; Wesley Lu; Kenneth J. Livak; Kirsten Meid; Alberto Guijosa; Catherine A. Flynn

Sensitive detection of cancer antigens enabled by user-defined peptide libraries 通过用户定义的肽库实现癌症抗原的灵敏检测

Nature Biotechnology

IF41.7

2026-02-09

PREAI

Kasidet Manakongtreecheep; Claudia Ctortecka; Luis O. Correa-Medero; Timothy Zhu; Isabelle Lippincott; Griffin M. Lawrence; Alexis Howard; Gabrielle M. Hernandez; Cleo Forman; Emma C. Duggan; Marta A. Wilbrink; Eva K. Verzani; Alexander B. Afeyan; Jiaxun Li; Alexey I. Nesvizhskii; Giacomo Oliveira; Derin B. Keskin; Patrick A. Ott; Karl R. Clauser; Matthew Bakalar; Siranush Sarkizova; Nir Hacohen; Steven A. Carr; Jennifer G. Abelin; Catherine J. Wu

CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity CoREST复合物抑制改变RNA剪接以促进新抗原表达并增强肿瘤免疫

JCI Insight

IF6.1

2026-01-23

PREAI

Fisher, Robert J.; Park, Kihyun; Lee, Kwangwoon; Pinjusic, Katarina; Vanasse, Allison; Ennis, Christina S.; Farokh, Parisa; Ficaro, Scott B.; Marto, Jarrod A.; Jiang, Hanjie; Nam, Eunju; Stransky, Stephanie; Duke-Cohan, Joseph; Akinci, Melis A.; Geethadevi, Anupa; Raabe, Eric; Fiszbein, Ana; Demehri, Shadmehr; Sidoli, Simone; Hicks, Chad W.; Keskin, Derin B.; Wu, Catherine J.; Cole, Philip A.; Alani, Rhoda M.

Selection of targeted neoantigens for ongoing personalized cancer vaccine trials at Dana Farber Cancer Institute

JOURNAL OF IMMUNOLOGY

IF3.4

2025-11-01

PREAI

Keskin, Derin B.; Braun, David A.; Forman, Cleo; Tu, Chloe R.; Sarkizova, Siranush; Hacohen, Nir Nir; Fritsch, Edward F.; Ott, Patrick; Wu, Catherine J.

A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma 多佐剂个性化新抗原疫苗在黑素瘤中产生强效免疫

Cell

IF42.5

2025-07-10

PREAI

Eryn Blass; Derin B. Keskin; Chloe R. Tu; Cleo Forman; Allison Vanasse; Haley E. Sax; Bohoon Shim; Vipheaviny Chea; Nawoo Kim; Isabel Carulli; Jackson Southard; Haoxiang Lyu; Wesley Lu; Micah Rickles-Young; Alexander B. Afeyan; Oriol Olive; Ambica Mehndiratta; Haley Greenslade; Keerthi Shetty; Joanna Baginska; Ilana Gomez Diaz; Allison Nau; Kathleen L. Pfaff; Andrew Gans; Srinika Ranasinghe; Elizabeth I. Buchbinder; Tamara A. Sussman; Megan L. Insco; Charles H. Yoon; Scott J. Rodig; Sachet A. Shukla; Shuqiang Li; Jon C. Aster; David A. Braun; Carrie Cibulskis; Nir Hacohen; Donna S. Neuberg; Anita Giobbie-Hurder; Kenneth J. Livak; Edward F. Fritsch; Giacomo Oliveira; Jeremy M. Simon; Catherine J. Wu; Patrick A. Ott

HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy HIF调节多种翻译的内源性逆转录病毒：对癌症免疫治疗的启示

CELL

IF42.5

2025-02-01

OAAI

Jiang, Qinqin; Braun, David A.; Clauser, Karl R.; Ramesh, Vijyendra; Shirole, Nitin H.; Duke-Cohan, Joseph E.; Nabilsi, Nancy; Kramer, Nicholas J.; Forman, Cleo; Lippincott, Isabelle E.; Klaeger, Susan; Phulphagar, Kshiti M.; Chea, Vipheaviny; Kim, Nawoo; Vanasse, Allison P.; Saad, Eddy; Parsons, Teagan; Carr-Reynolds, Melissa; Carulli, Isabel; Pinjusic, Katarina; Jiang, Yijia; Li, Rong; Syamala, Sudeepa; Rachimi, Suzanna; Verzani, Eva K.; Stevens, Jonathan D.; Lane, William J.; Camp, Sabrina Y.; Meli, Kevin; Pappalardi, Melissa B.; Herbert, Zachary T.; Qiu, Xintao; Cejas, Paloma; Long, Henry W.; Shukla, Sachet A.; Allen, Eliezer M. Van; Choueiri, Toni K.; Churchman, L. Stirling; Abelin, Jennifer G.; Gurer, Cagan; Macbeath, Gavin; Childs, Richard W.; Carr, Steven A.; Keskin, Derin B.; Wu, Catherine J.; Kaelin Jr, William G.

A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings

FRONTIERS IN IMMUNOLOGY

IF5.9

2025-01-21

OAAI

Treon, Steven P.; Kotton, Camille N.; Park, David J.; Moranzoni, Giorgia; Lemvigh, Camilla K.; Gathe Jr, Joseph C.; Varughese, Tilly A.; Barnett, Christopher F.; Belenchia, Johnny M.; Clark, Nina M.; Farber, Charles M.; Abid, Muhammad Bilal; Ahmed, Gulrayz; Patterson, Christopher J.; Guerrera, Maria L.; Soumerai, Jacob D.; Chea, Vipheaviny A.; Carulli, Isabel P.; Southard, Jackson; Li, Shuqiang; Wu, Catherine J.; Livak, Kenneth J.; Holmgren, Eric; Kim, Pil; Shi, Carrie; Lin, Holly; Ramakrishnan, Vanitha; Ou, Ying; Olszewski, Scott; Olsen, Lars Ronn; Keskin, Derin B.; Hunter, Zachary R.; Tankersley, Christopher; Zimmerman, Todd; Dhakal, Binod

Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation 次要组织相容性抗原的系统鉴定可预测异基因造血细胞移植的结果

NATURE BIOTECHNOLOGY

IF41.7

2024-08-21

PREAI

Cieri, Nicoletta; Hookeri, Nidhi; Stromhaug, Kari; Li, Liang; Keating, Julia; Diaz-Fernandez, Paula; Gomez-Garcia de Soria, Valle; Stevens, Jonathan; Kfuri-Rubens, Raphael; Shao, Yiren; Kooshesh, Kameron A.; Powell, Kaila; Ji, Helen; Hernandez, Gabrielle M.; Abelin, Jennifer; Klaeger, Susan; Forman, Cleo; Clauser, Karl R.; Sarkizova, Siranush; Braun, David A.; Penter, Livius; Kim, Haesook T.; Lane, William J.; Oliveira, Giacomo; Kean, Leslie S.; Li, Shuqiang; Livak, Kenneth J.; Carr, Steven A.; Keskin, Derin B.; Munoz-Calleja, Cecilia; Ho, Vincent T.; Ritz, Jerome; Soiffer, Robert J.; Neuberg, Donna; Stewart, Chip; Getz, Gad; Wu, Catherine J.

Selection of targeted neoantigens for personalized cancer vaccines

CANCER RESEARCH

IF16.6

2024-04-05

PREAI

Keskin, Derin

Comparative molecular profiling of sporadic and Lynch syndrome MSI tumors: Unraveling insights for vaccine design

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Ladany, Hagay; Grossman, Mark; Hess, Julian; Lu, Nicole; Keskin, Derin; Wu, Catherine J.; Hacohen, Nir; Gallon, Richard; Burn, John; Hampel, Heather; Stadler, Zsofia; Getz, Gad; Maruvka, Yosef E.; Lipkin, Steven

Fine tuning of CpG spatial distribution with DNA origami for improved cancer vaccination

NATURE NANOTECHNOLOGY

IF34.9

2024-03-15

PREAI

Zeng, Yang C.; Young, Olivia J.; Wintersinger, Christopher M.; Anastassacos, Frances M.; MacDonald, James I.; Isinelli, Giorgia; Dellacherie, Maxence O.; Sobral, Miguel; Bai, Haiqing; Graveline, Amanda R.; Vernet, Andyna; Sanchez, Melinda; Mulligan, Kathleen; Choi, Youngjin; Ferrante, Thomas C.; Keskin, Derin B.; Fell, Geoffrey G.; Neuberg, Donna; Wu, Catherine J.; Mooney, David J.; Kwon, Ick Chan; Ryu, Ju Hee; Shih, William M.

CKLF instigates a cold microenvironment to promote MYCN-mediated tumor aggressiveness

SCIENCE ADVANCES

IF12.5

2024-03-15

OAAI

Qin, Xiaodan; Lam, Andrew; Zhang, Xu; Sengupta, Satyaki; Iorgulescu, J. Bryan; Ni, Hongru; Das, Sanjukta; Rager, Madison; Zhou, Zhenwei; Zuo, Tao; Meara, Grace K.; Floru, Alexander E.; Kemet, Chinyere; Veerapaneni, Divya; Kashy, Daniel; Lin, Liang; Lloyd, Kenneth; Kwok, Lauren; Smith, Kaylee S.; Nagaraju, Raghavendar T.; Meijers, Rob; Ceol, Craig; Liu, Ching-Ti; Alexandrescu, Sanda; Wu, Catherine J.; Keskin, Derin B.; George, Rani E.; Feng, Hui

Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons 通过人类Degrons的机器学习设计细胞毒性T细胞表位

ACS CENTRAL SCIENCE

IF10.4

2024-03-06

OAAI

Truex, Nicholas L.; Mohapatra, Somesh; Melo, Mariane; Rodriguez, Jacob; Li, Na; Abraham, Wuhbet; Sementa, Deborah; Touti, Faycal; Keskin, Derin B.; Wu, Catherine J.; Irvine, Darrell J.; Gomez-Bombarelli, Rafael; Pentelute, Bradley L.

Personalized targeted circulating tumor DNA (ctDNA) and T-cell responses after combined neoantigen vaccine and immune checkpoint blockade in ovarian cancer

CANCER RESEARCH

IF16.6

2024-03-04

PREAI

Sellars, MacLean C.; Porter, Rebecca; Liu, Ruolin; Howard, Alexis A.; Xiong, Kan; Crnjac, Andela; Tayob, Nabihah; Keskin, Derin; Adalsteinsson, Vicktor; Wu, Catherine; Konstantinopoulos, Panagiotis

A tumor-associated chemokine attracts CCR4-expressing CD4+cells to foster immune repression and tumor aggressiveness in MYCN-driven neuroblastoma

MOLECULAR CANCER THERAPEUTICS

IF5.5

2023-12-01

PREAI

Qin, Xiaodan; Lam, Andrew; Zhang, Xu; Sengupta, Satyaki; Lorgulescu, J. Bryan; Das, Sanjukta; Zhou, Zhenwei; Zuo, Tao; Meara, Grace K.; Rager, Madison; Floru, Alexander E.; Ni, Hongru; Kemet, Chinyere; Veerapaneni, Divya; Kashy, Daniel; Lin, Liang; Lloyd, Kenneth; Kwok, Lauren; Smith, Kaylee S.; Nagaraju, Raghavendar T.; Meijers, Rob; Ceol, Craig; Liu, Ching-Ti; Alexandrescu, Sanda; Wu, Catherine J.; Keskin, Derin B.; George, Rani E.; Feng, Hui

Integrated Immunopeptidomic and Proteomic Analysis of COVID-19 lung biopsies

FRONTIERS IN IMMUNOLOGY

IF5.9

2023-10-20

OAAI

Yin, Shanye; Klaeger, Susan; Chea, Vipheaviny A.; Carulli, Isabel P.; Rachimi, Suzanna; Black, Katharine E.; Filbin, Michael; Hariri, Lida P.; Knipe, Rachel S.; Padera, Robert F.; Stevens, Jonathan D.; Lane, William J.; Carr, Steven A.; Wu, Catherine J.; Kim, Edy Yong; Keskin, Derin B.

The BRD4-NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma

CANCER RESEARCH

IF16.6

2023-10-11

OAAI

Durall, R. Taylor; Huang, Julianna; Wojenski, Luke; Huang, Yeying; Gokhale, Prafulla C.; Leeper, Brittaney A.; Nash, Joshua O.; Ballester, Pedro L.; Davidson, Scott; Shlien, Adam; Sotirakis, Emmanuel; Bertaux, Fabien; Dubus, Vincent; Luo, Jia; Wu, Catherine J.; Keskin, Derin B.; Eagen, Kyle P.; Shapiro, Geoffrey I.; French, Christopher A.

Tumor-specific immunity generated by a personalized neoantigen vaccination incorporating locally delivered ipilimumab in renal cell carcinoma.

CANCER RESEARCH

IF16.6

2023-08-15

PREAI

Braun, David A.; Keskin, Derin B.; Shukla, Sachet A.; McGregor, Bradley A.; Schindler, Nicholas R.; Blass, Eryn; Klaeger, Susan; Pomerance, Lucas; Sarkizova, Siranush; Li, Shuqiang; Southard, Jackson; Moranzoni, Giorgia; Pedersen, Christina B.; Liu, Yiwen; Chang, Steven L.; Hirsch, Michelle S.; LeBoeuf, Nicole R.; Mossanen, Matthew; Chea, Vipheaviny; Carulli, Isabel; Olive, Oriol; Mehndiratta, Ambica; Greenslade, Haley; Oliveira, Giacomo; Iorgulescu, J. Bryan; Signoretti, Sabina; Aster, Jon C.; Elagina, Liudmila; Leshchiner, Ignaty; Getz, Gad; Harden, Maegan; Gabriel, Stacey; Olsen, Lars R.; Neuberg, Donna S.; Fritsch, Edward F.; Hacohen, Nir; Livak, Kenneth J.; Carr, Steven; Ott, Patrick A.; Wu, Catherine J.; Choueiri, Toni K.

Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy (vol 37, 109992, 2021)

CELL REPORTS

IF6.9

2023-08-01

OAAI

Bachireddy, Pavan; Azizi, Elham; Burdziak, Cassandra; Nguyen, Vinhkhang N.; Ennis, Christina S.; Maurer, Katie; Park, Cameron Y.; Choo, Zi-Ning; Li, Shuqiang; Gohil, Satyen H.; Ruthen, Neil G.; Ge, Zhongqi; Keskin, Derin B.; Cieri, Nicoletta; Livak, Kenneth J.; Kim, Haesook T.; Neuberg, Donna S.; Soiffer, Robert J.; Ritz, Jerome; Alyea, Edwin P.; Pe'er, Dana; Wu, Catherine J.

研究方向