Brian D. Strahl - Publications, H-index & Citations

Brian D. Strahl

university of north carolina at chapel hill

74H指数

380论文数

3.4W被引数

收录论文 143

发表时间

Discovery of Small-Molecule Antagonists of PHF1 and 19 Demonstrates the Ligandability of PRC2 Accessory Proteins PHF1和19的小分子拮抗剂的发现表明了PRC2附属蛋白的配体可结合性

ACS Bio & Med Chem Au

IF4.3

2026-03-02

OAAI

Isabelle E. Amick; Rebecca L. Johnson; Jiuyang Liu; Cameron R. Bussey-Sutton; Ikeer Y. Mancera-Ortiz; Jacqueline L. Norris-Drouin; Shelton R. Boyd; Stephanie H. Cholensky; Cathy J. Spangler; Robert K. McGinty; Brian D. Strahl; Tatiana G. Kutateladze; Stephen V. Frye; Lindsey I. James

HMGN1 and HMGN2 are recruited to acetylated and histone variant H2A.Z-containing nucleosomes to regulate chromatin state and transcription HMGN1和HMGN2被招募到乙酰化和含有组蛋白变体H2A.Z的核小体上，以调节染色质状态和转录。

Journal of Biological Chemistry

IF3.9

2025-11-29

OAAI

Riya Gohil; Zhihan Gao; Rebecca A. Lewis; Nathaniel T. Burkholder; Brian D. Strahl; Jill M. Dowen

A needed nomenclature for nucleosomes 核小体所需的命名法

Molecular Cell

IF16.6

2025-10-02

PREAI

Michael-Christopher Keogh; Genevieve Almouzni; Andrew J. Andrews; Karim-Jean Armache; Cheryl H. Arrowsmith; Sung Hee Baek; Mark T. Bedford; Emily Bernstein; Jacques Côté; Yael David; John M. Denu; Beat Fierz; Benjamin A. Garcia; Karen C. Glass; Or Gozani; Kristian Helin; Steven Henikoff; Ole N. Jensen; Steven Z. Josefowicz; Neil L. Kelleher; Tatiana G. Kutateladze; Herbert H. Lindner; Chao Lu; Karolin Luger; Parag Mallick; Catherine A. Musselman; Tom W. Muir; Ljiljana Paša-Tolić; Robert Schneider; Xiaobing Shi; Yang Shi; Simone Sidoli; Lloyd M. Smith; Jessica K. Tyler; Cynthia Wolberger; Jerry L. Workman; Brian D. Strahl; Nicolas L. Young

SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model, and its catalytic activity is regulated by histone acetylation SETD2抑制KRASG12C驱动的肺癌模型中的肿瘤发生，并且其催化活性受组蛋白乙酰化的调控。

ELIFE

IF0

2025-09-15

OAAI

Mack, Ricardo J.; Flores, Natasha M.; Fox, Geoffrey C.; Dong, Hanyang; Cebeci, Metehan; Hausmann, Simone; Chasan, Tourkian; Dowen, Jill M.; Strahl, Brian D.; Mazur, Pawel K.; Gozani, Or

A SETD2–CDK1–lamin axis maintains nuclear morphology and genome stability SETD2–CDK1–lamin轴维持细胞核形态和基因组稳定性

Nature Cell Biology

IF19.1

2025-08-11

PREAI

Abid Khan; Cheng Zhang; Phu G. Nguyen; James M. Metts; Lucas C. Collins; Kanishk Jain; C. Allie Mills; Logan Vlach; Kelin Li; Amanda L. Brademeyer; Brittany M. Bowman; Michael B. Major; Jeffrey Aubé; Laura E. Herring; W. Kimryn Rathmell; Frank M. Mason; Ian J. Davis; Qing Zhang; Brian D. Strahl

Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response PHRF1的PHD finger对组蛋白H3 N末端的识别对于正常的DNA损伤应答是必需的。

NUCLEIC ACIDS RESEARCH

IF13.1

2025-07-22

PREAI

Jain, Kanishk; Tchara, Pata-Eting Kougnassoukou; Khan, Abid; Mengistalem, Amanuel B.; Holland, Aidan P.; Bowman, Christopher N.; Marunde, Matthew R.; Engel, Tiffany A.; Popova, Irina K.; Cooke, Spencer W.; Krajewski, Krzysztof; Keogh, Michael-Christopher; Lambert, Jean-Philippe; Strahl, Brian D.

Written in chromatin: The enduring legacy of C. David Allis 染色质中的书写：C. David Allis的持久遗产

Journal of Biological Chemistry

IF3.9

2025-07-01

OAAI

Brian D. Strahl; Gang Greg Wang

Spt6-Spn1 interaction is required for RNA polymerase II association and precise nucleosome positioning along transcribed genes Spt6-Spn1相互作用对于RNA聚合酶II的结合以及转录基因上精确核小体定位是必需的。

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2025-05-01

OAAI

Chen, Boning; Dronamraju, Raghuvar; Smith-Kinnaman, Whitney R.; Justice, Sarah A. Peck; Hepperla, Austin J.; Macalpine, Heather K.; Simon, Jeremy M.; Mosley, Amber L.; MacAlpine, David M.; Strahl, Brian D.

H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium H3K36甲基化调控肠道上皮细胞的可塑性和再生。

NATURE CELL BIOLOGY

IF19.1

2025-01-08

PREAI

Pashos, Alison R. S.; Meyer, Anne R.; Bussey-Sutton, Cameron; O'Connor, Erin S.; Coradin, Mariel; Coulombe, Marilyne; Riemondy, Kent A.; Potlapelly, Sanjana; Strahl, Brian D.; Hansson, Gunnar C.; Dempsey, Peter J.; Brumbaugh, Justin

Histone H3K18 & H3K23 acetylation directs establishment of MLL-mediated H3K4 methylation

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-08-01

OAAI

Fox, Geoffrey C.; Poncha, Karl F.; Smith, B. Rutledge; van der Maas, Lara N.; Robbins, Nathaniel N.; Graham, Bria; Dowen, Jill M.; Strahl, Brian D.; Young, Nicolas L.; Jain, Kanishk

Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex

NATURE COMMUNICATIONS

IF15.7

2024-06-24

OAAI

Nguyen, Minh Chau; Rostamian, Hosein; Raman, Ana; Wei, Pengcheng; Becht, Dustin C.; Erbse, Annette H.; Klein, Brianna J.; Gilbert, Tonya M.; Zhang, Gongyi; Blanco, M. Andres; Strahl, Brian D.; Taverna, Sean D.; Kutateladze, Tatiana G.

The histone methyltransferase SETD2 regulates HIV expression and latency

PLOS PATHOGENS

IF4.9

2024-06-07

OAAI

Bussey-Sutton, Cameron R.; Ward, Airlie; Fox, Joshua A.; Turner, Anne-Marie W.; Peterson, Jackson J.; Emery, Ann; Longoria, Arturo R.; Gomez-Martinez, Ismael; Jones, Corbin; Hepperla, Austin; Margolis, David M.; Strahl, Brian D.; Browne, Edward P.

Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment 相关单分子晶格光片成像揭示核小体与局部染色质环境之间的动态关系

NATURE COMMUNICATIONS

IF15.7

2024-05-16

OAAI

Daugird, Timothy A.; Shi, Yu; Holland, Katie L.; Rostamian, Hosein; Liu, Zhe; Lavis, Luke D.; Rodriguez, Joseph; Strahl, Brian D.; Legant, Wesley R.

Chromatin mechanisms and genome maintenance functions of histone code writers 组蛋白编码编写器的染色质机制和基因组维持功能

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-03-01

OAAI

Strahl, Brian

Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation 组蛋白甲基转移酶G9a在慢性炎症翻译调控中的非经典功能

CELL CHEMICAL BIOLOGY

IF7.2

2023-12-01

OAAI

Muneer, Adil; Wang, Li; Xie, Ling; Zhang, Feng; Wu, Bing; Mei, Liu; Lenarcic, Erik M.; Feng, Emerald Hillary; Song, Juan; Xiong, Yan; Yu, Xufen; Wang, Charles; Jain, Kanishk; Strahl, Brian D.; Cook, Jeanette Gowen; Wan, Yisong Y.; Moorman, Nathaniel John; Song, Hongjun; Jin, Jian; Chen, Xian

SETD2 safeguards the genome against isochromosome formation

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-09-18

OAAI

Mason, Frank M.; Kounlavong, Emily S.; Tebeje, Anteneh T.; Dahiya, Rashmi; Guess, Tiffany; Khan, Abid; Vlach, Logan; Norris, Stephen R.; Lovejoy, Courtney A.; Dere, Ruhee; Strahl, Brian D.; Ohi, Ryoma; Ly, Peter; Walker, Cheryl Lyn; Rathmell, W. Kimryn

The bromo-adjacent homology domains of PBRM1 associate with histone tails and contribute to PBAF-mediated gene regulation

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-08-01

OAAI

Petell, Christopher J.; Burkholder, Nathaniel T.; Ruiz, Paloma A.; Skela, Jessica; Foreman, Jake R.; Southwell, Lauren E.; Temple, Brenda R.; Krajewski, Krzysztof; Strahl, Brian D.

Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4 (vol 9, 51, 2023)

CELL DISCOVERY

IF12.5

2023-06-30

OAAI

Chen, Zhenzhen; Lundy, Taylor; Zhu, Zhongliang; Hoskins, Victoria E. E.; Zhang, Jiahai; Yao, Xuebiao; Strahl, Brian D. D.; Xu, Chao

Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4

CELL DISCOVERY

IF12.5

2023-05-26

OAAI

Chen, Zhenzhen; Lundy, Taylor; Zhu, Zhongliang; Hoskins, Victoria E.; Zhang, Jiahai; Yao, Xuebiao; Strahl, Brian D.; Xu, Chao

An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

ELIFE

IF0

2023-05-19

OAAI

Jain, Kanishk; Marunde, Matthew R.; Burg, Jonathan M.; Gloor, Susan L.; Joseph, Faith M.; Poncha, Karl F.; Gillespie, Zachary B.; Rodriguez, Keli L.; Popova, Irina K.; Hall, Nathan W.; Vaidya, Anup; Howard, Sarah A.; Taylor, Hailey F.; Mukhsinova, Laylo; Onuoha, Ugochi C.; Patteson, Emily F.; Cooke, Spencer W.; Taylor, Bethany C.; Weinzapfel, Ellen N.; Cheek, Marcus A.; Meiners, Matthew J.; Fox, Geoffrey C.; Namitz, Kevin E. W.; Cowles, Martis W.; Krajewski, Krzysztof; Sun, Zu-Wen; Cosgrove, Michael S.; Young, Nicolas L.; Keogh, Michael-Christopher; Strahl, Brian D.

研究方向