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R

Ronald Melki

université paris-saclay and cnrs

74H指数
288论文数
2.0W被引数
收录论文 134
发表时间
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Design, Synthesis and Evaluation of the First 2-Alkynyl(aza)indole 18F Probe Targeting α-Synuclein Aggregates设计、合成及评价靶向α-突触核蛋白聚集物的首个2-炔基(氮)吲哚18F探针
errPharmaceuticals
IF4.8
err2026-03-03
err0
errOAAI
errLiliana Boiaryna; Laura Pieri; Sylvie Chalon; Sophie Serrière; Sylvie Bodard; Gabrielle Chicheri; Elisa Chenaf; Franck Suzenet; Ronald Melki; Frédéric Buron; Sylvain Routier; Johnny Vercouillie
err分享
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In vivo validation of novel non-invasive PHP.eB AAVs as a potential therapeutic approach for alpha-synucleinopathies在体验证新型非侵入性PHP.eB AAV作为α-突触核蛋白病的潜在治疗策略
errActa Neuropathologica Communications
IF5.7
err2025-09-30
err0
errOAAI
errMaria Fouka; Iraklis Tsakogias; Elena-Georgia Gialinaki; Athanasios Stavropoulos; Christiane Volbracht; Louis De Muynck; Diederik Moechars; Ronald Melki; George K. Tofaris; Leonidas Stefanis; Maria Xilouri
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α-synuclein fibrils per se but not α-synuclein seeded aggregation causes mitochondrial dysfunction and cell death in human neuronsα-synuclein纤维本身而非α-synuclein诱导的聚集会导致人类神经元中线粒体功能障碍和细胞死亡。
errRedox Biology
IF11.9
err2025-08-10
err0
PREAI
errPlamena R. Angelova; Noemi Esteras; James Evans; Marko Kostic; Ronald Melki; Jochen H.M. Prehn; Sonia Gandhi; Andrey Y. Abramov
err分享
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An approach to characterize mechanisms of action of anti-amyloidogenic compounds in vitro and in situ一种表征抗淀粉样变性化合物作用机制的方法，包括体外和原位研究。
errNPJ PARKINSONS DISEASE
IF8.2
err2025-05-10
err0
errOAAI
errStalder, P.; Serdiuk, T.; Ghosh, D.; Fleischmann, Y.; Ait-Bouziad, N.; Quast, J. -P; Malinovska, L.; Ouared, A.; Davranche, A.; Haenseler, W.; Boudou, C.; Tsika, E.; Stoehr, J.; Melki, R.; Riek, R.; de Souza, N.; Picotti, P.
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Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical useAlpha-synuclein种子扩增试验：数据共享和标准化对临床应用至关重要
errSCIENCE ADVANCES
IF12.5
err2025-04-04
err0
PREAI
errLashuel, Hilal A.; Surmeier, D. James; Simuni, Tanya; Merchant, Kalpana; Caughey, Byron; Soto, Claudio; Fares, Mohamed-Bilal; Heym, Roland G.; Melki, Ronald
err分享
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Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes
errNEURON
IF15
err2024-09-01
err6
errOAAI
errScheiblich, Hannah; Eikens, Frederik; Wischhof, Lena; Opitz, Sabine; Juengling, Kay; Cserep, Csaba; Schmidt, Susanne, V; Lambertz, Jessica; Bellande, Tracy; Posfai, Balazs; Geck, Charlotte; Spitzer, Jasper; Odainic, Alexandru; Castro-Gomez, Sergio; Schwartz, Stephanie; Boussaad, Ibrahim; Kruger, Frejko; Glaab, Enrico; Di Monte, Donato A.; Bano, Daniele; Denes, Adam; Latz, Eike; Melki, Ronald; Pape, Hans-Christian; Heneka, Michael T.
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Neuromodulation modifies α-synuclein spreading dynamics in vivo and the pattern is predicted by changes in whole-brain function
errBRAIN STIMULATION
IF8.4
err2024-07-01
err0
errOAAI
errDadgar-Kiani, Ehsan; Bieri, Gregor; Melki, Ronald; Hossain, Aronee; Gitler, Aaron D.; Lee, Jin Hyung
err分享
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Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis
errMOVEMENT DISORDERS
IF7.6
err2024-06-30
err4
errOAAI
errBurre, Jacqueline; Edwards, Robert H.; Halliday, Glenda; Lang, Anthony E.; Lashuel, Hilal A.; Melki, Ronald; Murayama, Shigeo; Outeiro, Tiago F.; Papa, Stella M.; Stefanis, Leonidas; Woerman, Amanda L.; Surmeier, Dalton James; Kalia, Lorraine V.; Takahashi, Ryosuke
err分享
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Aptamer binding footprints discriminate α-synuclein fibrillar polymorphs from different synucleinopathies
errNUCLEIC ACIDS RESEARCH
IF13.1
err2024-06-25
err0
errOAAI
errBouvier-Mueller, Alix; Fourmy, Deborah; Fenyi, Alexis; Bousset, Luc; Melki, Ronald; Duconge, Frederic
err分享
err收藏
Alpha-synuclein aggregates are phosphatase resistant
errACTA NEUROPATHOLOGICA COMMUNICATIONS
IF5.7
err2024-05-31
err1
errOAAI
errChoi, S. G.; Tittle, T.; Garcia-Prada, D.; Kordower, J. H.; Melki, R.; Killinger, B. A.
err分享
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Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy
errNPJ PARKINSONS DISEASE
IF8.2
err2024-05-21
err0
errOAAI
errWalton, Sara; Fenyi, Alexis; Tittle, Tyler; Sidransky, Ellen; Pal, Gian; Choi, Solji; Melki, Ronald; Killinger, Bryan A.; Kordower, Jeffrey H.
err分享
err收藏
Ligand Profiling as a Diagnostic Tool to Differentiate Patient-Derived α-Synuclein Polymorphs
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2024-05-01
err1
errOAAI
errChisholm, Timothy S.; Melki, Ronald; Hunter, Christopher A.
err分享
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Parkinson's disease-derived α-synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotype
errJOURNAL OF NEUROINFLAMMATION
IF10.1
err2024-02-21
err8
errOAAI
errYildirim-Balatan, Cansu; Fenyi, Alexis; Besnault, Pierre; Gomez, Lina; Sepulveda-Diaz, Julia E.; Michel, Patrick P.; Melki, Ronald; Hunot, Stephane
err分享
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Kinetic models reveal the interplay of protein production and aggregation
errCHEMICAL SCIENCE
IF7.4
err2024-01-01
err0
errOAAI
errWei, Jiapeng; Meisl, Georg; Dear, Alexander; Oosterhuis, Matthijs; Melki, Ronald; Emanuelsson, Cecilia; Linse, Sara; Knowles, Tuomas P. J.
err分享
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Synapses do not facilitate prion-like transfer of alpha-synuclein: a quantitative study in reconstructed unidirectional neural networks
errCELLULAR AND MOLECULAR LIFE SCIENCES
IF6.2
err2023-09-09
err5
errOAAI
errCourte, Josquin; Le, Ngoc Anh; Pan, Teng; Bousset, Luc; Melki, Ronald; Villard, Catherine; Peyrin, Jean-Michel
err分享
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a-Synuclein liquid condensates fuel fibrillar a-synuclein growtha-突触核蛋白液体冷凝物燃料原纤维a-突触核蛋白生长
errSCIENCE ADVANCES
IF12.5
err2023-08-18
err10
errOAAI
errPiroska, Leonard; Fenyi, Alexis; Thomas, Scott; Plamont, Marie-Aude; Redeker, Virginie; Melki, Ronald; Gueroui, Zoher
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Differential intracellular trafficking of extracellular vesicles in microglia and astrocytes小胶质细胞和星形胶质细胞中细胞外囊泡的差异细胞内运输
errCELLULAR AND MOLECULAR LIFE SCIENCES
IF6.2
err2023-06-30
err11
errOAAI
errPantazopoulou, Marina; Lamprokostopoulou, Agaristi; Karampela, Dimitra Sotiria; Alexaki, Anastasia; Delis, Anastasios; Coens, Audrey; Samiotaki, Martina; Kriebardis, Anastasios G.; Melki, Ronald; Pagakis, Stamatis N.; Stefanis, Leonidas; Vekrellis, Kostas
err分享
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AAV-mediated expression of a new conformational anti-aggregated α-synuclein antibody prolongs survival in a genetic model of α-synucleinopathies
errNPJ PARKINSONS DISEASE
IF8.2
err2023-06-15
err1
errOAAI
errDuechs, Matthias; Blazevic, Dragica; Rechtsteiner, Philipp; Kenny, Cynthia; Lamla, Thorsten; Low, Sarah; Savistchenko, Jimmy; Neumann, Manuela; Melki, Ronald; Schoenberger, Tanja; Stierstorfer, Birgit; Wyatt, David; Igney, Frederik; Ciossek, Thomas
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Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates注射不同的 α-突触核蛋白菌株引起的功能和神经病理变化: 非人类灵长类动物的初步研究
errNEUROBIOLOGY OF DISEASE
IF5.6
err2023-05-01
err7
errOAAI
errFayard, Audrey; Fenyi, Alexis; Lavisse, Sonia; Dovero, Sandra; Bousset, Luc; Bellande, Tracy; Lecourtois, Sophie; Jouy, Christophe; Guillermier, Martine; Jan, Caroline; Gipchtein, Pauline; Dehay, Benjamin; Bezard, Erwan; Melki, Ronald; Hantraye, Philippe; Badin, Romina Aron
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Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy (vol 12, 159, 2020)
errALZHEIMERS RESEARCH & THERAPY
IF7.6
err2023-01-21
err1
errOAAI
errNimmo, Jacqui T.; Verma, Ajay; Dodart, Jean-Cosme; Wang, Chang Yi; Savistchenko, Jimmy; Melki, Ronald; Carare, Roxana O.; Nicoll, James A. R.
err分享
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研究方向

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