Derek M. Dykxhoorn - Publications, H-index & Citations

Derek M. Dykxhoorn

university of miami

43H指数

217论文数

1.3W被引数

收录论文 62

发表时间

Disrupted lipid homeostasis as a pathogenic mechanism in ABCA7-associated Alzheimer's disease risk ABCA7相关阿尔茨海默病风险中的脂质稳态紊乱作为致病机制

alzheimer's & dementia

IF0

2026-03-30

OAAI

Younji Nam; Brooke A. DeRosa; Aura M. Ramirez; Biniyam A. Ayele; Patrice Whitehead-Gay; Larry D. Adams; Charles G. Golightly; Takiyah D. Starks; Mayra Juliana Laverde-Paz; Holly N. Cukier; Rufus Akinyemi; Fred Sarfo; Albert Akpalu; Michael L. Cuccaro; Scott M. Williams; Allison Caban-Holt; Christiane Reitz; Jonathan L. Haines; Goldie S. Byrd; Farid Rajabli; Derek M. Dykxhoorn; Juan I. Young; Jeffery M. Vance; Margaret A. Pericak-Vance

Generation of two isogenic induced pluripotent stem cell lines derived from a Hispanic individual with Alzheimer's Disease and mosaic for loss of the Y chromosome 源自一名患有阿尔茨海默病的西班牙裔个体的两条同基因诱导多能干细胞系，且呈Y染色体丢失嵌合状态

Stem Cell Research

IF0.7

2025-12-01

OAAI

Cukier, Holly N.; Derosa, Brooke A.; Coombs, Lauren E.; Tang, Eugene; Leyva, Denise R.; Lazzaro, Ainnara R.; Gu, Esther; Dykxhoorn, Derek M.; Haines, Jonathan L.; Pericak-Vance, Margaret A.; Song, Yeunjoo E.; Bush, William S.; Griswold, Anthony J.

Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease 少突胶质细胞的祖先基因组功能差异：对阿尔茨海默病的意义

Alzheimer's & Dementia

IF11.1

2025-09-12

PREAI

Aura M. Ramirez; Luciana Bertholim Nasciben; Sofia Moura; Lauren Coombs; Farid Rajabli; Brooke A. DeRosa; Patrice L. Whitehead; Larry D. Adams; Takiyah D. Starks; Pedro R. Mena; Maryenela Illanes-Manrique; Sergio Tejada; Goldie S. Byrd; Allison Caban-Holt; Michael L Cuccaro; Katalina McInerney; Mario R. Cornejo-Olivas; Briseida E. Feliciano-Astacio; Liyong Wang; Maria C. Robayo; Wanying Xu; Fulai Jin; Margaret A. Pericak-Vance; Anthony J. Griswold; Juan I. Young; Derek M. Dykxhoorn; Jeffery M. Vance

Integrator promotes the association of TFIID and RNA polymerase II to maintain pluripotency during development Integrator促进TFIID和RNA聚合酶II的关联，以维持发育过程中的多能性。

Molecular Cell

IF16.6

2025-08-07

PREAI

Raghu Ram Edupuganti; Felipe Beckedorff; Pradeep Kumar Reddy Cingaram; Saeid Mohammad Parast; Jingyin Yue; Gary LeRoy; Monica Guiselle Valencia; Sadat Dokaneheifard; Helena Gomes Dos Santos; Omar Lopez Ocejo; Mingjiang Xu; Brooke A. DeRosa; Derek M. Dykxhoorn; Guilherme Miura Lavezzo; Daniel Bilbao; Danny Reinberg; Lluis Morey; Ali Shilatifard; Ramin Shiekhattar

Exploring potential mechanisms of an African protective locus for Alzheimer's disease in APOEε4 carriers 探索APOEε4携带者中非洲保护性位点对阿尔茨海默病的潜在机制

Alzheimer's & Dementia

IF11.1

2025-07-24

OAAI

Luciana Bertholim-Nasciben; Karen Nuytemans; Derek Van Booven; Farid Rajabli; Sofia Moura; Aura M. Ramirez; Griffin S. Parker; Derek M. Dykxhoorn

MicroRNA-29c-3p and-126a Contribute to the Decreased Angiogenic Potential of Aging Endothelial Progenitor Cells MicroRNA-29c-3p和-126a参与衰老内皮祖细胞血管生成潜能的降低

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IF4.9

2025-04-30

OAAI

Dykxhoorn, Derek M.; Ferreira, Andrea Da Fonseca; Gomez, Karenn; Shi, Jianjun; Zhu, Shoukang; Zhang, Lukun; Wang, Huilan; Wei, Jianqin; Zhang, Qianhuan; Macon, Conrad J.; Hare, Joshua M.; Marzouka, George R.; Wang, Liyong; Dong, Chunming

Interactions among Merlin, Arkadia, and SKOR2 mediate NF2-associated human Schwann cell proliferation Merlin、Arkadia 和 SKOR2 之间的相互作用介导 NF2 相关的人类施万细胞增殖

STEM CELL RESEARCH & THERAPY

IF7.3

2025-04-05

OAAI

Tang, Pei-Ciao; Um, Seyoung; Mayfield, Anderson B.; Bracho, Olena R.; Castillo, Christian Del; Dinh, Christine T.; Dykxhoorn, Derek M.; Liu, Xue Zhong

The conductance of KCNQ2 and its pathogenic variants is determined by individual subunit gating KCNQ2及其致病性变异体的电导由单个亚基门控决定。

SCIENCE ADVANCES

IF12.5

2025-03-07

OAAI

Hinojo-Perez, Andy; Eldstrom, Jodene; Dou, Ying; Marinho-Alcara, Allan; Edmond, Michaela A.; de la Cruz, Alicia; Rodriguez, Marta E. Perez; Diaz-Solares, Maykelis; Dykxhoorn, Derek M.; Fedida, David; Barro-Soria, Rene

Comparing Alzheimer's genes in African, European, and Amerindian induced pluripotent stem cell-derived microglia 比较非洲、欧洲和美洲原住民诱导多能干细胞来源的小胶质细胞中的阿尔茨海默症基因

ALZHEIMERS & DEMENTIA

IF11.1

2025-02-26

OAAI

Moura, S; Nasciben, LB; Ramirez, AM; Coombs, L; Rivero, J; Van Booven, DJ; Derosa, BA; Hamilton-Nelson, KL; Whitehead, PL; Adams, LD; Starks, TD; Mena, PR; Illanes-Manrique, M; Tejada, S; Byrd, GS; Cornejo-Olivas, MR; Feliciano-Astacio, BE; Nuytemans, K; Wang, LY; Pericak-Vance, MA; Dykxhoorn, DM; Rajabli, F; Griswold, AJ; Young, JI; Vance, JM

Editorial: Prescription digital therapeutics in psychiatry

FRONTIERS IN PSYCHIATRY

IF3.2

2025-01-10

OAAI

Colbert, Brett M.; Dykxhoorn, Derek M.; Lakhan, Shaheen

Human organoids for rapid validation of gene variants linked to cochlear malformations

HUMAN GENETICS

IF3.6

2025-01-09

OAAI

Zafeer, Mohammad Faraz; Ramzan, Memoona; Duman, Duygu; Mutlu, Ahmet; Seyhan, Serhat; Kalcioglu, M. Tayyar; Fitoz, Suat; Derosa, Brooke A.; Guo, Shengru; Dykxhoorn, Derek M.; Tekin, Mustafa

Post-stroke hippocampal neurogenesis is impaired by microvascular dysfunction and PI3K signaling in cerebral amyloid angiopathy

CELL REPORTS

IF6.9

2024-10-01

OAAI

Osborne, Olivia M.; Daftari, Manav; Naranjo, Oandy; Johar, Adarsh N.; Brooks, Samantha; Colbert, Brett M.; Torices, Silvia; Lewis, Elizabeth; Sendaydiego, Jet; Drexler, Gillian; Bashti, Malek; Margetts, Alexander V.; Tuesta, Luis M.; Mason, Christian; Bilbao, Daniel; Vontell, Regina; Griswold, Anthony J.; Dykxhoorn, Derek M.; Toborek, Michal

Lipophilic compounds restore function to neurodevelopmental-associated KCNQ3 mutations

COMMUNICATIONS BIOLOGY

IF5.1

2024-09-19

OAAI

Edmond, Michaela A.; Hinojo-Perez, Andy; Efrem, Mekedlawit; Yi-Chun, Lin; Shams, Iqra; Hayoz, Sebastien; de la Cruz, Alicia; Rodriguez, Marta E. Perez; Diaz-Solares, Maykelis; Dykxhoorn, Derek M.; Luo, Yun Lyna; Barro-Soria, Rene

Investigating HLA-DRB1 genotypes as contributing risk factors for Staphylococcus aureus bacteremia

HUMAN IMMUNOLOGY

IF2.2

2024-09-01

PREAI

Kair, J.; Tao, Y.; Hung, F.; Drabik, A.; Harnois, M.; Scott, W.; Dykxhoorn, D.; Ruffin, F.; Chan, C.; Fowler, V.; Jackson, A.

The natural history and genotype-phenotype correlations of TMPRSS3 hearing loss: an international, multi-center, cohort analysis

HUMAN GENETICS

IF3.6

2024-04-30

OAAI

Colbert, Brett M.; Lanting, Cris; Smeal, Molly; Blanton, Susan; Dykxhoorn, Derek M.; Tang, Pei-Ciao; Getchell, Richard L.; Velde, Hedwig; Fehrmann, Mirthe; Thorpe, Ryan; Chapagain, Prem; Elkhaligy, Heidy; Kremer, Hannie; Yntema, Helger; Haer-Wigman, Lonneke; Redfield, Shelby; Sun, Tieqi; Bruijn, Saskia; Plomp, Astrid; Goderie, Thade; van de Kamp, Jiddeke; Free, Rolien H.; Wassink-Ruiter, Jolien Klein; Widdershoven, Josine; Vanhoutte, Els; Rotteveel, Liselotte; Kriek, Marjolein; van Dooren, Marieke; Hoefsloot, Lies; de Gier, Heriette H. W.; Aten, E.; Widdershoven, J. C. C.; Hof, J. R.; Hellingman, K.; Vernimmen, V.; Kremer, H.; Pennings, R. J. E.; Feenstra, I.; Lanting, C. P.; Yntema, H. G.; Cals, F. L. J.; Haer-Wigman, L.; Free, R. H.; Wassink-Ruiter, J. S. Klein; Smit, A. L.; van den Boogaard, M. J.; Lachmeier, A. M. A.; Smits, J. J.; Ebbens, F. A.; Maas, S. M.; Plomp, A.; Goderie, T. P. M.; Merkus, P.; van de Kamp, J.; Schaefer, Amanda; Kolbe, Diana; Azaiez, Hela; Rabie, Grace; Aburayyan, Armal; Kawas, Mariana; Kanaan, Moien; Holder, Jourdan; Usami, Shin-ichi; Chen, Zhengyi; Dai, Pu; Holt, Jeffrey; Nelson, Rick; Choi, Byung Yoon; Shearer, Eliot; Smith, Richard J. H.; Pennings, Ronald; Liu, Xue Zhong

An Alzheimer's disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons

NEUROBIOLOGY OF AGING

IF3.5

2023-11-01

OAAI

Cukier, Holly N.; Duarte, Carolina L.; Laverde-Paz, Mayra J.; Simon, Shaina A.; Van Booven, Derek J.; Miyares, Amanda T.; Whitehead, Patrice L.; Hamilton-Nelson, Kara L.; Adams, Larry D.; Carney, Regina M.; Cuccaro, Michael L.; Vance, Jeffery M.; Pericak-Vance, Margaret A.; Griswold, Anthony J.; Dykxhoorn, Derek M.

Sustained Small Interfering RNA-Mediated Human Immunodeficiency Virus Type 1 Inhibition in Primary Macrophages (vol 77, pg 7174, 2003)

JOURNAL OF VIROLOGY

IF3.8

2023-10-31

OAAI

Song, Erwei; Lee, Sang-Kyung; Dykxhoorn, Derek M.; Novina, Carl; Zhang, Dong; Crawford, Keith; Cerny, Jan; Sharp, Phillip A.; Lieberman, Judy; Manjunath, N.; Shankar, Premlata

ALZHEIMERS & DEMENTIA

IF11.1

2023-04-10

PREAI

Celis, Katrina; Moreno, Maria D. M. Muniz; Rajabli, Farid; Whitehead, Patrice; Hamilton-Nelson, Kara; Dykxhoorn, Derek M.; Nuytemans, Karen; Wang, Liyong; Flanagan, Margaret; Weintraub, Sandra; Geula, Changiz; Gearing, Marla; Dalgard, Clifton L.; Jin, Fulai; Bennett, David A.; Schuck, Theresa; Pericak-Vance, Margaret A.; Griswold, Anthony J.; Young, Juan I.; Vance, Jeffery M.

Downregulation of SOCS1 increases interferon-induced ISGylation during differentiation of induced-pluripotent stem cells to hepatocytes

JHEP REPORTS

IF7.5

2022-12-01

OAAI

Edwards, Jasmine S.; Delabat, Stephanie A.; Badilla, Alejandro D.; DiCaprio, Robert C.; Hyun, Jinhee; Burgess, Robert A.; Silva, Tiago; Dykxhoorn, Derek M.; Chen, Steven Xi; Wang, Lily; Ishida, Yuji; Saito, Takeshi; Thomas, Emmanuel

A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry

PLOS GENETICS

IF3.7

2022-07-05

OAAI

Rajabli, Farid; Beecham, Gary W.; Hendrie, Hugh C.; Baiyewu, Olusegun; Ogunniyi, Adesola; Gao, Sujuan; Kushch, Nicholas A.; Lipkin-Vasquez, Marina; Hamilton-Nelson, Kara L.; Young, Juan I.; Dykxhoorn, Derek M.; Nuytemans, Karen; Kunkle, Brian W.; Wang, Liyong; Jin, Fulai; Liu, Xiaoxiao; Feliciano-Astacio, Briseida E.; Schellenberg, Gerard D.; Dalgard, Clifton L.; Griswold, Anthony J.; Byrd, Goldie S.; Reitz, Christiane; Cuccaro, Michael L.; Haines, Jonathan L.; Pericak-Vance, Margaret A.; Vance, Jeffery M.

研究方向