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Markus Schirle

novartis biomedical research

52H指数
143论文数
1.9W被引数
收录论文 70
发表时间
Expanding the repertoire of chemically induced covalent neoantigens扩展化学诱导共价新抗原的多样性
err2026-07-30
err0
PREAI
errChen Zhou; Xiaokang Jin; Wei Huang; Haofeng Wu; Lynn M. McGregor; Markus Schirle; Chenlu Zhang; Xiaoyu Zhang
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Targeted Transcriptional Repression by Induced Proximity诱导邻近靶向转录抑制
err2026-06-11
err0
errOAAI
errChristian E. Stieger; Xinru Chen; Christina C. Kuismi; Dustin Dovala; Daniel Fuller; Andreas O. Frank; Mikias Woldegiorgis; Megan Bruce-Smythe; Fabian Wu; Nicolas Pizzato; Jeffrey McKenna; Cory Johannessen; Barna D. Fodor; Markus Schirle; Daniel K. Nomura
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Discovery of EGT710; an Oral Nonpeptidomimetic Reversible Covalent SARS-CoV-2 Main Protease InhibitorEGT710的发现:一种口服非肽类拟似可逆共价SARS-CoV-2主蛋白酶抑制剂
err2026-02-09
err0
PREAI
errJulien P. N. Papillon; Jun Yuan; Matthew J. Hesse; Lei Zhang; Richard I. Robinson; Nathaniel F. Ware; Viktor Hornak; Rajeshri G. Karki; Tom Kirrane; Keira Garland; Sajan Joseph; Stephanie A. Moquin; Suresh B. Lakshminarayana; Laura Tandeske; Dustin Dovala; Mark Knapp; Elizabeth Ornelas; Daniel Fuller; Pei-i Ho; Xuping Xie; Katarina Vulic; Suzanne M. Skolnik; Jinhai Gao; Mark Zambrowski; Meike Spiess; José S. Duca; Scott A. Busby; Markus Schirle; Michael Robinson; Pei-Yong Shi; Heinz E. Moser; Christopher Sarko; James E. Bradner; Thierry T. Diagana; John A. Tallarico
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Sulfinyl Aziridines as Stereoselective Covalent Destabilizing Degraders of the Oncogenic Transcription Factor MYC亚砜基偶氮环丙烷作为致癌转录因子MYC的立体选择性共价失稳降解剂
err2025-09-25
err0
PREAI
errHannah T. Rosen; Kelvin Li; Christian E. Stieger; Erin L. Li; Brynne Currier; Scott M. Brittain; Francisco J. Garcia; Diana C. Beard; Michael D. Jones; Sandra Haenni-Holzinger; Dustin Dovala; Jeffrey M. McKenna; Markus Schirle; Thomas J. Maimone; Daniel K. Nomura
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Light-Activated Reactivity of Nitrones with Amino Acids and Proteins
err2024-11-22
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errOAAI
errSkakuj, Kacper; Iglhaut, Maximilian; Shao, Qian; Garcia, Francisco J.; Huang, Bo-Yang; Brittain, Scott M.; Nesvizhskii, Alexey I.; Schirle, Markus; Nomura, Daniel K.; Toste, F. Dean
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DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance (vol 15, 275, 2024)
err2024-08-19
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errOAAI
errSchroeder, Martin; Renatus, Martin; Liang, Xiaoyou; Meili, Fabian; Zoller, Thomas; Ferrand, Sandrine; Gauter, Francois; Li, Xiaoyan; Sigoillot, Frederic; Gleim, Scott; Stachyra, Therese-Marie; Thomas, Jason R.; Begue, Damien; Khoshouei, Maryam; Lefeuvre, Peggy; Andraos-Rey, Rita; Chung, Boyee; Ma, Renate; Pinch, Benika; Hofmann, Andreas; Schirle, Markus; Schmiedeberg, Niko; Imbach, Patricia; Gorses, Delphine; Calkins, Keith; Bauer-Probst, Beatrice; Maschlej, Magdalena; Niederst, Matt; Maher, Rob; Henault, Martin; Alford, John; Ahrne, Erik; Tordella, Luca; Hollingworth, Greg; Thomae, Nicolas H.; Vulpetti, Anna; Radimerski, Thomas; Holzer, Philipp; Carbonneau, Seth; Thoma, Claudio R.
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Ophiobolin A Covalently Targets Mitochondrial Complex IV Leading to Metabolic Collapse in Cancer Cells
err2024-05-13
err1
PREAI
errGowans, Flor A.; Thach, Danny Q.; Zhu, Zhouyang; Wang, Yangzhi; Poblano, Belen E. Altamirano; Dovala, Dustin; Tallarico, John A.; Mckenna, Jeffrey M.; Schirle, Markus; Maimone, Thomas J.; Nomura, Daniel K.
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Enhancing the Small-Scale Screenable Biological Space beyond Known Chemogenomics Libraries with Gray Chemical Matter-Compounds with Novel Mechanisms from High-Throughput Screening Profiles
err2024-04-02
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errOAAI
errThomas, Jason R.; Shelton, Claude; Murphy, Jason; Brittain, Scott; Bray, Mark-Anthony; Aspesi, Peter; Concannon, John; King, Frederick J.; Ihry, Robert J.; Ho, Daniel J.; Henault, Martin; Hadjikyriacou, Andrea; Neri, Marilisa; Sigoillot, Frederic D.; Pham, Helen T.; Shum, Matthew; Barys, Louise; Jones, Michael D.; Martin, Eric J.; Blechschmidt, Anke; Rieffel, Sebastien; Troxler, Thomas J.; Mapa, Felipa A.; Jenkins, Jeremy L.; Jain, Rishi K.; Kutchukian, Peter S.; Schirle, Markus; Renner, Steffen
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DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
err2024-01-04
err21
errOAAI
errSchroder, Martin; Renatus, Martin; Liang, Xiaoyou; Meili, Fabian; Zoller, Thomas; Ferrand, Sandrine; Gauter, Francois; Li, Xiaoyan; Sigoillot, Frederic; Gleim, Scott; Stachyra, Therese-Marie; Thomas, Jason R.; Begue, Damien; Khoshouei, Maryam; Lefeuvre, Peggy; Andraos-Rey, Rita; Chung, Boyee; Ma, Renate; Pinch, Benika; Hofmann, Andreas; Schirle, Markus; Schmiedeberg, Niko; Imbach, Patricia; Gorses, Delphine; Calkins, Keith; Bauer-Probst, Beatrice; Maschlej, Magdalena; Niederst, Matt; Maher, Rob; Henault, Martin; Alford, John; Ahrne, Erik; Tordella, Luca; Hollingworth, Greg; Thomae, Nicolas H.; Vulpetti, Anna; Radimerski, Thomas; Holzer, Philipp; Carbonneau, Seth; Thoma, Claudio R.
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Activation of human STING by a molecular glue-like compound通过分子胶样化合物激活人类STING
err2023-10-12
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errOAAI
errLi, Jie; Canham, Stephen M.; Wu, Hua; Henault, Martin; Chen, Lihao; Liu, Guoxun; Chen, Yu; Yu, Gary; Miller, Howard R.; Hornak, Viktor; Brittain, Scott M.; Michaud, Gregory A.; Tutter, Antonin; Broom, Wendy; Digan, Mary Ellen; Mcwhirter, Sarah M.; Sivick, Kelsey E.; Pham, Helen T.; Chen, Christine H.; Tria, George S.; Mckenna, Jeffery M.; Schirle, Markus; Mao, Xiaohong; Nicholson, Thomas B.; Wang, Yuan; Jenkins, Jeremy L.; Jain, Rishi K.; Tallarico, John A.; Patel, Sejal J.; Zheng, Lianxing; Ross, Nathan T.; Cho, Charles Y.; Zhang, Xuewu; Bai, Xiao-Chen; Feng, Yan
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Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications (vol 144, pg 701, 2022)
err2023-09-14
err0
PREAI
errHenning, Nathaniel J.; Manford, Andrew G.; Spradlin, Jessica N.; Brittain, Scott M.; Zhang, Erika; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Rape, Michael; Nomura, Daniel K.
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Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control
err2023-09-01
err10
errOAAI
errGurzeler, Lukas-Adrian; Link, Marion; Ibig, Yvonne; Schmidt, Isabel; Galuba, Olaf; Schoenbett, Julian; Gasser-Didierlaurant, Christelle; Parker, Christian N.; Mao, Xiaohong; Bitsch, Francis; Schirle, Markus; Couttet, Philipp; Sigoillot, Frederic; Ziegelmueller, Jana; Uldry, Anne-Christine; Teodorowicz, Wojciech; Schmiedeberg, Niko; Muhlemann, Oliver; Reinhardt, Jurgen
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Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control (vol 42, 113056, 2023)
err2023-09-01
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errOAAI
errGurzeler, Lukas -Adrian; Link, Marion; Ibig, Yvonne; Schmidt, Isabel; Galuba, Olaf; Schoenbett, Julian; Gasser-Didierlaurant, Christelle; Parker, Christian N.; Mao, Xiaohong; Bitsch, Francis; Schirle, Markus; Couttet, Philipp; Sigoillot, Frederic; Ziegelmuller, Jana; Uldry, Anne-Christine; Teodorowicz, Wojciech; Schmiedeberg, Niko; Muhlemann, Oliver; Reinhardt, Jurgen
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Rational Chemical Design of Molecular Glue Degraders (vol 9, pg 915, 2023)
err2023-07-21
err0
errOAAI
errToriki, Ethan S.; Papatzimas, James W.; Nishikawa, Kaila; Dovala, Dustin; Frank, Andreas O.; Hesse, Matthew J.; Dankova, Daniela; Song, Jae-Geun; Bruce-Smythe, Megan; Struble, Heidi; Garcia, Francisco J.; Brittain, Scott M.; Kile, Andrew C.; McGregor, Lynn M.; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Nomura, Daniel K.
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Rational Chemical Design of Molecular Glue Degraders分子胶降解剂的合理化学设计
err2023-04-11
err58
errOAAI
errToriki, Ethan S.; Papatzimas, James W.; Nishikawa, Kaila; Dovala, Dustin; Frank, Andreas O.; Hesse, Matthew J.; Dankova, Daniela; Song, Jae-Geun; Bruce-Smythe, Megan; Struble, Heidi; Garcia, Francisco J.; Brittain, Scott M.; Kile, Andrew C.; McGregor, Lynn M.; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Nomura, Daniel K.
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Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-KB化学蛋白质组学-启用了针对nf-kb的共价分子胶降解剂的发现
err2023-04-01
err48
errOAAI
errKing, Elizabeth A.; Cho, Yoojin; Hsu, Nathan S.; Dovala, Dustin; Mckenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Nomura, Daniel K.
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Targeted Protein Degradation through E2 Recruitment通过E2募集靶向蛋白质降解
err2023-03-20
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errOAAI
errForte, Nafsika; Dovala, Dustin; Hesse, Matthew J.; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Nomura, Daniel K.
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An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4
err2022-12-09
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errOAAI
errGonzalez-Valero, Angel; Reeves, Audrey G.; Page, Annika C. S.; Moon, Patrick J.; Miller, Edward; Coulonval, Katia; Crossley, Steven W. M.; Xie, Xiao; He, Dan; Musacchio, Patricia Z.; Christian, Alec H.; McKenna, Jeffrey M.; Lewis, Richard A.; Fang, Eric; Dovala, Dustin; Lu, Yipin; McGregor, Lynn M.; Schirle, Markus; Tallarico, John A.; Roger, Pierre P.; Toste, F. Dean; Chang, Christopher J.
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Donor-Acceptor Pyridinium Salts for Photo-Induced Electron-Transfer-Driven Modification of Tryptophan in Peptides, Proteins, and Proteomes Using Visible Light
err2022-04-02
err39
errOAAI
errHoopes, Caleb R.; Garcia, Francisco J.; Sarkar, Akash M.; Kuehl, Nicholas J.; Barkan, David T.; Collins, Nicole L.; Meister, Glenna E.; Bramhall, Taylor R.; Hsu, Chien-Hsiang; Jones, Michael D.; Schirle, Markus; Taylor, Michael T.
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Deubiquitinase-targeting chimeras for targeted protein stabilization用于靶向蛋白质稳定的去泛素酶靶向嵌合体
err2022-02-24
err160
errOAAI
errHenning, Nathaniel J.; Boike, Lydia; Spradlin, Jessica N.; Ward, Carl C.; Liu, Gang; Zhang, Erika; Belcher, Bridget P.; Brittain, Scott M.; Hesse, Matthew J.; Dovala, Dustin; McGregor, Lynn M.; Misiolek, Rachel Valdez; Plasschaert, Lindsey W.; Rowlands, David J.; Wang, Feng; Frank, Andreas O.; Fuller, Daniel; Estes, Abigail R.; Randal, Katelyn L.; Panidapu, Anoohya; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Nomura, Daniel K.
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